47 Works

Tomato Protein Phosphatase 2C (SlPP2C3) influences fruit ripening onset and fruit glossiness

Ping Leng
Abscisic acid (ABA) plays a vital role in coordinating physiological processes during fresh fruit ripening. ABA can bind to ABA receptors which interacts and inhibits their co-receptors type 2C phosphatases (PP2Cs). However, the dissected mechanism of PP2C during fruit ripening is unclear. In this study, we identify the role of SlPP2C3, a tomato type 2C phosphatase, as a negative regulator of ABA signaling and fruit ripening. SlPP2C3 selectively interacted with monomeric ABA receptors and SlSnRK2.8...

Molecular characteristics of eae-positive clinical Shiga toxin-producing Escherichia coli in Sweden

Ying Hua, Xiangning Bai, Ji Zhang, Cecilia Jernberg, Milan Chromek, Sverker Hansson, Anne Frykman, Xi Yang, Yanwen Xiong, Chengsong Wan & Andreas Matussek
Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, also plays a critical role in STEC pathogenesis. Herein, we investigated the prevalence and genetic diversity of eae among clinical STEC isolates from patients with diarrhea, BD, HUS as well as from asymptomatic STEC-positive individuals in Sweden with whole-genome sequencing. We found...

Crocin inhibits the activation of mouse hepatic stellate cells via the lnc-LFAR1/MTF-1/GDNF pathway

Ji Xuan, Dongmei Zhu, Zhengyuan Cheng, Yuping Qiu, Mei Shao, Ya Yang, Qi Zhai, Fangyu Wang & Feng Qin
Crocin is the main monomer of saffron, which is a momentous component of traditional Chinese medicine Lang Qing A Ta. Here, we tried to probe into the role of crocin in liver fibrosis. Hematoxylin-eosin staining and Sirius Red staining were used to observe the pathological changes of liver tissues. After hepatic stellate cells (HSCs) were isolated from liver tissues, lnc-LFAR1, MTF-1, GDNF, and α-SMA expressions were detected by qRT-PCR and western blot. Immunohistochemistry and immunofluorescence...

Crocin inhibits the activation of mouse hepatic stellate cells via the lnc-LFAR1/MTF-1/GDNF pathway

Ji Xuan, Dongmei Zhu, Zhengyuan Cheng, Yuping Qiu, Mei Shao, Ya Yang, Qi Zhai, Fangyu Wang & Feng Qin
Crocin is the main monomer of saffron, which is a momentous component of traditional Chinese medicine Lang Qing A Ta. Here, we tried to probe into the role of crocin in liver fibrosis. Hematoxylin-eosin staining and Sirius Red staining were used to observe the pathological changes of liver tissues. After hepatic stellate cells (HSCs) were isolated from liver tissues, lnc-LFAR1, MTF-1, GDNF, and α-SMA expressions were detected by qRT-PCR and western blot. Immunohistochemistry and immunofluorescence...

Population genetics and forensic efficiency of 30 InDel markers in four Chinese ethnic groups residing in Sichuan

Fei Wang, Guanglin He, Zheng Wang, Mengge Wang, Jing Liu, Xing Zou, Shouyu Wang, Mengyuan Song, Ziwei Ye, Mingkun Xie & Yiping Hou
Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains. It also serves as the corridor of Sino-Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period (3300–2000 BC). However, the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear. Thus, we genotyped 30 insertion-deletion (InDel) markers in 444 samples from four ethnic groups...

Analysis of RNA-seq, DNA target enrichment, and Sanger nucleotide sequence data resolves deep splits in the phylogeny of cuckoo wasps (Hymenoptera: Chrysididae)

Thomas Pauli, Karen Meusemann, Sandra Kukowka, Manuela Sann, Alexander Donath, Christoph Mayer, Jan Philip Oeyen, Yolanda Ballesteros, Alexander Berg, Eric Van Den Berghe, Hermes Escalona, Adalgisa Guglielmino, Manfred Niehuis, Massimo Olmi, Lars Podsiadlowski, Carlo Polidori, Jeroen De Rond, Paolo Rosa, Thomas Schmitt, Franco Strumia, Mareike Wurdack, Shanlin Liu, Xin Zhou, Bernhard Misof, Ralph Peters … & Oliver Niehuis
The wasp family Chrysididae (cuckoo wasps, gold wasps) comprises exclusively parasitoid and kleptoparasitic species, many of which feature a stunning iridescent coloration and phenotypic adaptations to their parasitic life style. Previous attempts to infer phylogenetic relationships among the family’s major lineages (subfamilies, tribes, genera) based on Sanger sequence data were insufficient to statistically resolve the monophyly and the phylogenetic position of the subfamily Amiseginae and the phylogenetic relationships among the tribes Allocoeliini, Chrysidini, Elampini, and...

