562 Works

Additional file 1 of Construction of a transposase accessible chromatin landscape reveals chromatin state of repeat elements and potential causal variant for complex traits in pigs

Tao Jiang, Ziqi Ling, Zhimin Zhou, Xiaoyun Chen, Liqing Chen, Sha Liu, Yingchun Sun, Jiawen Yang, Bin Yang, Jianzhen Huang & Lusheng Huang
Additional file 1: Table S1. Summary information on the ATAC-seq samples investigated in this study. Table S2. Summary information on the RNA-seq samples investigated in this study. Table S3. The information of download data. Table S4. Comparison with peaks of previous study designed by zhou et al. Table S5. Motif enrichment analysis of shared peaks. Table S6. The information of PERV overlapped peaks. Table S7. The information of GWAS SNPs which located in peak regions....

Additional file 1 of Genetic analysis of 55 cases with fetal skeletal dysplasia

Ying Bai, Yue Sun, Ning Liu, Li Wang, Zhihui Jiao, Yaqin Hou, Huikun Duan, Qianqian Li, Xiaofan Zhu, Jingjing Meng & Xiangdong Kong
Additional file 1. Table S1: 811 genes of a genetic skeletal disease panel; Table S2: Primer sequence in this study; Table S3: Summary of clinical information and molecular results for 55 cases with skeletal abnormalities.

Supplementary Information

Jingyu Lin, Brett Bryan, Xudong Zhou, Peirong Lin, Hong Xuan Do, Lei Gao, Xinchen Gu, Zhifeng Liu, Luwen Wang, Shanlin Tong, Jiacong Huang, Qian Wang, Yuan Zhang, Hongkai Gao, Zilong Chen, Weili Duan, Zheyu Xie, Tong Cui, Junzhi Liu, Mingqian Li, Xiaodong Li, Zhenwu Xu, Fei Guo, Lele Shu, Bin Li … & Zhifeng Yang
This is the Supplementary Information for the paper

lipidomics raw data for CaV2.3

Xia Yao, Yan Wang, Zhifei Wang, Xiao Fan, Di Wu, Jian Huang, Alexander Mueller, Sarah Gao, Miaohui Hu, Carol V. Robinson, Yong Yu, Shuai Gao & Nieng Yan
ZIP archive containing raw LC-MS data of CaV2.3

Additional file 1 of Chronic constriction injury-induced changes in circular RNA expression profiling of the dorsal root ganglion in a rat model of neuropathic pain

Wanxia Xiong, Min Wei, Li Zhang, Jie Wang, Fan Liu & Zhiyao Wang
Additional file 1: Table S1. List of DNA primer sequences designed for qPCR.

Additional file 13 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 13: Supplementary Table 1. The primer sequences in PCR analysis.

Additional file 4 of CD19+CD24hiCD38hi regulatory B cells deficiency revealed severity and poor prognosis in patients with sepsis

Chunmei Wang, Huihui Xu, Rui Gao, Fengying Leng, Fangjie Huo, Yinzhen Li, Siting Liu, Mingzheng Xu & Jianwen Bai
Additional file 4. All original data generated or analyzed in the study.

Additional file 13 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 13: Supplementary Table 1. The primer sequences in PCR analysis.

Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China

Xiaohao Xu, Qi Chen, Min Tan, Jia Liu, Xiyan Li, Lei Yang, Yuelong Shu, Dayan Wang & Wenfei Zhu
H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in birds globally. To investigate the current situation and characteristics of H6 AIVs circulating in China, we analysed the epidemiology, genetic evolution and pathogenic features of this subtype. During 2000-2021, H6 subtype AIVs spread widely through Southern China and presented high host diversity. On analysing 171 H6 viruses isolated during 2009-2021, dynamic reassortments were observed among H6 and other co-circulating AIV subtypes,...

