38 Works

Selection in males purges the mutation load on female fitness

Karl Grieshop, Paul Maurizio, Göran Arnqvist & David Berger
Theory predicts that the ability of selection and recombination to purge mutation load is enhanced if selection against deleterious genetic variants operates more strongly in males than females. However, direct empirical support for this tenet is limited, in part because traditional quantitative genetic approaches allow dominance and intermediate-frequency polymorphisms to obscure the effects of the many rare and partially recessive deleterious alleles that make up the main part of a population’s mutation load. Here, we...

Rhagoletis cingulata and Rhagoletis cerasi genome comparison

Thomas Wolfe, Daniel Bruzzese, Lisa Klasson, Erika Corretto, Sonja Lečić, Christian Stauffer, Jeffrey Feder & Hannes Schuler
Wolbachia is a maternally inherited obligate endosymbiont that can induce a wide spectrum of effects in its host, ranging from mutualism to reproductive parasitism. At the genomic level, recombination within and between strains, transposable elements, and horizontal transfer of strains between host species make Wolbachia an evolutionarily dynamic bacterial system. The invasive cherry fruit fly Rhagoletis cingulata arrived in Europe from North America ~40 years ago, where it now co-occurs with the native cherry pest...

Cytb + ND2 Prinia gracilis complex

Per Alstrom, Pamela Rasmussen, Canwei Xia, Lijun Zhang, Jesper Magnusson, Arya Shafaeipour & Urban Olsson
Prinias (Cisticolidae: Prinia) are resident warblers of open areas across Africa and Asia and include many polytypic species whose species limits have not been seriously reevaluated recently. Based on an integrative taxonomic analysis of morphology, song, and mitochondrial DNA (mtDNA), we suggest that 2 species should be recognized in the Graceful Prinia (Prinia gracilis) complex. In addition, our morphological analyses show the existence of a well-marked undescribed form in southeastern Somalia, which we name herein...

Data from: Go large or go conical: allometric trajectory of an early Cambrian acrotretide brachiopod

Zhiliang Zhang, Timothy Topper, Yanlong Chen, Luke Stroze, Feiyang Chen, Lars Holmer, Glenn Brock & Zhifei Zhang
Acrotretides are extinct micromorphic brachiopods that exhibited considerable morphological variation during their rapid evolution in the early Palaeozoic. The plano-conical shells of acrotretides are distinct in comparison to other brachiopod groups and despite their diversity and abundance in early Palaeozoic communities, their origins, early evolution, life history and phylogeny are poorly understood. Here, we employ advanced geometric morphometrics to quantitatively investigate ontogenetic variation and allometry in the ventral valve of the oldest known acrotretide species...

Invasion and maintenance of meiotic drivers in populations of ascomycete fungi

Ivain Martinossi-Allibert, Carl Veller, S. Lorena Ament-Velásquez, Aaron A. Vogan, Claus Rueffler & Hanna Johannesson
Meiotic drivers are selfish genetic elements that are able to become over-represented among the products of meiosis. This transmission advantage makes it possible for them to spread in a population even when they impose fitness costs on their host organisms. Whether a meiotic driver can invade a population, and subsequently reach fixation or coexist in a stable polymorphism, depends on the one hand on the biology of the host organism, including its life-cycle, mating system,...

A machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning

Anusha Bishop, Giuseppe Amatulli, Chaz Hyseni, Evlyn Pless, Rosemary Bateta, Winnie Okeyo, Paul Mireji, Sylvance Okoth, Imna Malele, Grace Murilla, Serap Aksoy & Norah Saarman
Introduction - Control of vector populations is an effective strategy for addressing vector-borne disease transmission. Effective vector control requires knowledge of habitat use and connectivity. Our goal was to improve this knowledge for the tsetse species Glossina pallidipes, a vector of animal African trypanosomiasis, which is a wasting disease in livestock and represents a serious socioeconomic burden across sub-Saharan Africa. Methods and Results - We used random forest regression to: (i) Build and integrate models...

Supporting data: Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?

Jon Kapla, Ismael Rodriguez Espigares, Flavio Ballante, Jana Selent & Jens Carlsson
The determination of G protein-coupled receptor (GPCR) structures at atomic resolution has improved understanding of cellular signaling and will accelerate the development of new drug candidates. However, experimental structures still remain unavailable for a majority of the GPCR family. GPCR structures and their interactions with ligands can also be modelled computationally, but such predictions have limited accuracy. In this work, we explored if molecular dynamics (MD) simulations could be used to refine the accuracy of...

