29 Works

VerbaAlpina Version 19/2

Thomas Krefeld & Stephan Lücke

Extensive introgression at late stages of species formation: Insights from grasshopper hybrid zones

Linda Hagberg, Enrique Celemín, Iker Irisarri, Oliver Hawlitschek, José Bella, Tamí Mott & Ricardo Pereira
The process of species formation is characterised by the accumulation of multiple reproductive barriers. The evolution of hybrid male sterility, or Haldane’s rule, typically characterises later stages of species formation, when total reproductive isolation is strongest. Yet, understanding how quickly reproductive barriers evolve and their consequences for maintaining genetic boundaries between emerging species remains a challenging task because it requires studying taxa that hybridise in nature. Here, we address these questions using the meadow grasshopper...

Nuclear and plastid phylogenomic analyses provide insights into the reticulate evolution, species delimitation and biogeography of the Sino-Japanese disjunctive Diabelia (Caprifoliaceae)

Xiu-Rong Ke, Diego F. Morales-Briones, Hong-Xin Wang, Qing-Hui Sun, Jacob B. Landis, Jun Wen & Hua-Feng Wang
Understanding biological diversity and the mechanisms of the Sino-Japanese disjunctions are major challenges in eastern Asia biogeography. The Sino-Japanese flora has been broadly studied as an ideal model for plant phylogeography. Diabelia (Caprifoliaceae) is an East Asian genus, with a disjunctive distribution across the Sino-Japanese region. However, relationships within Diabelia remain elusive. In this study, we reconstructed the phylogeny of Diabelia and inferred historical biogeography and evolutionary patterns based on nuclear and plastid sequences from...

Data from: Clinical presentation and management of SMART syndrome

Sebastian F. Winter, Joshua P. Klein, Eugene J. Vaios, Philipp Karschnia, Eudocia Q. Lee, Helen A. Shih, Franziska Loebel & Jorg Dietrich
Stroke-like migraine attacks after radiation therapy (SMART) syndrome represents a rare but serious condition manifesting years after cranial radiation therapy (RT). Characterized by migraine-type headaches, stroke-like deficits and/or seizures and MR imaging abnormalities, including cortical gyriform enhancement in irradiated brain regions, SMART remains diagnostically and therapeutically challenging. Distinction from tumor progression is difficult and treatment options are limited. Although frequently reversible, SMART episodes can recur and effectuate persistent neurologic and/or imaging sequelae.

Recovery from hybrid breakdown reveals a complex genetic architecture of mitonuclear incompatibilities

Thiago Lima, Ricardo Pereira, Ronald Burton, Tessa Pierce & Lin Chao
Reproductive isolation is often achieved when genes that are neutral or beneficial in their genomic background become functionally incompatible in a foreign genome, causing inviability, sterility or low fitness in hybrids. Recent studies suggest that mitonuclear interactions are among the initial incompatibilities to evolve at early stages of population divergence across taxa. Yet, the genomic architecture of mitonuclear incompatibilities has rarely been elucidated. We employ an experimental evolution approach starting with low-fitness F2 interpopulation hybrids...

VerbaAlpina Version 19/1

Thomas Krefeld & Stephan Lücke

Repositories for taxonomic data: Where we are and what is missing

Aurélien Miralles, Teddy Bruy, Katherine Wolcott, Mark Scherz, Dominik Begerow, Bank Beszteri, Michael Bonkowski, Janine Felden, Birgit Gemeinholzer, Frank Glaw, Frank Oliver Glöckner, Oliver Hawlitschek, Ivaylo Kostadinov, Tim Nattkemper, Christian Printzen, Jasmin Renz, Nataliya Rybalka, Marc Stadler, Tanja Weibulat, Thomas Wilke, Susanne Renner & Miguel Vences
Natural history collections are leading successful large-scale projects of specimen digitization (images, metadata, DNA barcodes), transforming taxonomy into a big data science. Yet, little effort has been directed towards safeguarding and subsequently mobilizing the considerable amount of original data generated during the process of naming 15–20,000 species every year. From the perspective of alpha-taxonomists, we provide a review of the properties and diversity of taxonomic data, assess their volume and use, and establish criteria for...

