A system-level framework of complex microbe–microbe and host–microbe chemical cross-talk would help elucidate the role of our gut microbiota in health and disease. Here we report a literature-curated interspecies network of the human gut microbiota, called NJS16. This is an extensive data resource composed of ∼570 microbial species and 3 human cell types metabolically interacting through >4,400 small-molecule transport and macromolecule degradation events. Based on the contents of our network, we develop a mathematical approach...

Background: Assisted reproductive technologies (ARTs) have made great progress. However, whether tube baby born after ART were at an increased risk of birth defects is not clear. Objective: To assess whether the ART increases the risk of birth defects in children born after ART. Search strategy: Medline, Google Scholar, and the Cochrane Library were searched. Selection criteria: Clinical trials that evaluate the risk of birth defect in children born after in vitro fertilization (IVF)/intracytoplasmic sperm...

Objective: To identify novel genes involved in the etiology of intracranial aneurysms (IA) and / or subarachnoid hemorrhages (SAH) using whole exome sequencing. Methods. In the present study we performed whole exome sequencing in thirteen individuals from three families with an autosomal dominant IA/SAH inheritance pattern to look for candidate genes for disease. Additionally, we sequenced PCNT exon 38 in 161 sporadic IA/SAH patients in order to find additional carriers of potential pathogenic variants. Results....

Additional file 13: Table S8. The genotypic and phenotypic matrix of the population in ICIMapping format.

Although numerous studies have linked asthma to air temperature and pollution, few studies have examined their interactive effects on asthma outpatient visits. This study investigated how air pollutants and their interactions with temperature affect asthma outpatient visits in a city in northern Chinaduring the time period 2018 - 2020 . . As the results, 24,163 asthma outpatients were recorded, a 10-μg/m3 increase in PM10, PM2.5, SO2, and NO2 concentrations was associated with significant increases in...

Gut microbiota composition in patients with advanced malignancies with anti-PD-1 therapy by 16s rDNA sequencing

Spiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or treating this. Macroautophagy/autophagy plays a critical role in SGN development, but the effect of autophagy on cisplatin-induced SGN injury is unclear. Here, we first found that autophagic flux was activated in SGNs after...

Objective: We investigated different dimensions of subjective cognitive decline (SCD) to determine which was the best prognostic risk factor for incident mild cognitive impairment (MCI) among cognitively unimpaired (CU) participants. Methods: We included 1167 CU participants, aged 70-95 years from the Mayo Clinic Study of Aging based on 2 concurrent SCD scales (part of the Blessed memory test and the 39-item ECog, which included a validated 12-item derivative) and a single question assessing worry about...

Objective: To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. Methods: Retrospective, observational clinical study of all patients who presented from 1/1/14 to 6/1/17 with unilateral optic neuritis and OCT available at least three months after the attack. We compared OCT retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thicknesses between affected and unaffected contralateral eyes. We excluded patients with concomitant glaucoma or other optic neuropathies....

Whether combined CsA with androgen therapy was superior to androgen therapy alone in NSAA remains controversial. This study aimed to assess the efficacy and safety of combined therapy versus androgen therapy for NSAA patients using a meta-analytic approach. An electronic database of PubMed, EmBase, Cochrane library, CNKI, VIP, and Wanfang was systematically searched for randomized controlled trials (RCTs) from their inception to February 2020. The primary endpoint was effective rate, while the secondary endpoints included...

Additional file 2: Table S2. Some summary statistics from two-way analysis of variance of 12 traits of rice hybrid QYSM, derived RIL and BCF1 hybrid (RIL × Q9311) populations evaluated in three environments (Hefei, Nanning and Deyang).

Additional file 8: Table S5. Classification of 2,736 epistatic QTL pairs into 13 types according to their gene actions identified in the Q9311/WSSM combined population.

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Additional file 12: Table S7. The function of 45 cloned yield related genes identified as the candidate genes for determining the performance of hybrid rice variety QYSM.

Objective: To define the in-hospital course, complications, short- and long-term functional outcomes of patients with angiographically negative subarachnoid hemorrhage (anSAH), particularly those with aneurysmal-pattern anSAH (aanSAH). Methods: Retrospective cohort study of patients with aneurysmal subarachnoid hemorrhage (aSAH), aanSAH and perimesencephalic-pattern anSAH (panSAH) treated at a single tertiary referral center between January 2006 and April 2018. Ninety-nine patients with anSAH (33 aanSAH and 66 panSAH) and 464 patients with aSAH were included in this study. Outcomes...

Whether combined CsA with androgen therapy was superior to androgen therapy alone in NSAA remains controversial. This study aimed to assess the efficacy and safety of combined therapy versus androgen therapy for NSAA patients using a meta-analytic approach. An electronic database of PubMed, EmBase, Cochrane library, CNKI, VIP, and Wanfang was systematically searched for randomized controlled trials (RCTs) from their inception to February 2020. The primary endpoint was effective rate, while the secondary endpoints included...

Additional file 10: Table S6. Allele frequencies of Q9311B and WSSM in 1946 accessions from 3 K-RG.

Additional file 12: Table S7. The function of 45 cloned yield related genes identified as the candidate genes for determining the performance of hybrid rice variety QYSM.

Additional file 2: Table S2. Some summary statistics from two-way analysis of variance of 12 traits of rice hybrid QYSM, derived RIL and BCF1 hybrid (RIL × Q9311) populations evaluated in three environments (Hefei, Nanning and Deyang).

Additional file 7: Table S4. Epistasis QTLs for 12 traits in the three environments.

Gut microbiota composition in patients with advanced malignancies with anti-PD-1 therapy by 16s rDNA sequencing

Monocarboxylate transporters (MCTs) play vital roles in carbon source assimilation, drug resistance and virulence. However, the underlying function of MCTs in fungal pathogenesis and development has not been investigated in detail. In this study, we identified and characterized the monocarboxylate transporter gene MCT1 of Colletotrichum gloeosporioides, which is the causal agent of Glomerella leaf spot of apple. Mct1 is localized to the mitochondria and may mediate the uptake of lactate to the cell. However, MCT1...

Additional file 1: Table S1. Composition and sequences of the synthetic DNA material sequins. Table S2. Characteristics of library construction kits. Table S3. 495 core microbial contaminations at the genus level.

Additional file 1: Table S1. Composition and sequences of the synthetic DNA material sequins. Table S2. Characteristics of library construction kits. Table S3. 495 core microbial contaminations at the genus level.

Additional file 1: Table S1. Phenotypic performance and heterosis of traits in Q9311B/WSSM RILs and backcross F1s (Q9311A × RIL).