30 Works

Data from: They are likely to be there: using a family-centered index-testing approach to identify HIV-positive children in Kenya

Jayne Lewis-Kulzer, Nicollate Okoko, Kirsten Ohe, Margaret Mburu, Hellen Muttai, Lisa Abuogi, Elizabeth Bukusi, Craig Cohen & Jeremy Penner
In Kenya, only half of children with an HIV-positive parent have been tested for HIV. The effectiveness of a family-centred index-testing approach to identify children (0-14 years) living with HIV was examined. A retrospective clinical record review was conducted among adult index patients newly enrolled in HIV care between May–July 2015 and family outcomes were followed through May 2016 at 60 high-volume clinics in western Kenya. HIV testing uptake and results, health facility level, enrollment...

Seasonal changes in mosquito population densities in irrigated and non-irrigated areas in Bura, Tana River County, Kenya (2013-2014)

R. Sang, J. Lutomiah, J.F. Lindahl, D. Grace & B. Bett
These data comprise apparent densities, species and sex and of mosquitos collected in irrigated and non-irrigated areas in Bura, Tana River County Kenya, between September 2013 and November 2014. Sampling was repeated four times over the period to cover the wet season, dry season, irrigation season and fallow periods. Mosquitoes were trapped using carbon dioxide-baited (CDC) light traps. Mosquitoes harvested from each of these traps were immobilized using 99.5% triethyleamine (Sigma-Aldrich, St. Louis, Missouri) and...

Schistosoma mansoni IgG antibody response and Kato-Katz infection among pre-school aged children in Mbita, Western Kenya 2012-2014

Benjamin Arnold, Henry Kanyi, Sammy Njenga, Fredrick Rawago, Jeffrey Priest, W. Evan Secor, Patrick Lammie, Kimberly Won & Maurice Odiere
We compared serological measures of transmission based on antibody response to S. mansoni soluble egg antigen (SEA) with stool-based measures of infection among 3,663 preschool-age children in an area endemic for S. mansoni in western Kenya. We estimated force of infection among children using the seroconversion rate examined how it varied geographically and by age.

Larval site characteristics of mosquito Aedes aegypti in La Lope, Gabon

Siyang Xia, Hany K. M. Dweck, Joel Lutomiah, Rosemary Sang, Carolyn S. McBride, Noah H. Rose, Diego Ayala & Jeffrey R. Powell
This dataset is described and analyzed in the paper: "Xia, S., Dweck, H. K. M., Lutomiah, J., Sang, R., McBride, C. S., Rose, N. H., Ayala, D., & Powell, J. R. (2021). Larval sites of the mosquito Aedes aegypti formosus in forest and domestic habitats in Africa and the potential association with oviposition evolution. Ecology and Evolution, 00, 1– 17. https://doi.org/10.1002/ece3.8332" The mosquito Ae. aegypti is a major vector of several arboviral diseases. In Africa,...

Data from: Modelling vaccination strategies against Rift Valley fever in livestock in Kenya: model code

John M. Gachohi, M. Kariuki Njenga, Phillip M. Kitala, Bernard K. Bett, Bernard Bett & Philip Kitala
The impacts of vaccination on the transmission of Rift Valley fever virus (RVFV) have not been evaluated. We have developed a RVFV transmission model comprising two hosts -- cattle as a separate host and sheep and goats as one combined host (herein after referred to as sheep) -- and two vectors -- Aedes species (spp) and Culex spp -- and used it to predict the impacts of: (1) reactive vaccination implemented at various levels of...

Comparison of the costs of HPV testing through Community health campaigns versus Home-based testing in rural western Kenya: A micro-costing study

Easter Olwanda, James Khan, Yujung Choi, Jessica Islam & Megan Huchko
Objectives: To estimate the cost of HPV-based screening through Community health campaigns (CHCs) and home-based testing. Setting: Community health campaigns (CHCs) and home-based testing in six communities in rural western Kenya. Participants: CHCs and home-based screening reached 2297 and 1002 women aged 25 to 65 years respectively. Outcome measures: Outcome measures were overall cost per woman screened achieved through the CHCs and home-based testing, and the cost per woman for each activity comprising the screening...

