6 Works

Data from: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

Lin Li, Xiaodong Jiao, Ilaria D’Atri, Fumihito Ono, Ralph Nelson, Chi-Chao Chan, Naoki Nakaya, Zhiwei Ma, Yan Ma, Xiaoying Cai, Longhua Zhang, Siying Lin, Abdul Hameed, Barry A. Chioza, Holly Hardy, Gavin Arno, Sarah Hull, Muhammad Imran Khan, James Fasham, V. Gaurav Harlalka, Michel Michaelides, Anthony T. Moore, Zeynep Hande Coban Akdemir, Shalini Jhangiani, James R. Lupski … & Frans P. M. Cremers
We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride channel highly expressed in the retina, associated with autosomal recessive retinitis pigmentosa (arRP) in eight consanguineous families of Pakistani descent. The p.D25E alteration decreased CLCC1 channel function accompanied by accumulation of mutant protein in granules within the ER lumen, while siRNA knockdown of CLCC1 mRNA induced apoptosis in cultured ARPE-19 cells. TALEN KO in zebrafish was lethal 11 days post...

Data from: A robust and tunable mitotic oscillator in artificial cells

Ye Guan, Zhengda Li, Shiyuan Wang, Patrick M Barnes, Xuwen Liu, Haotian Xu, Minjun Jin, Allen P Liu & Qiong Yang
Single-cell analysis is pivotal to deciphering complex phenomena like heterogeneity, bistability, and asynchronous oscillations, where a population ensemble cannot represent individual behaviors. Bulk cell-free systems, despite having unique advantages of manipulation and characterization of biochemical networks, lack the essential single-cell information to understand a class of out-of-steady-state dynamics including cell cycles. Here, by encapsulating Xenopus egg extracts in water-in-oil microemulsions, we developed artificial cells that are adjustable in sizes and periods, sustain mitotic oscillations for...

Data from: Understanding the transition from water to land: insights from multi-omic analyses of the perivitelline fluid of apple snail eggs

Jack C.H. Ip, Huawei Mu, Yanjie Zhang, Jin Sun, Horacio Heras, Ka Hou Chu & Jian-Wen Qiu
Most gastropods deposit their eggs either on land or underwater, but the family Ampullariidae includes members that exhibit both underwater and aerial oviposition, making it an ideal model for understanding mechanisms underlying the evolutionary transition from water to land. We applied SDS-PAGE and LC-MS/MS to analyse the proteome of the egg perivitelline fluid (PVF) of Marisa cornuarietis – an aquatic ovipositing ampullariid. Comparison with the reported PVF proteomes of two aerial ovipositing ampullariids (Pomacea canaliculata...

Data from: Soluble hexamethyl-substituted subphthalocyanine as a dopant-free hole transport material for planar perovskite solar cells

Feng Wang, Xiaoyuan Liu, Ehsan Rezaee, Haiquan Shan, Yuxia Zhou & Zong-Xiang Xu
Boron subphthalocyanine (SubPc) has special physical and chemical properties, originating from its non-centrosymmetric, near-planar taper structure and large conjugated system; it can act as an alternative to the small molecule hole-transporting material 2,2’,7,7’-tetrakis-(N,N-di-p-methoxyphenylamine)-9,9’-spirobifluorene in perovskite solar cells. To achieve a higher solubility in common organic solvents and a more suitable highest occupied molecular orbital (HOMO) energy level that aligns with the valence band of the perovskite material, a SubPc molecule with a hexamethyl substitution at...

Data from: Molecular mechanism of viscoelastic polymer enhanced-oil-recovery in nanopores

Jing Cun Fan, Feng Chao Wang, Jie Chen, Yin Bo Zhu, De Tang Lu, He Liu & Heng An Wu
Polymer flooding is a promising chemical enhanced oil recovery method, which realizes more efficient extraction in porous formations characterized with nanoscale porosity and complicated interfaces. Understanding the molecular mechanism of viscoelastic polymer enhanced-oil-recovery in nanopores is of great significance for the advancement of oil exploitation. Using molecular dynamics simulations, we investigated the detailed process of the viscoelastic polymer displacing oil at the atomic scale. We found that the interactions between polymer chains and oil provide...

Data from: The physiological cold tolerance of warm-climate plants is correlated with their latitudinal range limit

Yin Wen, De-Wen Qin, Bing Leng, Yun-Fei Zhu & Kun-Fang Cao
Plants are moving poleward and upward in response to climate warming. However, such movements lag behind the expanding warming front for many reasons, including the impediment of plant movement caused by unusual cold events. In this study, we measured the maximum photochemical efficiency of PSII (Fv/Fm) in 101 warm-climate angiosperm species to assess their cold tolerance at the end of a severe chilling period of 49 days in a southern subtropical region (Nanning) in China....

Registration Year

  • 2018

Resource Types

  • Dataset


  • University of Science and Technology of China
  • University of Michigan-Ann Arbor
  • COMSATS Institute of Information Technology
  • The Hong Kong University of Science and Technology
  • Chinese University of Hong Kong
  • Wayne State University
  • University of the Punjab
  • Hong Kong Baptist University
  • University of California, San Diego
  • Radboud University Nijmegen