295,565 Works

Evaluation of Immunological Parameters in Pregnant Women: Low Levels of B and NK Cells

Juliana Araújo De Carvalho Schettini, Thomás Virgílio Gomes, Claudeir Dias Da Silva Júnior, Sandra De Andrade Heráclio, Isabela Cristina Coutinho De Albuquerque Neiva Coelho & Leuridan Cavalcante Torres
Abstract Objective To describe the immunological and hematological reference intervals of low-risk pregnant women. Methods A cross-sectional retrospective database analysis of a basic and translational study analyzing the hematological evaluation blood counts and immunophenotyping of TCD3 + , TCD4 + , TCD8 + , B, and natural killer (NK) cells of the peripheral blood in 79 low-risk pregnant women and of 30 control women from the state of Pernambuco, Brazil, was performed. Results No significant...

Evaluation of Immunological Parameters in Pregnant Women: Low Levels of B and NK Cells

Juliana Araújo De Carvalho Schettini, Thomás Virgílio Gomes, Claudeir Dias Da Silva Júnior, Sandra De Andrade Heráclio, Isabela Cristina Coutinho De Albuquerque Neiva Coelho & Leuridan Cavalcante Torres
Abstract Objective To describe the immunological and hematological reference intervals of low-risk pregnant women. Methods A cross-sectional retrospective database analysis of a basic and translational study analyzing the hematological evaluation blood counts and immunophenotyping of TCD3 + , TCD4 + , TCD8 + , B, and natural killer (NK) cells of the peripheral blood in 79 low-risk pregnant women and of 30 control women from the state of Pernambuco, Brazil, was performed. Results No significant...

Supplementary Material for: β-Catenin Expression and Activation in Conjunctival Melanoma

E. Larivé, M. Nicolas, G. Kaya, N. Riggi & A.P. Moulin
Purpose: To assess the role of the canonical Wnt pathway via activation of β-catenin in tumor progression of conjunctival melanoma. Methods: β-Catenin localization was assessed by immunohistochemistry in 43 conjunctival nevi, 48 primary acquired melanoses (PAM; conjunctival melanocytic intraepithelial neoplasia), and 44 conjunctival melanomas. Activation of the canonical or the noncanonical Wnt pathway was tested in vitro in 4 conjunctival melanoma cell lines with stimulation of either Wnt5a or Wnt3a. Wound healing assays were performed...

Supplementary Material for: β-Catenin Expression and Activation in Conjunctival Melanoma

E. Larivé, M. Nicolas, G. Kaya, N. Riggi & A.P. Moulin
Purpose: To assess the role of the canonical Wnt pathway via activation of β-catenin in tumor progression of conjunctival melanoma. Methods: β-Catenin localization was assessed by immunohistochemistry in 43 conjunctival nevi, 48 primary acquired melanoses (PAM; conjunctival melanocytic intraepithelial neoplasia), and 44 conjunctival melanomas. Activation of the canonical or the noncanonical Wnt pathway was tested in vitro in 4 conjunctival melanoma cell lines with stimulation of either Wnt5a or Wnt3a. Wound healing assays were performed...

The effect of concentrated transversal force on the moment resistance of rectangular hollow steel section beams

Jacqueline Maria Flor, Ricardo Hallal Fakury, Rodrigo Barreto Caldas & Davi Pedrosa De Aguiar
Abstract This article reports on a preliminary investigation about the effect of concentrated transversal force on the bending moment resistance of rectangular hollow steel section (RHS) beams. Two six-meter-long specimens with yield strength of 300 MPa and cross-section size of 250×150×6.4 mm were subjected to bending tests using a four-point load configuration. A three-dimensional nonlinear finite element model was developed by using the software ABAQUS to simulate the flexural behavior of the RHS beams. The...

The effect of concentrated transversal force on the moment resistance of rectangular hollow steel section beams

Jacqueline Maria Flor, Ricardo Hallal Fakury, Rodrigo Barreto Caldas & Davi Pedrosa De Aguiar
Abstract This article reports on a preliminary investigation about the effect of concentrated transversal force on the bending moment resistance of rectangular hollow steel section (RHS) beams. Two six-meter-long specimens with yield strength of 300 MPa and cross-section size of 250×150×6.4 mm were subjected to bending tests using a four-point load configuration. A three-dimensional nonlinear finite element model was developed by using the software ABAQUS to simulate the flexural behavior of the RHS beams. The...

The Collaborative Construction of the Act of Teaching: Impacts of the A World of Englishes Project in the Context of Initial Training

Alessandra Da Silva Quadros-Zamboni
ABSTRACT This article aims to analyze four aspects related to the implementation of an initial English teacher training project: option for teaching and the project; impressions on the project; impacts of the project on future teachers in training; and what challenges are presented in terms of academic and professional education. The project was based on theoretical conceptions of language as discourse (BAKHTIN, 2010; JORDÃO; FOGAÇA, 2007), critical literacy (CERVETTI; PARDALES; DAMICO, 2001; MUSPRATT; LUKE; FREEBODY,...

