212 Works

MAGNETIZATION DYNAMICS IN A MODIFIED SQUARE ARTIFICIAL SPIN ICE

Amrit P. Kaphle
Artificial spin ices are magnetic metamaterials consisting of nanomagnet arrays in a 2-D lattice. Typically, these nanomagnet arrays are binary macrospins that can only be in an up or down state similar to the Ising spins. They have been intensively used to study magnetic frustration and ordering phenomena in a controlled environment. The hexagonal artificial spin ice and square artificial spin ice are among the most heavily studied systems. In this dissertation, we designed a...

SYNTHESIS OF 6,6- AND 7,7-DIFLUORO-1-ACETAMIDOPYRROLIZIDINES AND THEIR OXIDATION CATALYZED BY THE NONHEME Fe OXYGENASE LolO

Nabin Panth
One of the remarkable steps in loline alkaloid biosynthesis is the installation of an ether bridge between two unactivated C atoms in 1-exo-acetamidopyrrolizidine (AcAP). LolO, a 2-oxoglutarate-dependent nonheme Fe oxygenase, catalyzes both the hydroxylation of AcAP and the resulting alcohol's cycloetherification to give N-acetylnornoline (NANL). The mechanism of hydroxylation is well understood, but the mechanism of the oxacyclization is not. I synthesized difluorinated analogs of AcAP in an attempt to further understand the mechanism of...

APOE GENOTYPE AND CEREBRAL GLUCOSE METABOLISM

Holden Williams
Apolipoprotein E (APOE) is encoded by the APOE gene, present in humans as three main isoforms (E2, E3, and E4). E4 carriers face up to a 15-fold increased risk for developing late-onset Alzheimer’s disease (AD), while E2 carriers are protected. Understanding the risk conferred by E4 has been an extensive research focus for nearly three decades, but the exact mechanism has yet to be proven. Many studies have demonstrated attenuated roles of E4 in classical...

\"IT'S NOT RAINBOWS AND UNICORNS\"

Hugh Deaner
This dissertation examines the regulated oilsands mining industry of Alberta, Canada, widely considered the world’s largest surface mining project. The industrial processes of oilsands mining produce well over one million barrels of petroleum commodities daily, plus even larger quantities of airborne and semisolid waste. The project argues for a critical account of production concretized in the co-constitutional relations of obdurate materiality and labor activity within a framework of regulated petro-capitalism. This pursuit requires multiple methods...

When Should Sales Managers Get Involved in Their Salesteams' Transactions

Daniel E. Chavez
The existing literature on sales teams explores various aspects of team members and their effects on sales performance. The literature on sales management has described how managers can promote better results from salespeople. The question at the intersection of these two streams of literature – if managers should be part of sales teams -- has not been addressed and is what we explore. Using data from a Fortune 1,000 firm that operates automotive service stores...

Mild Cognitive Impairment in Presurgical Deep Brain Stimulation for Parkinson's Disease

Elizabeth Wallace
Although clinically characterized by motor impairments, Parkinson's disease (PD) often affects cognition early in the disease course. Cognitive changes common in PD include visuospatial abnormalities and prominent executive function (EF) deficits, with 30% of individuals eventually developing Parkinson’s disease dementia (PDD). Mild cognitive impairment (MCI) has been identified as a transitional state between normal cognition and PDD. A large cohort of individuals with PD at the Kentucky Neuroscience Institute have undergone pre-surgical evaluations for deep...

OTAVALAN WOMEN WEAVERS

Kaitlin Zapel
This research focuses on the gendered labor of craft production and distribution of Otavaleños, an indigenous group in the Imbabura Valley in the Andes Mountains of Ecuador. Otavalans are often described as a society of weavers with strong gender divisions. Households typically function as units of production, with tasks ideally broken down along gender lines. Women are generally depicted as secondary workers who do not weave the textiles that make Otavalans famous; however, they are...

A Decoupled Engineering Methodology for Accurate Prediction of Ablative Surface Boundary Conditions in Thermal Protection Systems

Justin Cooper
The main objective of the present work is to demonstrate a method for prediction of aerothermal environments in the engineering design of hypersonic vehicles as an alternative to the current heritage method. Flat plate and stagnation point boundary layer theory require multiple assumptions to establish the current engineering paradigm. Chief among these assumptions is the similarity between mass and heat transfer. Origins of these assumptions are demonstrated and their relationship to conservative engineering design is...

