Fish species are commonly used as experimental models in the laboratory. DNA is routinely collected from these animals to permit identification of their genotype. The current standard procedure to sample DNA is fin clipping, which involves anaesthetising individuals and removing a portion of the caudal fin. While fin clipping reliably generates good quality DNA samples for downstream applications, there is evidence that it can alter health and welfare, leading to infection and impacting on the...

These extended data documents relate to the manuscript titled " Genome-wide association study of susceptibility to hospitalised respiratory infections", which has been submitted to Wellcome Open Research, and include the following files: · Supplementary materials and methods · Supplementary figures · Table S1: ICD-10 codes used to define the hospitalised respiratory infection phenotype. · Table S2: ICD-9 codes used to define the hospitalised respiratory infection phenotype in CHS and Partners Biobank. · Table S3: Summary...

This dataset is the 2012 revised Corine Land Cover (CLC) map, consisting of 44 classes in the hierarchical three level Corine nomenclature, produced during the CLC2018 production to improve the CLC2012 inventory. CLC 2018, CLC change 2012-2018 and CLC 2012 revised are three of the datasets produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land cover and land cover changes across Europe; these two...

Palaeozoic brittle stars are not equipped with the fused arm ossicles (vertebrae) that facilitate the remarkable mode of walking that characterizes living forms. Here we describe a stem ophiuroid from the Herefordshire Lagerstätte (Silurian, Wenlock Series) which is remarkable in preserving the body cavity uncompacted and long tube feet which lack suckers. We tentatively assign the specimen to Protaster. The morphology of the arms and attitude of the specimen suggest that locomotion was achieved by...

These extended data documents relate to the manuscript titled " Genome-wide association study of susceptibility to hospitalised respiratory infections", which has been submitted to Wellcome Open Research, and include the following files: · Supplementary materials and methods · Supplementary figures · Table S1: ICD-10 codes used to define the hospitalised respiratory infection phenotype. · Table S2: ICD-9 codes used to define the hospitalised respiratory infection phenotype in CHS and Partners Biobank. · Table S3: Summary...

This dataset is the 2018 Corine Land Cover map, consisting of 44 classes in the hierarchical three level Corine nomenclature. Corine Land Cover (CLC) 2018, CLC change 2012-2018 and CLC 2012 revised are three of the datasets produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land cover and land cover changes across Europe; these two maps are the UK component of Europe. This inventory...

This dataset is the Corine Land Cover (CLC) change map between 2012 and 2018, consisting of 44 classes in the hierarchical three level Corine nomenclature. The Corine land cover changes between 2012 and 2018 for the UK, Isle of Man, Jersey and Guernsey dataset forms part of the Corine Land Cover Maps collection and is produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land...

External institutions: University of Leicester, Beckman Research Institute of City of Hope

The data contains urination metrics including frequency, volume, chemical composition, estimated urine patch N loading rates and metabolomics profile of individual urine events from sheep (Welsh Mountain ewe) grazing a semi-improved upland pasture and a lowland improved pasture located in North Wales, UK. Urine collection studies were run in the spring, summer and autumn of 2016 for the semi-improved site and in autumn of 2016 on the lowland improved pasture. Sheep were housed in urine...

Background and Aims: Frailty is highly prevalent in adults with chronic kidney disease (CKD) and is associated with adverse health outcomes. However, exercise training may improve physical function leading to associated improvements in outcomes. The EX-FRAIL CKD trial (ISRCTN87708989) aimed to inform the design of a randomised controlled trial (RCT) that investigates the efficacy of a progressive home-based exercise programme in pre-frail and frail older adults with CKD. Methods: Patients aged ≥65 years with CKD...

This dataset contains records on the abundance and species richness of wild bees along transects in ten 1x1 km survey squares of the Leighfield forest region of Leicestershire and Rutland, UK collected in the Spring and Summer of 2020. The dataset also contains a 10 m resolution raster land cover map of the survey sites and spatially referenced GIS files of the survey transect paths. The work was carried out by the data authors to...

The first Silurian trilobite known with soft parts preserved, a Dalmanites species, is described from the Herefordshire Lagerstätte. Biramous appendages and much of the alimentary system are evident. High-fidelity three-dimensional preservation reveals a novel, double arrangement of the exopod filaments, interconnected by a presumed membranous sheet. This morphology explains a misinterpretation of the exopod as supporting spiral structures, originally reported nearly 150 years ago. The new exopod morphology is considered primarily respiratory in function and...