Additional file 1: Supplementary Figure 1.

Additional file 2: Supplementary Figure 2.

Additional file 3: Supplementary Figure 3.

Additional file 4: Figure sup 4. Transcriptional changes of selected astrocyte-enrichedgenes in apoE-TR mice upon cuprizone-induced demyelination. The CC region of apoE-TR mice treated with normal or CPZ diet was subjected to transcriptomic profiling. Heat map showing transcriptional changes (CPZ vs CTL groups) of selected astrocyte-enriched genes identified from RNA-Seq. The scaled expression value (row Z score) is shown with a blue-red color scheme, denoting red as higher expression, and blue as lower expression.

Additional file 3: Figure sup 3. Similar levels of astrogliosis were observed in apoE-TR mice upon cuprizone-induced demyelination. The astrogliosis in the CC area of CTL (n=5/genotype) and CPZ-treated (n=5-6/genotype) apoE-TR mice was examined by immunostaining for GFAP. (A) Representative images of GFAP+astrocytes in the CC area of apoE-TR mice are shown. Scale bar, 100 µm. (B) The morphology of GFAP+astrocytes in apoE-TR mice are shown. Scale bar, 25 µm. (C) The fold change of...

Additional file 2: Figure sup 2. Lack of effects of cuprizone-induceddemyelination on the blood-brainbarrier integrity among apoE-TR mice. (A) Brain samples ofapoE-TR mice from CPZ-treated group (n=16/genotype) were subjected toimmunofluorescence staining for CLDN5(a tight junction-associated protein) and Glut1 (vascular marker). Representative images of CLDN5 (Green) staining and Glut1 (Red)staining in the CC region of apoE-TR mice are shown. Scale bar, 50 µm. Values are mean ± SEM. One-way ANOVA.N.S. not significant.

Additional file 2: Fig S2. The solid portion was pancreatic tissues composed of acini, ducts, and islets of Langerhans (hematoxylin and eosin [H&E] stain, ×10).

Additional file 2: Fig. S2. Validation of the expression of miRNA targets between NSCLC cells and HBE cells. (A) CircInteractome database ( https://circinteractome.nia.nih.gov/ ) revealed multiple potential miRNA targets of circ_0017109. (B) qRT-PCR analysis of miRNA expression between NSCLC cells and HBE cells. All data were normalized to the expression level in HBE cells. ***, P < 0.001.

Additional file 1: Fig. S1. Circ_0017109 promotes cell growth and inhibits apoptosis of NSCLC cells. (A) Circ_0017109 expression within H1299 and A549 cells after the transfection of si-circ_0017109#2 or si-NC. (B) CCK-8 assay in H1299 and A549 cells after the transfection of si-circ_0017109#2 or si-NC. (C) Apoptosis detection in H1299 and A549 cells after the transfection of si-circ_0017109 or si-NC. **, P < 0.01, and ***, P < 0.001.

Additional file 2: Fig. S2. Validation of the expression of miRNA targets between NSCLC cells and HBE cells. (A) CircInteractome database ( https://circinteractome.nia.nih.gov/ ) revealed multiple potential miRNA targets of circ_0017109. (B) qRT-PCR analysis of miRNA expression between NSCLC cells and HBE cells. All data were normalized to the expression level in HBE cells. ***, P < 0.001.

Additional file 3: Fig. S3. qRT-PCR analysis of FZD2, FZD3, FZD4 and FZD7 in NSCLC cells and HBE cells. All data were normalized to the expression level in HBE cells. *, P < 0.05, **, P < 0.01***, P < 0.001.

Supplementary materials to the article ' National survey on unplanned readmissions for diabetic kidney disease: Insight from a new paradigm of obesity '

Supplementary materials to the article ' National survey on unplanned readmissions for diabetic kidney disease: Insight from a new paradigm of obesity '

Supplementary materials to the article ' National survey on unplanned readmissions for diabetic kidney disease: Insight from a new paradigm of obesity'

Additional file 3: Supplementary Figure 3.

Additional file 4: Supplementary Figure 4.

Additional file 5: Supplementary Figure 5.

Additional file 1: SupplementaryFigure 1. The top 10 cited countrys related to this field.

Additional file 2: SupplementaryFigure 2. The network map of top 10 institutions (A) and the top 10 cited networkmap of institutions in this field (B).

Additional file 3: Figure sup 3. Similar levels of astrogliosis were observed in apoE-TR mice upon cuprizone-induced demyelination. The astrogliosis in the CC area of CTL (n=5/genotype) and CPZ-treated (n=5-6/genotype) apoE-TR mice was examined by immunostaining for GFAP. (A) Representative images of GFAP+astrocytes in the CC area of apoE-TR mice are shown. Scale bar, 100 µm. (B) The morphology of GFAP+astrocytes in apoE-TR mice are shown. Scale bar, 25 µm. (C) The fold change of...

Additional file 5: Supplementary Figure 5.

Additional file 1: Supplementary Figure 1.

Additional file 2: Supplementary Figure 2.

Additional file 1: SupplementaryFigure 1. The top 10 cited countrys related to this field.

Additional file 1: Fig. S1. Circ_0017109 promotes cell growth and inhibits apoptosis of NSCLC cells. (A) Circ_0017109 expression within H1299 and A549 cells after the transfection of si-circ_0017109#2 or si-NC. (B) CCK-8 assay in H1299 and A549 cells after the transfection of si-circ_0017109#2 or si-NC. (C) Apoptosis detection in H1299 and A549 cells after the transfection of si-circ_0017109 or si-NC. **, P < 0.01, and ***, P < 0.001.