The Collaborative Construction of the Act of Teaching: Impacts of the A World of Englishes Project in the Context of Initial Training

Alessandra Da Silva Quadros-Zamboni
ABSTRACT This article aims to analyze four aspects related to the implementation of an initial English teacher training project: option for teaching and the project; impressions on the project; impacts of the project on future teachers in training; and what challenges are presented in terms of academic and professional education. The project was based on theoretical conceptions of language as discourse (BAKHTIN, 2010; JORDÃO; FOGAÇA, 2007), critical literacy (CERVETTI; PARDALES; DAMICO, 2001; MUSPRATT; LUKE; FREEBODY,...

What does the Portuguese Language Textbook Propose When It Comes to the Genre Opinion Article? Investigations on the Portuguese Work: Context, Interlocution and Meaning

Lenilton Damião Da Silva Junior & Débora Amorim Gomes Da Costa-Maciel
ABSTRACT In this work, the didactization of the genre of opinion article is investigated in the textbook collection Português: contexto, interlocução e sentido, with the objective to identify the teaching strategies of the opinion article genre and to reflect on the proposal of the work for the teaching-learning process. The relevance of the object of reflection is emphasized because the article of opinion is a textual/discursive genre that, when didactized, can favor the development of...

Lexical diversity and lexical density description of news written by journalism student

Karina Fuentes Riffo, Sergio Hernández Osuna & Pedro Salcedo Lagos
ABSTRACT The aim of this study is to quantitatively describe the lexical richness in informative news articles written by journalism students through indicators of lexical diversity and lexical density. A comparative analysis of a corpus of news articles written by two groups of undergraduate students (first and fourth year) and a group of graduate journalists was performed. In order to compare the corpora, measures of lexical density and diversity were used while statistical tests were...

What does the Portuguese Language Textbook Propose When It Comes to the Genre Opinion Article? Investigations on the Portuguese Work: Context, Interlocution and Meaning

Lenilton Damião Da Silva Junior & Débora Amorim Gomes Da Costa-Maciel
ABSTRACT In this work, the didactization of the genre of opinion article is investigated in the textbook collection Português: contexto, interlocução e sentido, with the objective to identify the teaching strategies of the opinion article genre and to reflect on the proposal of the work for the teaching-learning process. The relevance of the object of reflection is emphasized because the article of opinion is a textual/discursive genre that, when didactized, can favor the development of...

Lexical diversity and lexical density description of news written by journalism student

Karina Fuentes Riffo, Sergio Hernández Osuna & Pedro Salcedo Lagos
ABSTRACT The aim of this study is to quantitatively describe the lexical richness in informative news articles written by journalism students through indicators of lexical diversity and lexical density. A comparative analysis of a corpus of news articles written by two groups of undergraduate students (first and fourth year) and a group of graduate journalists was performed. In order to compare the corpora, measures of lexical density and diversity were used while statistical tests were...

GRANULOMETRY AND ENERGY CONSUMPTION AS INDICATORS OF DISINTEGRATION EFFICIENCY IN A HAMMER MILL ADAPTED TO EXTRACTING ARROWROOT STARCH (Maranta arundinacea) IN COMPARISON TO STARCH EXTRACTION FROM CASSAVA

Fabiano P. Branco, Marco H. Naka & Marney P. Cereda
ABSTRACT The commercial sector of starch extraction has fully automated plants with a minimum scale of 200 ton.day–1, which extracts starch from maize and cassava in Brazil. Although these starches are commodities, the market demands starches with special properties obtained without chemical modifications. A higher-priced starch can compensate for small-scale extraction, as in the case of arrowroot starch, which would correspond to an alternative income for the producer. As a small-scale equipment was not available...

GRANULOMETRY AND ENERGY CONSUMPTION AS INDICATORS OF DISINTEGRATION EFFICIENCY IN A HAMMER MILL ADAPTED TO EXTRACTING ARROWROOT STARCH (Maranta arundinacea) IN COMPARISON TO STARCH EXTRACTION FROM CASSAVA

Fabiano P. Branco, Marco H. Naka & Marney P. Cereda
ABSTRACT The commercial sector of starch extraction has fully automated plants with a minimum scale of 200 ton.day–1, which extracts starch from maize and cassava in Brazil. Although these starches are commodities, the market demands starches with special properties obtained without chemical modifications. A higher-priced starch can compensate for small-scale extraction, as in the case of arrowroot starch, which would correspond to an alternative income for the producer. As a small-scale equipment was not available...

Recovery of pellet feed from tailings dams

Pedro Ferreira Pinto & Homero Delboni Junior
Abstract Not long ago, certain iron ore processing plants in Brazil were unable to efficiently recover iron ore fines and, as a result, operated only with high grade iron ore. For this reason, material stored in some iron ore tailings dams have considerable amounts of iron content with a potential to produce pellet feed fines through a concentration process. This study presents the results of magnetic concentration tests carried out on samples from four iron...

Recovery of pellet feed from tailings dams

Pedro Ferreira Pinto & Homero Delboni Junior
Abstract Not long ago, certain iron ore processing plants in Brazil were unable to efficiently recover iron ore fines and, as a result, operated only with high grade iron ore. For this reason, material stored in some iron ore tailings dams have considerable amounts of iron content with a potential to produce pellet feed fines through a concentration process. This study presents the results of magnetic concentration tests carried out on samples from four iron...

