Additional file 1: Fig. S1. The mRNA levels of candidate genes in different molecular subtypes of breast cancer. ER/PR+ (ER/PR+ and HER−, n = 685), HER2+ (n = 168), and TNBC (n = 177). TCGA BRCA ER, PR, and HER2 status were retrieved from Thennavan et al. [21].

Additional file 2. Partial plots for continuous candidate predictors of the global logistic generalized additive model. The y-axis contains the REST outcome on the log-odds scale $$(ln(\frac{\hat{y}}{1-\hat{y}}))$$ ( l n ( y ^ 1 - y ^ ) ) , with the patient's predicted probability $$\hat{y}$$ y ^ of developing REST symptoms.

Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. We hypothesized that c-Myc constitutes an important hyperthermia treatment target, and we investigated its contribution to hyperthermia responses in NPC. The growth of the human NPC cell lines CNE1 and CNE2 was analyzed using CCK-8 and clonogenicity assays after 43 °C hyperthermia, knockdown or overexpression of...

Additional file 1: Fig. S1 Leaf- related QTLs on 32 linkage groups from a genetic linkage map of paternal parent (P1).

Supplementary Material 3

Supplementary Material 3

Additional file 1. Complementary transcriptional levels of PACAP receptors and neuronal markers. Overall brain gene expression levels for (A) PACAP receptors, (B) glutamate decarboxylases GAD65 and GAD67, and (C) GABA receptors. Additional naïve dataset was introduced as comparison to previously unknown transcriptional levels in the brain of the analyzed genes, but the values were normalized by the control group (infected) as shown in the previous figures for appropriate comparison. Bar charts represent mean values +...

Additional file 2. Complementary protein levels of neurotrophin receptor TrkB. Overall brain expression levels of TrkB in control vs PACAP-treated animals. Western blot membrane shows two representative samples of each group, and bar charts represent mean values + SEM, n = 4.

Additional file 3. Calibration plots for the logistic regression models MABE = MABESS (left side) and MMBRP (right side) based on the derivation cohort. The Brier score and scaled Brier score of MABE, MABESS was 0.14 and 17.01%, respectively. In contrast, MMBRP had a Brier score and scaled Brier score of 0.14 and 15.41%, respectively.

Previous fMRI research on conscious tactile perception has focused on activity amplitudes instead of utilizing the spatial patterns. In the visual domain, low (spatial) variability of neural responses has been discussed as a marker of stimulus awareness. Here, we take a similar approach to tactile stimulation by investigating trial-to-trial variability of activation patterns as a measure of variability in neural representation.

Additional file 2: Fig. S2 Leaf- related QTLs on 32 linkage groups from a genetic linkage map of maternal parent (P2).

Previous fMRI research on conscious tactile perception has focused on activity amplitudes instead of utilizing the spatial patterns. In the visual domain, low (spatial) variability of neural responses has been discussed as a marker of stimulus awareness. Here, we take a similar approach to tactile stimulation by investigating trial-to-trial variability of activation patterns as a measure of variability in neural representation.

Additional file 2. Complementary protein levels of neurotrophin receptor TrkB. Overall brain expression levels of TrkB in control vs PACAP-treated animals. Western blot membrane shows two representative samples of each group, and bar charts represent mean values + SEM, n = 4.

Additional file 1. Histogram, smooth function and Pearson's correlation coefficients for continuous candidate predictors.

Additional file 2. Partial plots for continuous candidate predictors of the global logistic generalized additive model. The y-axis contains the REST outcome on the log-odds scale $$(ln(\frac{\hat{y}}{1-\hat{y}}))$$ ( l n ( y ^ 1 - y ^ ) ) , with the patient's predicted probability $$\hat{y}$$ y ^ of developing REST symptoms.

Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. We hypothesized that c-Myc constitutes an important hyperthermia treatment target, and we investigated its contribution to hyperthermia responses in NPC. The growth of the human NPC cell lines CNE1 and CNE2 was analyzed using CCK-8 and clonogenicity assays after 43 °C hyperthermia, knockdown or overexpression of...

Additional file 1: Figure S1. Images of neutrophils response to PMA in HC as well as AQP4 + NMOSD patients. Representative fluorescent microscope image of neutrophils from HC (top panel) and AQP4 + NMOSD (lower panel) after exposure to PMA. DNA (Hoechst 33342) in blue, neutrophil elastase (NE) in green and DNA fragments (TUNEL) as well as merged images are shown. Images obtained at 40 × magnification; scale bar 20 µm. HC: n = 3;...

Additional file 1: Figure S1. Images of neutrophils response to PMA in HC as well as AQP4 + NMOSD patients. Representative fluorescent microscope image of neutrophils from HC (top panel) and AQP4 + NMOSD (lower panel) after exposure to PMA. DNA (Hoechst 33342) in blue, neutrophil elastase (NE) in green and DNA fragments (TUNEL) as well as merged images are shown. Images obtained at 40 × magnification; scale bar 20 µm. HC: n = 3;...

Additional file 1: Fig. S1 Leaf- related QTLs on 32 linkage groups from a genetic linkage map of paternal parent (P1).

Cadmium (Cd) was measured in bulk exports of Canada Western Amber Durum collected from 1992–1993 to 2019–2020 shipping years. Cd concentrations decreased by more than a factor of two over this period, from the highest annual median concentration of 0.160 mg/kg in 2003–2004 to the most recent annual median of 0.070 mg/kg for 2019–2020. Over the same time period there was no trend in Cd concentrations in bulk exports of Canada Western Red Spring wheat....

Additional file 1. Histogram, smooth function and Pearson's correlation coefficients for continuous candidate predictors.

Additional file 3. Calibration plots for the logistic regression models MABE = MABESS (left side) and MMBRP (right side) based on the derivation cohort. The Brier score and scaled Brier score of MABE, MABESS was 0.14 and 17.01%, respectively. In contrast, MMBRP had a Brier score and scaled Brier score of 0.14 and 15.41%, respectively.

Supplementary Material 4

Supplementary Material 4

Additional file 2: Fig. S2 Leaf- related QTLs on 32 linkage groups from a genetic linkage map of maternal parent (P2).