47 Works

Location specific risk factors for intracerebral hemorrhage: Systematic review and meta-analysis

Wilmar Jolink, Kim Wiegertjes, Gabriël Rinkel, Ale Algra, Frank-Erik De Leeuw & Karin Klijn
Objective To conduct a systematic review and meta-analysis of studies reporting on risk factors according to the location of the intracerebral hemorrhage. Methods We searched PubMed and Embase for cohort and case-control studies reporting on ≥100 patients with spontaneous intracerebral hemorrhage, that specified the location of the hematoma and reported associations with risk factors published until June 27th 2019. Two authors independently extracted data on risk factors. Estimates were pooled with the generic variance-based random...

A randomized clinical trial to compare P. falciparum gametocytaemia and infectivity following blood-stage or mosquito bite induced controlled malaria infection

Teun Bousema, Manon Alkema, Isaie Reuling, Gerdie De Jong, Kjerstin Lanke, Luc Coffeng, Geert-Jan Van Gemert, Marga Van De Vegte-Bolmer, Quirijn De Mast, Reinout Van Crevel, Christian Ockenhouse, Karen Ivinson, James McCarthy, Robert Sauerwein & Katharine Collins
For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and to develop models to allow early clinical evaluation of transmission-blocking interventions. We previously described a Controlled Human Malaria Infection protocol for induction of gametocytemia in malaria naïve volunteers by mosquito bite (CHMI-trans) (Reuling et al., 2018). Here, we compared gametocyte production and infectivity in the CHMI-trans model after bites of Plasmodium falciparum (Pf)- infected mosquitoes to that after intravenous administration...

Data from: A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Xiaojing Chu, Yang Li, Cees Tack, Anna Janssen & Hans Koenen
Background: The large inter-individual variability in immune-cell cell composition and function determines immune responses in general and susceptibility to immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown. Methods: Blood samples were collected from 243 patients with T1D of Dutch descent. We applied genetic association analysis on > 200 immune cell traits and...

Additional file 1 of Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Jin Wang, Jun Ye, Liqi Yang, Xiangfeng Chen, Haoshu Fang, Zhou Liu, Guomei Xia, Yafei Zhang & Zhenhua Zhang
Additional file 1: The results of next generation sequencing of cerebrospinal fluid.

Additional file 2 of Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Jin Wang, Jun Ye, Liqi Yang, Xiangfeng Chen, Haoshu Fang, Zhou Liu, Guomei Xia, Yafei Zhang & Zhenhua Zhang
Additional file 2: Comparison of the etiological results between conventional detection methods and next-generation sequencing technology.

Confirmation of fifth Candida auris clade by whole genome sequencing

Bram Spruijtenburg, Hamid Badali, Mahdi Abastabar, Hossein Mirhendi, Sadegh Khodavaisy, Joobin Sharifisooraki, Mojtaba Taghizadeh Armaki, Theun de Groot & Jacques F. Meis
Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while...

Data from: Identification of novel variants in LTBP2 and PXDN using whole-exome sequencing in developmental and congenital glaucoma

Shazia Micheal, Sorath Noorani Siddiqui, Saemah Nuzhat Zafar, Aftab Iqbal, Muhammad Imran Khan & Anneke I. Den Hollander
Background Primary congenital glaucoma (PCG) is the most common form of glaucoma in children. PCG occurs due to the developmental defects in the trabecular meshwork and anterior chamber of the eye. The purpose of this study is to identify the causative genetic variants in three families with developmental and primary congenital glaucoma (PCG) with a recessive inheritance pattern. Methods DNA samples were obtained from consanguineous families of Pakistani ancestry. The CYP1B1 gene was sequenced in...

Natural history, phenotypic spectrum, and discriminative features of multisystemic RFC1-disease

Andreas Traschütz, Andrea Cortese, Selina Reich, Natalia Dominik, Jennifer Faber, Heike Jacobi, Annette Hartmann, Dan Rujescu, Solveig Montaut, Andoni Echaniz-Laguna, Sevda Erer, Valerie Cornelia Schütz, Alexander Tarnutzer, Marc Sturm, Tobias Haack, Nadège Vaucamps-Diedhiou, Helene Puccio, Ludger Schöls, Thomas Klockgether, Bart P. Van De Warrenburg, Martin Paucar, Dagmar Timmann, Ralf-Dieter Hilgers, Jose Gazulla, Michael Strupp … & Matthis Synofzik
Objective: To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of RFC1-repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). Methods: Multimodal RFC1 repeat screening (PCR, southern blot, whole-exome/genome (WES/WGS)-based approaches) combined with cross-sectional and longitudinal deep-phenotyping in (i) cross-European cohort A (70 families) with ≥2 features of CANVAS and/or ataxia-with-chronic-cough (ACC); and (ii) Turkish cohort B (105 families) with unselected late-onset ataxia. Results:...

