27 Works

Data from: Patient and disease characteristics associated with activation for self-management in patients with diabetes, chronic obstructive pulmonary disease, chronic heart failure and chronic renal disease: a cross-sectional survey study

Irene Bos-Touwen, Marieke Schuurmans, Evelyn M. Monninkhof, Yvonne Korpershoek, Lotte Spruit-Bentvelzen, Inge Ertugrul-Van Der Graaf, Niek De Wit & Jaap Trappenburg
A substantial proportion of chronic disease patients do not respond to self-management interventions, which suggests that one size interventions do not fit all, demanding more tailored interventions. To compose more individualized strategies, we aim to increase our understanding of characteristics associated with patient activation for self-management and to evaluate whether these are disease-transcending. A cross-sectional survey study was conducted in primary and secondary care in patients with type-2 Diabetes Mellitus (DM-II), Chronic Obstructive Pulmonary Disease...

Epidemiology of epilepsy in Nigeria: A community-based study from 3 sites

Musa Mamman Watila, Salisu A. Balarabe, Morenikeji A. Komolafe, Stanley C. Igwe, Michael B. Fawale, Willem M. Otte, Eric Van Diessen, Olaitan Okunoye, Anthony A. Mshelia, Ibrahim Abdullahi, Joseph Musa, Erick W. Hedima, Yakub W. Nyandaiti, Gagandeep Singh, Andrea S. Winkler & Josemir W. Sander
Background: We determined the prevalence, incidence, and risk factors for epilepsy in Nigeria. Methods: We conducted a door-to-door survey to identify cases of epilepsy in three regions. We estimated age-standardized prevalence adjusted for non-response and sensitivity and the one-year retrospective incidence for active epilepsy. To assess potential risk factors, we conducted a case-control study by collecting sociodemographic and risk factor data. We estimated odds ratios (ORs) using logistic regression analysis and corresponding population attributable fractions...

Source data for: Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections

Lisanne De Vor
Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here we show that mAbs targeting common surface components of S. aureus can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different...

Data from: Patients’ experiences with a behaviour change intervention to enhance physical activity in primary care: a mixed methods study

Heleen Westland, Jill Sluiter, Sophie Te Dorsthorst, Carin D. Schröder, Jaap C. A. Trappenburg, Sigrid C. J. M. Vervoort & Marieke J. Schuurmans
Objective: To explore the experiences of patients at risk for cardiovascular disease in primary care with the Activate intervention in relation to their success in increasing their physical activity. Methods: A convergent mixed-methods design, parallel to a cluster-randomised controlled trial in primary care, using a questionnaire and semi-structured interviews was conducted. Questionnaires from 67 patients were analysed, and semi-structured interviews of 22 patients were thematically analysed. Experiences of patients who had objectively increased their physical...

Data from: Analytical performance, agreement and user-friendliness of six point of care testing urine analysers for urinary tract infection in general practice.

Marjolein J. C. Schot, Sanne Van Delft, Antoinette M. J. Kooijman-Buiting, Niek J. De Wit & Rogier M. Hopstaken
Objective: Various point-of-care testing (POCT) urine analysers are commercially available for routine urine analysis in general practice. The present study compares analytical performance, agreement and user-friendliness of six different POCT urine analysers for diagnosing urinary tract infection in general practice. Setting: All testing procedures were performed at a diagnostic centre for primary care in the Netherlands. Urine samples were collected at four general practices. Primary and secondary outcome measures: Analytical performance and agreement of the...

Location specific risk factors for intracerebral hemorrhage: Systematic review and meta-analysis

Wilmar Jolink, Kim Wiegertjes, Gabriël Rinkel, Ale Algra, Frank-Erik De Leeuw & Karin Klijn
Objective To conduct a systematic review and meta-analysis of studies reporting on risk factors according to the location of the intracerebral hemorrhage. Methods We searched PubMed and Embase for cohort and case-control studies reporting on ≥100 patients with spontaneous intracerebral hemorrhage, that specified the location of the hematoma and reported associations with risk factors published until June 27th 2019. Two authors independently extracted data on risk factors. Estimates were pooled with the generic variance-based random...

