69 Works

Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions

Yong Song, RenWei Su, Niraj R. Joshi, Tae Hoon Kim, Bruce A Lessey, Jae-Wook Jeong & Asgerally T Fazleabas
Context: NOTCH signaling is activated in endometriotic lesions but the exact mechanisms remains unclear. Interleukin-6 (IL-6), which is increased in the peritoneal fluid of women with endometriosis, induces NOTCH1 through E-proteins including E2A and HEB in cancer development. Objective: To study the role of E-proteins in inducing NOTCH1 expression under the regulation of IL-6 in endometriosis. Setting and Design: The expression of E2A, HEB and NOTCH1 was first investigated in endometrium of women with endometriosis...

Citizen science improves our understanding of the impact of soil management on wild pollinator abundance in agroecosystems

Logan Appenfeller, Sarah Lloyd & Zsofia Szendrei
Native bees provide essential pollination services in both natural and managed ecosystems. However, declines in native bee species highlight the need for increased understanding of land management methods that can promote healthy, persistent populations and diverse communities. This can be challenging and costly using traditional scientific methods, but citizen science can overcome many limitations. In this study, we examined the distribution and abundance of an agriculturally important wild bee species, the squash bee (Eucera (Peponapis)...

Age predicts risky investment better than residual reproductive value

David Delaney, Luke Hoekstra & Fredric Janzen
Life-history theory predicts that investment into reproduction should increase as future reproductive opportunities (i.e., residual reproductive value, RRV) decrease. Researchers have thus intuitively used age as a proxy for RRV and assume RRV decreases with age when interpreting age-specific investment. Yet, age is an imperfect proxy for RRV and may even be a poor correlate in some systems. We used a 30-year study of the nesting ecology of painted turtles ( Chrysemys picta ) to...

Local diversity, beta diversity and climate influence the regional stability of bird biomass across North America

Christopher Catano, Trevor Fristoe, Joseph LaManna & Jonathan Myers
Biodiversity often stabilizes aggregate ecosystem properties (e.g., biomass) at small spatial scales. However, the importance of species diversity within communities and variation in species composition among communities (β-diversity) for stability at larger scales remains unclear. Using a continental-scale analysis of 1,657 North American breeding-bird communities spanning 20-years and 35 ecoregions, we show local species diversity and β-diversity influence two components of regional stability: local stability (stability of bird biomass within sites) and spatial asynchrony (asynchronous...

Afrobarometer Survey 2008, Merged 20 Country

Juvenile rank acquisition is associated with fitness independent of adult rank

Eli Strauss, Shizuka Daizaburo & Holekamp Kay
Social rank has been identified as a significant determinant of fitness in a variety of species. The importance of social rank suggests that the process by which juveniles come to establish their position in the social hierarchy is a critical component of development. Here, we use the highly predictable process of rank acquisition in spotted hyenas to study the consequences of variation in rank acquisition in early life. In spotted hyenas, rank is ‘inherited’ through...

Least-cost habitat linkages for American black bear, Rafinesque's big-eared bat, and timber rattlesnake.

Jennifer Costanza, James Watling, Ron Sutherland, Curtis Belyea, Bistra Dilkina, Heather Cayton, David Bucklin, Stephanie Romañach & Nicholas Haddad
This data set contains 3 shapefiles and associated files that map linkages, which are least-cost paths between adjacent habitat cores for three wildlife species in the Southeastern U.S. The species are: the American black bear (Ursus americanus), Rafinesque's big-eared bat (Corynorhinus rafinesquii), and Timber rattlesnake (Crotalus horridus). We mapped habitat cores based on c. 2006 land cover, then used LinkageMapper software to identify least-cost paths between them, and buffered the least-cost paths by 2.5 km...

