Self-organization is an ubiquitous and fundamental process that underlies all living systems. In cellular organisms, many vital processes, such as cell division and growth, are spatially and temporally regulated by proteins -- the building blocks of life. To achieve this, proteins self-organize and form spatiotemporal patterns. In general, protein patterns respond to a variety of internal and external stimuli, such as cell shape or inhomogeneities in protein activity. As a result, the dynamics of intracellular...

DNA is the carrier of the genetic information in all kingdoms of life. Cells face the challenge to pack DNA and ensure its integrity on the one hand while enabling access to the genetic code on the other hand. This holds in particular true for eukaryotes, whose genomes are typically larger than those of prokaryotes and organized in multiple linear DNA molecules, termed chromosomes, within the nuclear envelope. Their genetic information is stored as a...

Wie sind Wissenschaft und Gesellschaft verzahnt und welche Auswirkung haben soziale Prozesse auf die Entwicklung wissenschaftlicher Theorien? Dieses Buch beschreibt einen Rahmen für die übergreifende Betrachtung der Wissenschaft. Von der Wissenschaftstheorie ausgehend werden soziologische wie gesellschaftswissenschaftliche Perspektiven in einer Computersimulation zusammengeführt. Eine eigens in Prolog entwickelten Simulationsumgebung bildet die Grundlage für konkrete Simulationsexperimente und zeigt so Querbeziehungen zwischen verschiedenen Betrachtungsebenen mit entsprechenden Einflussfaktoren auf wissenschaftliche Prozesse. Gefragt wird zum Beispiel danach, welche Auswirkungen Plagiate auf...

In order to answer humanity's ancient question of other life within the Universe, a widely approved starting point is the search for planets in orbit around stars other than our Sun. The effort to find these so-called exoplanets has been steadily advancing throughout the last 25 years. Besides photometric instruments, high-resolution spectrographs are an essential tool in this search for these new worlds. The Wendelstein Observatory in the Bavarian Alps in Germany is a facility...

BACKGROUND: Transcatheter edge-to-edge repair (M-TEER) is the most commonly used non-surgical treatment technique for patients with relevant secondary mitral regurgitation (SMR) and heart failure with reduced ejection fraction (HFrEF). A broad variety of studies and registries have identified different survival predictors after M-TEER and hence outlined the importance of meticulous preprocedural patient selection. So far, two major possible outcome predictors have not been evaluated in the setting of M-TEER treated SMR. First, anatomic and functional...

Recently, the supply of raw materials has come more into focus and with it the potential of waste as a source of secondary raw materials. Municipal solid waste incineration (MSWI) fly ash is regarded as hazardous waste due to its high content of easily soluble salts, heavy metals, and persistent organic pollutants. Therefore, it is disposed of in special landfills, either directly or after processing by stabilization/solidification techniques or recycled underground as filler. The usual...