16 Works

Data from: The earliest reef-building anthaspidellid sponge Rankenella zhangxianensis n. sp. from the Zhangxia Formation (Cambrian Series 3), Shandong Province, China

Jeong-Hyun Lee, Jusun Woo & Dong-Jin Lee
This study reports the earliest known reef-building anthaspidellid sponge, Rankenella zhangxianensis n. sp., from the Cambrian Series 3 (late Stage 5–early Guzhangian) deposit of the Zhangxia Formation, Shandong Province, China. Rankenella zhangxianensis mostly occurs within Epiphyton-Rankenella-Cambroctoconus reefs, with minor occurrence from inter-reef grainstone. The species has anthaspidellid-type regular ladderlike spicule networks consisting of dendroclones and trabs, and is characterized by trabs parallel/subparallel to the gastral surface that diverge and meet the dermal surface, which is...

Data from: Sublingual immunotherapy (SLIT) for house dust mites does not prevent new allergen sensitization and bronchial hyper-responsiveness in allergic rhinitis children

Jae Hyun Lim, Jin Youp Kim, Doo Hee Han, Chul Hee Lee, Seung-No Hong, Jee Hye Wee, Sue K. Park & Chae-Seo Rhee
Introduction: The aim of this study is to identify the effects of sublingual immunotherapy (SLIT) on immunologic parameters and bronchial-hyper-responsiveness in children with allergic rhinitis to house-dust mite (HDM), through long-term follow-up cohort. Methods: Among the Allergic Rhinitis Cohort Study for Kids, pediatric patients who visited the hospital for rhinitis symptoms and proven allergy to HDM through skin prick test were studied. In this cohort, 37 patients received SLIT more than 3-years (SLIT group), and...

Neurological deterioration in patients with acute ischemic stroke or transient ischemic attack

Tai Hwan Park, Jeong-Kon Lee, Moo-Seok Park, Sang-Soon Park, Keun-Sik Hong, Wi-Sun Ryu, Dong-Eog Kim, Man Seok Park, Kang-Ho Choi, Joon-Tae Kim, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Jun Lee, Jae-Kwan Cha, Dae-Hyun Kim, Jae Guk Kim, Soo Joo Lee, Yong-Jin Cho, Jee-Hyun Kwon, Dong-Ick Shin, Min-Ju Yeo, Sung Il Sohn, Jeong-Ho Hong, Ji Sung Lee … & Hee-Joon Bae
Objective: To improve epidemiological knowledge of neurological deterioration (ND) in patients with acute ischemic stroke (AIS). Methods: In this prospective observational study, we captured ND prospectively in 29,446 AIS patients admitted to 15 hospitals in Korea within 7 days of stroke onset. ND was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor or consciousness), or any new neurological symptoms. Change of incidence rate after stroke...

Data from: Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth Study

Young-Jun Rhie, Jae-Ho Yoo, Jin-Ho Choi, Hyun-Wook Chae, Jae Hyun Kim, Sochung Chung, , Choong Ho Shin, Eun Young Kim & Ho-Seong Kim
Purpose The aim of this registry study was to analyze the long-term safety and effectiveness of recombinant human growth hormone (rhGH) in South Korean pediatric patients (≥2 years of age) with growth hormone deficiency GHD) of idiopathic or organic etiology, idiopathic short stature, Turner syndrome, small for gestational age and chronic renal failure. Methods The study patients were followed-up till two years after the epiphyseal closure, with visits scheduled every six months. The outcome measures...

Data from: Audio-visual interactions uniquely contribute to resolution of visual conflict in people possessing absolute pitch

Sujin Kim, Randolph Blake, Minyoung Lee & Chai-Youn Kim
Individuals possessing absolute pitch (AP) are able to identify a given musical tone or to reproduce it without reference to another tone. The present study sought to learn whether this exceptional auditory ability impacts visual perception under stimulus conditions that provoke visual competition in the form of binocular rivalry. Nineteen adult participants with 3 - 19 years of musical training were divided into two groups according to their performance on a task involving identification of...

