16 Works

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Niels Herluf Paulsen, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen, Anne Ramlov, Birgitte Bertelsen, Maria Rossing, Claus Gyrup Nielsen, Elke Hoffmann-Lücke, Eva Greibe, Hanne Spangsberg Holm, Heidi Hvid Nielsen, Ihab Bishara Yousef Lolas, Jonna Skov Madsen, Marianne Lerbaek Bergmann, Morten Mørk, Palle B. Nielsen Fruekilde, Pernille Bøttger, Peter Clausager Petersen, Peter Henrik Nissen, Søren Feddersen, Troels K. Bergmann, Per Pfeiffer & Per Damkier
Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer

Marta Kramer Mikkelsen, Nana Aviaja Frederikke Lindblom, Anne Dyhl-Polk, Carsten Bogh Juhl, Julia Sidenius Johansen & Dorte Nielsen
Inflammation is an enabling characteristic of the hallmarks of cancer. There has therefore been increasing interest in the clinical value of circulating inflammatory biomarkers in cancer. In this review, we summarize results on C-reactive protein (CRP), alone or as part of the Glasgow Prognostic Score (GPS, composed of CRP and serum albumin), as a biomarker of prognosis or prediction and monitoring of therapeutic response in patients with breast cancer. A systematic literature search was performed...

Additional file 15 of Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer

Robson Francisco Carvalho, Luisa Matos do Canto, Cecilie Abildgaard, Mads Malik Aagaard, Monica Søgaard Tronhjem, Marianne Waldstrøm, Lars Henrik Jensen, Karina Dahl Steffensen & Silvia Regina Rogatto
Additional file 14: Supplementary Tables (S1-S10).

Coevolution of relative brain size and life expectancy in parrots

Simeon Q. Smeele, Dalia A. Conde, Annette Baudisch, Simon Bruslund, Andrew Iwaniuk, Johanna Staerk, Timothy F. Wright, Anna M. Young, Mary Brooke McElreath & Lucy Aplin
Previous studies have demonstrated a correlation between longevity and brain size in a variety of taxa. Little research has been devoted to understanding this link in parrots; yet parrots are well-known for both their exceptionally long lives and cognitive complexity. We employed a large-scale comparative analysis that investigated the influence of brain size and life history variables on longevity in parrots. Specifically, we addressed two hypotheses for evolutionary drivers of longevity: the Cognitive Buffer Hypothesis,...

Single-cell phenotypic characteristics of tolerance under recurring antibiotic exposure in Escherichia coli

Silvia Kollerová, Lionel Jouvet, Julia Smelková, Sara Zunk-Parras, Alexandro Rodriguez-Rojas & Ulrich Steiner
Non-heritable drug resistance, such as tolerance and persistence towards antibiotics, is little characterized compared to genetic resistance. Tolerance and persistence allow cells to survive application of antibiotics that are bactericidal to non-tolerant cells. Non-heritable drug resistance challenges antibiotic treatment, particularly of recurrent infections, and have implications towards heritable resistance evolution. Tolerant cells have commonly been characterized as growth arrested cells prior and during antibiotic application that quickly resume growth post-application. Here, we explore characteristic of...

The reliability and agreement of scores in a novel balance measure for older adults: Specific Training According to BaLance Evaluation (STABLE)

Kasper Søndergaard, Derek John Curtis, Per Caye-Thomasen & Carsten Bogh Juhl
Falls are the leading cause of injury and premature death among community dwelling elderly but can be prevented through comprehensive balance rehabilitation which ideally targets the patient’s specific needs. In this study, we evaluate the reliability and agreement of six novel clinical measures of different balance domains which applied in a patient-specific balance profile guides exercise prescription in balance rehabilitation. The intra-rater reliability and agreement of the six measures were evaluated on the same day...

The reliability and agreement of scores in a novel balance measure for older adults: Specific Training According to BaLance Evaluation (STABLE)

Kasper Søndergaard, Derek John Curtis, Per Caye-Thomasen & Carsten Bogh Juhl
Falls are the leading cause of injury and premature death among community dwelling elderly but can be prevented through comprehensive balance rehabilitation which ideally targets the patient’s specific needs. In this study, we evaluate the reliability and agreement of six novel clinical measures of different balance domains which applied in a patient-specific balance profile guides exercise prescription in balance rehabilitation. The intra-rater reliability and agreement of the six measures were evaluated on the same day...

How do people with chronic pain explain their use, or non-use, of pain-related healthcare services? A qualitative study of patient experiences

Søren Mose, Cecile Rud Budtz, Helle Rønn Smidt, Peter Kent, Anne Smith, Johan Hviid Andersen & David Høyrup Christiansen
This study aims to explore how people with chronic pain explain their use or non-use of pain-related healthcare services and their expectations of the healthcare provider, and explore how explanations and expectations vary between different levels of pain-related healthcare use. We conducted 20 individual semi-structured interviews with purposely sampled adults between 39 and 77 years of age with chronic pain. All interviews were audio-recorded, transcribed and analysed using a thematical template analysis approach. Four key...

