Macroautophagy/autophagy is a cellular and energy homeostatic mechanism that contributes to maintain the number of primordial follicles, germ cell survival, and anti-ovarian aging. However, it remains unknown whether autophagy in granulosa cells affects oocyte maturation. Here, we show a clear tendency of reduced autophagy level in human granulosa cells from women of advanced maternal age, implying a potential negative correlation between autophagy levels and oocyte quality. We therefore established a co-culture system and show that...

Sanitary landfills and uncontrolled dumpsites are plastic wastes (PWs) reservoirs containing ∼60% of all the plastics ever made, amounting to 5,000 × 106 tons as of 2017. The distribution, long-term behavior, and release of macro- and microplastics (MPs) from disposal sites are critical to global plastics pollution, but are poorly understood and lack systematic assessments. We review comprehensively the available knowledge in the three aspects herein. The spatial and temporal distribution of PW in 616...

Reliable data for causal implication of neonatal survival in China are lacking. We assumed that by analyzing surviving data of in-hospital neonatal care based on all livebirths in Huai’an, prevalence of neonatal morbidity, mortality and causal relations may be derived comprehensively. Data of all regionally hospitalized neonates were retrospectively linked with corresponding whole livebirths (59,056) in 2015 as a cohort. Diagnoses of diseases and causes of deaths were redefined and categorized. Disease patterns, prevalence of...

This meta-analysis aimed to determine the accuracy of transvaginal ultrasound (TVS) and pelvic magnetic resonance imaging (MRI) in diagnosing urinary tract endometriosis (UTE). A comprehensive search of the Pubmed and Embase was conducted between January 1989 and June 2020. Studies that described the accuracy of MRI or TVS for the diagnosis of UTE using surgical data as the reference standard were included. Of the 913 citations identified, 23 studies were analysed. For detection of endometriosis...

The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study, we explored the role of WIPI2 in PINK1-PRKN/parkin-mediated mitophagy. First, we found that WIPI2 is recruited to damaged mitochondria upon mitophagy induction. Second, loss of WIPI2 impedes mitochondrial damaging agents-induced mitophagy. Third, at molecular level, WIPI2 binds to and promotes AAA-ATPase...

Electroadhesion provides a promising route to augment robotic functionalities with continuous, astrictive, and reversible adhesion force. However, the lack of suitable conductive/dielectric materials and processing capabilities have impeded the integration of electroadhesive modules into soft robots requiring both mechanical compliance and robustness. We present herein a novel iontronic adhesive based on a dynamically crosslinked gel-elastomer system, including an ionic organohydrogel as adhesive electrodes and a resilient polyurethane with high electrostatic energy density as dielectric layers....

Additional file 2. Clinicopathological Data for 40 TNBC.

Additional file 3. Digital raw data.

Additional file 13: Supplementary Table 1. The primer sequences in PCR analysis.

Additional file 13: Supplementary Table 1. The primer sequences in PCR analysis.

Source_Data_Figure_2 and 3

Additional file 4: Table S1. Targeted sequencing primer information.

Additional file 6: Table S3. Primers for authenticity verification of mutant individuals.

Additional file 7: Table S4. Grain type datas.

Additional file 8: Table S5. Mutation mixed sample information screened by targeted sequencing.

Additional file 4. Table S4: The subgroup analyses for patients aged younger than 50 years: univariable and multivariable logistic regression analyses.

Additional file 4. Table S4: The subgroup analyses for patients aged younger than 50 years: univariable and multivariable logistic regression analyses.

Additional file 4: Table S1. GC content of the CPGs of the six subgenus Gynopodium species.

Additional file 4: Table S1. GC content of the CPGs of the six subgenus Gynopodium species.

Additional file 6: Table S3. List of SSRs in the CPGs of six subgenus Gynopodium species.

The detailed information of sampling stations, the carbon, nitrogen, and amino acids levels in DOM and POM, as well as other parameters including temperature, salinity, nutrients, chlorophyll-a, and biological parameters (heterotrophic bacteria, Synechococcus, and picoeukaryotes) are dispalyed in this dataset.

Investigation of the sealing performance of the gearbox sealing system of high-speed trains-data

Supplemental material, sj-rar-3-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering

Additional file 6. Individual data values. Raw data of Fig. 3A,B,F,G,7C and 7I.

Additional file 1: Supplementary Table S1. List of genes within the 120 kb upstream and downstream extension of significant SNPs identified via GWAS. Supplementary Table S2. SNPs detected for lodging resistance-related traits using BLUP value in the association mapping panel. Supplementary Table S3. List of genes within the 120 kb upstream and downstream extension of significant SNPs identified via GWAS.