Rhagoletis cingulata and Rhagoletis cerasi genome comparison

Thomas Wolfe, Daniel Bruzzese, Lisa Klasson, Erika Corretto, Sonja Lečić, Christian Stauffer, Jeffrey Feder & Hannes Schuler
Wolbachia is a maternally inherited obligate endosymbiont that can induce a wide spectrum of effects in its host, ranging from mutualism to reproductive parasitism. At the genomic level, recombination within and between strains, transposable elements, and horizontal transfer of strains between host species make Wolbachia an evolutionarily dynamic bacterial system. The invasive cherry fruit fly Rhagoletis cingulata arrived in Europe from North America ~40 years ago, where it now co-occurs with the native cherry pest...

Data for: Neural divergence and hybrid disruption between ecologically isolated Heliconius butterflies

Stephen Montgomery, Matteo Rossi, W. Owen McMillan & Richard Merrill
The importance of behavioral evolution during speciation is well established, but we know little about how this is manifest in sensory and neural systems. A handful of studies have linked specific neural changes to divergence in host or mate preferences associated with speciation. However, the degree to which brains are adapted to local environmental conditions, and whether this contributes to reproductive isolation between close relatives that have diverged in ecology, remains unknown. Here, we examine...

Supplemental Data to: Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Tommaso Ballarini, Debora Melo Van Lent, Julia Brunner, Alina Schröder, Steffen Wolfsgruber, Slawek Altenstein, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Emrah Düzel, Birgit Ertl-Wagner, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, Wenzel Glanz, Dietmar Hauser, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline Danielle Metzger, Matthias H. Munk … & Michael Wagner
Objective: To determine whether following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive Impairment and Dementia Study. Method: The sample (n = 512, mean age 69.5 ± 5.9 years) included 169 cognitively normal participants and individuals at higher AD risk (53 with relatives with AD, 209 with subjective cognitive decline, and 81 with mild cognitive impairment). We defined...

Major population splits coincide with episodes of rapid climate change in a forest-dependent bird

Vera-Maria Warmuth, Malcolm Burgess, Marko Mägi, Toni Laaksonen, Andrea Manica, Andreas Nord, Craig Primmer, Glenn-Peter Sætre, Wolfgang Winkel & Hans Ellegren
Climate change influences population demography by altering patterns of gene flow and reproductive isolation. Direct mutation rates offer the possibility for accurate dating on the within-species level but are currently only available for a handful of vertebrate species. Here, we use the first directly estimated mutation rate in birds to study the evolutionary history of pied flycatchers (Ficedula hypoleuca). Using a combination of demographic inference and environmental niche modelling, we show that all major population...

Epigenetic mechanisms of partial dosage compensation in an avian, female heterogametic system

Ana Catalan, Jochen Wolf, Justin Merondun & Ulrich Knief
The evolution of genetic sex determination is often accompanied by degradation of one of the proto sex chromosomes. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid autosomes (AA) and the hemizygous sex chromosome (X). Female heterogametic systems (AAf ZWf, AAm ZZm) tend to only show partial dosage compensation (0.5 < Zf:AAf < 1) and dosage balance (0.5f:ZZm<1). The underlying mechanism remains largely elusive. Here, we quantified...

Silk-borne chemicals of spider nuptial gifts elicit female gift acceptance

Michelle Beyer, Julia Mangliers & Cristina Tuni
Chemical communication is important in a reproductive context by conveying information used for mate recognition and/or assessment during courtship and mating. Spider silk is common as vehicle for chemical communication between the sexes. However, despite being well described in females, male silk-borne chemicals remain largely unexplored. Males of the spider Pisaura mirabilis silk-wrap prey (i.e. nuptial gifts) that is offered to females during courtship and eaten by the female during copulation. Interestingly, rejected males often...