Additional file 1 of Clinicopathological features of patients with wide local excision of eyelid malignant neoplasms: a more than five years retrospective study from China

Yuanyuan Han, Miao Kong, Yan Luo, Bin Sun, Zhiqiang Wang & Hong Zhang
Additional file 1.

Additional file 29 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Yan Li, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang, Ziyan Xu, Jiangyan Zhao, Xiaolei Zhang, Yang Liu, Sha Tian, Zhaoyu Qin, Jinwen Feng, Fan Zhang, Jiajun Zhu, Yifan Xu, Wenhui Lou, Yuan Ji, Jianyuan Zhao, Fuchu He, Yingyong Hou … & Chen Ding
Additional file 29: Table S7. Characterization of Immune Infiltration in PDAC. Table S7A Matrix of xCell signatures significantly altered in 5 immune subgroups. Table S7B Matrix describing the expression of proteins in 5 immune subgroups. Table S7C Matrix of GSVA scores of pathways significantly altered in 5 immune subgroups, transcriptome level. Table S7D Matrix of amplification/deletion events of genes in 5 immune subgroups. Table S7E Matrix describing the expression of proteins involved in TCA cycle.

Multimodal molecular imaging in the second near-infrared window - Supplementary material

Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang & Xiao-Dong Zhang
Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of physiological and pathological activities in living organisms with high spatiotemporal resolution. However, the penetration depth of fluorescence restricts its ability to provide deep anatomical information. Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and quantitative information with deeper penetration by using multifunctional probes. This review offers...

Multimodal molecular imaging in the second near-infrared window - Supplementary material

Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang & Xiao-Dong Zhang
Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of physiological and pathological activities in living organisms with high spatiotemporal resolution. However, the penetration depth of fluorescence restricts its ability to provide deep anatomical information. Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and quantitative information with deeper penetration by using multifunctional probes. This review offers...

Additional file 3 of Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Ming Wang, Qi Wang, Hui Jiang, Yongqiang Du & Xiansheng Zhang
Additional file 3:

Additional file 5 of Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Ming Wang, Qi Wang, Hui Jiang, Yongqiang Du & Xiansheng Zhang
Additional file 5:

Induction of significant neutralizing antibodies against SARS-CoV-2 by a highly attenuated pangolin coronavirus variant with a 104nt deletion at the 3'-UTR

Shanshan Lu, Shengdong Luo, Chang Liu, Muli Li, Xiaoping An, Mengzhe Li, Jun Hou, Huahao Fan, Panyong Mao, Yigang Tong & Lihua Song
SARS-CoV-2 related coronaviruses (SARS-CoV-2r) from Guangdong and Guangxi pangolins have been implicated in the emergence of SARS-CoV-2 and future pandemics. We previously reported the culture of a SARS-CoV-2r GX_P2V from Guangxi pangolins. Here we report the GX_P2V isolate rapidly adapted to Vero cells by acquiring two genomic mutations: an alanine to valine substitution in the nucleoprotein and a 104-nucleotide deletion in the hypervariable region (HVR) of the 3′-terminus untranslated region (3′-UTR). We further report the...

Additional file 2 of Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

Wei Dong, Zeyu Xia, Zehua Chai, Zhidong Qiu, Xuehong Wang, Zebin Yang, Junnan Wang, Tingrui Zhang, Qinqin Zhang & Junfei Jin
Additional file 2. The information and the statistical results for all DEPs in sEVs.

support information-1110.docx

Min Wang, Zhan Wang, Zhaojun Chen, Xiaopeng Wang & Ruichan Lv
Supporting information.

Additional file 8 of Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

Wei Dong, Zeyu Xia, Zehua Chai, Zhidong Qiu, Xuehong Wang, Zebin Yang, Junnan Wang, Tingrui Zhang, Qinqin Zhang & Junfei Jin
Additional file 8. The raw data of band density in the discovery cohort.