Nerve ultrasound for diagnosing chronic inflammatory neuropathy: a multicenter validation study

Ingrid Herraets
Objective To validate the diagnostic accuracy of a previously described short sonographic protocol to identify chronic inflammatory neuropathy (CIN), including chronic inflammatory demyelinating polyneuropathy (CIDP), Lewis Sumner syndrome (LSS) and multifocal motor neuropathy (MMN) and to determine the added value of nerve ultrasound to detect treatment-responsive patients compared to nerve conduction studies (NCS) in a prospective multicenter study. Methods We included 100 consecutive patients clinically suspected of CIN in three centers. The study protocol consisted...

Data from: Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

Laurent M. A. Favié, Floris Groenendaal, Marcel P. H. Van Den Broek, Carin M. A. Rademaker, Timo R. De Haan, Henrica L. M. Van Straaten, Peter H. Dijk, Arno Van Heijst, Jeroen Dudink, Koen P. Dijkman, Monique Rijken, Inge A. Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H. Van Der Lee, Debbie H. G. M. Nuytemans, Frank Van Bel, Toine C. G. Egberts & Alwin J. R. Huitema
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Study design: Term and near-term encephalopathic neonates treated with therapeutic hypothermia and...

Data from: Sex allocation adjustment to mating group size in a simultaneous hermaphrodite

Tim Janicke, Lucas Marie-Orleach, Katrien De Mulder, Eugene Berezikov, Peter Ladurner, Dita Brigida Vizoso & Lukas Schärer
Sex allocation theory is considered as a touchstone of evolutionary biology, providing some of the best supported examples for Darwinian adaptation. In particular, Hamilton’s local mate competition theory has been shown to generate precise predictions for extraordinary sex ratios observed in many separate-sexed organisms. In analogy to local mate competition, Charnov’s mating group size model predicts how sex allocation in simultaneous hermaphrodites is affected by the mating group size (i.e., the number of mating partners...

Nerve ultrasound improves detection of treatment-responsive chronic inflammatory neuropathies

Ingrid Herraets, Stephan Goedee, Johan Telleman, Ruben Van Eijk, Thies Van Asseldonk, Leo Visser, Leonard Van Den Berg & Ludo Van Der Pol
Objective To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis Sumner syndrome and multifocal motor neuropathy, and to determine the added value in the detection of treatment-responsive patients. Methods Between February 2015 and July 2018, we included 100 consecutive incident patients with a clinical suspicion of chronic inflammatory neuropathy. All patients underwent nerve ultrasound, extensive...

Data from: Intracranial atherosclerosis on 7T MRI and cognitive functioning – the SMART-MR study

Maarten H.T. Zwartbol, Anja G. Van Der Kolk, Rashid Ghaznawi, Yolanda Van Der Graaf, Jeroen Hendrikse & Mirjam I. Geerlings
Objective: To investigate the association between intracranial atherosclerosis (ICAS) and cognitive functioning in patients with a history of vascular disease. Methods: Within the SMART-MR study cross-sectional analyses were performed in 130 patients (mean±SD age 68±9 years) with 7T vessel wall–magnetic resonance imaging data. Vessel wall lesions were rated according to established criteria and summed into a circulatory and artery-specific ICAS burden. Associations between ICAS burden and Z-scores of memory, executive functioning, working memory and processing...

Challenging the established order: innovating clinical trials for amyotrophic lateral sclerosis

Ruben Van Eijk
Development of effective treatment for amyotrophic lateral sclerosis (ALS) has been hampered by disease heterogeneity,a limited understanding of underlying pathophysiology and methodological design challenges. Here we have evaluated two major themes in the design of pivotal, phase 3 clinical trials for ALS: (1) patient selection and (2) analytical strategy, and discussed potential solutions with the European Medicines Agency (EMA). Several design considerations were assessed using data from five placebo-controlled clinical trials (N = 988), four...

