Data from: Systems biology of tissue-specific response to Anaplasma phagocytophilum reveals differentiated apoptosis in the tick vector Ixodes scapularisNieves Ayllón, Margarita Villar, Ruth C. Galindo, Katherine M. Kocan, Radek Sima, Juan A. López, Jesús Vázquez, Pilar Alberdi, Alejandro Cabezas-Cruz, Petr Kopáček & José De La Fuente
Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection...
Data from: \"Transcriptome sequence identity between Lyme disease tick vectors, Ixodes scapularis and Ixodes ricinus\" in Genomic Resources Notes accepted 1 April 2014 to 31 May 2014Marinela Contreras, Raquel Tobes, Libor Grubhoffer, Agustin Estrada-Peña & Jose De La Fuente
Ixodes scapularis and I. ricinus transmit the Lyme disease agent Borrelia burgdorferi in the U.S. and Europe, respectively. The only tick genome sequence available is that of I. scapularis, which constitutes a limitation for tick research. Recent evidences suggest that I. ricinus and I. scapularis transcriptomes share some degree of sequence identity. However, only the global transcriptome comparison reported here demonstrated that I. ricinus and I. scapularis share a 99.232±0.005 percent sequence identity with a...
Data from: Colonization of the Mediterranean Basin by the vector biting midge species Culicoides imicola: an old storyStephanie Jacquet, Claire Garros, Eric Lombaert, Catherine Walton, Johana Restrepo, Xavier Allene, Thierry Baldet, Catherine Cetre-Sossah, Alexandra Chaskopoulou, Jean-Claude Delecolle, Amelie Desvars, Mouloud Djerbal, Moussa Fall, Laetitia Gardes, Michel De Garine-Wichatitsky, Maria Goffredo, Yuval Gottlieb, Assane Gueye Fall, Muo Kasina, Karien Labuschagne, Youssef Lhor, Javier Lucientes, Thibaud Martin, Bruno Mathieu, Miguel Miranda … & J.-C. Delecolle
Understanding the demographic history and genetic make-up of colonizing species is critical for inferring population sources and colonization routes. This is of main interest for designing accurate control measures in areas newly colonized by vector species of economically important pathogens. The biting midge Culicoides imicola is a major vector of orbiviruses to livestock. Historically, the distribution of this species was limited to the Afrotropical region. Entomological surveys first revealed the presence of C. imicola in...
Data from: Gut microbiome composition and metabolomic profiles of wild western lowland gorillas (Gorilla gorilla gorilla) reflect host ecologyAndres Gomez, Klara Petrzelkova, Carl J. Yeoman, Klara Vlckova, Jakub Mrázek, Ingrid Koppova, Franck Carbonero, Alexander Ulanov, David Modry, Angelique Todd, Manolito Torralba, Karen Nelson, H. Rex Gaskins, Brenda Wilson, Rebecca M. Stumpf, Bryan A. White, Steven R. Leigh & Karen E. Nelson
The metabolic activities of gut microbes significantly influence host physiology; thus, characterizing the forces that modulate this micro-ecosystem is key to understanding mammalian biology and fitness. To investigate the gut microbiome of wild primates and determine how these microbial communities respond to the host's external environment, we characterized faecal bacterial communities and, for the first time, gut metabolomes of four wild lowland gorilla groups in the Dzanga-Sangha Protected Areas, Central African Republic. Results show that...
Parasites employ proteases to evade host immune systems, feed and replicate and are often the target of anti-parasite strategies to disrupt these interactions. Myxozoans are obligate cnidarian parasites, alternating between invertebrate and fish hosts. They are highly divergent from other metazoans with regard to their gene sequences, and available genomic and transcriptomic datasets are limited. Some myxozoans are important aquaculture pathogens such as Sphaerospora molnari replicating in the blood of farmed carp before reaching the...
Data from: The joint evolution of the Myxozoa and their alternate hosts: a cnidarian recipe for success and vast biodiversityAstrid S. Holzer, Pavla Bartosova-Sojkova, Ana Born-Torrijos, Alena Lövy, Ashlie Hartigan & Ivan Fiala
The relationships between parasites and their hosts are intimate, dynamic and complex; the evolution of one is inevitably linked to the other. Despite multiple origins of parasitism in the Cnidaria, only parasites belonging to the Myxozoa are characterized by a complex life cycle, alternating between fish and invertebrate hosts, as well as by exceptionally high species diversity. This inspired us to examine the history of reciprocal interactions and adaptive radiations in myxozoans and their hosts...
Data from: MHC, parasites and antler development in red deer: no support for the Hamilton & Zuk hypothesisMateusz Buczek, Henryk Okarma, Aleksander W. Demiaszkiewicz & Jacek Radwan
The Hamilton-Zuk hypothesis proposes that the genetic benefits of preferences for elaborated secondary sexual traits have their origins in the arms race between hosts and parasites, which maintains genetic variance in parasite resistance. Infection, in turn, can be reflected in the expression of costly sexual ornaments. However, the link between immune genes, infection, and the expression of secondary sexual traits has rarely been investigated. Here, we explored whether the presence and identity of functional variants...
Institute of Parasitology7
University of Zaragoza2
Oklahoma State University2
Kenya Agricultural and Livestock Research Organization1
Institute of Animal Physiology and Genetics1
Institute of Parasitology1
Polish Academy of Sciences1
United States Department of Agriculture1
French National Institute for Agricultural Research1
University of Manchester1