Data from: Symbiotic soil fungi enhance resistance and resilience of an experimental grassland to drought and nitrogen deposition

Yangyang Jia, Marcel Van Der Heijden, Cameron Wagg, Gu Feng & Florian Walder
Ecosystem stability is threatened by multiple global change factors such as drought and elevated nitrogen deposition. Yet, it is still poorly understood whether soil organisms can buffer against such perturbations. Here we focus on arbuscular mycorrhizal fungi (AMF), a common and widespread group of soil fungi. AMF form symbiotic associations with the majority of terrestrial land plants and promote a range of ecosystem services including plant production, diversity and nutrient cycling. We tested whether AMF...

Supplemental Material, original_data - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, original_data for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Toward Optimal Fingerprinting in Detection and Attribution of Changes in Climate Extremes

Zhuo Wang, Yujing Jiang, Hui Wan, Jun Yan & Xuebin Zhang
Abstract–Detection and attribution of climate change plays a central role in establishing the causal relationship between the observed changes in the climate and their possible causes. Optimal fingerprinting has been widely used as a standard method for detection and attribution analysis for mean climate conditions, but there has been no satisfactory analog for climate extremes. Here, we turn an intuitive concept, which incorporates the expected climate responses to external forcings into the location parameters of...

Data from: An integrative phylogenomic approach to elucidate the evolutionary history and divergence times of Neuropterida (Insecta: Holometabola)

Alexandros Vasilikopoulos, Bernhard Misof, Karen Meusemann, Doria Lieberz, Tomáš Flouri, Rolf G. Beutel, Oliver Niehuis, Torsten Wappler, Jes Rust, Ralph S. Peters, Alexander Donath, Lars Podsiadlowski, Christoph Mayer, Daniela Bartel, Alexander Böhm, Shanlin Liu, Paschalia Kapli, Carola Greve, James E. Jepson, Xingyue Liu, Xin Zhou, Horst Aspöck & Ulrike Aspöck
Background The latest advancements in DNA sequencing technologies have facilitated the resolution of the phylogeny of insects, yet parts of the tree of Holometabola remain unresolved. The phylogeny of Neuropterida has been extensively studied, but no strong consensus exists concerning the phylogenetic relationships within the order Neuroptera, and the timeline of diversification of thelineages of Neuropterida. Here, we assembled a novel transcriptomic dataset to address previously unresolved issues in the phylogeny of Neuropterida and to...

Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris

Yingying Cheng, Yong Chen, Yang Liu, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao & Kai Zhou
Tigecycline is one of the last-resort antibiotics to treat severe infections. Recently, tigecycline resistance has sporadically emerged with an increasing trend, and Tet(X) family represents a new resistance mechanism of tigecycline. In this study, a novel chromosome-encoded tigecycline resistance gene, tet(X14), was identified in a tigecycline-resistant and colistin-resistant Empedobacter stercoris strain ES183 recovered from a pig fecal sample in China. Tet(X14) shows 67.14-96.39% sequence identity to the other variants [Tet(X) to Tet(X13)]. Overexpression of Tet(X14)...

AGU Centennial Grand Challenge: Quantifying nutrient budgets for sustainable nutrient management

Xin Zhang, Eric Davidson, Tan Zou, Luis Lassaletta, Zhi Quan, Tingyu Li & Weifeng Zhang
Nutrients, such as nitrogen and phosphorus, provide vital support for human life, but overloading nutrients to the Earth system leads to environmental concerns, such as water and air pollution on local scales and climate change on the global scale. With an urgent need to feed the world’s growing population and the growing concern over nutrient pollution and climate change, sustainable nutrient management has become a major challenge for this century. To address this challenge, the...

Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

Chupeng Hu, Wei Liu, Ningyin Xu, An Huang, Zhenxing Zhang, Menghui Fan, Guojing Ruan, Yue Wang, Tao Xi & Yingying Xing
Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections. Our previous study reported that gastric subserous layer (GSL) vaccination induced a “pool” of protective tissue-resident memory CD4+T (CD4+TRM) cells in the gastric epithelium. However, the mechanistic details how CD4+TRM cells form in the gastric epithelium are unknown. Here, our results suggested that the vaccine containing CCF in combination with Silk fibroin hydrogel (SF) broadened...

Population genetics and forensic efficiency of 30 InDel markers in four Chinese ethnic groups residing in Sichuan

Fei Wang, Guanglin He, Zheng Wang, Mengge Wang, Jing Liu, Xing Zou, Shouyu Wang, Mengyuan Song, Ziwei Ye, Mingkun Xie & Yiping Hou
Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains. It also serves as the corridor of Sino-Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period (3300–2000 BC). However, the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear. Thus, we genotyped 30 insertion-deletion (InDel) markers in 444 samples from four ethnic groups...

