1,144 Works

Numerical simulation of ball bearing flow field using the moving particle semi-implicit method

Wei Wu, Chunhui Wei & Shihua Yuan
The distribution of lubricating oil in the bearing cavity is of great significance to bearing lubrication and cooling. A new idea is provided to further study the ball bearings lubrication, to achieve effective lubrication of bearings. The flow field of oil injection lubrication ball bearings is studied by the moving particle semi-implicit (MPS) method. The accuracy of the numerical calculation method is verified by experiments. The oil distribution of the bearing lubrication flow field and...

Mafic-ultramafic rocks in the Buqingshan Complex of the East Kunlun Orogen, northern Tibetan Plateau: remnants of the Paleo-Tethys Ocean

Yuangang Yue, Yunpeng Dong, Shengsi Sun, Dengfeng He, Bo Hui, Xiang Ren, Bin Zhang & Weidong He
The Buqingshan Complex, the eastern part of the Muztagh–Buqingshan–Anemaqen ophiolitic mélange zone (MBAM), contains a series of oceanic rocks that represent the remnants of the Paleo-Tethys Ocean. Field investigations reveal that the mafic-ultramafic rocks consist mainly of serpentinite, diabase, massive basalt, and pillow basalt. The serpentinites show similar geochemical characteristics to abyssal peridotites, which is probably the residual part of the depleted upper mantle after 17–20% melt extraction. The mafic rocks have geochemical affinities similar...

Mafic-ultramafic rocks in the Buqingshan Complex of the East Kunlun Orogen, northern Tibetan Plateau: remnants of the Paleo-Tethys Ocean

Yuangang Yue, Yunpeng Dong, Shengsi Sun, Dengfeng He, Bo Hui, Xiang Ren, Bin Zhang & Weidong He
The Buqingshan Complex, the eastern part of the Muztagh–Buqingshan–Anemaqen ophiolitic mélange zone (MBAM), contains a series of oceanic rocks that represent the remnants of the Paleo-Tethys Ocean. Field investigations reveal that the mafic-ultramafic rocks consist mainly of serpentinite, diabase, massive basalt, and pillow basalt. The serpentinites show similar geochemical characteristics to abyssal peridotites, which is probably the residual part of the depleted upper mantle after 17–20% melt extraction. The mafic rocks have geochemical affinities similar...

The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression

Shaolei Wang, Dehua Liu, Hong Wei, Yang Hua, Guodong Shi & Jinhan Qiao
A growing body of research has illuminated that non-coding RNAs (ncRNAs) plays an important role in the development of drug resistance in hepatocellular carcinoma (HCC) cells. The expression profiles of differential expressed genes (DEGs) and ncRNAs related to the sorafenib resistance in HCC cells were analyzed according to the Gene Expression Omnibus (GEO) dataSets and The Cancer Genome Atlas (TCGA) datasets. Bioinformatics technology was used to construct the interaction network of DEGs and ncRNAs. Cell...

Gravity induces asymmetric Ca2+ spikes in the root cap in the early stage of gravitropism

Ruoxin Zhao, Zonghao Liu, Ziwei Li, Shi Xu & Xianyong Sheng
Gravitropism is an important strategy for the adaptation of plants to the changing environment. Previous reports indicated that Ca2+ participated in plant gravity response. However, present information on the functions of Ca2+ in plant gravitropism was obtained mainly on coleoptiles, hypocotyls, and petioles, little is known about the dynamic changes of Ca2+ during root gravitropism. In the present study, the transgenic Arabidopsis thaliana R-GECO1 was placed horizontally and subsequently vertically on a refitted Leica SP8...

A Gypsy element contributes to the nuclear retention and transcriptional regulation of the resident lncRNA in locusts

Xia Zhang, Ya′Nan Zhu, Bing Chen & Le Kang
The majority of long noncoding RNAs (lncRNAs) contain transposable elements (TEs). PAHAL, a nuclear-retained lncRNA that is inserted by a Gypsy retrotransposon, has been shown to be a vital regulator of phenylalanine hydroxylase (PAH) gene expression that controls dopamine biosynthesis and behavioural aggregation in the migratory locust. However, the role of the Gypsy retrotransposon in the transcriptional regulation of PAHAL remains unknown. Here, we identified a Gypsy retrotransposon (named Gypsy element) as an inverted long...