Deep historical borrowing framework to prospectively and simultaneously synthesize control information in confirmatory clinical trials with multiple endpoints

Tianyu Zhan, Yiwang Zhou, Ziqian Geng, Yihua Gu, Jian Kang, Li Wang, Xiaohong Huang & Elizabeth H. Slate
In current clinical trial development, historical information is receiving more attention as it provides utility beyond sample size calculation. Meta-analytic-predictive (MAP) priors and robust MAP priors have been proposed for prospectively borrowing historical data on a single endpoint. To simultaneously synthesize control information from multiple endpoints in confirmatory clinical trials, we propose to approximate posterior probabilities from a Bayesian hierarchical model and estimate critical values by deep learning to construct pre-specified strategies for hypothesis testing....

SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy

Jie Yu, Lin Han, Feng Yang, Mingliang Zhao, Hong Zhou & Linwang Hu
Temozolomide (TMZ) is the primary chemotherapeutic drug for treating glioblastoma (GBM); however, the final clinical outcome is considerably limited by the poor response and resistance to TMZ. Although autophagy is thought to be associated with chemotherapy resistance and cancer cell survival, the precise molecular mechanisms underlying this process remain elusive. The suppressor of cytokine signaling (SOCS) family is widely distributed in vivo and exerts a range of effects on tumors; however, the expression pattern and...

A Covariate-regulated Sparse Subspace Learning Model and Its Application to Process Monitoring and Fault Isolation

Xingchen Liu, Juan Du & Zhi-Sheng Ye
Multivariate functional data are increasingly common in various applications. The cross-correlation of different process variables is typically complex in that a variable might be weakly correlated or not correlated with most of the other variables, and the cross-correlation is time-varying and might be regulated by some exogenous covariates. To address these two challenges, we propose a covariate-regulated sparse subspace learning (CSSL) model. We consider the scenario that these process variables lie in multiple subspaces, and...

Bayesian Optimal Phase II Design for Randomized Clinical Trials

Yujie Zhao, Bo Yang, J. Jack Lee, Li Wang & Ying Yuan
Randomized clinical trials are the gold standard to evaluate the efficacy of an experimental treatment. We propose a flexible Bayesian optimal phase II (BOP2) design for two-arm randomized trials. The proposed two-arm BOP2 design is flexible and can handle single, multiple primary and coprimary endpoints for superiority and noninferiority trials under a unified framework. It also allows users to specify the number and timing of interim analyses to meet clinical needs. While enjoying the flexibility...

Circular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma

Yongwei Zhang, Jun Li, Quanwei Cui, Panyi Hu, Shuangjiu Hu & Yeben Qian
Circular RNAs (circRNAs) are stable and extensively distributed non-coding RNA molecules that are differentially expressed in liver cancer tissues in the human body. In this study, we aimed to investigate circRNA as a novel candidate biomarker for hepatocellular carcinoma (HCC). For three groups of HCC and neighboring healthy tissues, the differentially expressed circRNAs were identified through high-throughput sequencing analysis. Reverse transcription PCR (RT-PCR) and quantitative polymerase chain reaction (qPCR) were employed for the evaluation of...

MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression

Miao Liu, Qiang Du, Gang Mao, Ning Dai & Fan Zhang
Optic atrophy 3 (OPA3) is an integral protein of the mitochondrial outer membrane. The current study explored the expression of OPA3 in hepatocellular carcinoma (HCC), its association with the prognosis and its involvement in HCC cell proliferation and aerobic glycolysis. In addition, the transcription factors that activate its expression were screened and validated. Gene expression data in normal liver and liver cancer were acquired from the Genotype-Tissue Expression Project (GTEx) and The Cancer Genome Atlas...

Registration Year

  • 2022
    562

Resource Types

  • Dataset
    562

Affiliations

  • Second Military Medical University
    562
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    389
  • Fudan University
    352
  • Shanghai Jiao Tong University
    345
  • Zhejiang University
    329
  • Chinese Academy of Sciences
    328
  • Sichuan University
    320
  • Sun Yat-sen University
    319
  • Capital Medical University
    317
  • Peking University
    266