Identification and characterization of QTLs for fruit quality traits in peach through a multi-family approach

Zena Rawandoozi, Timothy P. Hartmann, Silvia Carpenedo, Ksenija Gasic, Cassia Da Silva Linge, Lichun Cai, Eric Van De Weg & David H. Byrne
Background Fruit quality traits have a significant effect on consumer acceptance and subsequently on peach (Prunus persica (L.) Batsch) consumption. Determining the genetic bases of key fruit quality traits is essential for the industry to improve fruit quality and increase consumption. Pedigree-based analysis across multiple peach pedigrees can identify the genomic basis of complex traits for direct implementation in marker-assisted selection. This strategy provides breeders with better-informed decisions and improves selection efficiency and, subsequently, saves...

Stepping into the past to conserve the future: archived skin swabs from extant and extirpated populations inform genetic management of an endangered amphibian

Andrew P. Rothstein, Roland A. Knapp, Gideon Bradburd, Daniel M. Boiano, Cheryl J. Briggs & Erica Bree Rosenblum
Moving animals on a landscape through translocations and reintroductions is an important management tool used in the recovery of endangered species, particularly for the maintenance of population genetic diversity and structure. Management of imperiled amphibian species rely heavily on translocations and reintroductions, especially for species that have been brought to the brink of extinction by the fungal pathogen, Batrachochytrium dendrobatidis. One striking example of disease-related declines and associated management efforts is in California’s Sequoia and...

Rapid adaptation (or not) in restored plant populations

Susan Magnoli
Mismatches between the traits of a colonizing population and a novel habitat can generate strong selection, potentially resulting in rapid adaptation. However, for most colonization events, it can be difficult to detect rapid adaptation or distinguish it from non-adaptive evolutionary changes. Here I take advantage of a replicated prairie restoration experiment to compare recently established plant populations in two closely-located restored prairies to each other and to their shared source population to test for rapid...

Data from: Genome assembly of Chiococca alba uncovers key enzymes involved in the biosynthesis of unusual terpenoids

Kin Lau, Wajid Waheed Bhat, John P. Hamilton, Joshua C. Wood, Brieanne Vaillancourt, Krystle Wiegert-Rininger, Linsey Newton, Britta Hamberger, Daniel Holmes, Bjoern Hamberger & C. Robin Buell
Chiococca alba (L.) Hitchc. (snowberry), a member of the Rubiaceae, has been used as a folk remedy for a range of health issues including inflammation and rheumatism and produces a wealth of specialized metabolites including terpenes, alkaloids, and flavonoids. We generated a 558 Mb draft genome assembly for snowberry which encodes 28,707 high confidence genes. Comparative analyses with other angiosperm genomes revealed enrichment in snowberry of lineage-specific genes involved in specialized metabolism. Synteny between snowberry...

Lasting signature of planting year weather on restored grasslands

Anna Groves, Jonathan Bauer & Lars Brudvig
Ecological restoration — the rebuilding of damaged or destroyed ecosystems — is a critical component of conservation efforts, but is hindered by inconsistent, unpredictable outcomes. We investigated a source of this variation that is anecdotally suggested by practitioners, but for which empirical evidence is rare: the weather conditions during the first growing season after planting. The idea of whether natural communities face long-term consequences from conditions even many years in the past, called historical contingency,...

Shifts in plant composition mediate grazing effects on carbon cycling in grasslands

Maowei Liang, Nicholas Smith, Jiquan Chen, Yantao Wu, Zhiwei Guo, Elise Gornish & Cunzhu Liang
Carbon cycling in grasslands can be impacted by livestock grazing, partially as an indirect result of herbivory-induced compositional shifts in the plant community. However, the underlying mechanisms of how these shifts impact carbon cycling are not well documented. We conducted a long-term grazing experiment with four sheep stocking rates in the semi-arid grasslands of Inner Mongolia, China, to examine grazing effects on the ratio of C3 to C4 species (C3:C4), shoot biomass, root biomass, root:shoot,...