Phylogenomic analyses of the East Asian endemic Abelia (Caprifoliaceae) shed insights into the temporal and spatial diversification history with widespread hybridization

Qing-Hui Sun, Diego F. Morales-Briones, Hong-Xin Wang, Jacob Landis, Jun Wen & Hua-Feng Wang
• Background and Aims Abelia (Caprifoliaceae) is a small genus with five species, including one man-made hybrid and several natural hybrids. The genus has a discontinuous distribution in Mainland China, the Taiwan Island, and the Ryukyu Islands, providing a model system to explore mechanisms of species dispersal in the East Asian flora. However, the current phylogenetic relationships within Abelia remain uncertain. • Methods In this study, we reconstructed the phylogenetic relationships within Abelia using nuclear...

Data from: Physical and ecological isolation contribute to maintain genetic differentiation between fire salamander subspecies

Bernardo Antunes, Guillermo Velo-Antón, David Buckley, Ricardo J. Pereira & Iñigo Martínez-Solano
Landscape features shape patterns of gene flow among populations, ultimately determining where taxa lay along the continuum between panmixia to complete reproductive isolation. Gene flow can be restricted leading to population differentiation in two non-exclusive ways: “physical isolation”, in which geographic distance in combination with the landscape features restricts movement of individuals promoting genetic drift, and “ecological isolation”, in which adaptive mechanisms constrain gene flow between different environments via divergent natural selection. In central Iberia,...

Density-dependent individual variation in male attractiveness in a wild field cricket

Petri Niemelä, Stefano Tiso & Niels Dingemanse
Social environments modify a male’s ability to attract females and thus affect its fitness. Theory implies that an individual’s fitness should trade-off with its ability to cope with competition. Individuals are expected to solve this trade-off differently: some males should be more attractive at low but others instead at high density. This prediction has rarely been tested in the wild. We used an automated RFID-surveillance system to quantify for each hour of the day, over...

Phylogenomic discordance in the Eared Seals is best explained by incomplete lineage sorting following explosive radiation in the Southern Hemisphere

Fernando Lopes, Larissa Oliveira, Amanda Kessler, Yago Beux, Enrique Crespo, Susana Cárdenas-Alayza, Patricia Majluf, Maritza Sepulveda, , Valentina Franco-Trecu, Diego Paez-Rosas, Jaime Chaves, Carolina Loch, Bruce Robertson, Karina Acevedo-Whitehouse, Fernando Elorriaga-Verplancken, Stephen Kirkman, Claire Peart, Jochen Wolf & Sandro Bonatto
The phylogeny and systematics of fur seals and sea lions (Otariidae) have long been studied with diverse data types, including an increasing amount of molecular data. However, only a few phylogenetic relationships have reached acceptance pointing at strong gene-tree species tree discordance. Divergence times in the group also vary largely between studies. These uncertainties impeded the understanding of the biogeographical history of the group, such as when and how trans-equatorial dispersal and subsequent speciation events...

Life-history trade-offs, density, lay date—not personality—explain multibroodedness in great tits

Sarah Senécal, Alexia Mouchet & Niels J. Dingemanse
In various taxa, multibroodedness is a common breeding strategy. Life-history theory predicts that individuals can increase fitness by producing multiple broods within a season. Despite the apparent increase in the number of offspring parents might produce per season, not all individuals are multibrooded, suggesting a trade-off. We studied ecological and behavioral factors influencing the initiation of second clutches in great tits (Parus major), an optionally multibrooded bird species, by distinguishing two types of clutches: replacement...

History taking online: Opportunities and limitations in comparison to traditional bedside teaching

Silvan Lange
Objective Obtaining a systematic medical history (MH) from a patient is a core competency in medical education and plays a vital role in the diagnosis of diseases. At the Faculty of Medicine at LMU Munich, students have their first course in MH taking during their second year. Due to the COVID-19 pandemic, the traditional bedside MH taking course had to be transformed into an online course (OC). Our objectives were to implement an online MH...

Data from: Diabetes mellitus, glycemic traits, and cerebrovascular disease: A Mendelian randomization study

Marios Georgakis, Eric Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas Wareham, Hugh Markus & Martin Dichgans
Objective: We employed Mendelian randomization (MR) to explore the effects of genetic predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and β-cell dysfunction on risk of stroke subtypes and related cerebrovascular phenotypes. Methods: We selected instruments for genetic predisposition to T2D (74,124 cases, 824,006 controls), HbA1c levels (n=421,923), fasting glucose levels (n=133,010), insulin resistance (n=108,557), and β-cell dysfunction (n=16,378) based on published genome-wide association studies. Applying two-sample MR, we examined associations with ischemic stroke...

