Objective: To characterize peri-ictal apnea and post-ictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy. Methods: Prospective, multi-center epilepsy monitoring study of autonomic and breathing biomarkers of SUDEP in patient’s ≥18 years old with intractable epilepsy and monitored GCS. Video EEG, thoraco-abdominal excursions, nasal airflow, capillary oxygen saturation and electrocardiography were analyzed. Results: We studied 148 GCS in 87 patients. Nineteen patients had generalized epilepsy, 65 had focal, one had both and in two,...

Objective: To investigate staff attitudes toward assisted suicide in the hospital and factors influencing its practices in Switzerland. Design: Cross-sectional study Setting: Two University Hospitals in French speaking regions of Switzerland. Participants: 13’834 health care professionals including all personal caring for patients were invited to participate. Main outcome measures and other variables: Attitudes towards the participation of hospital health care professionals in assisted suicide were investigated with an online questionnaire. Results: Among all invited professionals,...

Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3-Aminobenzamide (3-AB), an inhibitor of poly (ADP-ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm ischemia (WI). Here we determined the effects of 3-AB reconditioning on graft outcome after LTx. Three groups of donor lungs were studied: Control (Ctrl): 1 hour WI + 3 hours cold ischemia (CI) + LTx; EVLP: 1 hour WI...

Candida species are the most commonly isolated opportunistic fungal pathogens in humans. These species exhibit very different infection strategies, since they acquired pathogenesis independently throughout evolution. Candida albicans causes most of the diagnosed infections, closely followed by Candida glabrata. C. albicans is well studied, and many genes have been shown to be important for infection and colonization of the host. It is, however, less clear how C. glabrata infects the host. With the help of...

Additional file 1. Individual radiomics features for the free-breathing and data-driven gating PET/CT data sets. Individual radiomics features values for the free-breathing (flow) and data-driven gating (DDG) PET/CT reconstruction of each pulmonary lesion. The radiomics features table is the output from the QuantImage platform (see Cid et al. (2017)).

Abstract This paper presents a synchronic analysis of the diseases during the emergence of COVID-19, the management and impact of the lockdown, and how the media narrated these events in working-class neighborhoods of the metropolitan areas of Buenos Aires and Gran Resistencia from March to November 2020. We resorted to quantitative methods on secondary sources to describe poverty and syndemics and conducted week-by-week ethnographic and media research on 38 neighborhoods with water shortages and critical...

The intrinsic connectivity of the salience network (SN) plays an important role in social behavior, however the directional influence that individual nodes have on each other has not yet been fully determined. In this study, we used spectral Dynamic Causal Modeling to characterize the effective connectivity patterns in the SN for 44 healthy older adults and for 44 patients with behavioral variant frontotemporal dementia (bvFTD) who have focal SN dysfunction. We examined the relationship of...

Background: Little is known about publication agreements between industry and academic investigators in trial protocols and the consistency of these agreements with corresponding statements in publications. We aimed to investigate (i) the existence and types of publication agreements in trial protocols, (ii) the completeness and consistency of the reporting of these agreements in subsequent publications, and (iii) the frequency of co-authorship by industry employees. Methods and Findings: We used a retrospective cohort of randomized clinical...

Additional file 1. Individual radiomics features for the free-breathing and data-driven gating PET/CT data sets. Individual radiomics features values for the free-breathing (flow) and data-driven gating (DDG) PET/CT reconstruction of each pulmonary lesion. The radiomics features table is the output from the QuantImage platform (see Cid et al. (2017)).

Additional file 2. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features as derived from the QuantImage Excel output (see Cid et al. (2017)).

The aim of the present study was to investigate the genetic structure of the Valais shrew (Sorex antinorii) by a combined phylogeographical and landscape genetic approach, and thereby to infer the locations of glacial refugia and establish the influence of geographical barriers. We sequenced part of the mitochondrial cytochrome b (cyt b) gene of 179 individuals of S. antinorii sampled across the entire species' range. Six specimens attributed to S. arunchi were included in the...

Many studies indicate a crucial role for the vitamin B12 and folate-dependent enzyme methionine synthase (MS) in brain development and function, but vitamin B12 status in the brain across the lifespan has not been previously investigated. Vitamin B12 (cobalamin, Cbl) exists in multiple forms, including methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), serving as cofactors for MS and methylmalonylCoA mutase, respectively. We measured levels of five Cbl species in postmortem human frontal cortex of 43 control subjects,...

Lung transplantation (LTx) is associated with sterile inflammation, possibly related to the release of damage associated molecular patterns (DAMPs) by injured allograft cells. We have measured cellular damage and the release of DAMPs and cytokines in an experimental model of LTx after cold or warm ischemia and examined the effect of pretreatment with ex-vivo lung perfusion (EVLP).

Abstract This paper presents a synchronic analysis of the diseases during the emergence of COVID-19, the management and impact of the lockdown, and how the media narrated these events in working-class neighborhoods of the metropolitan areas of Buenos Aires and Gran Resistencia from March to November 2020. We resorted to quantitative methods on secondary sources to describe poverty and syndemics and conducted week-by-week ethnographic and media research on 38 neighborhoods with water shortages and critical...

Candida species are the most commonly isolated opportunistic fungal pathogens in humans. Candida albicans causes most of the diagnosed infections, closely followed by Candida glabrata. C. albicans is well studied, and many genes have been shown to be important for infection and colonization of the host. It is however less clear how C. glabrata infects the host. With the help of fungal RNA enrichment, we here investigated for the first time the transcriptomic profile of...

Additional file 2. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features as derived from the QuantImage Excel output (see Cid et al. (2017)).

Additional file 3. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions localisation. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on each group “superior” and “inferior” depending on their anatomical localisation: lesions in the superior lobes versus the inferior regions. Non-reproducible features are marked with a star.

Additional file 4. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions size. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on two lesions groups “big” and “small” depending on their long-axis length < or > median. Non-reproducible features are marked with a star.

Additional file 4. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions size. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on two lesions groups “big” and “small” depending on their long-axis length < or > median. Non-reproducible features are marked with a star.

Additional file 3. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions localisation. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on each group “superior” and “inferior” depending on their anatomical localisation: lesions in the superior lobes versus the inferior regions. Non-reproducible features are marked with a star.

Candida species are the most commonly isolated opportunistic fungal pathogens in humans. Candida albicans causes most of the diagnosed infections, closely followed by Candida glabrata. C. albicans is well studied, and many genes have been shown to be important for infection and colonization of the host. It is however less clear how C. glabrata infects the host. With the help of fungal RNA enrichment, we here investigated for the first time the transcriptomic profile of...