Team-based care is recognized as a foundational building block of high-performing primary care. The purpose of this study was to identify primary care practice characteristics associated with team functioning and examine whether there is relationship between team composition or size and team functioning. We sought to answer the following research questions: (1) are primary care practice characteristics associated with team functioning; and (2) does team composition or size influence team functioning. This cross-sectional correlational study...

The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of...

The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of...

This data set contains the at sea data collected aboard the R/V TINRO for the IYS survey in 2022 in the Northeast Pacific Ocean. Collected data offers important insights to achieve further understanding of changing ocean conditions and their effects on salmon in the open ocean. This data package contains, among other things, event, catch and specimen data. The event data contains all of the sampling event information, including time, location, and duration. All dates...

Understanding the drivers of biodiversity in cities is a central goal of urban ecology. There is currently intense scientific and public interest in the factors that influence pollinator diversity in cities and their surroundings. Existing studies point to a variety of landscape and local factors as potentially important, including urbanization (often defined as impervious surface cover in the surrounding lands), tree canopy cover and the diversity and abundance of locally flowering plants. However, few studies...

Currently, there are still no definitive consensus in the treatment of intrahepatic cholangiocarcinoma (iCCA). This study aimed to build a clinical decision support tool based on machine learning using the Surveillance, Epidemiology, and End Results (SEER) database and the data from the Fifth Medical Center of the PLA General Hospital in China. 4,398 eligible patients from the SEER database and 504 eligible patients from the hospital data, who presented with histologically proven iCCA, were enrolled...

Additional file 25: Table S3. Integrated Multi-omics Features in Tumor Tissues Compared with NATs of the PDAC. Table S3A Matrix of 7,055 protein groups and their relative intensities in at least 1/6 of the samples (226 tumors and 220 NATs). Table S3B 19,992 mRNA and their ratio of tumors/NATs (54 tumors and 51 NATs). Table S3C A list of protein identified both in protein and mRNA level. Table S3D A list of phosphosites used for...

Additional file 25: Table S3. Integrated Multi-omics Features in Tumor Tissues Compared with NATs of the PDAC. Table S3A Matrix of 7,055 protein groups and their relative intensities in at least 1/6 of the samples (226 tumors and 220 NATs). Table S3B 19,992 mRNA and their ratio of tumors/NATs (54 tumors and 51 NATs). Table S3C A list of protein identified both in protein and mRNA level. Table S3D A list of phosphosites used for...

Additional file 28: Table S6. Proteomic Subtypes of PDAC Patients. Table S6A Proteomic subtypes, transcriptomic subtypes and phosphoproteomic subtypes of PDAC patients. Table S6B A list of differentially expressed proteins among three subtypes. Table S6C Pathway alterations in the proteomic subtypes of the PDAC cohort. Table S6D Matrix of protein expression and kinase activity of kinase activated in S-III. Table S6E Matrix of differential pathway enrichment between patients located in H-PDAC and BT-PDAC. Table S6F...

A new type of polyhedral oligomeric silsesquioxanes bisDOPO-NH2-POSS flame retardant consisting of one polyhedral oligomeric silsesquioxane (POSS), two units of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and reactive –NH2 groups, was synthesized and characterized by FTIR, 1H NMR, and 31P NMR. It was applied to modified conventional environmentally friendly E0 grade urea formaldehyde (UF) resin to prepare flame-retardant plywood. Two other POSS structure flame retardants were used for comparison. The results showed that the addition of bisDOPO-NH2-POSS flame retardant...

Additional file 4: Table S3. Putative ERE and AP1 element in chicken ELOVL genes promoter.

This data set contains the zooplankton data collected using paired bongo tows from the R/V TINRO, NOAA Bell M. Shimada and F/V Northwest Explorer from February 2 - April 18, 2022 in the North Pacific Ocean. The paired bongo nets (60 cm in diameter, 253 micron mesh size) were deployed to a depth of approximately 250 m and retrieved vertically at 1 m s-1. Collected data are used to offer insights in zooplankton community composition,...

We investigate the effect of ice sheet geometry on groundwater flow patterns and meltwater ingress in a hypothetical sedimentary basin. The simulation results indicate that meltwater ingress is much greater in 3D domains with a relatively narrow ice sheet extent compared to a wide ice sheet, or a simplified 2D model. In high permeability units (HPUs), the simulated meltwater penetration depth can reach up to 750 m in 3D domains compared to 400 m in...

Predicting fitness in natural populations is a major challenge in biology. It may be possible to leverage fast-accumulating genomic datasets to infer the fitness effects of mutant alleles, allowing evolutionary questions to be addressed in any organism. In this paper, we investigate the utility of one such tool, called PROVEAN. This program compares a query sequence with existing data to provide an alignment-based score for any protein variant, with scores categorized as neutral or deleterious...

Supplementary Material 1

Additional file 4: Supplementary Table S1. The clustering results from the tested methods for SARS-CoV-2 sequences found in epidemiologically supported clusters isolated in British Columbia, Canada.

Over the last few decades, there has been increasing recognition of seagrasses' contribution to the functioning of nearshore ecosystems and climate change mitigation. Nevertheless, seagrass ecosystems have been deteriorating globally at an accelerating rate during recent decades. In 2017, research into the condition of eelgrass (Zostera marina) along the eastern coast of James Bay, Canada, was initiated in response to reports of eelgrass decline by the Cree First Nations of Eeyou Istchee. As part of...

Additional file 1 Supplemental Table 1 Alignment of the sequencing reads to the reference genome. Supplemental Table 2 Statistical analyses of lncRNAs in each sample. Supplemental Table 3 Statistical analyses of the DE lncRNAs. Supplemental Table 4 Statistical analyses of the DE lncRNA cis-regulated target genes. Supplemental Table 5 GO terms enriched for the DE mRNA genes. Supplemental Table 6 The lncRNA–mRNA coexpression pairs. Supplemental Table 7 Specific primer sequences of the validated mRNAs and...

Historical museum records provide potentially useful data for identifying drivers of change in species occupancy. However, because museum records are typically obtained via many collection methods, methodological developments are needed in order to enable robust inferences. Occupancy-detection models, a relatively new and powerful suite of statistical methods, are a potentially promising avenue because they can account for changes in collection effort through space and time. We use simulated datasets to identify how and when patterns...

Aim: Altitudinal and latitudinal treeline ecotones have not consistently responded to climate warming the in direction and/or magnitude as predicted by climate alone, suggesting that non-climatic mechanisms (e.g., biotic interactions) are also mediating treeline range dynamics. Through a collaborative research approach, we assessed environmental conditions associated with insect cone granivory and how this biotic interaction may govern the reproductive potential, and therefore range dynamics, of spruce-dominated treelines across northern Canada. Location: Ten boreal forest treelines,...

Additional file 4: Table S3. Gene contents of the eleven Seseli plastomes.

Additional file 5: Table S4. The repeat sequences distribution in the eleven Seseli plastomes.

Additional file 7: Table S6. Nucleotide diversity (Pi) of coding and non-coding regions.

Additional file 8: Table S7. Codon usage and relative synonymous codon usage (RSCU) values of protein-coding genes of the eighteen plastomes.

Additional file 1: Table S1. Summary of TF ChIP-seq datasets of mouse cell/tissue types. Table S2. Unique motifs (UMs) matching known motifs of TFs in the Hocomoco and JASPAR databases.