298 Works

Weakest Link Manuscript Datasets

Lauren Pandori & Cascade Sorte
Paired data to accompany the manuscript.

Supporting data for Formation of Highly Oxidized Molecules from NO3 Radical Oxidation of Δ-3-Carene: A Computational Mechanism

Danielle Draper, Nanna Myllys, Noora Hyttinen, Kristian Moller, Henrik Kjaergaard, Juliane Fry, James Smith & Theo Kurten
NO3 radical oxidation of most monoterpenes is a significant source of secondary organic aerosol (SOA) in many regions influenced by both biogenic and anthropogenic emissions, but there are very few published mechanistic studies of NO3 chemistry beyond simple 1st generation products. Here, we present a computationally-derived mechanism detailing the unimolecular pathways available to the 2nd generation of peroxy radicals following NO3 oxidation of Δ-3-carene, defining generations based on the sequence of peroxy radicals formed rather...

Mortality risk across life stages and habitats of an intertidal mussel (Mytilus californianus)

Lauren Pandori & Cascade Sorte
These data are associated with the manuscript "Mortality risk across life stages and habitats of an intertidal mussel (Mytilus californianus)". Code for statsitical analyses can be found on L. Pandori's GitHub (https://github.com/llmpandori/Mussel_Habitat_Risk). Feel free to conatct L. Pandori with any requests regarding this dataset.

Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis

James F. Howard, Vera Bril, Ted M. Burns, Renato Mantegazza, Malgorzata Bilinska, Andrzej Szczudlik, Said Beydoun, Francisco Javier Rodriguez De Rivera Garrido, Fredrik Piehl, Mariarosa Rottoli, Philip Van Damme, Tuan Vu, Amelia Evoli, Miriam Freimer, Tahseen Mozaffar, E. Sally Ward, Torsten Dreier, Peter Ulrichts, Katrien Verschueren, Antonio Guglietta, Hans De Haard, Nicolas Leupin & Jan J. G. M. Verschuuren
Objective: To investigate safety and explore efficacy of efgartigimod (ARGX-113), an anti-neonatal Fc receptor immunoglobulin G1 Fc fragment, in patients with generalized myasthenia gravis (gMG) with a history of anti-acetylcholine receptor (AChR) autoantibodies, who were on stable standard-of-care myasthenia gravis (MG) treatment. Methods: A phase 2, exploratory, randomized, double-blind, placebo-controlled, 15-center study is described. Eligible patients were randomly assigned (1:1) to receive 4 doses over a 3-week period of either 10 mg/kg IV efgartigimod or...

Model Setup of Thwaites Glacier

Hongju Yu
We set up our Thwaites model to study its evolution in the next 100 years. We use BEDMAP-2 data for ice surface elevation and ice shelf draft elevation (Fretwell et al., 2013). We apply the bed elevation from mass conservation on grounded ice (Morlighem et al., 2011, 2013) and the sea floor bathymetry from a gravity inversion beneath floating ice (Millan et al., 2017). We use the surface mass balance data from RACMO 2.3 (Lenaerts...

Data from: Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury

David J. Titus, Timothy Johnstone, Nathan H. Johnson, Sidney H. London, Meghana Chapalamadugu, Derk Hogenkamp, Kelvin W. Gee & Coleen M. Atkins
Cognitive impairments are a common consequence of traumatic brain injury (TBI). The hippocampus is a subcortical structure that plays a key role in the formation of declarative memories and is highly vulnerable to TBI. The α7 nicotinic acetylcholine receptor (nAChR) is highly expressed in the hippocampus and reduced expression and function of this receptor are linked with cognitive impairments in Alzheimer’s disease and schizophrenia. Positive allosteric modulation of α7 nAChRs with AVL-3288 enhances receptor currents...

Phase-Based Antarctica Ice Velocity Map

Jeremie Mouginot, Eric Rignot & Bernd Scheuchl
Complete map of ice motion in Antarctica combining phase data in the interior and speckle tracking in the fast-moving sectors. We present a new map of Antarctic ice velocity that is ten times more precise than prior maps and reveals ice motion at a high precision over 80% of the continent versus 20% in the past. The ice motion vector map provides novel constrains on interior ice motion and its connection with the glaciers and...

Thinner bark increases sensitivity of wetter Amazonian tropical forests to fire

Ann Carla Staver, Paulo M. Brando, Jos Barlow, Douglas C. Morton, C.E. Timothy Paine, Yadvinder Malhi, Alejandro Araujo Murakami & Jhon Pasquel
Understory fires represent an accelerating threat to Amazonian tropical forests and can, during drought, affect larger areas than deforestation itself. These fires kill trees at rates varying from < 10 to c. 90% depending on fire intensity, forest disturbance history and tree functional traits. Here, we examine variation in bark thickness across the Amazon. Bark can protect trees from fires, but it is often assumed to be consistently thin across tropical forests. Here, we show...