Pregnancy outcomes in facility deliveries in Kenya and Uganda: A large cross-sectional analysis of maternity registers illuminating opportunities for mortality prevention

Peter Waiswa, Brennan V. Higgins, Paul Mubiri, Leah Kirumbi, Elizabeth Butrick, Rikita Merai, Nancy L. Sloan, Dilys Walker & Kenya
Introduction As facility-based deliveries increase globally, maternity registers offer a promising way of documenting pregnancy outcomes and understanding opportunities for perinatal mortality prevention. This study aims to contribute to global quality improvement efforts by characterizing facility-based pregnancy outcomes in Kenya and Uganda including maternal, neonatal, and fetal outcomes at the time of delivery and neonatal discharge outcomes using strengthened maternity registers. Methods Cross sectional data were collected from previously strengthened maternity registers at 23 facilities...

How do foundation year and internship experience shape doctors’ career intentions and decisions? A meta-ethnography

Yingxi Zhao, Daniel Mbuthia, Claire Blacklock, David Gathara, Catia Nicodemo, Sassy Molyneux & Mike English
Foundation years or internships are an important period for junior doctors to apply their knowledge and gain clinical competency. Experiences gained during the foundation years or internships are likely to inform newly qualified doctors’ opinions about how they want to continue their career. We aimed to understand how medical doctors’ internship experiences influence their career intention/decision. We conducted qualitative evidence synthesis using meta-ethnography. We searched six electronic bibliographic databases for papers published between 2000–2020 and...

Additional file 2 of Examining socioeconomic status disparities in facility-based childbirth in Kenya: role of perceived need, accessibility, and quality of care

Ntemena Kapula, Stephen Shiboski, Christine Dehlendorf, Linet Ouma & Patience A. Afulani
Supplementary Material 2

Data from: Deep sequencing reveals extensive variation in the gut microbiota of wild mosquitoes from Kenya.

Jewelna Osei-Poku, Charles M. Mbogo, William J. Palmer & Francis M. Jiggins
The mosquito midgut is a hostile environment that vector-borne parasites must survive in order to be transmitted. Commensal bacteria in the midgut can reduce the ability of mosquitoes to transmit disease, either by having direct anti-parasite effects or by stimulating basal immune responses of the insect host. As different bacteria have different effects on parasite development, the composition of the bacterial community in the mosquito gut is likely to affect the probability of disease transmission....

Data from: Multiple evolutionary origins of Trypanosoma evansi in Kenya

Christine M. Kamidi, Norah P. Saarman, Kirstin B. Dion, Paul O. Mireji, Collins Ouma, Grace Murilla, Serap Aksoy, Achim Schnaufer, Adalgisa Caccone & Kirstin Dion
Trypanosoma evansi is the parasite causing surra, a form of trypanosomiasis in camels and other livestock, and a serious economic burden in Kenya and many other parts of the world. Trypanosoma evansi transmission can be sustained mechanically by tabanid and Stomoxys biting flies, whereas the closely related African trypanosomes T. brucei brucei and T. b. rhodesiense require cyclical development in tsetse flies (genus Glossina) for transmission. In this study, we investigated the evolutionary origins of...

Data from: Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity

Bronner P. Gonçalves, Melissa C. Kapulu, Patrick Sawa, Wamdaogo M. Guelbéogo, Alfred B. Tiono, Lynn Grignard, Will Stone, Joel Hellewell, Kjerstin Lanke, Guido J. H. Bastiaens, John Bradley, Issa Nébié, Joyce M. Ngoi, Robin Oriango, Dora Mkabili, Maureen Nyaurah, Janet Midega, Dyann F. Wirth, Kevin Marsh, Thomas S. Churcher, Philip Bejon, Sodiomon B. Sirima, Chris Drakeley & Teun Bousema
A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both sites, we identified 39 infectious individuals. In high endemicity settings, infectious individuals were identifiable by research-grade microscopy (92.6%; 25/27), whilst one of three infectious individuals in the lowest endemicity setting was detected by...

Data from: Microbiome sharing between children, livestock and household surfaces in western Kenya

Emily Mosites, Matt Sammons, Elkanah Otiang, Alexander Eng, Ceclia Noecher, Ohad Manor, Sarah Hilton, Samuel M. Thmbi, Clayton Onyango, Gemina Garland-Lewis, Douglas R. Call, M. Kariuki Njenga, Judith N. Wasserheit, Jennifer A. Zambriski, Judd L. Walson, Guy H. Palmer, Joel Montgomery, Elhanan Borenstein, Richard Omore, Peter M. Rabinowitz, Samuel M. Thumbi & Cecilia Noecker
The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we...

