Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but...

We propose a nonparametric bivariate time-varying coefficient model for longitudinal measurements with the occurrence of a terminal event that is subject to right censoring. The time-varying coefficients capture the longitudinal trajectories of covariate effects along with both the followup time and the residual lifetime. The proposed model extends the parametric conditional approach given terminal event time in recent literature, and thus avoids potential model misspecification. We consider a kernel smoothing method for estimating regression coefficients...

We propose a nonparametric bivariate time-varying coefficient model for longitudinal measurements with the occurrence of a terminal event that is subject to right censoring. The time-varying coefficients capture the longitudinal trajectories of covariate effects along with both the followup time and the residual lifetime. The proposed model extends the parametric conditional approach given terminal event time in recent literature, and thus avoids potential model misspecification. We consider a kernel smoothing method for estimating regression coefficients...

Supplementary figure 1 Supplementary tables 1-6

To evaluate dry eye and anterior segment inflammation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK), and investigate their association. This prospective and observational study included 96 eyes from 48 myopic patients. The evaluation was performed at baseline, postoperative day 1, week 1, month 1 and month 3. Outcome measures included anterior chamber flare, bulbar redness (BR), limbal redness (LR), ocular surface disease index (OSDI), tear meniscus height (TMH), the...

To evaluate dry eye and anterior segment inflammation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK), and investigate their association. This prospective and observational study included 96 eyes from 48 myopic patients. The evaluation was performed at baseline, postoperative day 1, week 1, month 1 and month 3. Outcome measures included anterior chamber flare, bulbar redness (BR), limbal redness (LR), ocular surface disease index (OSDI), tear meniscus height (TMH), the...

This is the dataset for paper "Overestimated nitrogen loss from denitrification for natural terrestrial ecosystems in CMIP6 Earth System Models" authored by Feng et al.
The dataset contains six .nc files, and each file contains soil_N15, fgas, and N loss and their quantiles derived with different combinations of N weathering, N depostion and BNF.
Figure1_data.nc is the data for Figure 1 in the main.

Soil d15N and isotope benchmarking based fdenit and N loss

soil d15N and isotope benchmarking based fdenit and N loss

Really Interesting New Gene (RING) proteins are referred to as CHY zinc and ring finger protein (CHYR) members because they have the CHY domain, a type of protein that responds to abiotic stress. However, there are scant data on CHYR members in Phaseolus vulgaris (common bean). This study identified eight CHYR members (PvCHYRs) in the reference genome. A comprehensive analysis was performed to determine function, location, basic information, evolution, motifs, gene structure, cis-acting elements, collinearity,...

Really Interesting New Gene (RING) proteins are referred to as CHY zinc and ring finger protein (CHYR) members because they have the CHY domain, a type of protein that responds to abiotic stress. However, there are scant data on CHYR members in Phaseolus vulgaris (common bean). This study identified eight CHYR members (PvCHYRs) in the reference genome. A comprehensive analysis was performed to determine function, location, basic information, evolution, motifs, gene structure, cis-acting elements, collinearity,...

This paper deals with the study of the chemical composition of cow dung and the paper-making from cow dung. With the insight into such data, we considered the effect of cooking temperatures and the potassium hydroxide concentration on paper performance. The relationship between cow dung fiber, such as morphology, chemical composition, crystallization, and chemical state structure, and paper performance were studied. Meanwhile, the mechanical performance of cow dung paper and the degradation of cow dung...

This paper deals with the study of the chemical composition of cow dung and the paper-making from cow dung. With the insight into such data, we considered the effect of cooking temperatures and the potassium hydroxide concentration on paper performance. The relationship between cow dung fiber, such as morphology, chemical composition, crystallization, and chemical state structure, and paper performance were studied. Meanwhile, the mechanical performance of cow dung paper and the degradation of cow dung...

High-fat diet (HFD) can cause obesity, inducing dysregulation of the visceral adipose tissue (VAT). This study aimed to explore potential biological pathways and hub genes involved in obese VAT, and for that, bioinformatic analysis of multiple datasets was performed. The expression profiles (GSE30247, GSE167311 and GSE79434) were downloaded from Gene Expression Omnibus. Overlapping differentially expressed genes (ODEGs) between normal diet and HFD groups in GSE30247 and GSE167311 were selected to run protein–protein interaction network, GO...

Statistics of the whole-genome resequencing data.

Statistics of the skin transcriptome sequencing data generated from WT and YM snakehead.

Statistics of the skin transcriptome sequencing data generated from WT and YM snakehead.

Body color of offspring from YM and WT snakehead hybridization with indications of expected ratios and chi-square test.

Abstract Chemotherapy is the main treatment option for advanced osteosarcoma, which is the most common type of primary bone malignancy. However, patients develop resistance rapidly and many succumb to the disease. Niclosamide, an anthelmintic drug, has been recently identified to display potent and selective anti-cancer activity. In this work, we show that niclosamide at sub-micromolar concentrations inhibits proliferation and migration, and induces apoptosis in both parental and chemo-resistant osteosarcoma cells, with much less toxicity in...

Plantago asiatica L. is a representative individual species of Plantaginaceae, whose high reputation is owed to its edible and medicinal values. However, the phylogeny and genes of the P. asiatica chloroplast have not yet been well described. Here we report the findings of a comprehensive analysis of the P. asiatica chloroplast genome. The P. asiatica chloroplast genome is 164,992 bp, circular, and has a GC content of 37.98%. The circular genome contains 141 genes, including...

Full paper, supplementary files, spreadsheets, and videos are available.

Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins in GC. Results: A total of 2774 differentially expressed membrane proteins were identified between GC and normal cell lines. Conjoint analysis of transcriptomes and proteomes provided 11 potential biomarkers (GPRC5A, PSAT1, NUDCD1, RCC2, IPO4, FAM91A1, KANK2, PRADC1, NME4, METTL7A and...

Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins in GC. Results: A total of 2774 differentially expressed membrane proteins were identified between GC and normal cell lines. Conjoint analysis of transcriptomes and proteomes provided 11 potential biomarkers (GPRC5A, PSAT1, NUDCD1, RCC2, IPO4, FAM91A1, KANK2, PRADC1, NME4, METTL7A and...

Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins in GC. Results: A total of 2774 differentially expressed membrane proteins were identified between GC and normal cell lines. Conjoint analysis of transcriptomes and proteomes provided 11 potential biomarkers (GPRC5A, PSAT1, NUDCD1, RCC2, IPO4, FAM91A1, KANK2, PRADC1, NME4, METTL7A and...

Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins in GC. Results: A total of 2774 differentially expressed membrane proteins were identified between GC and normal cell lines. Conjoint analysis of transcriptomes and proteomes provided 11 potential biomarkers (GPRC5A, PSAT1, NUDCD1, RCC2, IPO4, FAM91A1, KANK2, PRADC1, NME4, METTL7A and...