Differentiating causes of febrile illness in Burkina Faso: data from an accuracy study comparing gold standard culture techniques with a haemocytometry based algorithm (IMS), procalcitonin (PCT) and C-reactive protein (CRP)

Annelies Post, Berenger Kaboré, André Van Der Ven & Quirijn De Mast
Different causes of acute febrile illness due to different infectious diseases (e.g. bacterial, viral malaria) may present with a similar clinical presentation. We performed a clinical diagnostic study to assess the diagnostic accuracy of a new tool - the Infection Manager System (IMS) - an algorithm which uses haemocytometric data to predict the cause of infection (e.g. bacterial, viral, malaria). The current dataset is a subset of data obtained during this study which was performed...

sj-rar-3-tej-10.1177_20417314221132093 – Supplemental material for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles

Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao & Guolin He
Supplemental material, sj-rar-3-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering

sj-xlsx-4-npx-10.1177_1934578X221131126 - Supplemental material for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology

Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang & Xiao Liu
Supplemental material, sj-xlsx-4-npx-10.1177_1934578X221131126 for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology by Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang and Xiao Liu in Natural Product Communications

Additional file 1 of Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Jin Wang, Jun Ye, Liqi Yang, Xiangfeng Chen, Haoshu Fang, Zhou Liu, Guomei Xia, Yafei Zhang & Zhenhua Zhang
Additional file 1: The results of next generation sequencing of cerebrospinal fluid.

Additional file 2 of Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Jin Wang, Jun Ye, Liqi Yang, Xiangfeng Chen, Haoshu Fang, Zhou Liu, Guomei Xia, Yafei Zhang & Zhenhua Zhang
Additional file 2: Comparison of the etiological results between conventional detection methods and next-generation sequencing technology.

Morphology and phylogeny of two new Thalassiosiroid taxa (Bacillariophyceae), with two marginal rimoportulae

Biaobiao Niu, Yaqiong Guo, Nina Lundholm & Yang Li
Thalassiosira and related taxa i.e. the taxa within Thalassiosirales are among the most abundant and widespread diatoms. The vast majority have one marginal rimoportula, but very few always have two. The knowledge on Thalassiosiroid taxa in Chinese waters is restricted, and to explore the diversity, monoclonal strains were established from southern Chinese coastal waters. Morphological data were based on light and scanning electron microscopy. The D1‒D3 region of the ribosomal large subunit (LSU) and the...

Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

Hannah C. Slater, Amanda Ross, Ingrid Felger, Natalie E. Hofmann, Leanne Robinson, Jackie Cook, Bronner P. Gonçalves, Anders Björkman, Andre Lin Ouedraogo, Ulrika Morris, Mwinyi Msellem, Cristian Koepfli, Ivo Mueller, Fitsum Tadesse, Endalamaw Gadisa, Smita Das, Gonzalo Domingo, Melissa Kapulu, Janet Midega, Seth Owusu-Agyei, Cécile Nabet, Renaud Piarroux, Ogobara Doumbo, Safiatou Niare Doumbo, Kwadwo Koram … & Lucy C. Okell
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission...

Data from: Nasopharyngeal microbiome profiles in rural Venezuelan children are associated with respiratory and gastrointestinal infections

Lilly M. Verhagen, Ismar A. Rivera-Olivero, Melanie Clerc, Mei Ling N. Chu, Jody Van Engelsdorp Gastelaars, Maartje I. Kristensen, Guy A. M. Berbers, Peter W. M. Hermans, Marien I. De Jonge, Jacobus H. De Waard & Debby Bogaert
Background: Recent research suggests that the microbiota affects susceptibility to both respiratory tract infections (RTIs) and gastrointestinal infections (GIIs). In order to optimize global treatment options, it is important to characterize microbiota profiles across different niches and geographic/socioeconomic areas where RTI and GII prevalences are high. Methods: We performed 16S sequencing of nasopharyngeal swabs from 209 Venezuelan Amerindian children aged 6 weeks–59 months who were participating in a 13-valent pneumococcal conjugate vaccine (PCV13) study. Using...