Elevated temperature increases genome-wide selection on de novo mutations

David Berger, Josefine Stångberg, Julian Baur & Richard Walters
Adaptation in new environments depends on the amount of genetic variation available for evolution, and the efficacy by which natural selection discriminates among this variation. However, whether some ecological factors reveal more genetic variation, or impose stronger selection pressures than others, is typically not known. Here, we apply enzyme kinetic theory to show that rising global temperatures are predicted to intensify natural selection throughout the genome by increasing the effects of DNA sequence variation on...

Tooth morphology elucidates shark evolution across the end-Cretaceous mass extinction

Mohamad Bazzi, Nicolás Campione, Per Ahlberg, Henning Blom & Benjamin Kear
Sharks (Selachimorpha) are iconic marine predators that have survived multiple mass extinctions over geologic time. Their prolific fossil record is represented mainly by isolated shed teeth, which provide the basis for reconstructing deep time diversity changes affecting different selachimorph clades. By contrast, corresponding shifts in shark ecology, as measured through morphological disparity, have received comparatively limited analytical attention. Here, we use a geometric morphometric approach to comprehensively examine tooth morphologies in multiple shark lineages traversing...

eNOS/NO and their role in modifying the vascular barrier in retinopathy - Source data

Dominic Love, Takeshi Ninchoji & Lena Claesson-Welsh
Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. Methods: Oxygen-induced retinopathy was used as a model to test the role of nitric oxide (NO) in pathological neovascularization and vessel permeability. Suppression of NO formation was achieved chemically using L-NMMA, or genetically, in endothelial NO synthase (eNOS) serine to alanine (S1176A) mutant mice....

Long- and short-read metabarcoding technologies reveal similar spatio-temporal structures in fungal communities

Brendan Furneaux, Mohammad Bahram, Anna Rosling, Nourou Yorou & Martin Ryberg
Fungi form diverse communities and play essential roles in many terrestrial ecosystems, yet there are methodological challenges in taxonomic and phylogenetic placement of fungi from environmental sequences. To address such challenges we investigated spatio-temporal structure of a fungal community using soil metabarcoding with four different sequencing strategies: short amplicon sequencing of the ITS2 region (300--400\ bp) with Illumina MiSeq, Ion Torrent Ion S5, and PacBio RS II, all from the same PCR library, as well...

Major population splits coincide with episodes of rapid climate change in a forest-dependent bird

Vera-Maria Warmuth, Malcolm Burgess, Marko Mägi, Toni Laaksonen, Andrea Manica, Andreas Nord, Craig Primmer, Glenn-Peter Sætre, Wolfgang Winkel & Hans Ellegren
Climate change influences population demography by altering patterns of gene flow and reproductive isolation. Direct mutation rates offer the possibility for accurate dating on the within-species level but are currently only available for a handful of vertebrate species. Here, we use the first directly estimated mutation rate in birds to study the evolutionary history of pied flycatchers (Ficedula hypoleuca). Using a combination of demographic inference and environmental niche modelling, we show that all major population...

Data for: Predation risk and the evolution of a vertebrate stress response: parallel evolution of stress reactivity and sexual dimorphism

Jerker Vinterstare, Gustaf MO Ekelund Ugge, Kaj Hulthén, Alexander Hegg, Christer Brönmark, P Anders Nilsson, U Ronja Zellmer, Marcus Lee, Varpu Pärssinen, Yongcui Sha, Caroline Björnerås, Huan Zhang, Raphael Gollnisch, Simon David Herzog, Lars-Anders Hansson, Martin Škerlep, Nan Hu, Emma Johansson & R Brian Langerhans
Predation risk is often invoked to explain variation in stress responses. Yet, the answers to several key questions remain elusive, including: 1) how predation risk influences the evolution of stress phenotypes, 2) the relative importance of environmental versus genetic factors in stress reactivity, and 3) sexual dimorphism in stress physiology. To address these questions, we explored variation in stress reactivity (ventilation frequency) in a post-Pleistocene radiation of live-bearing fish, where Bahamas mosquitofish (Gambusia hubbsi) inhabit...

Registration Year

  • 2021

Resource Types

  • Dataset


  • Uppsala University
  • Lund University
  • Swedish University of Agricultural Sciences
  • Norwegian University of Science and Technology
  • University of Cambridge
  • University of East Anglia
  • Nord University
  • Ludwig Maximilian University of Munich
  • Stockholm University
  • KU Leuven