766 Works

Additional file 6 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 6. Identification of hUCMSC, primary astrocyte and hUCMSC-derived exosomes. A hUCMSCs were identified by the stem cell makers (CD73, CD90 and CD105) and nonstem cell markers (CD45, CD34 and HLA-DR) expression using flow cytometry. B Primary astrocytes were characterized by immunostaining of GFAP, S100β, Vimentin and morphology in bright filed. C The morphology of exosomes detected by transmission electron microscopy. Scale bar = 200 nm. D Diameters and concentrations of exosomes analyzed by...

Additional file 7 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 7. A Successful delivery of PKH-26 labeled exosomes to the spinal cord lesion. Scale bar = 50 nm. B The successful delivery of miR-146a-5p to the spinal cord lesion.

Additional file 1 of Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonica, in Sichuan province, China

Shen Chen, Ding Lu, Lei Duan, Ben Ma, Chao Lv, Yin-long Li, Shen-ning Lu, Lan-hua Li, Liang Xu, Zi-song Wu, Shang Xia, Jing Xu, Yang Liu & Shan Lv
Additional file 1: Figure S1. The increase rate of frequency by slope from low to high. The increase rate of frequency was defined as the frequency at a specific slope was divided by the accumulated frequency at all observed slopes that were less than the specific slope.

Additional file 10 of Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Additional file 10. Figure S10. (a) T-Distributed Stochastic Neighbor Embedding (t-SNE) plot depicting clusters of all immune and non-immune cells from 24 EMT-6 tumors analyzed by 10× genomics scRNA-seq. (b) Violin plot showing expression of Ptprc (encoding CD45) in all clusters from EMT-6 tumors.

Additional file 10 of Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Additional file 10. Figure S10. (a) T-Distributed Stochastic Neighbor Embedding (t-SNE) plot depicting clusters of all immune and non-immune cells from 24 EMT-6 tumors analyzed by 10× genomics scRNA-seq. (b) Violin plot showing expression of Ptprc (encoding CD45) in all clusters from EMT-6 tumors.

Additional file 4 of Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Additional file 4. Figure S4: The effects of MSA-2 and TGF-β on chemokine production in BMDM. (a-f) Unactivated BMDMs were cultured with MSA-2 for one day, and supernatants were collected for chemokine detection.

Additional file 5 of Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Additional file 5. Figure S5: MSA-2-stimulated IFN-β expression in cancer cells. Three cell lines B16, CT26, and EMT-6 were cultured with MSA-2 for one day, and supernatants were collected for IFN-β detection with ELISA. BMDM and BMDC were used as positive controls.

Additional file 11 of Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Additional file 11. Figure S11. Heatmap showing cluster-specific gene profiles. (a) Macrophage-specific gene profiles. (b) Neutrophil-specific gene profiles. (c) T cell-specific gene profiles. (d) NK cell-specific gene profiles. (e) B cell-specific gene profiles. (f) Monocyte-specific gene profiles. (g) cDC-specific gene profiles. (h) pDC-specific gene profiles. (i) Mast-specific gene profiles.

Additional file 8 of STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment

Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan & Jiang Chen
Additional file 8: Figure S5. The difference of transcriptional expression for NLRC3 and TBK1 between HCC samples and adjacent normal liver tissues in GSE84005 dataset. ***: P < 0.001.

Additional file 8 of STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment

Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan & Jiang Chen
Additional file 8: Figure S5. The difference of transcriptional expression for NLRC3 and TBK1 between HCC samples and adjacent normal liver tissues in GSE84005 dataset. ***: P < 0.001.

Additional file 5 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 5: Figure S5. TPM1 knockdown changes transcriptome associated with glial cells in WT mouse retina. A A heatmap showing DEGs associated with microglia and astrocytes in WT mice following treatments with PBS, or with LPS and siTPM1-1 or siCTR. B–G The expression levels of DEGs associated with M1 (B) or M2 microglia (C, D) and with A1 (E) or A2 astrocytes (F, G) in WT mice after treatment with PBS, or with LPS...

