Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso
Teun Bousema, Elamaran Meibalan, Aissata Barry, Matthew Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas Ouedraogo, Ines Barry-Some, Emilie Badoum, Traore Fagnima, Kjerstin Lanke, Bronner Goncalves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Guelbeogo, Alfred Tiono, Matthias Marti, Matthew P Gibbins, Fiona Achcar … & Alfred B Tiono
Background Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a blood meal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested. Methods In naturally infected gametocyte carriers from Burkina Faso, we assessed infectivity to mosquitoes by direct skin feeding and membrane feeding. We directly quantified male and female gametocytes and asexual parasites in finger-prick...
Affiliations
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London School of Hygiene & Tropical Medicine1
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University of Glasgow1
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African Training and Research Centre in Administration for Development1
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Institut de Cancérologie de l'Ouest1
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Harvard Medical School1
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Centre National de Recherche et de Formation sur le Paludisme1
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Radboud University Nijmegen Medical Centre1