219 Works

Assessing pre-pandemic carbon footprint of diet transitions in UK nations and regions

Mustafa Ali, S. C. Lenny Koh, Lingxuan Liu, Jing Zhang, William Roberts, Dawn Robins & Dave Cooper
Food supply chains hold significant embodied carbon emissions that need to be mitigated and neutralized. This study aimed to explore the historical Greenhouse Gas (GHG) emissions associated with household food consumption at a local scale i.e. across the eight English regions and the four nations that comprise the United Kingdom (UK). UK EatWell guidelines were used to explore the potential change in emissions and food costs in a scenario of transitions to healthier diets across...

Differentially expressed genes of M. anguillicaudatus_F_muscle-vs-M_muscle

Lifei Luo, Zisheng Xu, Danyang Li, Zhen Xu & ZeXia Gao
Differentially expressed genes between female and male muscles of loach

Tanshinone increases Hemopexin expression in lung cells and macrophages to protect against cigarette smoke-induced COPD and enhance antiviral responses

Ning Yang, Liang Zhang, Dongdong Tian, Ping Wang, Kai Men, Yiliang Ge & Cailian Zhang
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, while respiratory infections can elicit exacerbations in COPD patients to mediate increased mortality. Administration of Tanshinones (TS) derivatives has been demonstrated to protect against cigarette smoking (CS) and lipopolysaccharide (LPS)-induced COPD progression. However, the underlying molecular mechanisms and the roles of TS in mitigating the severity of viral-mediated exacerbations of COPD have not been elucidated. Here, we found that TS treatments significantly attenuated lung function...

Tanshinone increases Hemopexin expression in lung cells and macrophages to protect against cigarette smoke-induced COPD and enhance antiviral responses

Ning Yang, Liang Zhang, Dongdong Tian, Ping Wang, Kai Men, Yiliang Ge & Cailian Zhang
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, while respiratory infections can elicit exacerbations in COPD patients to mediate increased mortality. Administration of Tanshinones (TS) derivatives has been demonstrated to protect against cigarette smoking (CS) and lipopolysaccharide (LPS)-induced COPD progression. However, the underlying molecular mechanisms and the roles of TS in mitigating the severity of viral-mediated exacerbations of COPD have not been elucidated. Here, we found that TS treatments significantly attenuated lung function...

DNA repair in lung cancer: a large-scale quantitative analysis for polymorphisms in DNA repairing pathway genes and lung cancer susceptibility

Zexi Liao, Minhan Yi, Jiaxin Li & Yuan Zhang
The results of associations between single nucleotide polymorphisms (SNPs) of genes in DNA repairing pathway and lung cancer (LC) risk are inconsistent. We applied allele, dominant and recessive models to explore the risk of researched variants to LC in total LC and subgroups by ethnicity or LC subtypes with a cutoff point of p < 0.05. A total of 76,935 cases and 88,649 controls from 192 articles were included. Among the analyzed 40 variants from...

Additional file 2 of Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese

Junda Zhong, Chloe Y. Y. Cheung, Xiuli Su, Chi-Ho Lee, Yi Ru, Carol H. Y. Fong, Yan Liu, Cynthia K. Y. Cheung, Karen S. L. Lam, Zongwei Cai & Aimin Xu
Additional file 2: Table S1. Stepwise model selection coefficients and Wald-Z tests. Table S2. List of measured lipid species. Table S3. Weighted gene co-expression network analysis module components. Table S4. Boruta analysis result.

Additional file 3 of A circular network of purine metabolism as coregulators of dilated cardiomyopathy

Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu & Xiaoping Fan
Additional file 3: Table S3. The differential analysis results of metabolism pathway following the gene set variation analysis.

Additional file 5 of A circular network of purine metabolism as coregulators of dilated cardiomyopathy

Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu & Xiaoping Fan
Additional file 5: Table S5. The differential analysis results of purine metabolism related pathway basing on the gene set variation analysis.

Additional file 5 of A circular network of purine metabolism as coregulators of dilated cardiomyopathy

Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu & Xiaoping Fan
Additional file 5: Table S5. The differential analysis results of purine metabolism related pathway basing on the gene set variation analysis.

Additional file 2 of Housekeeping gene gyrA, a potential molecular marker for Bacillus ecology study

Yan Liu, Polonca Štefanič, Youzhi Miao, Yansheng Xue, Weibing Xun, Nan Zhang, Qirong Shen, Ruifu Zhang, Zhihui Xu & Ines Mandic-Mulec
Additional file 2: TableS1 The information of 127 strains for colony PCR. TableS2 The genomes information for nucleotide variability analysis of gyrA gene and 16S rRNA gene in inter- and intraspecies Bacillus. TableS3 The gyrA gene database information of Bacillus for computer simulation. TableS4 The general primers converted from degenerate primer pair gyrA3. TableS5 The genomes information for SNP analysis of gyrA gene and 16S rRNA gene in four Bacillus species. TableS6 The information of...