Data from: Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples

Majid H. Mohajerani, Javad Karimi Abadchi, Mojtaba Nazari-Ahangarkolaee, Sandra Gattas, Edgar Bermudez-Contreras & Bruce L. McNaughton
A prevalent model is that sharp-wave ripples (SWR) arise ‘spontaneously’ in CA3 and propagate recent memory traces outward to the neocortex to facilitate memory consolidation there. Using voltage and extracellular glutamate transient recording over widespread regions of mice dorsal neocortex in relation to CA1 multiunit activity (MUA) and SWR, we find that the largest SWR-related modulation occurs in retrosplenial cortex; however, contrary to the unidirectional hypothesis, neocortical activation exhibited a continuum of activation timings relative...

Multistate hybrid time-dependent density functional theory with surface hopping accurately captures ultrafast thymine photodeactivation

Shane Parker, Saswata Roy & Filipp Furche
Collected trajectories for paper "Multistate hybrid time-dependent density functional theory with surface hopping accurately captures ultrafast thymine photodeactivation".

Enhanced stromal H2S production via CBS upregulation promotes estrogen-stimulated human endometrial angiogenesis

Qian-Rong Qi, Thomas J. Lechuga, Basari Patel, Nicole A. Nguyen, Yi-Hua Yang, Yan Li, Sassi Sarnthiyakul, Quan-Wei Zhang, Jin Bai, Joshua Makhoul & Dong-Bao Chen
Angiogenesis is a physiological process for endometrial regeneration in the menstrual cycle and remodeling during pregnancy. Endogenous hydrogen sulfide (H2S), produced by cystathionine-β synthase (CBS) and cystathionine-γ lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown. This study was to test whether estrogens stimulate endometrial H2S biosynthesis to promote endometrial microvascular endothelial cell (EMEC) angiogenesis. CBS...

Drivers and projections of global surface temperature anomalies at the local scale

Susanne Benz, Steven Davis & Jennifer Burney
More than half of the world’s population now lives in urban areas, and trends in rural-to-urban migration are expected to continue through the end of the century. Although cities create efficiencies that drive innovation and economic growth, they also alter the local surface energy balance, resulting in urban temperatures that can differ dramatically from surrounding areas. Here we introduce a global 1-km resolution data set of seasonal and diurnal anomalies in urban surface temperatures relative...

Passive restoration in coastal sage scrub data

Priscilla Ta
Contains all datasets pertaining to the results of the manuscript "Effects of Invasive Plant Removal on Native Species in Coastal Sage Scrub Communities Across Orange County." The datasets contained in this file include plant density data collected from 2014-2016 and established native shrub size data collected in 2012 and 2014.

California building footprints

Vu Dao
This data set is a conversion of Califonia building footprint file from GeoJSON format to shapefile format. The California building footprint file which contains 10,988,525 computer generated building footprints in California state is extracting from US building footprint dataset by Microsoft (2018).

The sensory basis of schooling by intermittent swimming in the rummy-nose tetra (Hemigrammus rhodostomus) -- [Data analysis]

Matthew McHenry
Schooling is a collective behavior that enhances the ability of a fish to sense and respond to its environment. Although schooling is essential to the biology of a diversity of fishes, it is generally unclear how this behavior is coordinated by different sensory modalities. We used experimental manipulation and kinematic measurements to test the role of vision and flow sensing in the rummy-nose tetra (Hemigrammus rhodostomus), which swims with intermittent phases of bursts and coasts....

Data from: Widespread grounding line retreat of Totten Glacier, East Antarctica, over the 21st century

Tyler Pelle, Mathieu Morlighem, Helene Seroussi & Yoshihiro Nakayama
Totten Glacier, the primary ice discharger of East Antarctica, contains 3.85 m sea level rise equivalent ice mass (SLRe) and has displayed ocean-driven dynamic change since at least the early 2000s. We project Totten’s evolution through 2100 in a fully coupled ice-ocean model, forced at the ocean boundaries with anomalies in CMIP6 projected temperature, salinity, and velocity. Consistent with previous studies, the Antarctic Slope Current continues to modulate warm water inflow towards Totten in future...

Dataset for: Fast retreat of Pope, Smith, and Kohler glaciers in West Antarctica observed by satellite interferometry

Pietro Milillo, Eric Rignot, Paola Rizzoli, Bernd Scheuchl, Jeremie Mouginot, Jose Luis Bueso Bello, Pau Prats Iraola & Luigi Dini
Pope, Smith, and Kohler glaciers, in the Amundsen Sea Embayment of West Antarctica, have experienced enhanced ocean-induced ice-shelf melt, glacier acceleration, ice thinning, and grounding line retreat in the past thirty years, in a glaciological setting with retrograde bedrock slopes conducive to marine ice sheet instability. Here we present observations of the grounding line retreat of these glaciers since 2014 using a constellation of interferometric radar satellites with a short revisit cycle combined with precision...

