57 Works

Cortical microstructural correlates of astrocytosis in autosomal dominant Alzheimer disease

Eduard Vilaplana, Elena Rodriguez-Vieitez, Daniel Ferreira, Victor Montal, Ove Almkvist, Anders Wall, Alberto Lleo, Eric Westman, Caroline Graff, Juan Fortea & Agneta Nordberg
Objective To study the macrostructural and microstructural MRI correlates of brain astrocytosis, measured with 11C-deuterium-L-deprenyl (11C-DED)–PET, in familial autosomal dominant Alzheimer disease (ADAD). Methods The total sample (n = 31) comprised ADAD mutation carriers (n = 10 presymptomatic, 39.2 ± 10.6 years old; n = 3 symptomatic, 55.5 ± 2.0 years old) and noncarriers (n = 18, 44.0 ± 13.7 years old) belonging to families with mutations in either the presenilin-1 or amyloid precursor protein...

Data from: Small Carbonaceous Fossils (SCFs) from North Greenland: new light on metazoan diversity in early Cambrian shelf environments

Elise Wallet, Ben Slater, Sebastian Willman & John Peel
The Sirius Passet Lagerstätte of North Greenland provides one of the oldest records of soft-bodied metazoan-dominated ecosystems from within the early Cambrian. The Lagerstätte site itself is restricted to just a single ~1 km-long outcrop located offshore from the shelf margin, in an area that has been affected by metamorphic alteration during the Ellesmerian Orogeny (Devonian–Early Carboniferous). The recent recovery of Small Carbonaceous Fossils (SCFs) to the south in areas that have escaped the effects...

Experimentally induced intrasexual mating competition and sex-specific evolution in female and male nematodes

Josefine Stångberg, Elina Immonen, Pilar Puimedon Moreno & Elisabeth Bolund
Sexual dimorphism in life history traits and their trade-offs is widespread among sexually reproducing animals, and is strongly influenced by the differences in reproductive strategies between the sexes. We investigated how intrasexual competition (pre- and postcopulatory) acted on specific life history traits, important to fitness, and their trade-offs in the outcrossing nematode Caenorhabditis remanei. Here, we imposed strong sex-specific selection through experimental evolution with increased potential for intrasexual competition by skewing the adult sex ratio...

Data from: Mechanisms of male-male interference during dispersal of orchid pollen

Lawrence Harder, Shane A. Richards, Jon Ågren & Steven D. Johnson
Siring success of flowering plants depends on the fates of male gametophytes, which compete for access to stigmas, stylar resources and ovules. Although rarely considered, pollen may often compete during dispersal, affecting the processes required for export to stigmas; pollen pickup, transport and deposition. We quantified dispersal interference by tracking bee dispersal of stained Anacamptis morio (Orchidaceae) pollen from individual donor flowers and inferred the affected dispersal mechanisms based on the fit of a process-based...

Raw fitness data (offspring number and weight), main dataset for manuscript: Female-specific resource limitation does not make the opportunity for selection more female biased

Ivain Martinossi-Allibert, Elina Immonen & Johanna L. Rönn
The present dataset contains the entirety of the raw empirical data used in the manuscript entitled: "Female-specific resource limitation does not make the opportunity for selection more female biased". This data is composed of offspring count and weight, which represent proxys of fitness. Fitness was assessed for males and females independently, and across three different experimental treatments. These fitness measures are used to calculate the opportunity for selection, as the variance in realtive fitness. Detailed...

Scripts and files for \"Small-scale population divergence is driven by local larval environment in a temperate amphibian\"

Patrik Rödin Mörch, Hugo Palejowski, Maria Cortazar-Chinarro, Simon Kärvemo, Alex Richter-Boix, Jacob Höglund & Anssi Laurila
Genomic variation within and among populations is shaped by the interplay between natural selection and the effects of genetic drift and gene flow. Adaptive divergence can be found in small scale natural systems even when population sizes are small and the potential for gene flow is high, suggesting that local environments exert selection pressures strong enough to counteract the opposing effects of drift and gene flow. Here, we investigated genomic differentiation in nine moor frog...