A quantitative genetics approach to cross-validate lab- versus field-based behavior in novel environments

Alexia Mouchet & Niels Dingemanse
Conclusions about the adaptive nature of repeatable variation in behavior (i.e., “personality”) are often based on laboratory-based behavioral assays. However, the expression of genetic variation differs between laboratory and field. Laboratory-based behavior might not predict field-based behavior thus, cross-context validation is required. We therefore estimated the correlation between an established laboratory and field assay of activity in a novel environment applied to wild great tits (Parus major), both of which have been used as proxies...

Stoichiometric mismatch causes a warming-induced regime shift in experimental plankton communities

Sebastian Diehl, Stella A. Berger, Wojciech Uszko & Herwig Stibor
Many plant and algal communities respond to warming with shifts towards more carbon-rich species and growth forms, thus diluting essential elements in their biomass and intensifying the stoichiometric mismatch with herbivore nutrient requirements. The dataset is from a 95-day mesocosm experiment on the spring succession of an assembled plankton community in which we manipulated temperature (ambient vs. +3.6°C) and presence vs. absence of two types of grazers (ciliates and Daphnia) in a 2x2x2 factorial design...

Data and code for Heterogeneous selection on exploration behavior within and among West European populations of a passerine bird

Alexia Mouchet, Ella Cole, Erik Matthysen, Marion Nicolaus, John Quinn, Allison Roth, Joost Tinbergen, Kees Van Oers, Thijs Van Overveld & Niels Dingemanse
Heterogeneous selection is often proposed as a key mechanism maintaining repeatable behavioral variation (“animal personality”) in wild populations. Previous studies largely focused on temporal variation in selection within single populations. The relative importance of spatial versus temporal variation remains unexplored, despite these processes having distinct effects on local adaptation. Using data from >3500 great tits (Parus major) and 35 nest box plots situated within five West-European populations monitored over 4-18 years, we show that selection...

Effects of biases in adult sex ratio and male body condition on the alternative reproductive tactics of a gift-giving spider

Cristina Tuni, Daniel Heimerl, Pavla Dudová, Karoline Wacker, Elisa Schenkel & Garance Despréaux
This dataset contains raw data from the manuscript entitled "Adult sex ratio and male body condition affect alternative reproductive tactics in a spider", from Daniel Heimerl, Pavla Dudová, Karoline Wacker, Elisa Schenkel, Garance Despréaux, Cristina Tuni, accepted for publication in the journal Behavioral Ecology, The study investigates how biases in adult sex ratios can affect mating tactics in a spider. Sex ratio variation can alter the intensity of sexual selection by enhancing competition for mates....

Molecular Tweezers with Varying Anions: A Comparative Study

Som Dutt, Constanze Wilch, Thomas Gersthagen, Peter Talbiersky, Kenny Bravo-Rodriguez, Matti Hanni, Elsa Sánchez-García, Christian Ochsenfeld, Frank-Gerrit Klärner & Thomas Schrader
Selective binding of the phosphate-substituted molecular tweezer 1a to protein lysine residues was suggested to explain the inhibition of certain enzymes and the aberrant aggregation of amyloid petide Aβ42 or α-synuclein, which are assumed to be responsible for Alzheimer’s and Parkinson’s disease, respectively. In this work we systematically investigated the binding of four water-soluble tweezers 1a–d (substituted by phosphate, methanephosphonate, sulfate, or O-methylenecarboxylate groups) to amino acids and peptides containing lysine or arginine residues by...

Registration Year

  • 2021

Resource Types

  • Dataset


  • Ludwig Maximilian University of Munich
  • Ludwig-Maximilians-Universität München
  • University of Cologne
  • University of Groningen
  • University of Cambridge
  • Autonomous University of Madrid
  • University of Otago
  • Smithsonian Institution
  • University of Göttingen
  • Hainan University