6 Works

Data from: Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

Leonard H Van Den Berg, Eric Sorenson, Gary Gronseth, Eric A. Macklin, Jinsy Andrews, Robert H. Baloh, Michael Benatar, James D. Berry, Adriano Chio, Philippe Corcia, Angela Genge, Amelie K. Gubitz, Catherine Lomen-Hoerth, Christopher J. McDermott, Erik P. Pioro, Jeffrey Rosenfeld, Vincenzo Silani, Martin R. Turner, Markus Weber, Benjamin Rix Brooks, Robert G. Miller & Hiroshi Mitsumoto
Objective: To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). Methods: A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patient representatives, research funding representatives, industry and regulatory agencies) addressed nine areas of need within ALS research: 1. Pre-clinical studies; 2. Biological and phenotypic heterogeneity; 3. Outcome measures; 4. Disease-modifying and symptomatic interventions;...

Data from: Palaeobiogeography and evolutionary patterns of the larger foraminifer Borelis de Montfort (Borelidae)

Davide Bassi, Juan Carlos Braga, Giovanni Di Domenico, Johannes Pignatti, Sigal Abramovich, Pamela Hallock, Janine Koenen, Zoltan Kovacs, Martin R. Langer, Giulio Pavia & Yasufumi Iryu
The palaeobiogeography of the alveolinoid Borelis species reveals the evolutionary patterns leading to the two extant representatives, which occur in shallow-water tropical carbonate, coral reef-related settings. Type material and new material of fossil Borelis species, along with Recent specimens were studied to assess their taxonomic status, species circumscriptions (based on proloculus size, occurrence of Y-shaped septula, and the index of elongation), palaeobiogeography and evolutionary dynamics. The species dealt with here are known from exclusively fossil...

Data from: Modelling the potential impacts of climate change on the distribution of ichthyoplankton in the Yangtze Estuary, China

Zhixin Zhang, Stefano Mammola, Weiwei Xian & Hui Zhang
Aim: Species distribution models (SDMs) are an effective tool to explore the potential distribution of terrestrial, freshwater, and marine organisms; however, SDMs have been seldom used to model ichthyoplankton distributions and thus our understanding of how larval stages of fishes will respond to climate change is still limited. Here, we developed SDMs to explore potential impacts of climate change on habitat suitability of ichthyoplankton. Location: Yangtze Estuary, China Methods: Using long-term ichthyoplankton survey data and...

Trait-modulated decline of carabid beetle occurrence along elevation gradients across the European Alps

Dan Chamberlain, Mauro Gobbi, Matteo Negro, Enrico Caprio, Claudia Palestrini, Luca Pedrotti, Pietro Brandmayr, Roberto Pizzolotto & Antonio Rolando
Aim: To assess how species traits modulate the responses of carabids to elevation gradients, and how consistent these relationships are across different Alpine regions. Location: Italian Alps. Taxon: Coleoptera, Carabidae (ground beetles) Methods: Carabid communities were sampled using pitfall traps along elevation gradients (697-2840 m) in 416 study sites comprising a range of habitat types. The probability of carabid occurrence was modelled in relation to elevation and its interaction with two key traits, body size...

Data from: Scientific output scales with resources. A comparison of US and European Universities

Benedetto Lepori, Aldo Geuna & Antonietta Mira
By using a comprehensive dataset of US and European universities, we demonstrate super-linear scaling between university revenues and their volume of publications and (field-normalized) citations. We show that this relationship holds both in the US and in Europe. In terms of resources, our data show that three characteristics differentiate the US system: (1) a significantly higher level of resources for the entire system, (2) a clearer distinction between education-oriented institutions and doctoral universities and (3)...

Data from: Molecular analyses identify hybridization-mediated nuclear evolution in newly discovered fungal hybrids

Fabiano Sillo, Paolo Gonthier, Blakey Lockman, Takao Kasuga & Matteo Garbelotto
Hybridization may be a major driver in the evolution of plant pathogens. In a high elevation Alpine larch stand in Montana, a novel hybrid fungal pathogen of trees originating from the mating of Heterobasidion irregulare with H. occidentale has been recently discovered. In this study, sequence analyses of one mitochondrial and four nuclear loci from 11 Heterobasidion genotypes collected in the same Alpine larch stand indicated that hybridization has increased allelic diversity by generating novel...

Registration Year

  • 2019

Resource Types

  • Dataset


  • University of Turin
  • Parco Nazionale d'Abruzzo
  • Massachusetts General Hospital
  • Stanford University
  • Kantonsspital St. Gallen
  • Columbia University
  • University of Milan
  • National Institutes of Health
  • Tohoku University
  • Eötvös Loránd University