Data from: Regulation of fatty acid composition related to ontogenetic changes and niche differentiation of a common aquatic consumer

Fernando Chaguaceda, Scharnweber Kristin & Peter Eklöv
Fatty acids (FAs) are key nutrients for fitness which take part in multiple physiological processes over the ontogeny of organisms. Yet, we lack evidence on how FA nutrition mediates life-history trade-offs and ontogenetic niche shifts in natural populations. In a field study, we analyzed ontogenetic changes in the FAs of Eurasian perch (Perca fluviatilis L.), a widespread fish that goes through ontogenetic niche shifts and can have high individual niche specialization. Diet explained most of...

Supplemental materials of: Ignored biodiversity in acid soil islands in karst areas, South China: Impatiens longlinensis (Balsaminaceae), a new critically endangered species

Tian-Tian Xue, Chang-Ying Xia, Magnus Lidén, Wei-Bin Xu, Zhao-Cen Lu, Hai-Ling Chen, Shu-Wan Li & Sheng-Xiang Yu
The karst area in South China is notable for its fragile vegetation and unique flora with many narrow endemics, and is one of the most threatened biodiversity hotspots in the world. However, the biodiversity of acid soil areas scattered in the karst area have previously been underestimated. With a recent increase of new discoveries of plants and animals, the conservation of biodiversity in these acid soil areas has become urgent. This study deals with a...

Data from: Trade-off between somatic and germline repair in a vertebrate supports the expensive germ line hypothesis

Simone Immler, Hwei-Yen Chen, Kasparas Bublys, Cecile Jolly & Daniel Marcu
The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301–304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B Biol. Sci. 205, 531–546 (1979); T. B. L. Kirkwood, S. N. Austad, Nature 408, 233–238 (2000)]. Limited resources and a possible trade-off between the repair and maintenance of the germ cells and growth and...

High variation in last male sperm precedence and genital morphology in the emerald damselfly Lestes sponsa

Frank Johansson, David Berger, Jacob Höglund, Yvonne Meyer-Lucht, Patrik Rödin-Mörch, Szymon Sniegula & Phillip Watts
In organisms where individuals mate multiply, knowledge on the proportion of offspring sired by the last male to mate (P2) under field conditions is important for a thorough understanding of how sexual selection works in nature. In many insect groups, pronounced intraspecific variation in P2 is commonplace. Interestingly, however, in stark contrast to these observations, compilation of P2 data in dragonflies and damselflies (Odonata) indicate that a high P2, seldom below 0.95, is a feature...

Data from: Scented nectar and the challenge of measuring honest signals in pollination

Amy Parachnowitsch, Rosalie Burdon, Rob Raguso, Robert Gegear, Ellen Pierce & André Kessler
1. Nectar scents are thought to function as honest signals of reward used by pollinators, but this hypothesis has rarely been tested. 2. Using Penstemon digitalis, we examined honest signalling of the nectar volatile (S)-(+)-linalool and pollinator responses to linalool in both field and laboratory settings. Because our previous work showed that linalool emission was associated with higher female fitness and that nectar is scented with linalool, we hypothesized that linalool was an honest signal...

Data from: Algal affinity and possible life cycle of the early Cambrian acritarch Yurtusia uniformis from South China

Xiaodong Shang, Pengju Liu, Małgorzata Moczydłowska & Ben Yang
Abundant, well-preserved specimens of spheroidal organic-walled microfossil Yurtusia uniformis are reported from the basal Cambrian Yanjiahe Formation in the Changyang area of Hubei Province, South China. Thin and hollow processes extend between the double walls of the vesicle. The single to multiple internal bodies within the vesicle cavity are observed in the genus for the first time, representing reproductive structures (dividing daughter cells). A small circular perforation may occur on the vesicle wall to release...

French (F) and Swedish (S) Founder (P) and Mutation Accumulation Line (MA) performance in France and Sweden

Charles Fenster, Mao-Lun Weng, Jon Agren, Henning Nottebrock, Eric Imbert & Matthew Rutter
Little is empirically known about the contribution of mutations to fitness in natural environments. However, Fisher's Geometric Model (FGM) provides a conceptual foundation to consider the influence of the environment on mutational effects. To quantify mutational properties in the field, we established eight sets of MA lines (7-10 generations) derived from eight founders collected from natural populations of Arabidopsis thaliana from French and Swedish sites, representing the range margins of the species in Europe. We...

