4 Works

Data from: Publication and reporting of clinical trial results: cross sectional analysis across academic medical centers

Ruijun Chen, Nihar R. Desai, Joseph S. Ross, Weiwei Zhang, Katherine H. Chau, Brian Wayda, Karthik Murugiah, Daniel Y. Lu, Amit Mittal & Harlan M. Krumholz
Objective: To determine rates of publication and reporting of results within two years for all completed clinical trials registered in ClinicalTrials.gov across leading academic medical centers in the United States. Design: Cross sectional analysis. Setting: Academic medical centers in the United States. Participants: Academic medical centers with 40 or more completed interventional trials registered on ClinicalTrials.gov. Methods: Using the Aggregate Analysis of ClinicalTrials.gov database and manual review, we identified all interventional clinical trials registered on...

Data from: Data sharing through an NIH central database repository: a cross-sectional survey of BioLINCC users

Joseph S. Ross, Jessica D. Ritchie, Emily Finn, Nihar R. Desai, Richard L. Lehman, Harlan M. Krumholz & Cary P. Gross
Objective To characterise experiences using clinical research data shared through the National Institutes of Health (NIH)'s Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) clinical research data repository, along with data recipients’ perceptions of the value, importance and challenges with using BioLINCC data. Design and setting Cross-sectional web-based survey. Participants All investigators who requested and received access to clinical research data from BioLINCC between 2007 and 2014. Main outcome measures Reasons for BioLINCC data...

Data from: HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

Petter Holland, Helene Knævelsrud, Kristiane Søreng, Benan John Mathai, Alf Håkon Lystad, Serhiy Pankiv, Gunnveig T. Bjørndal, Sebastian W. Schultz, Viola H. Lobert, Robin B. Chan, Bowen Zhou, Knut Liestøl, Sven R. Carlsson, Thomas J. Melia, Gilbert Di Paolo & Anne Simonsen
A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in zebrafish. HS1BP3 is localized to ATG16L1- and ATG9-positive autophagosome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain. Furthermore, we find the total PA content of...

Data from: Clinical trial registration, reporting, publication and FDAAA compliance: a cross-sectional analysis and ranking of new drugs approved by the FDA in 2012

Jennifer E. Miller, David Korn & Joseph S. Ross
Objective: To evaluate clinical trial registration, reporting and publication rates for new drugs by: (1) legal requirements and (2) the ethical standard that all human subjects research should be publicly accessible to contribute to generalisable knowledge. Design: Cross-sectional analysis of all clinical trials submitted to the Food and Drug Administration (FDA) for drugs approved in 2012, sponsored by large biopharmaceutical companies. Data sources: Information from Drugs@FDA, ClinicalTrials.gov, MEDLINE-indexed journals and drug company communications. Main outcome...

Registration Year

  • 2016
    4

Resource Types

  • Dataset
    4

Affiliations

  • Yale School of Medicine
    4
  • Columbia University
    2
  • Yale New Haven Hospital
    2
  • Massachusetts General Hospital
    1
  • New York University Langone Medical Center
    1
  • University of Oslo
    1
  • University of California, San Francisco
    1
  • University of Pennsylvania Health System
    1