25 Works

Atlante sintattico della Calabria 2 (AsiCa2)

Thomas Krefeld, Stephan Lücke, Veronika Gacia & Tobias Englmeier
Das AsiCa2-Corpus ist eine erweiterte Version des AsiCa-Corpus (2006) und besteht im Kern aus einer Sammlung von Tonaufnahmen mit Interviews von Sprechern des süditalienischen Dialekts "Calabrese". 2019 kam Material aus einem weiteren kalabresischen Ort, Praia a Mare, sowie Referenzmaterial aus Neapel und Apulien hinzu. Ein Teil der Informanten des ursprünglichen Korpushatte wenigstens zeitweise in Deutschland gelebt und somit Migrationserfahrung. Die Aufnahmen stammen hauptsächlich aus den Jahren 2004, 2005 und 2019. Die Dialektsprecher (Informanten) wurden von...

A major locus controls a biologically active pheromone component in Heliconius melpomene

Kelsey Byers, Kathy Darragh, Jamie Musgrove, Diana Abondano Almeida, Sylvia Fernanda Garza, Ian Warren, Pasi Rastas, Marek Kučka, Yingguang Frank Chan, Richard Merrill, Stefan Schulz, W. Owen McMillan & Chris Jiggins
Understanding the production, response, and genetics of signals used in mate choice can inform our understanding of the evolution of both intraspecific mate choice and reproductive isolation. Sex pheromones are important for courtship and mate choice in many insects, but we know relatively little of their role in butterflies. The butterfly Heliconius melpomene uses a complex blend of wing androconial compounds during courtship. Electroantennography in H. melpomene and its close relative H. cydno showed that...

Hearing sensitivity and amplitude coding in bats are differentially shaped by echolocation calls and social calls

Ella Lattenkamp, Martina Nagy, Markus Drexl, Sonja Vernes, Lutz Wiegrebe & Mirjam Knörnschild
Differences in auditory perception between species are influenced by phylogenetic origin and the perceptual challenges imposed by the natural environment, e.g. detecting prey- or predator-generated sounds and communication signals. Bats are well suited for comparative studies on auditory perception since they predominantly rely on echolocation to perceive the world, while their social calls and most environmental sounds have low frequencies. We tested if hearing sensitivity and stimulus level coding in bats differ between high and...

Genetic dissection of assortative mating behavior

Richard M. Merrill, Pasi Rastas, Simon H. Martin, Maria C. Melo, Sarah Barker, John Davey, W. Owen McMillan & Chris D. Jiggins
The evolution of new species is made easier when traits under divergent ecological selection are also mating cues. Such ecological mating cues are now considered more common than previously thought, but we still know little about the genetic changes underlying their evolution, or more generally about the genetic basis for assortative mating behaviors. Both tight physical linkage and the existence of large effect preference loci will strengthen genetic associations between behavioral and ecological barriers, promoting...

Data from: Deep Divergence between Island Populations in Lichenized Fungi

Silke Werth, Christoph Scheidegger & Peter Meidl
Macaronesia is characterized by a high degree of endemism and represents a noteworthy system to study the evolutionary history of populations and species. Here, we compare the population-genetic structure in three lichen-forming fungi, the widespread Lobaria pulmonaria and two Macaronesian endemics, L. immixta and L. macaronesica, based on microsatellites. We utilize population genetic approaches to explore population subdivision and evolutionary history of these taxa on the Canary Islands, Madeira, Azores, and the western Iberian Peninsula....

Natural history, phenotypic spectrum, and discriminative features of multisystemic RFC1-disease

Andreas Traschütz, Andrea Cortese, Selina Reich, Natalia Dominik, Jennifer Faber, Heike Jacobi, Annette Hartmann, Dan Rujescu, Solveig Montaut, Andoni Echaniz-Laguna, Sevda Erer, Valerie Cornelia Schütz, Alexander Tarnutzer, Marc Sturm, Tobias Haack, Nadège Vaucamps-Diedhiou, Helene Puccio, Ludger Schöls, Thomas Klockgether, Bart P. Van De Warrenburg, Martin Paucar, Dagmar Timmann, Ralf-Dieter Hilgers, Jose Gazulla, Michael Strupp … & Matthis Synofzik
Objective: To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of RFC1-repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). Methods: Multimodal RFC1 repeat screening (PCR, southern blot, whole-exome/genome (WES/WGS)-based approaches) combined with cross-sectional and longitudinal deep-phenotyping in (i) cross-European cohort A (70 families) with ≥2 features of CANVAS and/or ataxia-with-chronic-cough (ACC); and (ii) Turkish cohort B (105 families) with unselected late-onset ataxia. Results:...

Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

Alessandro Scacchetti & Peter Becker
Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcription. In Drosophila, the single DOMINO chromatin regulator complex is thought to combine both activities via an unknown mechanism. Here we show that alternative isoforms of the DOMINO nucleosome remodeling ATPase, DOM-A and DOM-B, directly specify two distinct multi-subunit complexes. Both complexes are necessary for transcriptional regulation but through different mechanisms. The DOM-B complex incorporates H2A.V (the fly ortholog of H2A.Z) genome-wide in...

Early sexual dimorphism in the developing gut microbiome of northern elephant seals

Martin Adam Stoffel, Karina Acevedo-Whitehouse, Nami Morales-Durán, Stefanie Grosser, Nayden Chakarov, Oliver Krüger, Hazel J. Nichols, Fernando R. Elorriaga-Verplancken & Joseph I. Hoffman
The gut microbiome is an integral part of a species’ ecology, but we know little about how host characteristics impact its development in wild populations. Here, we explored the role of such intrinsic factors in shaping the gut microbiome of northern elephant seals during a critical developmental window of six weeks after weaning, when the pups stay ashore without feeding. We found substantial sex-differences in the early-life gut microbiome, even though males and females could...

Leaf-out in northern ecotypes of wide-ranging trees requires less spring warming, enhancing the risk of spring frost damage at cold range limits

Constantin Zohner, Lidong Mo, Veronica Sebald & Susanne S Renner
Aim. Trees need to avoid frost damage to their young leaves by leafing out after the occurrence of the last frost, yet they also need to start photosynthesis early in the season to achieve sufficient growth. This trade-off leads to the hypothesis that ‘safety margins’ against spring frost should become shorter, the longer the winter duration, perhaps reaching an asymptotic limit where frost damage would occur in most years. Physiologically, shorter safety margins in high-latitude...

Genetically determined blood pressure, antihypertensive drug classes and risk of stroke subtypes

Marios Georgakis, Dipender Gill, Alastair Webb, Evangelos Evangelou, Paul Elliott, Cathie Sudlow, Abbas Dehghan, Rainer Malik, Ioanna Tzoulaki & Martin Dichgans
Objective: We employed Mendelian Randomization to explore whether the effects of blood pressure (BP) and BP lowering through different antihypertensive drug classes on stroke risk vary by stroke etiology. Methods: We selected genetic variants associated with systolic and diastolic BP and BP-lowering variants in genes encoding antihypertensive drug targets from a GWAS on 757,601 individuals. Applying two-sample Mendelian randomization, we examined associations with any stroke (67,162 cases; 454,450 controls), ischemic stroke and its subtypes (large...

Vacuolar sucrose homeostasis is critical for development, seed properties and survival of dark phases of Arabidopsis

Duc Phuong Vu, Cristina Martins Rodrigues, Benjamin Jung, Garvin Meissner, Patrick A.W. Klemens, Daniela Holtgräwe, Lisa Fürtauer, Thomas Nägele, Petra Nieberl, Benjamin Pommerrenig & Ekkehard H. Neuhaus
Although we know that most of the cellular sucrose is present in the cytosol and vacuole, our knowledge on the impact of this sucrose compartmentation on plant properties is still fragmentary. Here we attempted to alter the intracellular sucrose compartmentation of Arabidopsis mesophyll cells by either, overexpression of the vacuolar sucrose loader BvTST2.1 or by generation of mutants with decreased vacuolar invertase activity (amiR vi1-2). Surprisingly, BvTST2.1 overexpression led to increased monosaccharide levels in leaves,...

Joining a group diverts regret and responsibility away from the individual

Marwa El Zein & Bahador Bahrami
It has recently been proposed that a key motivation for joining groups is the protection from negative consequences of undesirable outcomes. To test this claim we investigated how experienced outcomes triggering loss and regret impacted people’s tendency to decide alone or join a group, and how decisions differed when voluntarily made alone vs in group. Replicated across two experiments, participants (N=125 and N=496) selected whether to play alone or contribute their vote to a group...

Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

Marion Cremer, Katharina Brandstetter, Andreas Maiser, Suhas S P Rao, Volker Schmid, Miguel Guirao-Ortiz, Namita Mitra, Stefania Mamberti, Kyle N Klein, David Gilbert, Heinrich Leonhardt, Maria Cristina Cardoso, Erez Lieberman Aiden, Hartmann Harz & Thomas Cremer
Cohesin plays an essential role in chromatin loop extrusion, but its impact on a compartmentalized nuclear architecture is debatable. Using live-cell and super-resolved 3D microscopy, we demonstrate that cohesin-depleted cells pass through an endomitosis and rebuild a single multilobulated nucleus (MLN) with chromosome territories (CTs) pervaded by interchromatin channels. CTs contain chromatin domain clusters with a zonal organization of repressed chromatin domains in the interior and transcriptionally competent domains located at the periphery. Splicing speckles...

