The bacterial symbiont Wolbachia can protect insects against viral pathogens, and the varying levels of antiviral protection are correlated with the endosymbiont load within the insects. To understand why Wolbachia strains differ in their antiviral effects, we investigated the factors controlling Wolbachia density in five closely related strains in their natural Drosophila hosts. We found that Wolbachia density varied greatly across different tissues and between flies of different ages, and these effects depended on the...
Supplement to: Hippocampal neurochemical profile and glucose transport kinetics in patients with type 1 diabetesPetr Bednařík, Pierre Gilles Henry, Ameer Khowaja, Nathan Rubin, Anjali Kumar, Dinesh Deelchand, Lynn Eberly, Elizabeth Seaquist, Gülin Öz & Moheet Amir
Context Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical profile and glucose transport is unknown. Objective To test the hypothesis that hippocampal neurochemical composition is altered in T1D and glucose transport is upregulated...
Data from: The genetic landscape of axonal neuropathies in the middle aged and elderly: focus on MME (supplementary information)Michaela Auer-Grumbach
OBJECTIVE: To test the hypothesis that monogenic neuropathies such as Charcot-Marie-Tooth disease (CMT) contribute to frequent but often unexplained neuropathies in the elderly, we performed genetic analysis of 230 patients with unexplained axonal neuropathies and disease onset >35 years. METHODS: We recruited patients, collected clinical data and conducted whole-exome sequencing (WES, n=126) and MME single-gene sequencing (n=104). We further queried WES repositories for MME variants and measured blood levels of the MME-encoded protein neprilysin. RESULTS:...
Data from: An integrative phylogenomic approach to elucidate the evolutionary history and divergence times of Neuropterida (Insecta: Holometabola)Alexandros Vasilikopoulos, Bernhard Misof, Karen Meusemann, Doria Lieberz, Tomáš Flouri, Rolf G. Beutel, Oliver Niehuis, Torsten Wappler, Jes Rust, Ralph S. Peters, Alexander Donath, Lars Podsiadlowski, Christoph Mayer, Daniela Bartel, Alexander Böhm, Shanlin Liu, Paschalia Kapli, Carola Greve, James E. Jepson, Xingyue Liu, Xin Zhou, Horst Aspöck & Ulrike Aspöck
Background The latest advancements in DNA sequencing technologies have facilitated the resolution of the phylogeny of insects, yet parts of the tree of Holometabola remain unresolved. The phylogeny of Neuropterida has been extensively studied, but no strong consensus exists concerning the phylogenetic relationships within the order Neuroptera, and the timeline of diversification of thelineages of Neuropterida. Here, we assembled a novel transcriptomic dataset to address previously unresolved issues in the phylogeny of Neuropterida and to...
Data from: Reconfiguration of functional brain networks and metabolic cost converge during task performanceAndreas Hahn, Michael Breakspear, Lucas Rischka, Wolfgang Wadsak, Godber Godbersen, Verena Pichler, Paul Michenthaler, Thomas Vanicek, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger & Luca Cocchi
The ability to solve cognitive tasks depends upon adaptive changes in the organization of whole-brain functional networks. However, the link between task-induced network reconfigurations and their underlying energy demands is poorly understood. We address this by multimodal network analyses integrating functional and molecular neuroimaging acquired concurrently during a complex cognitive task. Task engagement elicited a marked increase in the association between glucose consumption and functional brain network reorganization. This convergence between metabolic and neural processes...
Medical University of Vienna5
QIMR Berghofer Medical Research Institute1
University of Newcastle Australia1
University of Glasgow1
Zoological Research Museum Alexander Koenig1
University of Cambridge1
University of Minnesota1
University of Freiburg1
University College London1