Additional file 3 of SIRPα antibody combined with oncolytic virus OH2 protects against tumours by activating innate immunity and reprogramming the tumour immune microenvironment

Defeng Kong, Zhenrong Yang, Guoliang Li, Quanyou Wu, Zhaoru Gu, Duo Wan, Qi Zhang, Xiaoli Zhang, Shujun Cheng, Binlei Liu, Kaitai Zhang & Wen Zhang
Additional file 3: Figure S1. Cell proliferation assay results. Cell proliferation assay results of Raw264.7 cell lines treated with OH2 MOI=1 (red), OH2 MOI=0.5 (blue) and untreated (black) group by CCK8 assay in 72 hours. Figure S2. OH2 lysates induce RAW264.7 polarization and phagocytosis in vitro. A. Demonstration of the analysis of the phagocytosis by flow cytometry. B. Cell proliferation assay results of CT26, MC38 and 4T-1 cell lines treated with lysate (red), CFS (blue),...

MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer

Lizhen Ye, Tingting Fan, Ying Qin, Cheng Qiu, Lulu Li, Mengmeng Dai, Yaoyao Zhou, Yan Chen & Yuyang Jiang
Colorectal cancer (CRC) becomes the second leading cause of cancer-related deaths in 2020. Emerging studies have indicated that microRNAs (miRNAs) play a key role in tumorigenesis and progression. The dysfunctions of miR-455-3p are observed in many cancers. However, its biological function in CRC remains to be confirmed. By sequencing serum sample, miR-455-3p was found to be up-regulated in CRC patients. RT-qPCR demonstrated that the miR-455-3p expression was both higher in the serum and tumor tissues...

Additional file 3 of Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai, Gang Jin & Zhiyong Liang
Additional file 3: Table S1. Gene-set enrichment analysis (GSEA) of pathways (GO catergories) significantly represented in PDAC hypermethylated or PDAC hypomethylated MHB associated genes.

Additional file 5 of Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai, Gang Jin & Zhiyong Liang
Additional file 5: Table S3. Marker lists and annotations of PandaX models.

LINC02535/miR-30a-5p/GALNT3 axis contributes to lung adenocarcinoma progression via the NF- κ B signaling pathway

Yue Li, Jian Zhao, Weijie Zhang, Anqi Wang, Min Jiao, Xin Cai, Jianjie Zhu, Zeyi Liu & Jian-an Huang
Long non-coding RNAs (LncRNA) play important roles in multiple types of cancers. We addressed the role of LINC02535 by regulating the miR-30a-5p /GalNAc Transferase 3 (GALNT3) axis to promote the proliferation, migration, and invasion in lung adenocarcinoma (LUAD) cells. The Cancer Genome Atlas (TCGA) database screened differentially expressed lncRNAs. Quantitative real-time PCR analysis (qRT-PCR) confirmed that LINC02535 is highly expressed in LUAD tissues and cells. In vitro experiments showed that LINC02535 promotes the proliferation, migration,...

Additional file 1 of Detection of cytomegalovirus (CMV) by digital PCR in stool samples for the non-invasive diagnosis of CMV gastroenteritis

Jia Gu, Hongyan Ji, Tongyuan Liu, Caixia Chen, Siye Zhao, Yang Cao, Na Wang, Min Xiao, Liting Chen & Haodong Cai
Additional file 1. The dMIQE2020 checklist.

Additional file 3 of Detection of cytomegalovirus (CMV) by digital PCR in stool samples for the non-invasive diagnosis of CMV gastroenteritis

Jia Gu, Hongyan Ji, Tongyuan Liu, Caixia Chen, Siye Zhao, Yang Cao, Na Wang, Min Xiao, Liting Chen & Haodong Cai
Additional file 3. The details of dPCR oligonucleotides design and target information.

Additional file 9 of LncRNA CEBPA-DT promotes liver cancer metastasis through DDR2/β-catenin activation via interacting with hnRNPC

Yunshi Cai, Tao Lyu, Hui Li, Chang Liu, Kunlin Xie, Lin Xu, Wei Li, Hu Liu, Jiang Zhu, Yinghao Lyu, Xuping Feng, Tian Lan, Jiayin Yang & Hong Wu
Additional file 9. Supplementary RNA sequencing results.