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Niels Herluf Paulsen, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen, Anne Ramlov, Birgitte Bertelsen, Maria Rossing, Claus Gyrup Nielsen, Elke Hoffmann-Lücke, Eva Greibe, Hanne Spangsberg Holm, Heidi Hvid Nielsen, Ihab Bishara Yousef Lolas, Jonna Skov Madsen, Marianne Lerbaek Bergmann, Morten Mørk, Palle B. Nielsen Fruekilde, Pernille Bøttger, Peter Clausager Petersen, Peter Henrik Nissen, Søren Feddersen, Troels K. Bergmann, Per Pfeiffer & Per Damkier
Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Niels Herluf Paulsen, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen, Anne Ramlov, Birgitte Bertelsen, Maria Rossing, Claus Gyrup Nielsen, Elke Hoffmann-Lücke, Eva Greibe, Hanne Spangsberg Holm, Heidi Hvid Nielsen, Ihab Bishara Yousef Lolas, Jonna Skov Madsen, Marianne Lerbaek Bergmann, Morten Mørk, Palle B. Nielsen Fruekilde, Pernille Bøttger, Peter Clausager Petersen, Peter Henrik Nissen, Søren Feddersen, Troels K. Bergmann, Per Pfeiffer & Per Damkier
Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Genome-wide DNA methylation analysis in monozygotic twins identifies potential biomarkers of fasting plasma glucose

Weijing Wang, Wenqin Yao, Qihua Tan, Shuxia Li, Haiping Duan, Xiaocao Tian, Chunsheng Xu & Dongfeng Zhang
Purpose: An epigenome-wide association study (EWAS) was conducted to detect specific epigenetic variants potentially related to fasting plasma glucose (FPG) in middle-aged and elderly Chinese monozygotic twins. Methods: Association between DNA methylation (DNAm) of single CpG and FPG was tested by applying generalized estimation equation in 52 twin pairs. Differentially methylated regions (DMRs) were identified by comb-P approach. Inference about Causation through Examination of Familial Confounding (ICE FALCON) was utilized to perform the causal inference....

Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer

Marta Kramer Mikkelsen, Nana Aviaja Frederikke Lindblom, Anne Dyhl-Polk, Carsten Bogh Juhl, Julia Sidenius Johansen & Dorte Nielsen
Inflammation is an enabling characteristic of the hallmarks of cancer. There has therefore been increasing interest in the clinical value of circulating inflammatory biomarkers in cancer. In this review, we summarize results on C-reactive protein (CRP), alone or as part of the Glasgow Prognostic Score (GPS, composed of CRP and serum albumin), as a biomarker of prognosis or prediction and monitoring of therapeutic response in patients with breast cancer. A systematic literature search was performed...

Additional file 15 of Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer

Robson Francisco Carvalho, Luisa Matos do Canto, Cecilie Abildgaard, Mads Malik Aagaard, Monica Søgaard Tronhjem, Marianne Waldstrøm, Lars Henrik Jensen, Karina Dahl Steffensen & Silvia Regina Rogatto
Additional file 14: Supplementary Tables (S1-S10).

Phenology of Lupinus polyphyllus from Central to Northern Europe

Kristin Ludewig, Yves P. Klinger, Tobias W. Donath, Lukas Bärmann, Carsten Eichberg, Jacob Gadegaad Thomsen, Eugen Görzen, Wiebke Hansen, Eliza M. Hasselquist, Thierry Helminger, Frida Kaiskog, Emma Karlsson, Torsten Kirchner, Carola Knudsen, Nikola Lenzewski, Sigrid Lindmo, Per Milberg, Daniel Pruchniewicz, Elisabeth Richter, Tobias M. Sandner, Judith M. Sarneel, Ralf Schmiede, Simone Schneider, Kathrin Schwarz, Åsa Tjäder … & Rolf Lutz Eckstein
Plant phenology, i. e. the timing of life cycle events, is related to individual fitness and species distribution ranges. Among the environmental factors, phenology is mostly driven by temperature and day length. Rapid adaptation of their phenology may also be important for the success of invasive plant species. Our main aim was to understand how the performance, timing, and temperature dependence of the phenology of the invasive legume Lupinus polyphyllus varies with latitude. L. polyphyllus...

How do people with chronic pain explain their use, or non-use, of pain-related healthcare services? A qualitative study of patient experiences

Søren Mose, Cecile Rud Budtz, Helle Rønn Smidt, Peter Kent, Anne Smith, Johan Hviid Andersen & David Høyrup Christiansen
This study aims to explore how people with chronic pain explain their use or non-use of pain-related healthcare services and their expectations of the healthcare provider, and explore how explanations and expectations vary between different levels of pain-related healthcare use. We conducted 20 individual semi-structured interviews with purposely sampled adults between 39 and 77 years of age with chronic pain. All interviews were audio-recorded, transcribed and analysed using a thematical template analysis approach. Four key...

Data for: Natural infochemical DMSP stimulates the transfer of microplastics from freshwater zooplankton to fish: An olfactory trap

Wei Yang, Xinxin Peng, Wei Li, Yuyue Huang, Junxiao Luo, Shenhua Qian, Elvis Genbo Xu & Qian Tan
Natural infochemicals may largely affect the trophic transfer of microplastics (MPs) in ecosystems but such inforchemical effect and mechanisms are poorly understood. Here, a daphnids-zebrafish freshwater microcosm was designed to elucidate whether and how an algae-derived inforchemical, dimethylsulfoniopropionate (DMSP), affects the ingestion and transfer of MPs. Daphnids fast accumulated DMSP and MPs from water, DMSP in daphnids was mainly enriched from the DMSP in water but not from MPs. DMSP did not change the MP...

Registration Year

  • 2022
    16

Resource Types

  • Dataset
    16

Affiliations

  • University of Southern Denmark
    16
  • Copenhagen University Hospital
    4
  • Odense University Hospital
    3
  • Rigshospitalet
    3
  • São Paulo State University
    2
  • Danish Ramazzini Center
    2
  • Curtin University
    2
  • Lillebaelt Hospital
    2
  • Regional Hospital West Jutland
    2
  • University of Hamburg
    1