Background: Myeloid-derived suppressor cells (MDSCs) have become increasingly recognized as facilitators of tumor development. However, the role of MDSCs in papillary thyroid carcinoma (PTC) progression has not been clearly explored. Objective: We aimed to evaluate the levels and function of circulating MDSCs in PTC. Methods: The proportion of circulating polymorphonuclear (PMN)-MDSCs and mononuclearMDSCs from patients with PTC or benign thyroid nodules and healthy controls was measured using flow cytometry. For immunosuppressive activity analysis, sorted circulating...

Acinetobacter baumannii has become a major healthcare threat that causes nosocomial infections, especially in critically ill patients. The spread of carbapenem resistant A. baumannii (CRAB) strains has long been a clinical concern. It is important to study the epidemiology and virulence characteristics of different CRAB isolates in order to tailor infection prevention and antibiotic prescribing. In this study, a total of 71 CRAB isolates were collected in the hospital, and clinical characteristics of infections were...

In plants, recent studies have revealed that N6-methyladenosine (m6A) methylation of mRNA has potential regulatory functions of this mRNA modification in many biological processes. m6A methyltransferase, m6A demethylase and m6A-binding proteins can cause differential phenotypes, indicating that m6A may have critical roles in the plant. In this study, we depicted the m6A map of sea buckthorn (Hippophae rhamnoides Linn.) transcriptome. Similar to A. thaliana, m6A sites of sea buckthorn transcriptome is significantly enriched around the...

Mosquito-transmitted flaviviruses cause widespread disease across the world. To provide better molecular tools for drug screens and pathogenesis studies, we report a new approach to produce stable NanoLuc-tagged flaviviruses, including dengue virus serotypes 1-4, Japanese encephalitis virus, yellow fever virus, West Nile virus, and Zika virus. Since the reporter gene is often engineered at the capsid gene region, the capsid sequence must be duplicated to flank the reporter gene; such capsid duplication is essential for...

Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622 We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Haibo Zou, Xiangang Xu, Lanyun Luo, Yu Zhang, Le Luo, Yutong Yao, Guangming Xiang, Xiaolun Huang, and Guan Wang. Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622. Cell Cycle. 2019;18(19):2398-2413. doi: 10.1080/15384101.2019.1618120. Since publication, significant concerns have been raised about the integrity...

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar...

Sanitary landfills and uncontrolled dumpsites are plastic wastes (PWs) reservoirs containing ∼60% of all the plastics ever made, amounting to 5,000 × 106 tons as of 2017. The distribution, long-term behavior, and release of macro- and microplastics (MPs) from disposal sites are critical to global plastics pollution, but are poorly understood and lack systematic assessments. We review comprehensively the available knowledge in the three aspects herein. The spatial and temporal distribution of PW in 616...

The late Paleozoic tectonic evolution of the Lhasa terrane and subduction of Sumdo Paleo-Tethys ocean remains controversial due to limited data and variable Permian magmatism in central and southern Lhasa. We report new zircon U–Pb ages and Hf-isotope ratios as well as whole-rock major element, trace element, and Sr–Nd isotope data from middle Permian (266 ~ 257 Ma) arc-related magmatism, including high-Mg quartz diorite and trondhjemite in the Tangjia-Sumdo area. The quartz diorite has high...

The nutritional components and protein quality of genetically modified maize expressing phytase gene (GM) were analyzed and evaluated in this study. The nutritional components were analyzed by Chinese national standard methods. The ileostomy Bama miniature pigs were utilized to analyze the true digestibility of protein and amino acids. The digestible indispensable amino acid score (DIAAS) was adopted to evaluate the protein quality of GM, its parental maize (PM) and commercial available maize Zhengdan 958 (ZD)....

Collaborative geographic analysis can lead to better outcomes but requires complicated interactions among participants, support resources and analytic tools. A process expression with explicit structure and content can help coordinate and guide these interactions. For different geographic problems, the structure and content of collaborative geographic analysis are generally distinct. Since the process structure embodies the pathway of problem-solving and the process content contains the information flow and internal interactions, both the structure and the content...

Supplemental material, sj-xlsx-5-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

Additional file 1: Table S1. Phenotypic performance and heterosis of traits in Q9311B/WSSM RILs and backcross F1s (Q9311A × RIL).

Additional file 7: Table S4. Epistasis QTLs for 12 traits in the three environments.

Additional file 2: Table S2. Median survival times for the high- and low- risk groups ESCC patients of survival curves stratified by these clinical characteristics in the training, testing, and entire sets.

Additional file 4: Table S3. The results of univariate Cox proportional hazards regression analyses between clinical features and risk score in the training, testing, and entire sets.

Additional file 8: Table S4. The summary of imprinted lncRNA identified in 12 DAP sunflower endosperm.

Additional file 3. Differentially expressed protein data.

Additional file 10: Table S5. The summary of lncRNAs exhibiting allele-specific expression in cultivated sunflower lines for edible fruit and oil identified in 12 DAP sunflower endosperm.

Additional file 2: Table S2. The genomic information of lncRNAs in sunflower endosperm at 12DAP.

Additional file 3: Table S3. Codon usage and relative synonymous codon usage (RSCU) values of protain-coding genes of the 16 Sorbus s.s. chloroplast genomes

Additional file 6: Table S6. The nucleotide variability (Pi) of 16 Sorbus s.s. chloroplast genomes

Additional file 3: Table S3. DGEs identified in apple leaves infected with the Colletotrichum fructicola wild-type strain or Cfhos2 deletion mutant at the early infection phase (36 hpi). Table S4. DEGs identified between the Colletotrichum fructicola wild-type strain and Cfhos2 deletion mutant at the early infection phase (36 hpi).

Additional file 5. Table S4. The immunoreactive scores of GATA3, TRPS1 and MGP in 1201 cases of breast cancer.

Additional file 8: Table S4. The summary of imprinted lncRNA identified in 12 DAP sunflower endosperm.

Additional file 2: Appendix 2. Hazard ratios and their 95% confidence limits of Ki67, PR, ER, and age. Figure 1. Hazard ratios and their 95% confidence limits for a series of binary variables of Ki67. Figure 2. Hazard ratios and their 95% confidence limits for a series of binary variables of ER. Figure 3. Hazard ratios and their 95% confidence limits for a series of binary variables of PR. Figure 4. Hazard ratios and their...