334 Works

Early activity of the Kerguelen Mantle plume: geochronology, geochemistry and Sr-Nd-Pb isotopes of mafic dykes and sills from the Tethyan Himalaya

Zhen Wang, Yuruo Shi, Tianshui Yang, J. Lawford Anderson, Jianxin Zhao, Wenxiao Peng, Chenyang Hou, Huiyi Sun, Weiwei Bian & Yiming Ma
The remnant Comei igneous province in SE Tibet has been recognized as a product of early Kerguelen mantle plume activity. In this paper, we investigate mafic dykes and sills intruded into Lakang Formation in the southeastern Tethyan Himalaya. Based on new whole-rock geochemical, Sr-Nd-Pb isotopic and SHRIMP zircon U-Pb geochronological data, these rocks can be divided into three groups. Group 1 is composed of OIB-like mafic dykes and sills with lower εNd(t) (+1.78-+2.55) and dated...

Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China

Xuemei Yang, Qiaoling Sun, Jiaping Li, Yu Jiang, Yi Li, Jianping Lin, Kaichao Chen, Edward Wai-Chi Chan, Rong Zhang & Sheng Chen
The epidemiological features of the newly emerged carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) and its potential threat to human health are currently unknown. In this study, a total of 784 blaKPC-2-bearing CRKP strains collected from three hospitals located at different geographical locales in China during 2014–2017 were subjected to molecular typing, screening of virulence plasmid, string test and WGS (367/784 strains). The proportion of CRKP among all clinical K. pneumoniae strains increased sharply in China during...

Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway

Ying Zhou, Wei Cai & Hailin Lu
Chemoresistance is a major challenge for the treatment of breast cancer (BC). Previous studies showed that miR-145 level decreases in chemoresistant BC tissues. Nevertheless, the biological function of miR-145 on docetaxel resistance of BC cells remains unclear, which is what our research attempted to clarify. RT-qPCR analyzed miR-145 level, and cell viability and colony formation assays assessed the impact of miR-145 on docetaxel resistance. Molecular mechanisms of miR-145-mediated docetaxel sensitivity were examined by Luciferase reporter...

Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Hehe Liu, Qian Xu, Yang Xi, Shengchao Ma, Jianmei Wang, Lili Bai, Chunchun Han, Hua He & Liang Li
1. The following study examined the expression profiles of the receptor tyrosine kinases (RTK) family in the developing feather follicles of Pekin ducks and Nonghua ducks at 6-9 weeks of age. The RTK subfamilies related to feather development were summarised, and other candidate genes related to feather development were enriched. 2. To reveal the potential role of all RTK members in feather development, the feather follicles of two duck breeds (Pekin and Nonghua ducks) at...

Mass spectrometry-based metabolic profiling for identification of biomarkers in serum related to the change of laying ducks in different physiological periods

Qian Tang, Hehe Liu, Jingjing Qi, Xiping Yan, Ahsan Mustafa, Yang Xi, Junpeng Li, Lili Bai, Li Liang, Chunchun Han & Jiwen Wang
Eggs are a major animal protein source for humans. Egg formation is a complex process involved in coordinating various tissues and organs, while blood is necessary for gonad differentiation and egg formation. In this study, non-targeted metabolomics technology was employed to determine the serum metabolites at the time point of 70 days (before laying period, T0), 130 days (pre-laying period, T1), 300 days (peak laying period, T2), and 340 days (post laying period, T3) in...

NLRC5 Restricts Dengue Virus Infection by Promoting the Autophagic Degradation of Viral NS3 through E3 Ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection. Mechanistic...

High expression of HOXA4 in patients with glioma indicates unfavorable clinical outcomes

Zhenghong Yu, Zhendong Liu, Xiaoyu Lian, Xingbo Cheng, Binfeng Liu, Bo Zhang, Hongbo Wang, Jialin Wang, Ang Li, Zhishuai Ren, Bo Pang, Rongjun Qian & Yanzheng Gao
HOXA4 is a novel oncogene that has been observed in many kinds of tumors, but its role during glioma carcinogenesis and its clinical significance in diagnosing and prognosis human glioma remains unknown. In the present study, the Chinese Glioma Atlas (CGGA)-RNA sequencing database, CGGA microarray, and The Cancer Genome Atlas (TCGA)-RNA seq data from 1674 glioma patients were obtained from online databases and analyzed using quantitative reverse transcription-polymerase chain reaction (RT-qPCR) to detect changes in...