Contrasting patterns in biomass allocation, root morphology and mycorrhizal symbiosis for phosphorus acquisition among 20 chickpea genotypes with different amounts of rhizosheath carboxylates

Zhihui Wen, Jiayin Pang, Guillaume Tueux, Yifei Liu, Jianbo Shen, Megan Ryan, Hans Lambers & Kadambot Siddique
1. Adjustments in root biomass allocation, root morphology, carboxylate exudation and mycorrhizal symbiosis are well-known strategies for plants to cope with phosphorus (P) deficiency. Large genotypic variation in these functional traits has been demonstrated within numerous species. Yet, whether these functional traits are coordinated differently among genotypes of a species to enhance P acquisition remains unknown. 2. We characterised 11 root functional traits associated with P acquisition in 20 chickpea genotypes with contrasting amounts of...

Arbuscular mycorrhizal symbiosis increases P uptake and productivity of mixtures of maize varieties compared to monocultures

Gu Feng, Xinxin Wang, Ellis Hoffland, Gu Feng & Thomas Kuyper
Ecological intensification seeks to achieve crop yield increases through intensifying complementary or facilitative interactions between plant species or varieties. Different species of arbuscular mycorrhizal fungi (AMF) exhibit niche differentiation and show selectivity towards certain plants, which can further enhance complementarity. It is not clear whether in the presence of one AMF species, where mycelial networks connect crop species, opportunities for complementarity effects may be reduced. We grew monocultures and mixtures of maize varieties in a...

Supplemental Material, original_data - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, original_data for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Efficient estimation of optimal regimes under a no direct effect assumption*

Lin Liu, Zach Shahn, James M. Robins & Andrea Rotnitzky
We derive new estimators of an optimal joint testing and treatment regime under the no direct effect assumption that a given laboratory, diagnostic, or screening test has no effect on a patient’s clinical outcomes except through the effect of the test results on the choice of treatment. We model the optimal joint strategy with an optimal structural nested mean model (opt-SNMM). The proposed estimators are more efficient than previous estimators of the parameters of an...

Lineage-level distribution models lead to more realistic climate change predictions for a threatened crayfish

Zhixin Zhang, Jamie Kass, Stefano Mammola, Itsuro Koizumi, Xuecao Li, Kazunori Tanaka, Kousuke Ikeda, Toru Suzuki, Masashi Yokota & Nisikawa Usio
Aim: As climate change presents a major threat to biodiversity in the next decades, it is critical to assess its impact on species habitat suitability to inform biodiversity conservation. Species distribution models (SDMs) are a widely used tool to assess climate change impacts on species’ geographical distributions. As the term suggests, the species-level is the most commonly used taxonomic unit in SDMs. However, recently it has been demonstrated that SDMs considering taxonomic resolution below (or...

A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma

Huimin Shen, Hao Wu, Fengkai Sun, Jianni Qi & Qiang Zhu
Hepatocellular carcinoma (HCC) is a liver disease with a complex underlying mechanism, and patients with HCC have low survival rates. Iron metabolism plays a crucial role in the pathogenesis of HCC; however, the prognostic value of iron metabolism-related and methylated genes for HCC needs to be further explored. In the present study, we identified differentially expressed genes (DEGs) that play a role in iron metabolism and DNA methylation in HCC from The Cancer Genome Atlas....

A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma

Huimin Shen, Hao Wu, Fengkai Sun, Jianni Qi & Qiang Zhu
Hepatocellular carcinoma (HCC) is a liver disease with a complex underlying mechanism, and patients with HCC have low survival rates. Iron metabolism plays a crucial role in the pathogenesis of HCC; however, the prognostic value of iron metabolism-related and methylated genes for HCC needs to be further explored. In the present study, we identified differentially expressed genes (DEGs) that play a role in iron metabolism and DNA methylation in HCC from The Cancer Genome Atlas....

sj-xlsx-2-tam-10.1177_1758835920977117 – Supplemental material for Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma

Xia Ran, Jinyuan Xiao, Yi Zhang, Huajing Teng, Fang Cheng, Huiqian Chen, Kaifan Zhang & Zhongsheng Sun
Supplemental material, sj-xlsx-2-tam-10.1177_1758835920977117 for Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma by Xia Ran, Jinyuan Xiao, Yi Zhang, Huajing Teng, Fang Cheng, Huiqian Chen, Kaifan Zhang and Zhongsheng Sun in Therapeutic Advances in Medical Oncology

Registration Year

  • 2020
    47

Resource Types

  • Dataset
    47

Affiliations

  • China Agricultural University
    47
  • Shanghai Jiao Tong University
    24
  • Zhejiang University
    23
  • Fudan University
    23
  • Capital Medical University
    23
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    21
  • Central South University
    18
  • Peking University
    18
  • Sun Yat-sen University
    15
  • Sichuan University
    15