61 Works

Pelagiella exigua, an early Cambrian stem gastropod with chaetae: lophotrochozoan heritage and conchiferan novelty

Roger D. K. Thomas, Bruce Runnegar & Kerry Matt
Exceptionally well-preserved impressions of two bundles of bristles protrude from the apertures of small, spiral shells of Pelagiella exigua, recovered from the Kinzers Formation (Cambrian, Stage 4, “Olenellus Zone”, ~ 512 Ma) of Pennsylvania. These impressions are inferred to represent clusters of chitinous chaetae, comparable to those borne by annelid parapodia and some larval brachiopods. They provide an affirmative test in the early metazoan fossil record of the inference, from phylogenetic analyses of living taxa,...

Data from: eDNA metabarcoding bioassessment of endangered fairy shrimp (Branchinecta spp.) - Part A

Zachary Gold, Adam Wall, Paul Barber, Emily Curd, N. Dean Pentcheff, Lee Ripma & Regina Wetzer
Fairy shrimp are integral components of vernal pool ecosystems, providing key food resources for migratory birds and amphibians. However, habitat degradation and land use change severely threaten the health of both vernal pools and the survival of fairy shrimp species. Branchinecta sandiegonensis has been particularly affected by urban and agricultural development in its small native range within San Diego County, California, USA. It is listed as an endangered species under both state and federal laws...

Intracrater Terminal Dune Fields in Arabia Terra, Mars

Taylor Dorn & Mackenzie Day
Craters are the most prevalent basins and potential depo-centers of sediment on Mars. Within these craters and extending from them, terminal dune fields and wind streaks are abundant, indicating active sediment transport and providing a way to study how wind and sediment interact with crater topography. Here, we explore the role of craters as both sources and sinks in the modern martian sedimentary cycle. Our results show that craters with low albedo wind streaks (indicative...

On the cross-population generalizability of gene expression prediction models

Kevin L. Keys, Angel C.Y. Mak, Marquitta J. White, Walter L. Eckalbar, Andrew W. Dahl, Joel Mefford, Anna V. Mikhaylova, María G. Contreras, Jennifer R. Elhawary, Celeste Eng, Donglei Hu, Scott Huntsman, Sam S. Oh, Sandra Salazar, Michael A. Lenoir, Jimmie Chun Ye, Timothy A. Thornton, Noah Zaitlen, Esteban G. Burchard & Christopher R. Gignoux
The genetic control of gene expression is a core component of human physiology. For the past several years, transcriptome-wide association studies have leveraged large datasets of linked genotype and RNA sequencing information to create a powerful gene-based test of association that has been used in dozens of studies. While numerous discoveries have been made, the populations in the training data are overwhelmingly of European descent, and little is known about the generalizability of these models...

Data from: Little giants: a rapidly invading seagrass alters ecosystem functioning relative to native foundation species

Ranjan Muthukrishnan, Kelcie L. Chiquillo, Candice Cross, Peggy Fong, Thomas Kelley, C. Anna Toline, Regina Zweng & Demian A. Willette
The spread of invasive species is a major component of global ecological change and how and when to manage particular species is a diicult empirical question. Ideally, these decisions should be based on the speciic impacts of invading species including both their efects on native competitors and how they may or may not play similar roles in broader ecosystem functioning. Halophila stipulacea is an invasive seagrass currently spreading through the Caribbean, and as seagrasses are...

Data from: The American Kestrel (Falco sparverius) genoscape: implications for monitoring, management, and subspecies boundaries

Kristen Ruegg, Michaela Brinkmeyer, Christen M Bossu, Rachael Bay, Eric C Anderson & Julie Heath
Identifying population genetic structure is useful for inferring evolutionary process as well as defining subspecies boundaries and/or conservation units that can aid in species management. The American kestrel (Falco sparverius) is a widespread species with two described North American subspecies, (F. s. sparverius and F. s. paulus), the latter in the southeastern United States and the former across the remainder of its distribution. In many parts of their range, American kestrels have been declining, but...