A social license to operate: pre-mining effects and activities perspective

Adeyinka Oluwayomi Omotehinse & Giorgio De Tomi
Abstract This research proposes a new approach to recommend a responsible mining guideline on how to secure a social license to operate in Ondo state, Nigeria for oil sands mineral resources taking into account the bituminous natural effects. This is the case of bituminous oil sands in Southern Nigeria, where warm weather can induce the emission of natural bitumen fumes. Because this emission may bring occupational exposure to the local communities, mining is perceived to...

A social license to operate: pre-mining effects and activities perspective

Adeyinka Oluwayomi Omotehinse & Giorgio De Tomi
Abstract This research proposes a new approach to recommend a responsible mining guideline on how to secure a social license to operate in Ondo state, Nigeria for oil sands mineral resources taking into account the bituminous natural effects. This is the case of bituminous oil sands in Southern Nigeria, where warm weather can induce the emission of natural bitumen fumes. Because this emission may bring occupational exposure to the local communities, mining is perceived to...

Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress

Juying Zhong, Gonghua Li, Hong Xu, Yan Wang & Mingming Shi
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and 50 mg/kg) significantly increased sucrose consumption and reduced immobility times in the tail suspension and forced swim tests, demonstrating that BA alleviated depression-like behaviors. Moreover, BA reduced the levels of inflammatory cytokines, such as...

Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress

Juying Zhong, Gonghua Li, Hong Xu, Yan Wang & Mingming Shi
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and 50 mg/kg) significantly increased sucrose consumption and reduced immobility times in the tail suspension and forced swim tests, demonstrating that BA alleviated depression-like behaviors. Moreover, BA reduced the levels of inflammatory cytokines, such as...

FSH receptor binding inhibitor up-regulates ARID1A and PTEN genes associated with ovarian cancers in mice

Zhuandi Gong, Xiaoyun Shen, Juan Yang, Kun Yang, Shengju Bai & Suocheng Wei
Experiments were conducted to determine if the follicle-stimulating hormone (FSH) receptor binding inhibitor (FRBI) impacts the expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) in ovaries and blood, as well as expressions of follicle-stimulating hormone cognate receptor (FSHR) gene and proteins. Mice in FRBI-10, FRBI-20, FRBI-30, and FRBI-40 groups were intramuscularly injected with 10, 20, 30, and 40 mg FRBI/kg, respectively, for five consecutive days. Western blotting and...

FSH receptor binding inhibitor up-regulates ARID1A and PTEN genes associated with ovarian cancers in mice

Zhuandi Gong, Xiaoyun Shen, Juan Yang, Kun Yang, Shengju Bai & Suocheng Wei
Experiments were conducted to determine if the follicle-stimulating hormone (FSH) receptor binding inhibitor (FRBI) impacts the expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) in ovaries and blood, as well as expressions of follicle-stimulating hormone cognate receptor (FSHR) gene and proteins. Mice in FRBI-10, FRBI-20, FRBI-30, and FRBI-40 groups were intramuscularly injected with 10, 20, 30, and 40 mg FRBI/kg, respectively, for five consecutive days. Western blotting and...

Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute lung injury by suppression of TLR4/NF-κB signaling activation

Jia Wang, Shi Ming Fan & Jiong Zhang
Acute lung injury (ALI) is a serious clinical syndrome with a high rate of mortality. The activation of inflammation is well-recognized as a vital factor in the pathogenesis of lipopolysaccharide (LPS)-induced ALI. Therefore, suppression of the inflammatory response could be an ideal strategy to prevent ALI. Epigallocatechin-3-gallate (EGCG), mainly from green tea, has been shown to have an anti-inflammatory effect. The aim of the study was to explore whether EGCG alleviates inflammation in sepsis-related ALI....

Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute lung injury by suppression of TLR4/NF-κB signaling activation

Jia Wang, Shi Ming Fan & Jiong Zhang
Acute lung injury (ALI) is a serious clinical syndrome with a high rate of mortality. The activation of inflammation is well-recognized as a vital factor in the pathogenesis of lipopolysaccharide (LPS)-induced ALI. Therefore, suppression of the inflammatory response could be an ideal strategy to prevent ALI. Epigallocatechin-3-gallate (EGCG), mainly from green tea, has been shown to have an anti-inflammatory effect. The aim of the study was to explore whether EGCG alleviates inflammation in sepsis-related ALI....

T cell receptor excision circles as a tool for evaluating thymic function in young children

A. Levy, A. Rangel-Santos, L.C. Torres, G. Silveira-Abreu, F. Agena & M. Carneiro-Sampaio
The thymus is a primary lymphoid organ responsible for the maturation of T cells as well as the immunological central tolerance. It is in the antenatal period and infancy that it plays its major role. In clinical practice, T cell receptor excision circles (TRECs) are considered a direct and reliable measure of the thymic function. TRECs are a by-product of DNA formation in gene rearrangement of T cell receptors. They are stable and they do...

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