Genomic variation data for the wagtail hybrid zone

Georgy Semenov, Ethan Link, Erik Enbody, Rebecca Harris, David Khaydarov, Per Alström, Leif Andersson & Scott Taylor
Genome-wide variation in introgression rates across hybrid zones offers a powerful opportunity for studying population differentiation. One poorly understood pattern of introgression is the geographic displacement of a trait implicated in lineage divergence from genome-wide population boundaries. While difficult to interpret, this pattern can facilitate the dissection of trait genetic architecture because traits become uncoupled from their ancestral genomic background. We studied an example of trait displacement generated by the introgression of head plumage coloration...

The role of low-grade inflammation in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) - associations with symptoms

Anna Andreasson, Martin Jonsjö, Gunnar Olsson, Rikard K Wicksell, Kjell Alving & Linda Holmström
Background Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) often present with a range of flu-like symptoms resembling sickness behavior as well as widespread pain and concentration deficits. The aim of this study was to explore the association between inflammatory markers previously shown to be related to fatigue severity in ME/CFS and common ME/CFS symptoms post-exertional fatigue, impaired cognitive processing, musculoskeletal pain and recurrent flu-like symptoms, and the moderating effect of sex on these associations. Methods...

Data from: Shift in ecological strategy helps marginal populations of shepherd's purse (Capsella bursa-pastoris) to overcome a high genetic load

Marion Orsucci, Pascal Milesi, Johanna Hansen, Johanna Girodolle, Sylvain Glémin & Martin Lascoux
The outcome of species range expansion depends on the interplay of demographic, environmental and genetic factors. Self-fertilizing species usually show a higher invasive ability than outcrossers but selfing and bottlenecks during colonization also lead to an increased genetic load. The relationship between genomic and phenotypic characteristics of expanding populations has, hitherto, rarely been tested experimentally. We analyzed how accessions of the shepherd’s purse, C. bursa-pastoris, from the colonization front or from the core of the...

Intrinsic post-ejaculation sperm ageing does not affect offspring fitness in Atlantic salmon

Simone Immler, Cosima Hotzy, Bao Xuhui & Tuuli Larva
Postmeiotic sperm ageing, both before and after ejaculation, has been shown to negatively affect offspring fitness by lowering the rate of embryonic development, reducing embryonic viability, and decreasing offspring condition. These negative effects are thought to be caused by intrinsic factors such as oxidative stress and ATP depletion or extrinsic factors such as temperature and osmosis. Effects of post-ejaculation sperm ageing on offspring fitness have so far almost exclusively been tested in internal fertilisers. Here,...

Protein expression of hepatocellular carcinoma in a fibrotic liver in mice

Femke Heindryckx
Hepatocellular carcinoma (HCC) is a liver tumor that arises in patients with cirrhosis. One of the key players in the progression of cirrhosis to HCC is the hepatic stellate cell, which is activated during liver damage. Activated stellate cells play an essential role in the pathogenesis of HCC by creating a fibrotic micro-environment that sustains tumor growth and by producing growth factors and cytokines that enhance tumor cell proliferation and migration. We assessed the role...

Mathematical chromatography deciphers the molecular fingerprints of dissolved organic matter

Urban J. Wünsch & Jeffrey A. Hawkes
High-resolution mass spectrometry (HRMS) elucidates the molecular composition of dissolved organic matter (DOM) through the unequivocal assignment of molecular formulas. When HRMS is used as a detector coupled to high performance liquid chromatography (HPLC), the molecular fingerprints of DOM are further augmented. However, the identification of eluting compounds remains impossible when DOM chromatograms consist of unresolved humps. Here, we utilized the concept of mathematical chromatography to achieve information reduction and feature extraction. Parallel Factor Analysis...

Reference allele frequencies for populations pools of Atlantic Herring (Clupea harengus)

Mats Pettersson & Leif Andersson
Atlantic herring is widespread in North Atlantic and adjacent waters and is one of the most abundant vertebrates on earth. This species is well suited to explore genetic adaptation due to minute genetic differentiation at selectively neutral loci. Here we report hundreds of loci underlying ecological adaptation to different geographic areas and spawning conditions. Four of these represent megabase inversions confirmed by long read sequencing. The genetic architecture underlying ecological adaptation in herring deviates from...

