15 Works

Data from: Congestion reduction through efficient container movement under stochastic demand

Maged Dessouky
In today’s world, there is a significant amount of investigation regarding how to efficiently distribute loaded containers from the ports to the consignees. However, to fully maximize the process and become more environmentally friendly, one should also study how to allocate the empty containers created by these consignees. This is an essential part in the study of container movement since it balances out the load flow at each location. The problem of coordinating the container...

HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread

Tongcui Ma, Xiaoyu Luo, Ashley George, Gourab Mukherjee, Nandini Sen, Trimble Spitzer, Linda Giudice, Warner Greene & Nadia Roan
The female reproductive tract (FRT) is the most common site of infection during HIV transmission to women, but viral remodeling complicates characterization of cells targeted for infection. Here, we report extensive phenotypic analyses of HIV-infected endometrial cells by CyTOF, and use a "nearest neighbor" bioinformatics approach to trace cells to their original pre-infection phenotypes. Like in blood, HIV preferentially targets memory CD4+ T cells in the endometrium, but these cells exhibit unique phenotypes and sustain...

Least-cost habitat linkages for American black bear, Rafinesque's big-eared bat, and timber rattlesnake.

Jennifer Costanza, James Watling, Ron Sutherland, Curtis Belyea, Bistra Dilkina, Heather Cayton, David Bucklin, Stephanie Romañach & Nicholas Haddad
This data set contains 3 shapefiles and associated files that map linkages, which are least-cost paths between adjacent habitat cores for three wildlife species in the Southeastern U.S. The species are: the American black bear (Ursus americanus), Rafinesque's big-eared bat (Corynorhinus rafinesquii), and Timber rattlesnake (Crotalus horridus). We mapped habitat cores based on c. 2006 land cover, then used LinkageMapper software to identify least-cost paths between them, and buffered the least-cost paths by 2.5 km...

Pulsed electromagnetic field (PEMF) transiently stimulates the rate of mineralization in a 3-dimensional ring culture model of osteogenesis

Paul Benya, Aaron Kavanaugh, Martin Zakarian, Philip Söderlind, Tea Jashashvili, Nianli Zhang, Eric Waldorff, James Ryaby & Fabrizio Billi
Pulsed Electromagnetic Frequencies (PEMF) have shown efficacy in bone repair and yet the optimum characteristics of this modality and its molecular mechanism remain unclear. To determine the effects of timing of PEMF treatment we present a three-dimensional ring culture model of osteogenesis that demonstrates strong de novo generation of collagen and mineral matrix and exhibits stimulation by PEMF in multiple stages over 62 days of culture. Mouse postnatal day 2 calvarial pre-osteoblasts were cast within...

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling

Boksik Cha, Yen-Chun Ho, Xin Geng, , Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn Randolph, Xinwei Cao, Hong Chen & R. Sathish Srinivasan
Lymphatic vasculature is an integral part of digestive, immune and circulatory systems. The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and Vascular Endothelial Growth Factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs). In turn, VEGF-C signaling maintains PROX1 expression in LECs. However, the mechanisms...

Southern San Andreas Fault Zone

, , , &
The San Andreas Fault (SAF) in California is a mature plate boundary fault capable of great (magnitude 8 or greater) earthquakes. The southern section of the SAF has not produced a major event in historic times (over the last 300 years), and is currently believed to pose the largest seismic risk in California (Weldon et al., 2005; Field et al., 2014). While much progress was made toward understanding seismic potential of the Southern San Andreas...

Fine particulate matter and neuroanatomic risk for Alzheimer’s disease in older women

Diana Younan, Xinhui Wang, Ramon Casanova, Ryan Barnard, Sarah Gaussoin, Santiago Saldana, Andrew Petkus, Daniel Beavers, Susan Resnick, JoAnn Manson, Marc Serre, William Vizuete, Victor Henderson, Bonnie Sachs, Joel Salinas, Margaret Gatz, Mark Espeland, Helena Chui, Sally Shumaker, Stephen Rapp & Jiu-Chiuan Chen
Objective: To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer’s disease (AD) using a community-dwelling cohort of women (aged 71-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). Methods: AD pattern similarity (AD-PS) scores, developed by supervised machine learning and validated with MRI data from the AD Neuroimaging Initiative, was used to capture high-dimensional gray matter atrophy in brain areas...

Ligand-dependent effects of methionine-8 oxidation in parathyroid hormone peptide analogs

Thomas Gardella, Vsevolod Katritch, Saheem Zaidi, Eileen Daley, Ashok Khatri & Jean-Pierre Vilardaga
LA-PTH is a long-acting parathyroid hormone (PTH) peptide analog in pre-clinical development for hypoparathyroidism (HP). Like native PTH, LA-PTH contains a methionine at position 8 that is predicted to be critical for function. We assessed the impact of methionine oxidation on the functional properties of LA-PTH and control PTH ligands. Oxidation of PTH(1-34) resulted in marked (~20-fold) reductions in binding affinity on the PTH receptor-1 (PTHR1) in cell membranes, similarly diminished potency for cAMP signaling...