Gapless genome assembly of East Asian finless porpoise, Neophocaena asiaeorientalis sunameri

Denghua Yin, Chunhai Chen, Danqing Lin, Jialun Zhang, Congping Ying, Yan Liu, Wang Liu, Zhichen Cao, Chenxi Zhao, Chenhe Wang, Liping Liang, Pao Xu, Jianbo Jian & Kai Liu
There are the genome sequence, gene set, coding sequence and protein sequence of Neophocaena asiaeorientalis sunameri.

Additional file 3 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 3. Table S3: Performance of three strategies.

Additional file 9 of Small molecule modulation of microbiota: a systems pharmacology perspective

Qiao Liu, Bohyun Lee & Lei Xie
Additional file 9. Table S8. Background drugs list used in drug overrepresentation analysis.

Additional file 10 of Small molecule modulation of microbiota: a systems pharmacology perspective

Qiao Liu, Bohyun Lee & Lei Xie
Additional file 10. Table S9. Background targets list used in target functional annotation analysis.

Additional file 2 of Small molecule modulation of microbiota: a systems pharmacology perspective

Qiao Liu, Bohyun Lee & Lei Xie
Additional file 2. Table S1. Microbes with pathogenic effects on human health by manually literature review.

Additional file 10 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 10: Table S7. Differentially expressed miRNAs in atm mutated flies after X-ray irradiation.

Additional file 1 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 1.

Additional file 13 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 13: Table S10. Differentially expressed lncRNAs in atm mutated flies after X-ray irradiation.

Additional file 2 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 2.

Additional file 4 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 4: Table S1. mRNA counts.

Additional file 4 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 4: Table S1. mRNA counts.

Additional file 5 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 5: Table S2. Protein-coding genes sequenced.

NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that the expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection....

Additional file 6 of Small molecule modulation of microbiota: a systems pharmacology perspective

Qiao Liu, Bohyun Lee & Lei Xie
Additional file 6. Table S5. Drugs that are found in both drug screen results using Drugbank database and that using STITCH database.

Additional file 17 of Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins

Xuan-Wu Li, Ni Zhang, Zhuo-Lin Li, Nouhoum Dibo, Zhen-Rong Ma, Bin Lu, Ye-Hong Huang, Yun-Feng Chang, Hong-Zhi Chen & Xiang Wu
Additional file 17: Table S3 Alignment of experimentally verified epitopes and selected sequences in the vaccine construct.

Additional file 1 of Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins

Xuan-Wu Li, Ni Zhang, Zhuo-Lin Li, Nouhoum Dibo, Zhen-Rong Ma, Bin Lu, Ye-Hong Huang, Yun-Feng Chang, Hong-Zhi Chen & Xiang Wu
Additional file 1. Information on membrane proteins of Toxoplasma gondii obtained from the UniProt database.

Additional file 2 of Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins

Xuan-Wu Li, Ni Zhang, Zhuo-Lin Li, Nouhoum Dibo, Zhen-Rong Ma, Bin Lu, Ye-Hong Huang, Yun-Feng Chang, Hong-Zhi Chen & Xiang Wu
Additional file 2. Amino acid sequences of the proteins presented in Additional file 1.

Additional file 3 of Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins

Xuan-Wu Li, Ni Zhang, Zhuo-Lin Li, Nouhoum Dibo, Zhen-Rong Ma, Bin Lu, Ye-Hong Huang, Yun-Feng Chang, Hong-Zhi Chen & Xiang Wu
Additional file 3. Linear B cell epitopes predicted by the ABCPred server.

Registration Year

  • 2022
    334

Resource Types

  • Dataset
    334

Affiliations

  • Second Xiangya Hospital of Central South University
    334
  • Chinese Academy of Sciences
    193
  • Capital Medical University
    185
  • Zhejiang University
    184
  • Peking University
    171
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    170
  • Central South University
    166
  • Shanghai Jiao Tong University
    159
  • Huazhong University of Science and Technology
    136
  • Shandong University
    132