Dataset associated with 'Gene expression signatures of synovial fluid multipotential stromal cells (MSCs) in advanced knee osteoarthritis and following knee joint distraction'

Clara Sanjurjo-Rodríguez, Ala Altaie, Simon Mastbergen, Thomas Baboolal, Tim Welting, Floris Lafeber, Hemant Pandit, Dennis McGonagle & Elena Jones

Data from: Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials

Ruben Paul Adriaan Van Eijk, Henk-Jan Westeneng, Stavros Nikolakopoulos, Iris E. Verhagen, Michael A. Van Es, Marinus J.C. Eijkemans & Leonard H. Van Den Berg
Objective: To assess the effect of eligibility criteria on exclusion rates, generalizability and outcome heterogeneity in ALS clinical trials, and to assess the value of a risk-based inclusion criterion. Methods: A literature search was performed to summarize eligibility criteria of clinical trials. The extracted criteria were applied to an incidence cohort of 2,904 consecutive ALS patients to quantify their effects on generalizability and outcome heterogeneity. We evaluated the effect of a risk-based selection approach on...

Data from: Genetics of plasminogen activator inhibitor-1 (PAI-1) in a Ghanaian population

Marquitta J. White, Nuri M. Kodaman, Reed H. Harder, Folkert W. Asselbergs, Douglas E. Vaughan, Nancy J. Brown, Jason H. Moore & Scott M. Williams
Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity. PAI-1 is highly heritable, but the few genes associated with it explain only a small portion of its variation. Studies of PAI-1 typically employ linear regression to estimate the effects of genetic variants on PAI-1 levels, but PAI-1 is not normally distributed, even after transformation. Therefore, alternative statistical methods may provide greater...

Data from: Development of the corticospinal and callosal tracts from extremely premature birth up to 2 years of age

Rodrigo M. Braga, Elise Roze, Gareth Ball, Nazakat Merchant, Nora Tusor, Tomoki Arichi, David Edwards, Daniel Rueckert & Serena J. Counsell
White matter tracts mature asymmetrically during development, and this development can be studied using diffusion magnetic resonance imaging. The aims of this study were i. to generate dynamic population-averaged white matter registration templates covering in detail the period from 25 weeks gestational age to term, and extending to 2 years of age based on DTI and fractional anisotropy, ii. to produce tract-specific probability maps of the corticospinal tracts, forceps major and forceps minor using probabilistic...

Data from: Nasopharyngeal microbiome profiles in rural Venezuelan children are associated with respiratory and gastrointestinal infections

Lilly M. Verhagen, Ismar A. Rivera-Olivero, Melanie Clerc, Mei Ling N. Chu, Jody Van Engelsdorp Gastelaars, Maartje I. Kristensen, Guy A. M. Berbers, Peter W. M. Hermans, Marien I. De Jonge, Jacobus H. De Waard & Debby Bogaert
Background: Recent research suggests that the microbiota affects susceptibility to both respiratory tract infections (RTIs) and gastrointestinal infections (GIIs). In order to optimize global treatment options, it is important to characterize microbiota profiles across different niches and geographic/socioeconomic areas where RTI and GII prevalences are high. Methods: We performed 16S sequencing of nasopharyngeal swabs from 209 Venezuelan Amerindian children aged 6 weeks–59 months who were participating in a 13-valent pneumococcal conjugate vaccine (PCV13) study. Using...

Difference in rupture risk between familial and sporadic intracranial aneurysms: an individual patient data meta-analysis

Charlotte Zuurbier
Objective: We combined individual patient data (IPD) from prospective cohorts of patients with unruptured intracranial aneurysms (UIA) to assess to what extent patients with familial UIA have a higher rupture risk than those with sporadic UIA. Methods: For this IPD meta-analysis we performed an Embase and Pubmed search for studies published up to December 1, 2020. We included studies that 1) had a prospective study design; 2) included 50 or more patients with UIA; 3)...

Comparing Lifeact and Phalloidin for super-resolution imaging of actin in fixed cells

Michael J. Wester, Hanieh Mazloom-Farsibaf, Farzin Farzam, Mohamadreza Fazel, Marjolein B. M. Meddens & Keith A. Lidke
Visualizing actin filaments in fixed cells is of great interest for a variety of topics in cell biology such as cell division, cell movement, and cell signaling. We investigated the possibility of replacing phalloidin, the standard reagent for super-resolution imaging of F-actin in fixed cells, with the actin binding peptide `lifeact’. We compared the labels for use in single molecule based super-resolution microscopy, where AlexaFluor 647 labeled phalloidin was used in a (d)STORM modality and...