Data from: Beyond the limits: identifying the high-frequency detectors in the anuran ear

Ariadna Cobo-Cuan, T. Ulmar Grafe & Peter M. Narins
Despite the predominance of low-frequency hearing in anuran amphibians, a few frog species have evolved high-frequency communication within certain environmental contexts. Huia cavitympanum is the most remarkable anuran with regard to upper frequency limits; it is the first frog species known to emit exclusively ultrasonic signals. Characteristics of the Distortion Product Otoacoustic Emissions from the amphibian papilla and the basilar papilla were analysed to gain insight into the structures responsible for high-frequency/ultrasound sensitivity. Our results...

Data from: Environmental context shapes the long‐term role of nutrients in driving producer community trajectories in a top‐down dominated marine ecosystem

Rachel Clausing, Nicole E. Phillips & Peggy Fong
1. Two predominant anthropogenic impacts on ecosystems, nutrient enrichment and the removal of consumers, are predicted to interact in their effects on producer diversity. Yet, measures of diversity alone may not capture changes occurring in the underlying mechanisms structuring communities. Furthermore, evidence for these interactions in rocky intertidal systems is mixed and may be confounded by variable baseline productivity or short experimental durations that do not capture seasonality, environmental heterogeneity or successional processes. 2. We...

Iterative evolution of large-bodied hypercarnivory in canids benefits species but not clades

Mairin Balisi & Blaire Van Valkenburgh
Ecological specialization has costs and benefits at various scales: traits benefitting an individual may disadvantage its population, species or clade. In particular, large body size and hypercarnivory (diet over 70% meat) have evolved repeatedly in mammals; yet large hypercarnivores are thought to be trapped in a macroevolutionary “ratchet”, marching unilaterally toward decline. Here, we weigh the impact of this specialization on extinction risk using the rich fossil record of North American canids (dogs). In two...

Data from: eDNA metabarcoding bioassessment of endangered fairy shrimp (Branchinecta spp.) - Part B

Zachary Gold, Adam R. Wall, Emily E. Curd, Ryan P. Kelly, N. Dean Pentcheff, Lee Ripma, Paul H. Barber & Regina Wetzer
Fairy shrimp are integral components of vernal pool ecosystems, providing key food resources for migratory birds and amphibians. However, habitat degradation and land use change severely threaten the health of both vernal pools and the survival of fairy shrimp species. Branchinecta sandiegonensis Fugate, 1993 has been particularly affected by urban and agricultural development in its small native range within San Diego County, California, USA. It is listed as an endangered species under federal laws and...

Genetic Adaptation in New York City Rats

Arbel Harpak, Nandita Garud, Noah Rosenberg, Dmitri Petrov, Pleuni Pennings & Jason Munshi-South
Brown rats (Rattus norvegicus) thrive in urban environments by navigating the anthropocentric environment and taking advantage of human resources and by-products. From the human perspective, rats are a chronic problem that causes billions of dollars in damage to agriculture, health and infrastructure. Did genetic adaptation play a role in the spread of rats in cities? To approach this question, we collected whole-genome sequences from 29 brown rats from New York City (NYC) and scanned for...

Isotopologue distributions of fatty acid oxidation inhibition in U87 glioma cells

Jantzen Sperry, Michael C. Condro, Lea Guo, Daniel Braas, Nathan Vanderveer-Harris, Kristen K. O. Kim, Whitney B. Pope, Ajit S. Divakaruni, Albert Lai, Heather Christofk, Maria G. Castro, Pedro R. Lowenstein, Janel Le Belle & Harley I. Kornblum
Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in GBM and assessed the role of fatty acid oxidation (FAO) in promoting GBM propagation. In vitro assays revealed FA utilization throughout the GBM metabolome, and growth inhibition in nearly every cell line in a broad spectrum of patient-derived...

BioMar-ACG: A successful partnership to inventory and promulgate marine biodiversity

Jorge Cortés & Frank Joyce
Initiated in 2015, the marine inventory of Área de Conservación Guanacaste (BioMar-ACG) is rapidly advancing knowledge of biodiversity. Key aspects include: synergizing with parataxonomists, barcoding specimens and making information available. After 85 years, 594 species were reported. Now, after four years, BioMar-ACG documented 1,123 species, for a total of 1,479.