Data from: Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein coupled receptor

Arfaxad Reyes-Alcaraz, Yoo-Na Lee, Seongsik Yun, Jong-Ik Hwang & Jae Young Seong
Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while Galanin induces the activation of the galanin receptor 2 (Galr2) that leads to a robust stimulation toward Gαq-protein and β-arrestin1/2, an alternative ligand Spexin and its analog have biased agonism toward G-protein signaling relative to Galanin. We used intramolecular fluorescein...

Path-finding algorithm as a dispersal assessment method for invasive species with human-vectored long-distance dispersal event

Sung-Joo Lee, Hyojin Cho, Yuyoung Choi, Won Il Choi, Hye In Chung, No Ol Lim, Youngwoo Nam & Seongwoo Jeon
Aim: An assessment method that can precisely represent human-vectored long-distance dispersals (HVLDD) is currently in need for effective management of invasive species. Here, we focused on HVLDD happening along roads and proposed a path-finding algorithm as a more precise dispersal assessment tool than the most widely used Euclidean distance method by using pine wilt disease (PWD) as a case study. Location: Busan Metropolitan City, Republic of Korea Methods: A path-finding algorithm, which calculates distances by...

Data from: DNA methylation changes associated with type 2 diabetes and diabetic kidney disease in an East Asian population

Hakyung Kim, Jae Hyun Bae, Kyoung Soo Park, Joohon Sung & Soo Heon Kwak
Objective: There is growing body of evidence that epigenetic changes including DNA methylation influence the risk of type 2 diabetes and its microvascular complications. We conducted a methylome-wide association study (MWAS) to identify differentially methylated regions (DMRs) of type 2 diabetes and diabetic kidney disease (DKD) in Korean population. Methods: We performed an initial MWAS in 232 participants in a case-control study design with type 2 diabetes and 197 non-diabetic controls with Illumina EPIC bead...

Data from: Morphometrics and paleoecology of Catenipora (Tabulata) from the Xiazhen Formation (Upper Ordovician), Zhuzhai, South China

Kun Liang, Robert J. Elias, Suk-Joo Choh, Dong-Chan Lee & Dong-Jin Lee
Catenipora is one of the most common tabulate coral genera occurring in various lithofacies in the Upper Ordovician Xiazhen Formation at Zhuzhai in South China. A combination of traditional multivariate analysis and geometric morphometrics is applied to a large number of specimens to distinguish and identify species. Based on three major principal components extracted from 11 morphological characters, three major groups as determined by the cluster-analysis dendrogram are considered to be morphospecies. Their validity and...

Data from: Lateralized feeding behavior is associated with asymmetrical neuroanatomy and lateralized gene expressions in the brain in scale-eating cichlid fish

Hyuk Je Lee, Ralf F. Schneider, Tereza Manousaki, Ji Hyoun Kang, Etienne Lein, Paolo Franchini & Axel Meyer
Lateralized behavior (‘handedness’) is unusual, but consistently found across diverse animal lineages, including humans. It is thought to reflect brain anatomical and/or functional asymmetries, but its neuro-molecular mechanisms remain largely unknown. Lake Tanganyika scale-eating cichlid fish, Perissodus microlepis show pronounced asymmetry in their jaw morphology as well as handedness in feeding behavior – feeding scales preferentially only from one or the other side of their victims. This makes them an ideal model in which to...

Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7

Young-Gyu Ko, Hyun Lee, Dong-Min Yu, Myeong-Suk Bahn, Young-Jae Kwon, Min Jee Um, Seo Yeon Yoon, Ki-Tae Kim, Myoung-Woo Lee, Sung-Je Jo, Sungsoo Lee, Seung-Hoi Koo, Ki Hoon Jung & Jae-Seon Lee
Prominin-1 (PROM1), also known as CD133, is known to be expressed in hepatic progenitor cells (HPCs) and cholangiocytes of fibrotic liver. In this study, we show that PROM1 was upregulated in the plasma membranes of fibrotic hepatocytes. The hepatocellular expression of PROM1 was also demonstrated in the mice (Prom1CreER; R26TdTom) where cells express TdTom under the control of Prom1 promoter. To understand the role of hepatocellular PROM1 on liver fibrosis, global and liver- and cholangiocyte-specific...