Clinical outcomes in multifocal motor neuropathy: a combined cross-sectional and follow-up study

Ingrid Herraets
Objective To assess the clinical course of multifocal motor neuropathy (MMN) in a large cohort of patients and to identify predictive factors of a progressive disease course. Methods Between May 2015 and February 2016, we collected clinical data from 100 patients with MMN of whom 60 had participated in a nationwide cross-sectional cohort study in 2007. We documented clinical characteristics using standardized questionnaires and performed a standardized neurological examination. We used multiple linear regression analysis...

Data from: Association of white matter hyperintensity markers on MRI and long-term risk of mortality and ischemic stroke: The SMART-MR study

Rashid Ghaznawi
Objective To determine whether white matter hyperintensity (WMH) markers on MRI are associated with long-term risk of mortality and ischemic stroke. Methods We included consecutive patients with manifest arterial disease enrolled in the SMART-MR study. We obtained WMH markers (volume, type and shape) from brain MRI scans performed at baseline using an automated algorithm. During follow-up, occurrence of death and ischemic stroke was recorded. Using Cox regression, we investigated associations of WMH markers with risk...

Data from: Improving early diagnosis of pulmonary infections in patients with febrile neutropenia using low-dose chest computed tomography

Marije G. Gerritsen, M. J. Willemink, E. Pompe, T. Van Der Bruggen, A. Van Rhenen, J. W. J. Lammers, F. Wessels, R. W. Sprengers, P. A. De Jong & M. C. Minnema
We performed a prospective study in patients with chemotherapy induced febrile neutropenia to investigate the diagnostic value of low-dose computed tomography compared to standard chest radiography. The aim was to compare both modalities for detection of pulmonary infections and to explore performance of low-dose computed tomography for early detection of invasive fungal disease. The low-dose computed tomography remained blinded during the study. A consensus diagnosis of the fever episode made by an expert panel was...

Data from: Patient factors that influence decision-making in self-management support: a clinical vignette study

Irene D. Bos-Touwen, Jaap C. A. Trappenburg, Ineke Van Der Wulp, Marieke J. Schuurmans & Niek J. De Wit
Background and aim: Self-management support is an integral part of current chronic care guidelines. The success of self-management interventions varies between individual patients, suggesting a need for tailored self-management support. Understanding the role of patient factors in the current decision making of health professionals can support future tailoring of self-management interventions. The aim of this study is to identify the relative importance of patient factors in health professionals’ decision making regarding self-management support. Method: A...

A multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis

Hannelore Van Der Burgh
Objective: To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by investigating differential brain patterns of gray and white matter involvement in clinically or genetically defined subgroups of patients using cross-sectional, longitudinal and multimodal MRI. Methods: We assessed cortical thickness, subcortical volumes and white matter connectivity from T1-weighted and diffusion-weighted MRI in 292 ALS patients (follow-up: n=150) and 156 controls (follow-up: n=72). Linear mixed-effects models were used to assess changes in structural brain measurements...

Data from: Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Lina Cai, Eleanor Wheeler, Nicola D. Kerrison, Jian'an Luan, Panos Deloukas, Paul W. Franks, Pilar Amiano, Eva Ardanaz, Catalina Bonet, Guy Fagherazzi, Leif C. Groop, Rudolf Kaaks, José María Huerta, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Valeria Pala, Salvatore Panico, Miguel Rodriguez-Barranco, Olov Rolandsson, Carlotta Sacerdote, Matthias B. Schulze, Annemieke M.W. Spijkeman, Anne Tjonneland, Rosario Tumino … & Nicholas J. Wareham
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic...

Registration Year

  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2015
  • 2013

Resource Types

  • Dataset


  • University Medical Center Utrecht
  • National Institute for Public Health and the Environment
  • University College London
  • Maastricht University
  • University Medical Center Groningen
  • Imperial College London
  • Elisabeth-TweeSteden Ziekenhuis
  • Wilhelmina Children's Hospital
  • Radboud University Nijmegen Medical Centre
  • Institut d'Investigació Biomédica de Bellvitge