Maps of northern peatland extent, depth, carbon storage and nitrogen storage

Gustaf Hugelius, Julie Loisel, Sarah Chadburn, Robert B. Jackson, Miriam Jones, Glen MacDonald, Maija Marushchak, David Olefeldt, Maara Packalen, Matthias B. Siewert, Claire Treat, Merritt Turestsky, Carolina Voigt & Zicheng Yu
This dataset is grids of peatland extent, peat depth, peatland organic carbon storage, peatland total nitrogen storage and approximate extent of ombrotrophic/minerotrophic peatlands. The grids are geotiff files in 10 km pixel resolution projected in the World Azimuthal Equidistant projection. Note that the peat depth grid shows potential peat depth everywhere,also where there is no peatland cover. For files on peatland organic carbon, total nitrogen extent and extent of ombrotrophic/minerotrophic peatlands, there are separate files...

Data from: The subcortical basis of outcome and cognitive impairment in TBI: a longitudinal cohort study

Evan S Lutkenhoff, Matthew J Wright, Vikesh Shrestha, Courtney Real, David L. McArthur, Manuel Buitrago-Blanco, Paul M Vespa & Martin M Monti
Objective: To understand how, biologically, the acute event of traumatic brain injury gives rise to a long-term disease, we address the relationship between evolving cortical and subcortical brain damage and measures of functional outcome and cognitive functioning at six months post-injury. Methods: Longitudinal analysis of clinical and MRI data collected, in a tertiary neurointensive care setting, in a continuous sample of 157 patients surviving moderate to severe traumatic brain injury between 2000 and 2018. For...

Sex-dimorphic effects of Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1) deficiency on mouse perinatal brain development

Cristina Ghiani & Esteban Dell'Angelica
The function(s) of the Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1) during brain development is hitherto largely unknown. Here, we investigated how its absence alters the trajectory of postnatal brain development using as model the pallid mouse. Most of the defects observed early postnatally in the mutant mice were more prominent in males than in females and in the hippocampus. Male mutant mice, but not females, had smaller brains as compared to sex-matching wild-types at...

Data from: Animal models to understand the etiology and pathophysiology in polycystic ovary syndrome

Elisabet Stener-Victorin, Vasantha Padmanabhan, Kirsty A Walters, Rebecca E Campbell, Anna Benrick, Paolo Giacobini, Daniel A Dumesic & David H Abbott
More than one out of ten women worldwide are diagnosed with the leading cause of female reproductive and metabolic dysfunction, polycystic ovary syndrome (PCOS). Despite its high prevalence, PCOS and its accompanying morbidities are likely under-diagnosed, averaging >2 years and 3 physicians changes before women are diagnosed. Despite intensive research, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent...

When form does not predict function: empirical evidence violates functional form hypotheses for marine macroalgae

Emily Ryznar, Peggy Fong & Caitlin Fong
1) Functional groups are widely used to reduce complexity and generalize across ecological communities. These models assume that shared traits among species correspond to some ecological role, process, or function, and that these traits can be leveraged to generate meaningful and distinct functional groups so that intergroup trait variation exceeds intragroup variation. 2) We sought to validate the assumptions of the widely used Functional Group Model (FGM) for marine macroalgae, which groups species based on...

An incoherent feedforward loop interprets NFkappaB/RelA dynamics to determine TNF-induced necroptosis decisions

Marie Oliver Metzig
Balancing cell death is essential to maintain healthy tissue homeostasis and prevent disease. Tumor necrosis factor (TNF) not only activates nuclear factor kB (NFkappaB), which coordinates the cellular response to inflammation, but may also trigger necroptosis, a pro-inflammatory form of cell death. Whether TNF-induced NFkappaB affects the fate decision to undergo TNF-induced necroptosis is unclear. Live-cell microscopy and model-aided analysis of death kinetics identified a molecular circuit that interprets TNF-induced NFkappaB/RelA dynamics to control necroptosis...

Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23-26ºC

Marta Shocket, Anna Verwillow, Mailo Numazu, Hani Slamani, Jeremy Cohen, Fadoua El Moustaid, Jason Rohr, Leah Johnson & Erin Mordecai
The temperature-dependence of many important mosquito-borne diseases has never been quantified. These relationships are critical for understanding current distributions and predicting future shifts from climate change. We used trait-based models to characterize temperature-dependent transmission of 10 vector–pathogen pairs of mosquitoes (Culex pipiens, Cx. quinquefascsiatus, Cx. tarsalis, and others) and viruses (West Nile, Eastern and Western Equine Encephalitis, St. Louis Encephalitis, Sindbis, and Rift Valley Fever viruses), most with substantial transmission in temperate regions. Transmission is...