Structural basis of bacterial flagellin for NAIP5 binding and NLRC4 inflammasome activation and the mechanism of flagellin induced release of cytokines in vivo

Jian Cui
The bacterial flagellum is a whip-like structure that protrudes from the cell membrane and is one of the most complex and dynamic biological molecular machines that propels bacteria to swim toward beneficial environments and the sites of infection. It is composed of a basal body, a hook, and a long filament. The flagellar filament contains thousands of copies of the protein flagellin (FliC) monomer arranged helically and ending with a filament cap composed of oligomer...

QUANTITATIVE METHODS FOR TOTAL LIFECYCLE RISK LIKELIHOOD AND IMPACT ASSESSMENT IN SUSTAINABLE PRODUCT DESIGN DECISION MAKING

Christian Enyoghasi
Sustainable products promise significant economic, environmental, and societal benefits. Numerous methods are available for use during the new product development process to identify alternate product designs that optimize sustainability performance. Once any such design is selected and the product is launched, many uncertainties are likely to affect its performance over the total lifecycle. Such uncertainties give rise to risks that can influence the overall product sustainability performance. However, comprehensive quantitative methods to evaluate the likelihood...

Models and Optimal Controls for Smart Homes and their Integration into the Electric Power Grid

Huangjie Gong
Smart homes can operate as a distributed energy resource (DER), when equipped with controllable high-efficiency appliances, solar photovoltaic (PV) generators, electric vehicles (EV) and energy storage systems (ESS). The high penetration of such buildings changes the typical electric power load profile, which without appropriate controls, may become a “duck curve” when the surplus PV generation is high, or a “dragon curve” when the EV charging load is high. A smart home may contribute to an...

THE (MILLENNIAL) TIMES, THEY ARE A’CHANGIN’

Hayley Hoffman
Drawing from over a decade of research, it can be said with relative certainty what millennial learners expected of their instructors when they were in the college classroom. But what about the expectations and needs of our current group of students, Generation Z? Because few studies exist on Gen Z in higher education spaces, this dissertation establishes a baseline of what these students might need and expect from market and generational research on this group...

TRANSFORMATIVE LEARNING THROUGH ORAL NARRATIVE IN A PARTICIPATORY COMMUNICATION CONTEXT

Charles Madinger
This research investigates instructional narrative interventions for transformative learning among high orality reliant peoples. Two research questions asked: “Does an oral strategy of radio drama in a participatory environment lead to significant changes in knowledge and beliefs,” with a hypothesis stating there would be significant positive changes; and “When listeners experience narrative transport can it affect receptivity leading to knowledge and belief change,” and the hypothesis stated that narrative transport would correlate to higher positive...

REGULATORY MECHANISMS IN ARABIDOPSIS EMBRYOGENESIS

Sanjay Joshi
Plants have amazing regeneration properties with single somatic cells, or groups of cells able to give rise to fully formed plants. One means of regeneration is Somatic Embryogenesis (SE), by which an embryonic structure is formed that “converts” into a plantlet. Somatic embryogenesis has been used as a model for zygotic processes that are buried within layers of maternal tissues. Understanding mechanisms of somatic embryo induction and development are important as a more accessible model...

Quantifying Crop Phenology for Food Sustainability under Climate Change

yanjun yang
Climate change is projected to continue and accelerate significantly in the future if global greenhouse gas emissions are not curbed. Previous studies have shown that crop growth and production in agroecosystems are primarily determined by the weather conditions over the growing season. Crop phenology represents one of the most critical indicators in determining crop yield and adjusting the adaptation of crops to climate change. It provides essential information for monitoring and modeling crop growth dynamics...

PHOTOCATALYTIC APPLICATIONS OF TiO2 FOR CATECHOL DEGRADATION AND α-Fe2O3 FOR CARBON DIOXIDE REDUCTION AT AIR-SOLID INTERFACE

Md. Ariful Hoque
Natural and anthropogenic processes are emitting organic and inorganic pollutants, such as phenolic compounds, carbon dioxide (CO2), etc. in the atmosphere, which are increasing with time. In addition, to meet the energy demand of world’s growing population using nonrenewable fossil fuels are causing its depletion. Therefore, development of new technologies that can minimize atmospheric pollution and contribute to energy demand is imperative. Many methods or technologies have been developed for addressing those issues so far...