Preference, performance, and chemical defense in an endangered butterfly using novel and ancestral host plants

Nathan Haan
Adoption of novel host plants by herbivorous insects can require new adaptations and may entail loss of adaptation to ancestral hosts. We examined relationships between an endangered subspecies of the butterfly Euphydryas editha (Taylor’s checkerspot) and three host plant species. Two of the hosts (Castilleja hispida, Castilleja levisecta) were used ancestrally while the other, Plantago lanceolata, is exotic and was adopted more recently. We measured oviposition preference, neonate preference, larval growth, and secondary chemical uptake...

Shape matters: The relationship between cell geometry and diversity in phytoplankton

Alexey Ryabov, Onur Kerimoglu, Irina Olenina, Leonilde Roselli, Alberto Basset, Elena Stanca, Elena Litchman & Bernd Blasius
We compiled the most comprehensive data set of phytoplankton and other marine protists in terms of sizes, shapes, genus, and species names. Samples were obtained from seven globally distributed marine areas: Baltic Sea, North Atlantic (Scotland), Mediterranean Sea (Greece and Turkey), Indo-Pacific (the Maldives), South-western Pacific (Australia), Southern Atlantic (Brazil). See details in Ryabov et al Ecology Letters 'Shape matters: the relationship between cell geometry and diversity in phytoplankton', https://doi.org/10.1111/ele.13680

Genomic evidence for correlated trait combinations and antagonistic selection contributing to counterintuitive genetic patterns of adaptive diapause divergence in Rhagoletis flies

McCall Calvert, Meredith Doellman, Jeffrey Feder, Glenn Hood, Peter Meyers, Scott Egan, Thomas Powell, Mary Glover, Cheyenne Tait, Hannes Schuler, Stewart Berlocher, James Smith, Patrik Nosil, Dan Hahn & Gregory Ragland
Adaptation to novel environments often results in unanticipated genomic responses to selection. Here, we illustrate how multifarious, correlational selection helps explain a counterintuitive pattern of genetic divergence between the recently derived apple- and ancestral hawthorn-infesting host races of Rhagoletis pomonella (Diptera: Tephritidae). The Apple host race terminate diapause and emerge as adults earlier in the season than the hawthorn host race to coincide with the earlier fruiting phenology of their apple hosts. However, alleles at...

Genome sequencing of four culinary herbs reveals terpenoid genes underlying chemodiversity in the Nepetoideae

Nolan Bornowski, John P. Hamilton, Joshua Wood, Pan Liao, Natalia Dudareva & C. Robin Buell
Species within the mint family, Lamiaceae, are widely used for their culinary, cultural, and medicinal properties due to production of a wide variety of specialized metabolites, especially terpenoids. To further our understanding of genome diversity in the Lamiaceae and to provide a resource for mining biochemical pathways, we generated high-quality genome assemblies of four economically important culinary herbs, namely, sweet basil (Ocimum basilicum L.), sweet marjoram (Origanum majorana L.), oregano (Origanum vulgare L.), and rosemary...

Data on long-term demographic information for Alliaria petiolata in eastern North America

Bernd Blossey, Victoria Nuzzo, Andrea Dávalos, Mark Mayer, Richard Dunbar, Douglas Landis, Jeffrey Evans & Bill Minter
While biological invasions have the potential for large negative impacts on local communities and ecological interactions, increasing evidence suggests that species once considered major problems can decline over time. Declines often appear driven by natural enemies, diseases, or evolutionary adaptations that selectively reduce populations of naturalized species and their impacts. Using permanent long-term monitoring locations, we document declines of Alliaria petiolata (garlic mustard) in eastern North America with distinct local and regional dynamics as a...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Michigan State University
  • Ghana Center for Democratic Development
  • University of Florida
  • Binghamton University
  • Wayne State University
  • University of California, Davis
  • University of California, Berkeley
  • United States Department of Agriculture
  • Agricultural Research Service
  • Cornell University