Data from: Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection
Nasser M. Al-Daghri, Chiara Pontremoli, Rachele Cagliani, Diego Forni, Majed S. Alokail, Omar S. Al-Attas, Shaun Sabico, Stefania Riva, Mario Clerici & Manuela Sironi
Background: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic/glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels. Results: We analyzed the evolutionary history of G6Pase genes. Results indicated that the three...