1,229 Works

Functional connectivity analysis in health and brain disease using in vivo widefield calcium imaging

Julia Verena Cramer
Stroke is one of the leading causes of death and its prevalence is still raising with aging society in future. Despite its major impact, only two specific therapies are approved in clinical practice, today.Thus, hundreds of possible therapies were identified in experimental research, none of them has proven efficiency on human patients. To address this loss in translation from experimental research to clinical practise, several fronts can be scrutinized. Among several options, the establishment of...

Mechanoactivation of protein kinases

Magnus Sebastian Bauer
Zellen fühlen ihre Umgebung, reagieren auf externe Reize und regulieren entsprechend Zelladhäsion, Zellproliferation, Differenzierung, Beweglichkeit und Apoptose. Diese externen Reize umfassen auch mechanische Kräfte die in biochemische Signale umgewandelt werden. Verständnis der zugrundeliegenden molekularen Vorgänge sind ausschlaggebend, um zu erklären wie Kräfte Signaltransduktionswege anstoßen können, um damit eine eindeutige zelluläre Reaktion auszulösen. Mechanoresponsive Proteine ändern ihre Konformation unter der Einwirkung von Kräften und offenbaren dadurch versteckte Bindestellen, die es dem Protein ermöglicht, phosphoryliert zu werden,...

Kurz- und langfristige Ergebnisse der endovaskulären Thrombektomie arterieller Gefäßverschlüsse der unteren Extremitäten

Stephanie Kramer

Investigation of transcription factor alterations in core binding factor leukemia

Enric Redondo Monte

Einfluss RNA-bindender Proteine auf murine T-Zellen in der Tumortherapie

Lukas Mallaun

Psychiatrische Kurz-Psychotherapie (PKP) der Depression

Manuel Peters

Design principles to enhance optoelectronic properties in oligothiophene-based covalent organic frameworks

Niklas Keller

Grammatische Hierarchien in der Sprache von Menschen mit Aphasie

Katharina Bader
Das übergeordnete Ziel der vorliegenden Dissertationsschrift kann mit zwei Fragestellungen beschrieben werden: Einerseits ging es darum, mithilfe von sprachpathologischen, genauer genommen aphasischen Sprachdaten, die Existenz und den Aufbau von grammatischen Hierarchien in der Sprache - in diesem Fall der Hierarchie von verbalen grammatischen Kategorien - zu veranschaulichen und genügend Evidenz für ihr Vorhandensein zu sammeln. Andererseits ging es aber auch darum, basierend auf den ATMM-hierarchischen Erkenntnissen ein sogenanntes diagnostisches Instrumentarium für Sprachtherapeuten zu erstellen, welches...

Kindliche Theory of Mind und Mutter-Kind-Interaktion

Joana Taczkowski
In the current study it was investigated whether a maternal depressive disorder (postpartum or lifetime) influences the mother-infant-interaction in infancy and the later ToM-understanding. Therefore, it was examined if there is a relationship between early mother-infant-interaction and later ToM-understanding. To our knowledge this is the first study that investigated gender as moderator for this relationship and that investigated if the infant’s ability of self-regulation is a predictor for ToM-understanding. It was examined if boys and...

Weak lensing galaxy cluster mass estimates in the dark energy survey

Tamás Norbert Varga
The study of galaxy clusters opens a prominent pathway towards understanding the composition and evolution of the Universe and its hidden dark sector. As galaxy clusters are to a large extent composed of dark matter, practical methods to detect them in observational data do not give direct information about their total masses, and it becomes necessary to make use of other methods such as gravitational lensing to infer their mass distributions. In the first part...

‘I interact therefore I am’

Dimitrios Bolis
That psychological sciences suffer from a profound crisis is probably not extremely controversial. Yet, arguably, the recently debated replication failure is nothing but a symptom of deeply rooted dichotomies and ontological commitments lying at its core. Undeniably, essential aspects of the human condition are typically studied in isolation via applying static categories, while philosophical considerations and human practice are largely neglected. In this context and drawing inspiration from real-life experience through a Vygotskian lens, this...

Matrix algebras, irreducible representation spaces, and relation to particle physics

Brage Gording
In this thesis we study simultaneous realizations of multiple irreducible representations spaces within matrix algebras. In so doing we show how relations between irreducible representation spaces arise as a consequence of expressing fundamental and adjoint representation spaces as linearly independent subspaces. Our work proceeds in two parts. In both cases we work with the algebra M(8,C), which spans the space of eight by eight complex matrices. This space is chosen as it is: the smallest...

Theatrale Interventionen

Simone Niehoff

Munich Pop. Der Maler Michael Langer und sein \"absurder Realismus\" 1965-69

Luisa Nicolina Seipp

Wie ehrlich sollten Ärzte bei der Mitteilung schwerwiegender Diagnosen sein?

Richard Schaefer

Transcatheter Aortic Valve Implantation (TAVI) - Durchführung des minimalistischen Ansatzes (\"The minimalist approach\")

Stephan Schneider

Aspekte deregulierter Genexpression im Hepatoblastom

Alexandra Elisabeth Wagner
Das Hepatoblastom (HB) ist der häufigste maligne Lebertumor im Kindesalter. Seine Entstehung geht auf unreife Lebervorläuferzellen zurück, die eine abnormale Aktivierung von Genen der Embryonalentwicklung und Zelldifferenzierung aufweisen. Generell wird das HB mit einer guten Prognose assoziiert, welche sich allerdings bei gleichzeitiger Manifestation ungünstiger Charakteristika wie fortgeschrittenem Tumorstadium, multifokalem Wachstum oder Metastasierung deutlich verschlechtert. Die molekularen Mechanismen, die einen aggressiveren Tumorphänotyp bedingen, sind bis dato unklar. Die Analyse des Methyloms von 40 pädiatrischen Primärtumoren der...

Supersymmetric theories, boundaries and quantum invariants

Alexander Tabler

Structural and biochemical characterisation of the bacterial Mre11-Rad50 DNA repair complex

Lisa Christine Käshammer

Relation between acoustic and articulatory dimensions of speech sounds

Eugen Klein
In their daily communication, speakers produce speech by pushing a controlled air stream past their vocal folds and through a vocal tract configuration formed by a set of articulators which ultimately results in a certain acoustic output. In this sense, speech and, specifically, speech sounds can be understood as a relation between articulatory and acoustic dimensions. This idea is supported by more recent neuroimaging results which suggest that sensory representations of speech sounds are stored...

Development of new cryogenic detectors to extend the physics reach of the CRESST experiment

Elia Bertoldo

Human circulating T follicular helper cells during viral infection and autoimmunity

Johanna Elisabeth Huber
CD4+ T helper cells orchestrate the adaptive immune response. The differentiation of naïve CD4+ T cells into various functionally different subsets of T helper cells ensures the adaptation of the immune response to the invading pathogen. The T helper cell subset that is responsible for B cell help during affinity maturation in the germinal center (GC) reaction is called T follicular helper (Tfh) cells. Therefore, Tfh cells are crucial to develop long-lasting immunity by ensuring...

Registration Year

  • 2021
    1,229

Resource Types

  • Dissertation
    1,229

Affiliations

  • Ludwig-Maximilians-Universität München
    1,229