PCA coordinates describing dorsal colour pattern variation in 723 Morpho butterflies

Violaine Llaurens, Yann Le Poul, Agathe Puissant, Patrick Blandin & Vincent Debat
Species interactions such as mimicry can promote trait convergence but disentangling this effect from those of shared ecology, evolutionary history and niche conservatism is often challenging. Here by focusing on wing color pattern variation within and between three butterfly species living in sympatry in a large proportion of their range, we tested the effect of species interactions on trait diversification. These butterflies display a conspicuous iridescent blue coloration on the dorsal side of their wings...

Historical isolation facilitates species radiation by sexual selection: insights from Chorthippus grasshoppers

Zachary Nolen, Burcin Yildirim, Iker Irisarri, Shanlin Liu, Clara Groot Crego, Daniel Amby, Frieder Mayer, M. Gilbert & Ricardo Pereira
Theoretical and empirical studies have shown that species radiations are facilitated when a trait under divergent natural selection is also involved in sexual selection. It is yet unclear how quick and effective radiations are where assortative mating is unrelated to the ecological environment and primarily results from sexual selection. We address this question using sympatric grasshopper species of the genus Chorthippus, which have evolved strong behavioral isolation while lacking noticeable eco-morphological divergence. Mitochondrial genomes suggest...

Data from: Public health and cost consequences of time delays to thrombectomy for acute ischemic stroke

Wolfgang Kunz
Objective: To determine public health and cost consequences of time delays to EVT for patients, healthcare systems, and society, we estimated quality-adjusted life years (QALY) of EVT-treated patients and associated costs based on times to treatment. Methods: The Markov model analysis was performed from United States healthcare and societal perspectives over a lifetime horizon. Contemporary data from seven trials within the HERMES collaboration served as data source. Aside from cumulative lifetime costs, we calculated the...

Phenotypic variability in chorea-acanthocytosis associated with novel VPS13A mutations

Valter Niemelä, Ammar Salih, Daniela Solea, Björn Lindvall, Jan Weinberg, Gabriel Miltenberger, Tobias Granberg, Aikaterini Tzovla, Love Nordin, Torsten Danfors, Irina Savitcheva, Niklas Dahl & Martin Paucar
Objective: To perform a comprehensive characterization of a cohort of patients with chorea-acanthocytosis (ChAc) in Sweden. Methods: Clinical assessments, targeted genetic studies, neuroimaging with MRI,18F-fluorodeoxyglucose (FDG) PET and dopamine transporter with [123I] FP-CIT (DaTscan) SPECT. One patient underwent Magnetic Resonance Spectroscopy (MRS). Results: Four patients living in Sweden but with different ethnical backgrounds were included. Their clinical features were variable. Biallelic VPS13A mutations were confirmed in all patients, including three novel mutations. All tested patients...

Repeatable differences in exploratory behaviour predict tick infestation probability in wild great tits

Robert E. Rollins, Alexia Mouchet, Gabriele Margos, Lidia Chitimia-Dobler, Volker Fingerle, Noémie S. Becker & Niels J. Dingemanse
Ecological factors and individual-specific traits affect parasite infestation in wild animals. We studied various key ecological variables (breeding density, human disturbance) and phenotypic traits (exploratory behaviour, body condition) proposed to predict tick infestation probability and burden in great tits (Parus major). Our study spanned three years and 12 nest-box plots located in southern Germany. Adult breeders were assessed for exploration behaviour, body condition, and tick burden. Plots were open to human recreation; human disturbance was...

Biosonar spatial resolution along the distance axis: revisiting the clutter interference zone

Peter A. Wagenhäuser, Lutz Wiegrebe & A. Leonie Baier
Many echolocating bats forage close to vegetation - a chaotic arrangement of prey and foliage where multiple targets are positioned behind one another. Bats excel at determining distance: they measure the delay between outgoing call and returning echo. In their auditory cortex, delay-sensitive neurons form a topographic map, suggesting that bats can resolve echoes of multiple targets along the distance axis - a skill crucial for the forage-amongst-foliage scenario. We tested this hypothesis combining an...