Data from: Molecular underpinnings and biogeochemical consequences of enhanced diatom growth in a warming Southern Ocean

Loay Jabre, Andrew E. Allen, J. Scott P. McCain, John P. McCrow, Nancy Tenenbaum, Jenna L. Spackeen, Rachel E. Sipler, Beverley R. Green, Deborah A. Bronk, David A. Hutchins & Erin M. Bertrand
The Southern Ocean (SO) harbours some of the most intense phytoplankton blooms on Earth. Changes in temperature and iron availability are expected to alter the intensity of SO phytoplankton blooms, but little is known about how environmental change will influence community composition and downstream biogeochemical processes. We performed experimental manipulations on surface ocean microbial communities from McMurdo Sound in the Ross Sea, with and without iron addition, at -0.5 °C, 3 °C, and 6 °C....

Data from: Variations of mesozoic feathers: insights from the morphogenesis of extant feather rachises

Shuo Wang, Wei-Ling Chang, Qiyue Zhang, Menglu Ma, Feng Yang, De Zhuo, Harn I-Chen Hans, Rui Yang, Ping Wu, Michael Bruce Habib, Wen-Tau Juan & Cheng-Ming Chuong
The rachises of extant feathers, composed of dense cortex and spongy internal medulla, are flexible and light, yet stiff enough to withstand the load required for flight, among other functions. Incomplete knowledge of early feathers prevents a full understanding of how cylindrical rachises have evolved. Bizarre feathers with unusually wide and flattened rachises, known as “rachis-dominated feathers” (RDFs) have been observed in fossil non-avian and avian theropods. Newly discovered RDFs embedded in early Late Cretaceous...

Sex differences in moral judgements across 67 countries

Morteza Dehghani, Mohammad Atari, Mark Lai & Morteza Dehghani
Most of the empirical research on sex differences and cultural variations in morality has relied on within-culture analyses or small-scale cross-cultural data. To further broaden the scientific understanding of sex differences in morality, the current research relies on two international samples to provide the first large-scale examination of sex differences in moral judgements nested within cultures. Using a sample from 67 countries (Study 1; n = 336,691), we found culturally-variable sex differences in moral judgements,...

Ecological niche models for American black bear, Rafinesque's big-eared bat, and timber rattlesnake

James Watling, Jennifer Costanza, Ron Sutherland, Curtis Belyea, Bistra Dilkina, Heather Cayton, David Bucklin, Stephanie Romañach & Nick Haddad
This data set contains rasters that are predictive environmental suitability maps for three wildlife species: the American black bear (Ursus americanus), Rafinesque's big-eared bat (Corynorhinus rafinesquii), and Timber rattlesnake (Crotalus horridus). Rasters for each species include: individual prediction maps for each of 5 ENMs (GBM: generalized boosting model, GLM: generalized linear model, MARS: multivariate adaptive regression spline, MX: maximum entropy, and RF: random forest), as well as the ensemble prediction map from all five ecological...

Subducted lithospheric boundary tomographically imaged beneath arc-continent collision in Eastern Indonesia

Cooper Harris
We use travel-times from a temporary seismic deployment of 30 broadband seismometers and a national catalog of arrival times to construct a finite frequency teleseismic P-wave tomographic model of the upper mantle beneath astern Indonesia, where subduction of the Indo-Australian plate beneath the Banda Arc transitions to arc-continent collision. The change in tectonics is due to a change from oceanic to continental lithosphere in the lower plate as inferred from geologic mapping and geophysical, geochemical,...

Intentional Control of Type I Error Over Unconscious Data Distortion: A Neyman–Pearson Approach to Text Classification

Lucy Xia, Richard Zhao, Yanhui Wu & Xin Tong
This article addresses the challenges in classifying textual data obtained from open online platforms, which are vulnerable to distortion. Most existing classification methods minimize the overall classification error and may yield an undesirably large Type I error (relevant textual messages are classified as irrelevant), particularly when available data exhibit an asymmetry between relevant and irrelevant information. Data distortion exacerbates this situation and often leads to fallacious prediction. To deal with inestimable data distortion, we propose...

nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish

Ted Allison, Tetsuto Miyashita, Pranidhi Baddam, Joanna Smeeton, Adam Phillip Oel, Natasha Natarajan, Brogan Gordon, A. Richard Palmer, Gage Crump, Daniel Graf & W. Ted Allison
The vertebrate jaw is a versatile feeding apparatus. To function, it requires a joint between the upper and lower jaws, so jaw joint defects are often highly disruptive and difficult to study. To describe the consequences of jaw-joint dysfunction, we engineered two independent null alleles of a single jaw-joint marker gene, nkx3.2, in zebrafish. These mutations caused zebrafish to become functionally jawless via fusion of the upper and lower jaw cartilages (ankylosis). Despite lacking jaw...

Registration Year

  • 2020
    15

Resource Types

  • Dataset
    15

Affiliations

  • University of Southern California
    15
  • John Carroll University
    2
  • Massachusetts General Hospital
    2
  • University of Florida
    2
  • United States Geological Survey
    2
  • North Carolina State University
    2
  • Michigan State University
    2
  • Capital Normal University
    1
  • Boston Children's Hospital
    1
  • Stanford University
    1