Social and Biological Determinants of Pregnancy-Related Mortality and Morbidity in a Rural, Underserved Population

Anna Hansen
Cases of severe maternal morbidity (SMM) and pregnancy-related mortality (PRM) are increasing in the US. Research concerning SMM and PRM has neglected women in Central Appalachia; a largely rural, health-disparate population. The aims of this study are two-fold: (1) Examine patient-level and place-based predictors of SMM/PRM via hierarchical logistic regression modeling, and (2) Elucidate Appalachian healthcare patients’ and providers’ experiences with SMM/PRM, perceptions of contributing factors, and insights on points of intervention. This study uses...

The Role of Sexual Difference in Plato's Timaeus

Mary Cunningham
My dissertation is a reading of Plato’s Timaeus that centers sexual difference and in particular femininity. I analyze the role of sexual difference in the framing of the dialogue as well as its accounts of body in the first and second discourse and its account of health in the third discourse. I argue that sexual difference, and, in particular, sexual reproduction, serves as a guiding paradigm of Timaeus’ entire project. I argue in each part...

The Fantastic Debate

Morgan Keith Stewart
This dissertation analyzes fantastic short fiction in terms of its relationship to the traditionalist and progressive forces that were vying for hegemonic control over Spanish national identity in the ever-changing period of the nineteenth century, demonstrating how these powers shaped Spain’s past and future national character to suit ideologically driven narratives and revealing how fantastic literature can disrupt these narratives to unlock new patterns of thought. In Chapter 1, entitled “Fantastic Short Fiction and National...

KAROL LIPIŃSKI AS A MUSICAL INTERPRETER IN THE PRE-JOACHIM ERA

Andrzej Kunecki
The work concerns a study of Karol Lipiński – the early nineteenth century Polish violinist – focusing on his activity as a musical interpreter. The work is supported by a comparison with another violinist acknowledged in this field – Joseph Joachim. The work is divided between four chapters: The first chapter begins with a discussion on the development of the concept of musical interpretation in the context of the broader social and aesthetical changes of...

Inverse Boundary Value Problems for Polyharmonic Operators With Non-Smooth Coefficients

Landon Gauthier
We consider inverse boundary problems for polyharmonic operators and in particular, the problem of recovering the coefficients of terms up to order one. The main interest of our result is that it further relaxes the regularity required to establish uniqueness. The proof relies on an averaging technique introduced by Haberman and Tataru for the study of an inverse boundary value problem for a second order operator.

Tropical Geometry of T-Varieties with Applications to Algebraic Statistics

Joseph Cummings
Varieties with group action have been of interest to algebraic geometers for centuries. In particular, toric varieties have proven useful both theoretically and in practical applications. A rich theory blending algebraic geometry and polyhedral geometry has been developed for T-varieties which are natural generalizations of toric varieties. The first results discussed in this dissertation study the relationship between torus actions and the well-poised property. In particular, I show that the well-poised property is preserved under...

Analysis of Graded Sensorimotor Rhythms for Brain-Computer Interface Applications

Chase Haddix
The emerging field of neural engineering is tasked with applying engineering principles towards understanding neuroscience. A by-product of such a venture has been the development of a class of assistive devices known as brain-computer interfaces (BCIs) which link brain activity to actions performed by external devices. One application of this technology is in the rehabilitative sector for individuals with neuromuscular diseases and disorders. Despite tremendous efforts in the last few decades, a reliable signal that...

The microbiome of the equine roundworm, Parascaris spp.

Jennifer Cain
Parasitic nematodes, including the large roundworms colloquially known as ascarids, affect the health and well-being of livestock animals worldwide. The equine ascarid, Parascaris spp., was the first ascarid parasite to develop wide-spread anthelmintic drug resistance, with other species slowly following suit. There are no new classes of anthelmintics currently in development, and a solution to the ever-increasing prevalence of resistance is desperately needed. The microbiome has been shown to be an important factor in the...

DEVELOPMENT AND PSYCHOMETRIC TESTING OF AN INSTRUMENT TO IDENTIFY FACTORS THAT PREDICT INTENTIONS RELATED TO POST-MORTEM ORGAN DONATION AMONG SAUDI ARABIAN NURSES

Salman Alreshidi
Organ donation shortage is a major international concern. Global data on organ donation and transplantation activities from the World Health Organization indicate that in 2019 organs were available for less than 10% of transplantations needed. In Saudi Arabia alone, the organ donation shortage accounts for 28.8% of deaths annually. Nearly 31% of donated organs are from donors outside of the country because many eligible donors in Saudi Arabia do not donate. While post-mortem organ donation...

Registration Year

  • 2022
    212

Resource Types

  • Dissertation
    212

Affiliations

  • University of Kentucky
    212