Circ_0004904 suppresses trophoblast cell proliferation, invasion and migration in preeclampsia via upregulating the expression of DNA damage inducible alpha by interacting with miR-19a-3p

Zhenhao Chu, Yang Wang, Shuo Zhang & Pin Cao
Preeclampsia (PE) is the most common complication in the pregnancy of women. PE progression was found to be associated with dysregulated circular RNAs (circRNAs), and we aimed to explore the pathological mechanism with circ_0004904 in PE. The circ_0004904, microRNA-19a-3p (miR-19a-3p) and DNA damage inducible alpha (GADD45A) were quantified via reverse transcription-quantitative polymerase chain reaction assay. Trophoblast cell behaviors were examined by cell viability using Cell Counting Kit-8 assay, cell proliferation using EdU assay, cell apoptosis...

Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway

Bin Wang, Jing Zhang, Xin Liu, Qingqing Chai, Xiaoran Lu, Xiaoyu Yao, Zhichang Yang, Liangliang Sun, Silas F. Johnson, Richard C Schwartz & Yong-Hui Zheng
Zaire ebolavirus (EBOV) causes a severe hemorrhagic fever in humans and non-human primates with high morbidity and mortality. EBOV infection is dependent on its structural glycoprotein (GP), but high levels of GP expression also trigger cell rounding, detachment, and downregulation of many surface molecules that is thought to contribute to its high pathogenicity. Thus, EBOV has evolved an RNA editing mechanism to reduce its GP expression and increase its fitness. We now report that the...

Enhancing integrated denitrifying anaerobic methane oxidation and Anammox processes for nitrogen and methane removal: A review

Yan Chen, Guangming Jiang, Muttucumaru Sivakumar & Jiangping Wu
The integration of denitrifying anaerobic methane oxidation (DAMO) and anaerobic ammonium oxidation (Anammox) simultaneously converts ammonium, methane, and oxidized nitrogen species (nitrite and nitrate) to harmless N2 and CO2. This integrated and complementary process achieves the nitrogen and carbon cycles in wastewater with the potential to be applied widely at full scale to realize energy-positive wastewater treatment plants (WWTPs). In this review, we summarize the collaborative and competitive interactions of DAMO–Anammox microorganisms and systematically evaluate...

Autophagy Loss Impedes Cancer-Associated Fibroblast Activation via Downregulating Proline Biosynthesis

Jingru Bai, Tong Liu, Bo Tu, Meng Yuan, Zhaoqi Shu, Minghe Fan, Sihan Huo, Yuyao Guo, Lina Wang, Hua Wang & Ying Zhao
Cancer-associated fibroblasts (CAFs) are considered one of the most critical stromal cells that interact with pancreatic ductal adenocarcinoma (PDAC) and promote tumor growth, metastasis, and treatment resistance. Previous studies illustrated macroautophagy/autophagy contributes to CAF activation during tumor progression. Here in our study, we found that autophagy deficiency in CAFs impedes CAF activation by inhibiting proline biosynthesis and collagen production. Furthermore, we uncovered that autophagy promotes proline biosynthesis through mitophagy-mediated regulation of NADK2 (NAD kinase 2,...

Management guideline for the off-label use of medicine in China (2021)

Wei Zuo, Yajia Sun, Rongji Liu, Liping Du, Nan Yang, Wenjuan Sun, Ping Wang, Xiaowan Tang, Yunlan Liu, Yuanyuan Ma, Min Meng, Ruobing Lei, Xuelian Yan, Hua Peng, Qing Chang, Hui Pan, Bo Zhang, Yaolong Chen & Shuyang Zhang
Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other...

Management guideline for the off-label use of medicine in China (2021)

Wei Zuo, Yajia Sun, Rongji Liu, Liping Du, Nan Yang, Wenjuan Sun, Ping Wang, Xiaowan Tang, Yunlan Liu, Yuanyuan Ma, Min Meng, Ruobing Lei, Xuelian Yan, Hua Peng, Qing Chang, Hui Pan, Bo Zhang, Yaolong Chen & Shuyang Zhang
Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other...

Additional file 21 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 21. Number of immediate early genes (IEG) in the genes differentially expressed in the medial preoptic area (MPOA), nucleus accumbens (NAc), and lateral septum (LS).

Registration Year

  • 2022
    219

Resource Types

  • Dataset
    219

Affiliations

  • Third Affiliated Hospital of Sun Yat-sen University
    219
  • Sun Yat-sen University
    138
  • Zhejiang University
    124
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    123
  • Fudan University
    122
  • University of Chinese Academy of Sciences
    108
  • Chinese Academy of Sciences
    106
  • Tongji University
    92
  • Capital Medical University
    86
  • Shanghai Jiao Tong University
    85