2 Works

Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association with Insulin Clearance

Mark Goodarzi, Nicholette D Palmer, Jinrui Cui, Xiuqing Guo, Yii-Der I Chen, Kent D Taylor, Leslie J Raffel, Lynne E Wagenknecht, Thomas A Buchanan, Willa A Hsueh & Jerome I Rotter
Abstract Context Genome-wide association studies have identified >450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). Objective To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed to classify the SNPs based on physiology. We also sought to validate GRS associations with insulin-related traits in deeply-phenotyped Mexican Americans. Design, Setting, and Participants 457 T2D SNPs from the literature were assigned physiologic function based on association studies and cluster analyses....

Data from: Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertility

Jonathan Stieglitz, Benjamin C. Trumble, Study Team HORUS, Caleb Finch, Dong Li, Matthew J. Budoff, Hillard Kaplan & Michael Gurven
Modern humans have more fragile skeletons than other hominins, which may result from physical inactivity. Here we test whether reproductive effort also compromises bone strength, by measuring using computed tomography thoracic vertebral bone mineral density (BMD) and fracture prevalence among physically active Tsimane forager-horticulturalists. Earlier onset of reproduction and shorter interbirth intervals are associated with reduced BMD for women. Tsimane BMD is lower versus Americans, but only for women, contrary to simple predictions relying on...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • University of Southern California
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  • Harbor–UCLA Medical Center
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  • Emory University School of Medicine
    1
  • The Ohio State University Wexner Medical Center
    1
  • Wake Forest University
    1
  • MemorialCare Health System
    1
  • Cedars-Sinai Medical Center
    1
  • University of California, Santa Barbara
    1
  • Arizona State University
    1
  • Toulouse 1 Capitole University
    1