sj-rar-3-tej-10.1177_20417314221132093 – Supplemental material for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles

Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao & Guolin He
Supplemental material, sj-rar-3-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering

Clinical features in X-linked myotubular myopathy carriers

Stacha Reumers, Frederik Braun, Jennifer Spillane, Johann Böhm, Maartje Pennings, Meyke Schouten, Anneke Van Der Kooi, Reghan Foley, Carsten Bönnemann, Erik-Jan Kamsteeg, Corrie Erasmus, Ulrike Schara-Schmidt, Heinz Jungbluth & Nicol Voermans
Objective: To characterize the spectrum of clinical features in a cohort of X-linked myotubular myopathy (XL-MTM) carriers, including prevalence, genetic features, clinical symptoms and signs, as well as associated disease burden. Methods: We performed a cross-sectional online questionnaire study among XL-MTM carriers. Participants were recruited from patient associations, medical centers and registries in the United Kingdom, Germany and the Netherlands. We used a custom-made questionnaire, the Checklist Individual Strength (CIS), the Frenchay Activities Index (FAI),...

sj-xlsx-1-npx-10.1177_1934578X221131126 - Supplemental material for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology

Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang & Xiao Liu
Supplemental material, sj-xlsx-1-npx-10.1177_1934578X221131126 for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology by Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang and Xiao Liu in Natural Product Communications

sj-xlsx-4-npx-10.1177_1934578X221131126 - Supplemental material for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology

Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang & Xiao Liu
Supplemental material, sj-xlsx-4-npx-10.1177_1934578X221131126 for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology by Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang and Xiao Liu in Natural Product Communications

sj-xlsx-3-npx-10.1177_1934578X221131126 - Supplemental material for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology

Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang & Xiao Liu
Supplemental material, sj-xlsx-3-npx-10.1177_1934578X221131126 for Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology by Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang and Xiao Liu in Natural Product Communications

Clinical Significance of HSCARG for Atherosclerotic Coronary Heart Disease and Reduced ROS-Oxidative Stress in in Vivo and in Vitro Models via p47phox by NF-κB Activity

Xiaofang Zhou, Siwei Zhou, Yuanmei Li, Zhiyong Qian, Chao Zeng & Yang Li
ABSTRACT Introduction: Coronary heart disease (CHD) is a dynamic process in which there are interactions between endothelial dysfunction, oxidative stress, and inflammatory responses. The aim of the present study was to investigate the function and mechanism of HSCARG in the treatment of CHD. Methods: Male apolipoprotein E/low-density lipoprotein receptor-deficient mice were given a high-fat diet with 21% fat and 0.15% cholesterol for the in vivo model. Human umbilical vein endothelial cells were incubated with angiotensin...

Additional file 1 of Bacterial colonization of the upper airways of children positive and negative for SARS-CoV-2 during the COVID-19 pandemic

Vincentia Rizke Ciptaningtyas, Rebriarina Hapsari, Endang Sri Lestari, Helmia Farida, Quirijn de Mast & Marinus Isaäk de Jonge
Additional file 1. PCR Results.

Heat preparedness and exertional heat illness in Paralympic athletes: A Tokyo 2020 survey

Puck Alkemade, Hein A. M. Daanen, Thomas W. J. Janssen, Elizabeth Broad, Victoria L. Goosey-Tolfrey, Tatsuru Ibusuki, Hiske Kneepkens, Julien D. Périard & Thijs M. H. Eijsvogels
Paralympic athletes may be at increased risk for exertional heat illness (EHI) due to reduced thermoregulatory ability as a consequence of their impairment. This study investigated the occurrence of heat-stress related symptoms and EHI, and the use of heat mitigation strategies in Paralympic athletes, both in relation to the Tokyo 2020 Paralympic Games and previous events. Paralympic athletes competing in Tokyo 2020 were invited to complete an online survey five weeks prior to the Paralympics...

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Resource Types

  • Dataset
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Affiliations

  • Radboud University Nijmegen Medical Centre
    47
  • Sun Yat-sen University
    22
  • Air Force Medical University
    22
  • Sichuan University
    22
  • Capital Medical University
    22
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    22
  • Henan University
    18
  • Minzu University of China
    18
  • Guizhou Center for Disease Control and Prevention
    18
  • University of Michigan–Ann Arbor
    18