4 Works

Data from: Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians

Brandon L. Pierce, Lin Tong, Lin S. Chen, Ronald Rahaman, Maria Argos, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Harm-Jan Westra, Lude Franke, Tonu Esko, Rakibuz Zaman, Tariqul Islam, Mahfuzar Rahman, John A. Baron, Muhammad G. Kibriya & Habibul Ahsan
A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease. Less is known regarding the effects of genetic variation on expression of distant genes (trans-eQTLs) and their biological mechanisms. In this work, we use genome-wide data on SNPs and array-based expression measures from mononuclear cells obtained from a population-based cohort of 1,799 Bangladeshi individuals to characterize cis-...

Data from: Re-visiting the phylogeography and demography of European badgers (Meles meles) based on broad sampling, multiple markers and simulations

Alain C. Frantz, Allan D. McDevitt, Lisa C. Pope, Joanna Kochan, John Davison, Chris F. Clements, Morten Elmeros, Guillem Molina-Vacas, Aritz Ruiz-Gonzalez, Alessandro Balestrieri, Koen Van Den Berge, Peter Breyne, Emmanuel Do Linh San, Erik O. Ågren, Franz Suchentrunk, Laurent Schley, Rafał Kowalczyk, Berit I. Kostka, Dusko Ćirović, Nikica Šprem, Marc Colyn, Marco Ghirardi, Venislava Racheva, Christophe Braun, Rita Oliveira … & Terry Burke
Although the phylogeography of European mammals has been extensively investigated since the 1990s, many studies were limited in terms of sampling distribution, the number of molecular markers used and the analytical techniques employed, frequently leading to incomplete postglacial recolonisation scenarios. The broad-scale genetic structure of the European badger (Meles meles) is of interest as it may result from historic restriction to glacial refugia and/or recent anthropogenic impact. However, previous studies were based mostly on samples...

Data from: Larval melanism in a geometrid moth: promoted neither by a thermal nor seasonal adaptation but desiccating environments

Panu Välimäki, Sami M. Kivelä, Jani Raitanen, Veli-Matti Pakanen, Emma Vatka, Maarit I. Mäenpää, Netta Keret & Toomas Tammaru
1. Spatio-temporal variation in the degree of melanism is often considered in the context of thermal adaptation, melanism being advantageous under suboptimal thermal conditions. Yet, other mutually non-exclusive explanations exist. Analysis of geographical patterns combined with laboratory experiments on the mechanisms of morph induction helps to unveil the adaptive value of particular cases of polyphenism. 2. In the context of the thermal melanism hypothesis and seasonal adaptations, we explored an array of environmental factors that...

Data from: Brown and polar bear Y chromosomes reveal extensive male-biased gene flow within brother lineages

Tobias Bidon, Axel Janke, Steven R. Fain, Hans Geir Eiken, Snorre B. Hagen, Urmas Saarma, Björn M. Hallström, Nicolas Lecomte & Frank Hailer
Brown and polar bears have become prominent examples in phylogeography, but previous phylogeographic studies relied largely on maternally inherited mitochondrial DNA (mtDNA) or were geographically restricted. The male-specific Y chromosome, a natural counterpart to mtDNA, has remained under-explored. Although this paternally inherited chromosome is indispensable for comprehensive analyses of phylogeographic patterns, technical difficulties and low variability have hampered its application in most mammals. We developed 13 novel Y-chromosomal sequence and microsatellite markers from the polar...

Registration Year

  • 2014

Resource Types

  • Dataset


  • University of Tartu
  • University of the Basque Country
  • National Veterinary Institute
  • Queen's University Belfast
  • Research Institute for Nature and Forest
  • University of Zagreb
  • University of Queensland
  • University of Milan
  • University of Groningen
  • University of North Carolina