Prostate-specific membrane antigen modulates the progression of prostate cancer by regulating the synthesis of arginine and proline and the expression of androgen receptors and Fos proto-oncogenes

Xi Hong, Liang Mao, Luwei Xu, Qiang Hu & Ruipeng Jia
The expression of prostate-specific membrane antigen (PSMA) is strikingly upregulated during oncogenesis and prostate cancer (PCa) progression, but the functions of this antigen in PCa remain unclear. Here, we constructed PSMA-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on PCa metabolism and transcription. The metabolism of arginine and proline was detected using specific kits. The mRNA and protein expression levels of the identified differentially expressed...

Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research

Zhenghai Bai, Fangshi Xu, Xiaodan Feng, Yuan Wu, Junhua Lv, Yu Shi & Honghong Pei
Pyroptosis is an inflammatory programmed cell death, showing potentials to be a novel anti-cancer approach. However, the roles of pyroptosis-related (PR) genes (PRGs) in pancreatic adenocarcinoma (PAAD) remain elusive. In the present study, we constructed a novel PR risk signature through the lasso regression analysis. The risk signature was greatly conducive to PAAD prognostic assessment. PR risk score was identified as an independent prognostic factor and could distinguish the prognostic differences of most clinical subgroups....

The role of Populus MYB94 transcription factor in seed germination requires the expression of ABA-responsive genes

Haiyang Wang, Hui Huang & Qing Fang
Plant seed germination is easily influenced by endogenous gene expression, hormones and environmental conditions. Here, we investigated a Populus R2R3-MYB transcription factor (referred to as MYB94) that plays a role in seed germination in close relation to the hormone abscisic acid (ABA). Two independent Arabidopsis transgenic lines overexpressing MYB94 (Oe-lines) and wild-type (Wt) were no clear differences in the seed germination rates under normal conditions, but the germination rates of the two Oe-lines were both...

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li & Ming-Qing Li
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence remain largely unknown. Here, we observe that dMφ display an active glycerophospholipid metabolism. The activation of ENPP2-lysophosphatidic acid (LPA) facilitates the adhesion and retention, and M2 differentiation of dMφ during normal pregnancy. Mechanistically, this process is mediated...

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li & Ming-Qing Li
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence remain largely unknown. Here, we observe that dMφ display an active glycerophospholipid metabolism. The activation of ENPP2-lysophosphatidic acid (LPA) facilitates the adhesion and retention, and M2 differentiation of dMφ during normal pregnancy. Mechanistically, this process is mediated...

Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis

Yue Zhang, Yue Yu, Xuchen Cao & Peng Chen
Long non-coding RNAs (lncRNAs) are crucial regulators of cancer pathogenesis and are potentially useful diagnostic and prognostic biomarker tools. FAM83H antisense RNA1 (FAM83H-AS1) has been reported to be a vital regulator of different cancers; however, little attention has been paid to its significance in lung cancer. Non-tumorigenic lung cell line BEAS-2B and adenocarcinoma lung cancer cell lines NCI-H1299 and HCC827 were used in the present study. In addition, RNA immunoprecipitation, Western blotting, quantitative reverse transcription-PCR...

Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis

Yue Zhang, Yue Yu, Xuchen Cao & Peng Chen
Long non-coding RNAs (lncRNAs) are crucial regulators of cancer pathogenesis and are potentially useful diagnostic and prognostic biomarker tools. FAM83H antisense RNA1 (FAM83H-AS1) has been reported to be a vital regulator of different cancers; however, little attention has been paid to its significance in lung cancer. Non-tumorigenic lung cell line BEAS-2B and adenocarcinoma lung cancer cell lines NCI-H1299 and HCC827 were used in the present study. In addition, RNA immunoprecipitation, Western blotting, quantitative reverse transcription-PCR...

Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice

Audrius Kilikevicius, Jun Wang, Xiulong Shen, Frank Rigo, Thahza P. Prakash, Marek Napierala & David R. Corey
Friedreich’s ataxia (FA) is an inherited neurodegenerative disorder caused by decreased expression of frataxin (FXN) protein. Previous studies have shown that antisense oligonucleotides (ASOs) and single-stranded silencing RNAs can be used to increase expression of frataxin in cultured patient-derived cells. In this study, we investigate the potential for oligonucleotides to increase frataxin expression in a mouse model for FA. After confirming successful in vivo delivery of oligonucleotides using a benchmark gapmer targeting the nuclear noncoding...

Integrative analyses of hub genes and their association with immune infiltration in adipose tissue, liver tissue and skeletal muscle of obese patients after bariatric surgery

Kemin Yan, Pengyuan Zhang, Jiewen Jin, Xin Chen, Hongyu Guan, Yanbing Li & Hai Li
Bariatric surgery (BS) is an effective treatment for obesity. Adipose tissue, liver tissue and skeletal muscle are important metabolic tissues. This study investigated hub genes and their association with immune infiltration in these metabolic tissues of obese patients after BS by bioinformatic analysis with Gene Expression Omnibus datasets. Differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was constructed to identify hub genes. As a result, 121 common DEGs were identified and mainly...

Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model

Xi Tao, Siyuan Wu, Wenjing Tang, Lu Li, Lijun Huang, Danheng Mo, Chujuan Liu, Tao Song, Shuling Wang, Jia Wang & Juan He
Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment. An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed...

Prevalence of major morbidities and outcome of all hospitalized neonates. A retrospective cohort study of Huai’an neonatal survivals

Yaling Xu, Xiaoqin Zhu, Hui Wang, Zhaojun Pan, Xiaoqiong Li, Xiaojing Guo, Hongni Yue & Bo Sun
Reliable data for causal implication of neonatal survival in China are lacking. We assumed that by analyzing surviving data of in-hospital neonatal care based on all livebirths in Huai’an, prevalence of neonatal morbidity, mortality and causal relations may be derived comprehensively. Data of all regionally hospitalized neonates were retrospectively linked with corresponding whole livebirths (59,056) in 2015 as a cohort. Diagnoses of diseases and causes of deaths were redefined and categorized. Disease patterns, prevalence of...

Morphology and phylogeny of two new Thalassiosiroid taxa (Bacillariophyceae), with two marginal rimoportulae

Biaobiao Niu, Yaqiong Guo, Nina Lundholm & Yang Li
Thalassiosira and related taxa i.e. the taxa within Thalassiosirales are among the most abundant and widespread diatoms. The vast majority have one marginal rimoportula, but very few always have two. The knowledge on Thalassiosiroid taxa in Chinese waters is restricted, and to explore the diversity, monoclonal strains were established from southern Chinese coastal waters. Morphological data were based on light and scanning electron microscopy. The D1‒D3 region of the ribosomal large subunit (LSU) and the...

Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling in Arabidopsis

Jie Zhang, Yuxi Li, Qixin Bao, Hongbo Wang & Shuguo Hou
Plant immunity is initiated by cell surface-localized receptors upon perception of pathogen-derived microbe or pathogen-associated molecular patterns (MAMPs/PAMPs), damage/danger-associated molecular patterns (DAMPs), and phytocytokines. Different patterns activate highly overlapping immune signaling at the early stage but divergent physiological responses at the late stage. Here, we indicate that plant elicitor peptide 1 (Pep1), a well-known DAMP, induces lignin and callose depositions, two types of late immune responses for strengthening the plant cell wall. Pep1-induced lignin and...

FROM-GLC Plus: toward near real-time and multi-resolution land cover mapping

Le Yu, Zhenrong Du, Runmin Dong, Juepeng Zheng, Ying Tu, Xin Chen, Pengyu Hao, Bo Zhong, Dailiang Peng, Jiyao Zhao, Xiyu Li, Jianyu Yang, Haohuan Fu, Guangwen Yang & Peng Gong
Global land cover has undergone extensive and rapid changes as a result of human activities and climate change. These changes have had a significant impact on biodiversity, the surface energy balance, and sustainable development. Global land cover data underpins research on the development of earth system models, resource management, and evaluation of the ecological environment. However, there are limitations in the classification detail, spatial resolution, and rapid change monitoring capability of global land cover change...