Data from: The effects of drift and selection on latitudinal genetic variation

Filip Thörn, Patrik Rödin-Mörch, Maria Cortazar-Chinarro, Alex Richter-Boix, Anssi Laurila & Jacob Höglund
Clinal variation is paramount for understanding the factors shaping genetic diversity in space and time. During the last glacial maximum, northern Europe was covered by glacial ice that rendered the region uninhabitable for most taxa. Different evolutionary processes during and after the recolonisation of this area from different glacial refugia have affected the genetic landscape of the present-day European flora and fauna. In this study, we focus on the common toad (Bufo bufo) in Sweden...

Environmental drivers of Sphagnum growth in peatlands across the Holarctic region

Fia Bengtsson, Håkan Rydin, Jennifer Baltzer, Luca Bragazza, Zhao-Jun Bu, Simon Caporn, Ellen Dorrepaal, Kjell Ivar Flatberg, Olga Galanina, Mariusz Gałka, Anna Ganeva, Irina Goia, Nadezhda Goncharova, Michal Hajek, Akira Haraguchi, Lorna Harris, Elyn Humphreys, Martin Jiroušek, Katarzyna Kajukało, Edgar Karofeld, Natalia Koronatova, Natalia Kosykh, Anna Laine, Mariusz Lamentowicz, Elena Lapshina … & Richard J. Payne
The relative importance of global versus local environmental factors for growth and thus carbon uptake of the bryophyte genus Sphagnum – the main peat-former and ecosystem engineer in northern peatlands – remains unclear. 2) We measured length growth and net primary production (NPP) of two abundant Sphagnum species across 99 Holarctic peatlands. We tested the importance of previously proposed abiotic and biotic drivers for peatland carbon uptake (climate, N deposition, water table depth, and vascular...

Strong stabilizing selection on timing of germination in a Mediterranean population of Arabidopsis thaliana

Giulia Zacchello, Mariona Vinyeta & Jon Ågren
Premise Timing of germination can strongly influence plant fitness by affecting seedling survival and by having cascading effects on later life-history traits. In seasonal environments, the period favorable for seedling establishment and growth is limited, and timing of germination is likely to be under stabilizing selection because of conflicting selection through survival and fecundity. Moreover, optimal germination time may vary among genotypes because of inherent differences in later life-history traits. Methods To examine how germination...

Data from: Quantitative genetics of the use of conspecific and heterospecific social cues for breeding site choice

Jere Tolvanen, Sami Mikael Kivelä, Blandine Doligez, Jennifer Morinay, Lars Gustafsson, Piter Bijma, Veli-Matti Pakanen & Jukka T. Forsman
Social information use for decision-making is common and affects ecological and evolutionary processes, including social aggregation, species coexistence and cultural evolution. Despite increasing ecological knowledge on social information use, very little is known about its genetic basis and therefore its evolutionary potential. Genetic variation in a trait affecting an individual's social and non-social environment may have important implications for population dynamics, interspecific interactions and for expression of other, environmentally plastic traits. We estimated repeatability, additive...

Ediacaran metazoan fossils with siliceous skeletons from the Digermulen Peninsula of Arctic Norway – Supplementary Data

Malgorzata Moczydlowska-Vidal, Benjamin Kear, Daniel Snitting, Lei Liu, Peter Lazor & Jaroslaw Majka
In this study, a new assemblage of Ediacaran metazoan fossils is reported from the basal Stáhpogieddi Formation on the Digermulen Peninsula of Arctic Norway, including Anulitubus n. gen. Moczydłowska in Moczydłowska et al., Anulitubus formosus n. gen. n. sp. Moczydłowska in Moczydłowska et al., Coniculus n. gen. Moczydłowska in Moczydłowska et al., Coniculus elegantis n. gen. n. sp. Moczydłowska in Moczydłowska et al., Fistula n. gen. Moczydłowska in Moczydłowska et al., Fistula crenulata n. gen....

Registration Year

  • 2020

Resource Types

  • Dataset


  • Uppsala University
  • University of Copenhagen
  • University of East Anglia
  • University of Oulu
  • University of Cambridge
  • University of Lausanne
  • Swedish University of Agricultural Sciences
  • University of Calgary
  • Karolinska Institute
  • Stockholm University