Data from: Age influences the thermal suitability of Plasmodium falciparum transmission in the Asian malaria vector Anopheles stephensi

Courtney Murdock, Kerri Miazgowicz, Erin Mordecai, Sadie Ryan, Richard Hall, Harry Owen, Temitayo Adanlawo, Kavya Balaji, Marta Shocket, Oswaldo Villena, Leah Johnson, Blanka Tesla, Leah Demakovsky, Matt Bonds, Calistus Ngonghala & Melinda Brindley
Models predicting disease transmission are vital tools for long-term planning of malaria reduction efforts, particularly for mitigating impacts of climate change. We compared temperature-dependent malaria transmission models when mosquito life history traits were estimated from a truncated portion of the lifespan (a common practice) to traits measured across the full lifespan. We conducted an experiment on adult female Anopheles stephensi, the Asian urban malaria mosquito, to generate daily per capita values for mortality, egg production,...

Data from: Addressing incomplete lineage sorting and paralogy in the inference of uncertain salmonid phylogenetic relationships

Matthew Campbell, Thaddaeus Buser, Michael Alfaro & J. Andres Lopez
Recent and continued progress in the scale and sophistication of phylogenetic research has yielded substantial advances in knowledge of the tree of life; however, segments of that tree remain unresolved and continue to produce contradicting or unstable results. These poorly resolved relationships may be the product of methodological shortcomings or of an evolutionary history that did not generate the signal traits needed for its eventual reconstruction. Relationships within the euteleost fish family Salmonidae have proven...

Model output for: Attributing causes of future climate change in the California Current System with multi-model downscaling

Evan Howard, Hartmut Frenzel, Fayçal Kessouri, Lionel Renault, Daniele Bianchi, James McWilliams & Curtis Deutsch
Regional Ocean Modeling System outputs from dynamic downscaling of Coupled Model Intercomparison Project climate forcings in the California Current system, including projections with full climate forcings, as well as attribution experiments with only changes in wind, heat fluxes and other properties changing stratification, and boundary biogeochemical forcings. Output variables include euphotic zone integrated net primary productivity, and incident photosytnehtically available radiation, and ocean temperature, salinity, vertical velocity, and dissolved oxygen and nitrate concentrations at select...

Collective decision-making when quantity is more important than quality: Lessons from a kidnapping social parasite

Julie Miller
Identifying the general principles that shape mechanisms of collective decision-making requires studies that span a diversity of ecological contexts. However, collective decision-making has only been explored in a handful of systems. Here, I investigate the ecologically mediated costs and benefits of collective-decisions by socially parasitic kidnapping ants (Temnothorax americanus) over where to launch raids to steal host brood. I first investigate their sampling strategies and preferences with choice-tests. Using more realistic spatial scales, I confirm...

Data package from 'Pantropical variability in tree crown allometry' Global Ecology and Biogeography 2021. DOI: 10.1111/geb.13231

Grace Jopaul Loubota Panzou, Adeline Fayolle, Tommaso Jucker, Oliver Phillips, Stephanie Bohlman, Lindsay F. Banin, Simon L. Lewis, Kofi Affum-Baffoe, Luciana F. Alves, Cécile Antin, Eric Arets, Luzmila Arroyo, Timothy R. Baker, Nicolas Barbier, Hans Beeckman, Uta Berger, Yannick Enock Bocko, Frans Bongers, Sam Bowers, Thom Brade, Eduardo S. Brondizio, Arthur Chantrain, Jerome Chave, Halidou Compaore & David Coomes

Registration Year

  • 2020

Resource Types

  • Dataset


  • University of California Los Angeles
  • Stanford University
  • University of Washington
  • Virginia Tech
  • University of Florida
  • University of California, San Francisco
  • Columbia University
  • David Geffen School of Medicine at UCLA
  • Natural History Museum of Los Angeles County
  • Indiana University