4 Works

Data from: Deciphering the origin of mito-nuclear discordance in two sibling caddisfly species

Hannah Weigand, Martina Weiss, Huimin Cai, Yongping Li, Lili Yu, Christine Zhang & Florian Leese
An increasing number of phylogenetic studies have reported discordances among nuclear and mitochondrial markers. These discrepancies are highly relevant to widely used biodiversity assessment approaches, such as DNA barcoding, that rely almost exclusively on mitochondrial markers. Although the theoretical causes of mito-nuclear discordances are well understood, it is often extremely challenging to determine the principal underlying factor in a given study system. In this study, we uncovered significant mito-nuclear discordances in a pair of sibling...

Data from: Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Shyam Bandari, Stefanie Ohlig, Corinna Ortmann, Rocio Rebollido-Rios, Mandy Otto, Harald Nüsse, Daniel Hoffmann, Christian Klämbt, Milos Galic, Jürgen Klingauf & Kay Grobe
Cell fate determination during development often requires morphogen transport from producing to distant responding cells. Hedgehog (Hh) morphogens present a challenge to this concept, as all Hhs are synthesized as terminally lipidated molecules that form insoluble clusters at the surface of producing cells. While several proposed Hh transport modes tie directly into these unusual properties, the crucial step of Hh relay from producing cells to receptors on remote responding cells remains unresolved. Using wing development...

Data from: Long-lived rodents reveal signatures of positive selection in genes associated with lifespan

Arne Sahm, Martin Bens, Karol Szafranski, Susanne Holtze, Marco Groth, Matthias Görlach, Cornelis Calkhoven, Christine Müller, Matthias Schwab, Johann Kraus, Hans Armin Kestler, Alessandro Cellerino, Hynek Burda, Thomas Hildebrandt, Philip Dammann & Matthias Platzer
The genetics of lifespan determination is poorly understood. Most research has been done on short-lived animals and it is unclear if these insights can be transferred to long-lived mammals like humans. Some African mole-rats (Bathyergidae) have life expectancies that are multiple times higher than similar sized and phylogenetically closely related rodents. To gain new insights into genetic mechanisms determining mammalian lifespans, we obtained genomic and transcriptomic data from 17 rodent species and scanned eleven evolutionary...

Data from: A potential role for GSK3beta in glucose-driven intrauterine catch-up growth in maternal obesity

Sarah Appel, Jon Grothe, Sarah Storck, Ruth Janoschek, Inga Bae-Gartz, Maria Wohlfarth, Marion Handwerk, Eva Hucklenbruch-Rother, Alexandra Gellhaus & Jörg Dötsch
Obesity and an unhealthy nutrition are on the rise and affect also women in childbearing age and hence, during pregnancy. Despite normal or even high birth weight the offspring suffers from long term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Underlying molecular events remain elusive. Female mice were fed either a control diet (SD) or a high fat diet (HFD) after weaning until mating and during pregnancy. Pregnant mice...

Registration Year

  • 2018

Resource Types

  • Dataset


  • University of Duisburg-Essen
  • University of Münster
  • University of Cologne
  • University of Groningen
  • University of Ulm
  • Jena University Hospital
  • Fritz Lipmann Institute
  • City University of Hong Kong
  • Beijing Genomics Institute
  • Leibniz Institute for Zoo and Wildlife Research