Sevoflurane reduces lipopolysaccharide-induced apoptosis and pulmonary fibrosis in the RAW264.7 cells and mice models to ameliorate acute lung injury by eliminating oxidative damages

Fushuang Zheng, Xiuying Wu, Jin Zhang, Zhiling Fu & Yan Zhang
Sevoflurane is identified as an effective candidate drug for acute lung injury (ALI) treatment, but its curing effects and detailed mechanisms have not been fully disclosed. The present study was designed to resolve this academic issue. The ALI mice models were established, and Hematoxylin-eosin staining assay was performed to examine tissue morphologies. Cell viability was determined by CCK-8 assay, and Annexin V-FITC/PI double staining assay was used to examine cell apoptosis. The expression levels of...

Self-reported effects of perceived social support on marital quality in balanced translocation patients and their spouses undergoing preimplantation genetic testing in China: actor–partner interdependence model

Fengyi Mo, Xiaorui Hu, Qing Ma, Li Zhang & Lanfeng Xing
This study aimed to analyse the relationship between perceived social support and marital quality in balanced translocation patients and their spouses undergoing a preimplantation genetic testing (PGT) treatment cycle in China. The authors assessed the actor and partner effects of perceived social support on marital quality in patient–spouse dyads using a dyadic analysis approach. In total, 59 couples were assessed using self-report questionnaires for marital quality and perceived social support. There were significant differences in...

Clinical features of the first critical case of acute encephalitis caused by the avian influenza A (H5N6) virus

Libing Zhang, Kaituo Liu, Qin Su, Xiao Chen, Xiaoquan Wang, Qingfeng Li, Wenlei Wang, Xuhua Mao, Jinmei Xu, Xin Zhou, Qin Xu, Le Zhou, Xiufan Liu & Pinghu Zhang
Highly pathogenic avian influenza viruses (HPAIV), such as H5N1, H5N6, and H7N9, have been reported to frequently infect humans, but acute encephalitis caused by HPAIV in humans has been rarely reported. We report the first critical case of acute encephalitis with mild pneumonia caused by the H5N6 virus. On January 25 of 2022, a 6-year-old girl with severe neurological symptoms was admitted to our hospital and rapidly developed into seizures and coma. Brain imaging showed...

Anatexis of late Neoarchean-Early Paleoproterozoic and late Paleoproterozoic garnet-bearing leucogranite from the Khondalite Belt in the North China Craton

Qiang Shi, Zhong-Yuan Xu, Guo-Chun Zhao, Ding Ding, Guang-Wei Liu, Zhong-Hai Zhao, Jing-Yu Yu, Chen Li, Li-Qiang Bai, Yao Wang, Bing Guo, Kai Zhang & Chun-Feng Liu
Two episodes of late Neoarchean-early Paleoproterozoic and late Paleoproterozoic garnet-bearing leucogranite, named the Baotou and Jining–Liangcheng garnet-bearing leucogranite are recognized from the Khondalite Belt in the North China Craton. Geochemical studies show that garnet-bearing leucogranite has high Al2O3 content and FeOT/MgO ratio, with a large variation in the CaO content and K2O/Na2O ratio. Additionally, the garnet-bearing leucogranite is enriched in light rare earth elements and large ion lithophile elements and depleted in Nb, Ta, P,...

UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation

Mingyu Pan, Yue Yin, Tongyu Hu, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai, Haiyang Hu & Chen Wang
STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I IFN production of innate immunity. However, excessive or prolonged activation of STING1 is associated with autoinflammatory and autoimmune diseases. Thus, preventing STING1 from over-activation is important to maintain immune homeostasis. Here, we reported that UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, was essential to prevent the excessive activation of...

Registration Year

  • 2022
    1,144

Resource Types

  • Dataset
    1,144

Affiliations

  • Nanjing Medical University
    1,144
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    762
  • Zhejiang University
    666
  • Shanghai Jiao Tong University
    664
  • Huazhong University of Science and Technology
    624
  • Capital Medical University
    605
  • Chinese Academy of Sciences
    538
  • University of Chinese Academy of Sciences
    515
  • Fudan University
    514
  • Sun Yat-sen University
    509