Polygenic risk score in Africa populations: progress and challenges
Ezekiel Adebiyi, Yagoub Adam, Suraju Sadeeq, Judit Kumuthini, Olabode Ajayi, Gordon Wells, Rotimi Solomon, Olubanke Ogunlana, Emmanuel Adetiba, Emeka Iweala & Benedikt Brors
Polygenic Risk Score (PRS) analysis is a method that predicts the genetic risk of an individual towards targeted traits. Even when there are no significant markers, it gives evidence of a genetic effect beyond the results of Genome-Wide Association Studies (GWAS). Moreover, it selects SNPs that contribute to the disease with low effect size making it more precise at individual level risk prediction. PRS analysis addresses the shortfall of GWAS by taking into account the...