Additional file 2 of Examining socioeconomic status disparities in facility-based childbirth in Kenya: role of perceived need, accessibility, and quality of care

Ntemena Kapula, Stephen Shiboski, Christine Dehlendorf, Linet Ouma & Patience A. Afulani
Supplementary Material 2

Additional file 2 of The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania

Sumaiyya G. Thawer, Monica Golumbeanu, Khalifa Munisi, Sijenunu Aaron, Frank Chacky, Samwel Lazaro, Ally Mohamed, Noela Kisoka, Christian Lengeler, Fabrizio Molteni, Amanda Ross, Robert W. Snow & Emilie Pothin
Additional file 2: Table S3. Shows the proportion of heterogeneity per council.

Data from: Worldwide patterns of genetic differentiation imply multiple \"domestications\" of Aedes aegypti, a major vector of human diseases

Julia E. Brown, Carolyn S. McBride, Petrina Johnson, Scott Ritchie, Christophe Paupy, Hervé Bossin, Joel Lutomiah, Ildefonso Fernandez-Salas, Alongkot Ponlawat, Anthony J. Cornel, William C. Black, Norma Gorrochotegui-Escalante, Ludmel Urdaneta-Marquez, Massamba Sylla, Michel Slotman, Kristy O. Murray, Christopher Walker, Jeffrey R. Powell & W. C. Black
Understanding the processes by which species colonize and adapt to human habitats is particularly important in the case of disease-vectoring arthropods. The mosquito species Aedes aegypti, a major vector of dengue and yellow fever viruses, probably originated as a wild, zoophilic species in sub-Saharan Africa, where some populations still breed in tree holes in forested habitats. Many populations of the species, however, have evolved to thrive in human habitats and to bite humans. This includes...

Data from: Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and non-injection drug users from coastal Kenya

Mark W. Kilongosi, Valentine Budambula, Raphael Lihana, Francis O. Musumba, Anthony K. Nyamache, Nancy L. M. Budambula, Aabid A. Ahmed, Collins Ouma & Tom Were
Background: Information about HBV sero-markers, infection stages and genotypes in HIV-1 infected and uninfected injection and non-injection drug users (IDUs) in Kenya remains elusive. Methods: A cross-sectional study examining HBV sero-marker, infection stages and genotypes was conducted among HIV-1 infected and uninfected, respectively, IDUs (n = 157 and n = 214) and non-IDUs (n = 139 and n = 48), and HIV-1 uninfected non-drug using controls (n = 194) from coastal, Kenya. HBV sero-marker and...

Data from: The impact of hotspot-targeted interventions on malaria transmission in Rachuonyo south district in the western Kenyan highlands: a cluster-randomized controlled trial

Teun Bousema, Gillian Stresman, Amrish Y. Baidjoe, John Bradley, Philip Knight, William Stone, Victor Osoti, Euniah Makori, Chrispin Owaga, Wycliffe Odongo, Pauline China, Shehu Shagari, Ogobara K. Doumbo, Robert W. Sauerwein, Simon Kariuki, Chris Drakeley, Jennifer Stevenson & Jonathan Cox
Background: Malaria transmission is highly heterogeneous, generating malaria hotspots that can fuel malaria transmission across a wider area. Targeting hotspots may represent an efficacious strategy for reducing malaria transmission. We determined the impact of interventions targeted to serologically defined malaria hotspots on malaria transmission both inside hotspots and in surrounding communities. Methods and Findings: Twenty-seven serologically defined malaria hotspots were detected in a survey conducted from 24 June to 31 July 2011 that included 17,503...

Larval site characteristics of mosquito Aedes aegypti in Rabai, Kenya

Siyang Xia, Hany K. M. Dweck, Joel Lutomiah, Rosemary Sang, Carolyn S. McBride, Noah H. Rose, Diego Ayala & Jeffrey R. Powell
This dataset is described and analyzed in the paper: "Xia, S., Dweck, H. K. M., Lutomiah, J., Sang, R., McBride, C. S., Rose, N. H., Ayala, D., & Powell, J. R. (2021). Larval sites of the mosquito Aedes aegypti formosus in forest and domestic habitats in Africa and the potential association with oviposition evolution. Ecology and Evolution, 00, 1– 17. https://doi.org/10.1002/ece3.8332" The mosquito Ae. aegypti is a major vector of several arboviral diseases. In Africa,...

A machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning

Anusha Bishop, Giuseppe Amatulli, Chaz Hyseni, Evlyn Pless, Rosemary Bateta, Winnie Okeyo, Paul Mireji, Sylvance Okoth, Imna Malele, Grace Murilla, Serap Aksoy & Norah Saarman
Introduction - Control of vector populations is an effective strategy for addressing vector-borne disease transmission. Effective vector control requires knowledge of habitat use and connectivity. Our goal was to improve this knowledge for the tsetse species Glossina pallidipes, a vector of animal African trypanosomiasis, which is a wasting disease in livestock and represents a serious socioeconomic burden across sub-Saharan Africa. Methods and Results - We used random forest regression to: (i) Build and integrate models...

How do foundation year and internship experience shape doctors’ career intentions and decisions? A meta-ethnography

Yingxi Zhao, Daniel Mbuthia, Claire Blacklock, David Gathara, Catia Nicodemo, Sassy Molyneux & Mike English
Foundation years or internships are an important period for junior doctors to apply their knowledge and gain clinical competency. Experiences gained during the foundation years or internships are likely to inform newly qualified doctors’ opinions about how they want to continue their career. We aimed to understand how medical doctors’ internship experiences influence their career intention/decision. We conducted qualitative evidence synthesis using meta-ethnography. We searched six electronic bibliographic databases for papers published between 2000–2020 and...

Additional file 3 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 3. Code and data. IPD from co-authors who agreed to share it, results of all analyses presented in the paper, and R code files necessary to reproduce the analysis and figures.

Additional file 5 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 5: Figure S1. Assessment of publication bias. A Funnel plots. Symbols show the effect of the menstrual cycle (x-axis) and the standard error of that effect (y-axis, reversed). Each symbol shows an individual study. Vertical solid line shows no effect. Vertical dashed line shows the meta-estimate of effect. Diagonal dashed lines enclose the region expected to include 95% of studies based on the estimated meta-effect and the standard errors. B Results of Egger’s...

Patient preferences for HIV service delivery models: A discrete choice experiment in Kisumu, Kenya

Raphael Mando, Michelle Moghadassi, Eric Juma, Cirilus Ogollah, Laura Packel, Jayne Lewis-Kulzer, Julie Kadima, Francesca Odhiambo, Craig R. Cohen, Elizabeth A. Bukusi & Elvin Geng
Background: Novel “differentiated service delivery” models for HIV treatment that reduce clinic visit frequency, minimize waiting time, and deliver treatment in the community promise retention improvement for HIV treatment in Sub-Saharan Africa. Quantitative assessments of differentiated service delivery (DSD) feature most preferred by patient populations do not widely exist but could inform the selection and prioritization of different types of DSD models. Methods: We used a discrete choice experiment (DCE) to elicit patient preferences for...

Additional file 2 of The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania

Sumaiyya G. Thawer, Monica Golumbeanu, Khalifa Munisi, Sijenunu Aaron, Frank Chacky, Samwel Lazaro, Ally Mohamed, Noela Kisoka, Christian Lengeler, Fabrizio Molteni, Amanda Ross, Robert W. Snow & Emilie Pothin
Additional file 2: Table S3. Shows the proportion of heterogeneity per council.

Registration Year

  • 2022
    13
  • 2021
    1
  • 2020
    6
  • 2017
    4
  • 2016
    2
  • 2015
    1
  • 2014
    1
  • 2012
    1
  • 2010
    1

Resource Types

  • Dataset
    30

Affiliations

  • Kenya Medical Research Institute
    30
  • London School of Hygiene & Tropical Medicine
    8
  • University of Washington
    7
  • University of California, San Francisco
    6
  • Maseno University
    5
  • University of Nairobi
    5
  • Yale University
    5
  • Massachusetts General Hospital
    4
  • Fred Hutchinson Cancer Research Center
    4
  • Karolinska University Hospital
    4