Collision between biological process and statistical analysis revealed by mean-centering

David Westneat, Yimen Araya-Ajoy, Hassen Allegue, Barbara Class, Niels Dingemanse, Ned Dochtermann, Laszlo Garamszegi, Julien Martin, Shinichi Nakagawa, Denis Reale & Holger Schielzeth
1. Animal ecologists often collect hierarchically-structured data and analyze these with linear mixed-effects models. Specific complications arise when the effect sizes of covariates vary on multiple levels (e.g., within vs among subjects). Mean-centering of covariates within subjects offers a useful approach in such situations, but is not without problems. 2. A statistical model represents a hypothesis about the underlying biological process. Mean-centering within clusters assumes that the lower level responses (e.g. within subjects) depend on...

Clustering of loci controlling species differences in male chemical bouquets of sympatric Heliconius butterflies

Kelsey Byers, Kathy Darragh, Sylvia Fernanda Garza, Diana Abondano Almeida, Ian Warren, Pasi Rastas, Richard Merrill, Stefan Schulz, W. Owen McMillan & Chris Jiggins
The degree to which loci promoting reproductive isolation cluster in the genome – i.e. the genetic architecture of reproductive isolation - can influence the tempo and mode of speciation. Tight linkage between these loci can facilitate speciation in the face of gene flow. Pheromones play a role in reproductive isolation in many Lepidoptera species, and the role of endogenously-produced compounds as secondary metabolites decreases the likelihood of pleiotropy associated with many barrier loci. Heliconius butterflies...

The roles of temperature, nest predators and information parasites for geographical variation in egg covering behaviour of tits (Paridae)

Olli Loukola, Peter Adamik, Frank Adriaensen, Emilio Barba, Blandine Doligez, Einar Flensted-Jensen, Tapio Eeva, Sami Kivelä, Toni Laaksonen, Chiara Morosinotto, Raivo Mänd, Petri Niemelä, Vladimir Remeš, Jelmer Samplonius, Manrico Sebastiano, Juan Carlos Senar, Tore Slagsvold, Alberto Sorace, Barbara Tschirren, János Török & Jukka Forsman
Aim: Nest building is widespread among animals. Nests may provide receptacles for eggs, developing offspring and the parents, and protect them from adverse environmental conditions. Nests may also indicate the quality of the territory and its owner and can be considered as an extended phenotype of its builder(s). Nests may, thus, function as a sexual and social signal. Here, we examined ecological and abiotic factors—temperature, nest predation and interspecific information utilization—shaping geographical variation in a...

Hybridization and transgressive exploration of colour pattern and wing morphology in Heliconius butterflies

Claire Mérot, Vincent Debat, Yann Le Poul, Richard M Merrill, Russell E Naisbit, Adélie Tholance, Chris Jiggins & Mathieu Joron
Hybridization can generate novel phenotypes distinct from those of parental lineages, a phenomenon known as transgressive trait variation. Transgressive phenotypes might negatively or positively affect hybrid fitness, and increase available variation. Closely related species of Heliconius butterflies regularly produce hybrids in nature and hybridization is thought to play a role in the diversification of novel wing colour patterns despite strong stabilizing selection due to interspecific mimicry. Here, we studied wing phenotypes in first and second...

Data from: Novel sources of (co)variation in nestling begging behavior and hunger at different biological levels of analysis

Daniel Wetzel, Ariane Mutzel, Jonathan Wright & Niels Dingemanse
Biological hypotheses predicting patterns of offspring begging typically concern the covariance with hunger and/or development at specific hierarchical levels. For example, hunger drives within-individual patterns of begging, but begging also drives food intake among individuals within broods, and begging and food intake can covary positively or negatively among genotypes or broods. Testing biological phenomena that occur at multiple levels therefore requires the partitioning of covariance between traits of interest to ensure that each level-specific relationship...

Weather effects on nestling survival of great tits vary according to the developmental stage

Fernando Marques-Santos & Niels J. Dingemanse
Organisms change breeding investments as a function of the environment, thereby maximizing reproductive success. Climate change studies of avian life-history have long focused on plasticity of laying dates and clutch sizes in response to weather conditions prior to clutch initiation. By contrast, effects of unpredictable weather events occurring after initial reproductive decisions are made have largely been ignored, despite becoming increasingly important with ongoing climate change. We studied the detrimental effects of fluctuations in temperature...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Ludwig Maximilian University of Munich
  • University of Cambridge
  • Ludwig-Maximilians-Universität München
  • Bielefeld University
  • Smithsonian Tropical Research Institute
  • Karolinska University Hospital
  • Technische Universität Braunschweig
  • University College London
  • University of Helsinki
  • Swiss Federal Institute of Technology in Zurich