9 Works

Data from: Big data analysis of genes associated with neuropsychiatric disorders in an Alzheimer's disease animal model

Suji Ham, Tae Kyoo Kim, Heeok Hong, Yong Sik Kim, Ya-Ping Tang & Heh-In Im
Alzheimer’s disease is a neurodegenerative disease characterized by the impairment of cognitive function and loss of memory, affecting millions of individuals worldwide. With the dramatic increase in the prevalence of Alzheimer’s disease, it is expected to impose extensive public health and economic burden. However, this burden is particularly heavy on the caregivers of Alzheimer’s disease patients eliciting neuropsychiatric symptoms that include mood swings, hallucinations, and depression. Interestingly, these neuropsychiatric symptoms are shared across symptoms of...

Data from: Systematic revision of Symbiodiniaceae highlights the antiquity and diversity of coral endosymbionts

Todd C. LaJeunesse, John Everett Parkinson, Paul W. Gabrielson, Hae Jin Jeong, James Davis Reimer, Christian R. Voolstra & Scott R. Santos
The advent of molecular data has transformed the science of organizing and studying life on Earth. Genetics-based evidence provides fundamental insights into the diversity, ecology, and origins of many biological systems, including the mutualisms between metazoan hosts and their micro-algal partners. A well-known example is the dinoflagellate endosymbionts (“zooxanthellae”) that power the growth of stony corals and coral reef ecosystems. Once assumed to encompass a single panmictic species, genetic evidence has revealed a divergent and...

Data from: Comprehensive MicroRNAome analysis of the relationship between Alzheimer disease and cancer in PSEN double-knockout mice

Suji Ham, Tae Kyoo Kim, Jeewon Ryu, Yong Sik Kim, Ya-Ping Tang & Heh-In Im
Purpose: Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer because both involve substrates of γ-secretase. However, numerous clinical studies have reported an inverse correlation between AD and cancer. Interestingly, AD is a neurodegenerative disorder, whereas cancer is characterized by the proliferation of malignant cells. However, this inverse correlation in the PSEN double-knockout (PSEN dKO)...

Data from: Social brain volume is associated with in-degree social network size among older adults

Seyul Kwak, Won-Tak Joo, Yoosik Youm & Jeanyung Chey
The social brain hypothesis proposes that large neocortex size evolved to support cognitively demanding social interactions. Accordingly, previous studies have observed that larger orbitofrontal and amygdala structures predict the size of an individual's social network. However, it remains uncertain how an individual's social connectedness reported by other people is associated with the social brain volume. In this study, we found that a greater in-degree network size, a measure of social ties identified by a subject's...

Data from: Screening of cytotoxic or cytostatic flavonoids with quantitative FUCCI-based cell cycle assay

Young-Hyun Go, Hyo-Ju Lee, Hyeon-Joon Kong, Ho-Chang Jeong, Dong Young Lee, Soon-Ki Hong, Sang Hyun Sung, Ok-Seon Kwon & Hyuk-Jin Cha
The Fluorescence-Ubiquitin Cell Cycle Indicator (FUCCI) system can be used not only to study gene expression at a specific cell cycle stage, but also to monitor cell cycle transitions in real time. In this study, we used a single clone of FUCCI-expressing HeLa cells (FUCCI-HeLa cells) and monitored the cell cycle in individual live cells over time by determining the ratios between red fluorescence (RF) of RFP-Cdt1 and green fluorescence (GF) of GFP-Geminin. Cytotoxic and...

Data from: Evidence for personality conformity, not social niche specialization in social jays

Kelsey McCune, Piotr Jablonski, Sang-Im Lee & Renee Ha
Animal personality traits are defined as consistent individual differences in behavior over time and across contexts. Occasionally this inflexibility results in maladaptive behavioral responses to external stimuli. However, in social groups inflexible behavioral phenotypes might be favored as this could lead to more predictable social interactions. Two hypotheses seek to describe the optimal distribution of personality types within groups. The social niche specialization hypothesis states that individuals within groups should partition social roles, like personality...

Data from: Increased female resistance to mating promotes the effect of mechanical constraints on latency to pair

Chang Seok Han & Piotr G. Jablonski
Size-assortative mating, defined as a positive linear association of body size between members of mating pairs, can arise from mechanical constraints on pairing efficiency, particularly when mating success is affected by males' mate-grasping force. In this context, female resistance is predicted to have an important role in changing the threshold force necessary for males to hold females, thereby contributing to the effect of mechanical constraints. Thus, increased female resistance is expected to increase the paring...

Data from: Increased developmental density decreases the magnitude of indirect genetic effects expressed during agonistic interactions in an insect

Chang S. Han, Cristina Tuni, Jakob Ulcik & Niels J. Dingemanse
The expression of aggression depends not only on the direct genetic effects (DGEs) of an individual’s genes on its own behaviour, but also on indirect genetic effects (IGEs) caused by heritable phenotypes expressed by social partners. IGEs can affect the amount of heritable variance on which selection can act. Despite the important roles of IGEs in the evolutionary process, it remains largely unknown whether the strength of IGEs varies across life stages or competitive regimes....

Data from: Serum homocysteine level is related to cerebral small vessel disease in a healthy population

Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Hyuktae Kwon & Su-Min Jeong
Objective: To evaluate the relationship between serum total homocysteine (tHcy) levels and cerebral small vessel disease (cSVD) in a healthy population. Methods: We included consecutive participants who visited our department for health check-ups between 2006 and 2013. We rated white matter hyperintensity (WMH) volumes using both the Fazekas score and semi-automated quantitative methods. We also evaluated lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVSs) which are involved in cSVD. To assess the dose-dependent relationship...

Registration Year

  • 2018

Resource Types

  • Dataset


  • Seoul National University
  • Louisiana State University of Alexandria
  • Korea Institute of Science and Technology
  • University of Washington
  • Museum and Institute of Zoology
  • Oregon State University
  • University of North Carolina
  • King Abdullah University of Science and Technology
  • Yonsei University
  • University of Wisconsin-Madison