Genome-wide molecular phylogenetic analyses and mating experiments which reveal the evolutionary history and an intermediate stage of speciation of a giant water bug

Tomoya Suzuki, Koki Yano, Shin-Ya Ohba, Keisuke Kawano, Kazuki Sekiné, Yeon Jae Bae & Koji Tojo
The intermediate stages of speciation are important for understanding the processes involved in the creation of biodiversity, and also comprise a number of interesting phenomena. However, difficulties are associated with dividing clear speciation stages because speciation is a continuous process. Therefore, the elucidation of speciation is an interesting and important task in evolutionary biology. We herein present an example of a species in an intermediate stage of speciation using the giant water bug Appasus japonicus...

Data from: Statin therapy in acute cardioembolic stroke with no guidance-based indication

Hong-Kyun Park, Ji Sung Lee, Keun-Sik Hong, Yong-Jin Cho, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah Nah, Moon-Ku Han, Beom Joon Kim, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Joon-Tae Kim, Kang-Ho Choi, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi … & Hee-Joon Bae
Objective It is uncertain if patients with cardioembolic stroke and absence of a guidance-based indication for statin therapy should be administered a statin for prevention of subsequent vascular events. This study was performed to determine whether the statin therapy is beneficial to prevent major vascular events in this population. Methods Using a prospective multicenter stroke registry database, we identified acute cardioembolic stroke patients who were hospitalized between 2008 and 2015. Patients who had other established...

Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral hemorrhage

Jaeyoon Chung, Graham Hamilton, Minsup Kim, Sandro Marini, Bailey Montgomery, Jonathan Henry, Art Cho, Devin Brown, Bradford Worrall, James Meschia, Scott Silliman, Magdy Selim, David Tirschwell, Chelsea Kidwell, Brett Kissela, Steven Greenberg, Anand Viswanathan, Joshua Goldstein, Carl Langefeld, Kristiina Rannikmae, Catherine Sudlow, Neshika Samarasekera, Mark Rodrigues, Rustam Salman, James Prendergast … & Christopher Anderson
Objective To test the genetic contribution of rare missense variants in COL4A1 and COL4A2 in which common variants are genetically associated with sporadic intracerebral hemorrhage (ICH), we performed rare variant analysis in multiple sequencing data for the risk for sporadic ICH. Methods We performed sequencing across 559Kbp at 13q34 including COL4A1 and COL4A2 among 2,133 individuals (1,055 ICH cases; 1,078 controls) in US-based and 1,492 individuals (192 ICH cases; 1,300 controls) from Scotland-based cohorts, followed...

Data from: Pathology in repeated transurethral resection of a bladder tumor as a risk factor for prognosis of high-risk non-muscle-invasive bladder cancer

Bum Sik Tae, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon & Ja Hyeon Ku
The prognostic value of repeat transurethral resection of bladder tumor (TURBT) in patients with diagnosed high-risk, non-muscle-invasive bladder cancer (NMIBC) was investigated. We retrospectively reviewed the medical records of patients treated from October 2004 to December 2013 at Seoul National University who underwent repeated TURBT within 2–6 weeks after an initial resection. The study enrolled patients who had been diagnosed with NMIBC at both the initial and repeat TURBT; patients with muscle-invasive tumors on repeat...

Data from: Population genetic structure of eelgrass (Zostera marina) on the Korean coast: current status and conservation implications for future management

Jae Hwan Kim, Ji Hyoun Kang, Ji Eun Jang, Sun Kyeong Choi, Min Ji Kim, Sang Rul Park & Hyuk Je Lee
Seagrasses provide numerous ecosystem services for coastal and estuarine environments, such as nursery functions, erosion protection, pollution filtration, and carbon sequestration. Zostera marina (common name "eelgrass") is one of the seagrass bed-forming species distributed widely in the northern hemisphere, including the Korean Peninsula. Recently, however, there has been a drastic decline in the population size of Z. marina worldwide, including Korea. We examined the current population genetic status of this species on the southern coast...

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  • Korea University
  • Seoul National University Bundang Hospital
  • Seoul National University
  • Seoul Medical Center
  • Chonnam National University Hospital
  • Sangji University
  • Dongguk University Ilsan Hospital
  • Seoul National University Hospital
  • Inje University Ilsan Paik Hospital
  • University of Ulsan