Leaf gas exchange in Ipomopsis aggregata under manipulated snowmelt timing and summer precipitation

Jocelyn Navarro, John Powers, Ayaka Paul & Diane Campbell
Vegetative traits of plants can respond directly to changes in the environment, such as those occurring under climate change. That phenotypic plasticity could be adaptive, maladaptive, or neutral. We manipulated the timing of spring snowmelt and amount of summer precipitation in factorial combination and examined the responses of photosynthetic rate, stomatal conductance, and intrinsic water-use efficiency (iWUE) in the subalpine herb Ipomopsis aggregata. The experiment was repeated in three years differing in natural timing of...

Physical processes controlling the rifting of Larsen C Ice Shelf, Antarctica, prior to the calving of iceberg A68 in 2017

Eric Rignot, Eric Larour, Bernd Scheuchl & Mattia Poinelli
The sudden propagation of a major pre-existing rift (full-thickness crack) in late 2016 on the Larsen C Ice Shelf, Antarctica lead to the calving of tabular iceberg A68 in July 2017, one of the largest icebergs on record, posing a threat for the stability of the remainder of the ice shelf. As for other ice shelves, the physical processes that led to the activation of the A68 rift and controlled its propagation have not been...

Dataset S1: Results of modeled spectral competition between Synechococcus type IV chromatic acclimaters (CA4) and blue and green light-harvesting specialists

Raisha Lovindeer
This dataset is the output of a one-dimensional model that simulated the time evolution of growth of Synechococcus phycoerythrin pigment types, with low, high, and variable ratios of phycourobilin to phycoerythrobilin (PUB:PEB; pigment types 3a, 3c and 3d, respectively). The model used to generate the output was built on existing published equations of competition for light color within an ocean water column by Stomp and coworkers. Our version of the model was coded in MATLAB,...

Scaling and development of elastic mechanisms: the tiny strikes of larval mantis shrimp

Jacob Harrison, Megan Porter, Matthew McHenry, H. Eve Robinson & Sheila Patek
Latch-mediated spring actuation (LaMSA) is used by small organisms to produce high acceleration movements. Mathematical models predict that acceleration increases as LaMSA systems decrease in size. Adult mantis shrimp use a LaMSA mechanism in their raptorial appendages to produce extremely fast strikes. Until now, however, it was unclear whether mantis shrimp at earlier life-history stages also strike using elastic recoil and latch mediation. We tested whether larval mantis shrimp (Gonodactylaceus falcatus) use LaMSA and, because...

Post-fire resilience of restored coastal sage scrub and grassland communities

Michelle L. Dela Cruz, BryAnna J. Wertz, Jessica Rath, Rubeen KhunKhun, Sarah Kimball & Amy Henry
California coastal sage scrub (CSS) and native grassland systems are experiencing increased fire frequencies and extreme droughts due to climate change. These stressors, in addition to historical and ongoing disturbances, make native-dominated communities vulnerable to vegetation-type conversion to communities of non-native grassland. The challenge is to restore resilient native plant communities under these shifting conditions. Our study site, Bee Flat Canyon in the Santa Ana mountains, contains CSS, grasslands, and other plant communities degraded by...

CALFIN: Calving front dataset for East/West Greenland, 1972-2019

Daniel Cheng, Wayne Hayes & Eric Larour
We present Calving Front Machine (CALFIN), an automated method for extracting calving fronts from satellite images of marine-terminating glaciers. The results use Landsat imagery from 1972 to 2019 to generate 22,678 calving front lines across 66 Greenlandic glaciers. The method uses deep learning, and builds on existing work by Mohajerani et al., Zhang et al., and Baumhoer et al. Additional post-processing techniques allow for accurate segmentation of imagery into Shapefile outputs. This method is uniquely...

Greenland Marine-Terminating Glacier Retreat Data

Michael Wood, Eric Rignot, Anders Bjørk, Michiel Van En Broeke, Ian Fenty, Dimitris Menemenlis, Mathieu Morlighem, Jeremie Mouginot, Brice Noël, Bernd Scheuchl, Joshua Willis, Hong Zhang, Lu An, Cilan Cai, Emily Kane, Romain Millan & Isabella Velicogna
The thinning, acceleration, and retreat of Greenland glaciers since the mid-1990s has been attributed to the enhanced intrusion of warm Atlantic Waters (AW) into fjords, but this assertion has not been quantitatively tested on a Greenland-wide basis or included in numerical models. Here, we investigate how AW influenced the retreat of 226 marine-terminating glaciers by combining ocean modeling, remote sensing, and in-situ observations. We identify 74 glaciers standing in deep fjords with warm AW that...

Pursuit predation with intermittent locomotion in zebrafish

Alberto Soto & Matthew McHenry
The control of a predator's locomotion is critical to its ability to capture prey. Flying animals adjust their heading continuously with control similar to guided missiles. However, many animals do not move with rapid continuous motion, but rather interrupt their progress with frequent pauses. To understand how such intermittent locomotion may be controlled during predation, we examined the kinematics of zebrafish (Danio rerio) as they pursued larval prey of the same species. Like many fishes,...

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