Additional file 9 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 9: Figure S9. DNA sequencing for detecting Rd8-associated single nucleotide deletion. F: Forward; R: Reverse.

sj-tif-1-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-1-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-5-tej-10.1177_20417314221132093 – Supplemental material for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles

Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao & Guolin He
Supplemental material, sj-tif-5-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering

sj-tif-3-cll-10.1177_09636897221129171 – for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

Li Ling, Jiying Hou, Yan Wang, Han Shu & Yubin Huang
sj-tif-3-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

sj-tif-4-cll-10.1177_09636897221129171 – for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

Li Ling, Jiying Hou, Yan Wang, Han Shu & Yubin Huang
sj-tif-4-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

sj-tif-7-cll-10.1177_09636897221129171 – for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

Li Ling, Jiying Hou, Yan Wang, Han Shu & Yubin Huang
sj-tif-7-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

Additional file 3 of Integrated assessment of the clinical and biological value of ferroptosis-related genes in multiple myeloma

Bibo Fu, Ruonan Shao, Huizhong Wang, Guanjun Chen, Shenrui Bai & Hua Wang
Additional file 3: Figure S2. Genetic alterations of the 11 FRGs in CCLE.

Additional file 3 of The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Hongfeng Pan, Zeyi Zhao, Yu Deng, Zhifang Zheng, Ying Huang, Shenghui Huang & Pan Chi
Additional file 3: Figure S3. Age-standardized mortality rate at the global, regional, and national level. (A) Age-standardized mortality rate of early-onset colorectal cancer globally and for 21 GBD regions by SDI, 1990–2019. (B) Age-standardized mortality rates of early-onset colorectal cancer for 204 countries and territories in 2019. The black line represents the expected age-standardized mortality rate of rheumatic heart disease based solely on SDI. GBD: Global Burden of Diseases, Injuries, and Risk Factors Study; SDI:...

Additional file 12 of STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment

Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan & Jiang Chen
Additional file 12: Figure S8. The composition of immunohistochemistry (IHC) staining intensity of VAV1 (A), RHOA (B), and ZC3HAV1(C) in eight clinical tumor samples from patients with HCC and their adjacent liver tissues.

Additional file 14 of STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment

Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan & Jiang Chen
Additional file 14: Figure S10. The relationship between transcriptional expression of VAV1 (A), RHOA (B), and ZC3HAV1 (C) and the infiltration of immune cell subtypes in three independent single-cell sequencing HCC datasets from TISCH database. TISCH: Tumor Immune Single-cell Hub.

Additional file 3 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 3: Figure S3. TPM1 knockdown reduces LPS-induced inflammation and function decline in C57BL/6J mice. A, B mRNA level of TPM1 (A) and IL-10 (B) in C57BL/6 J mouse retinas after treatments with LPS and siCTR or siTPM1-1. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to LPS + siCTR or LPS + siTPM1-1, *p < 0.05, **p < 0.01). n = 4 or...

Additional file 4 of Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma

Jian Zhang, Jianjian Deng, Rui Ding, Jinghong Yuan, Jiahao Liu, Xiaokun Zhao, Tianlong Wu, Jingyu Jia & Xigao Cheng
Additional file 4: Fig. S2. The PPI network.

Additional file 4 of STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment

Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan & Jiang Chen
Additional file 4: Figure S1. The calibration curves at 1-year, 3-year, and 5-year time points were drawn in TCGA-all (A-C) and ICGC (D, E) HCC datasets. The 5-year follow-up data for the ICGC dataset currently is deficient.

Additional file 4 of Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

Changchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng & Shiyan Qiao
Additional file 4: Fig S4. Schematic illustration of DSB induction and homologous recombination. After preparing competent cells, the pTarget-gene and Donor DNA which harbored homology arms (HRR and HRL) that targeted a chromosomal locus spanning the middle of targeted gene and the DSB site were electroporated into cells.

Registration Year

  • 2022
    766

Resource Types

  • Image
    766

Affiliations

  • Sun Yat-sen University
    766
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    518
  • Fudan University
    484
  • Zhejiang University
    466
  • Sichuan University
    461
  • Shanghai Jiao Tong University
    447
  • Huazhong University of Science and Technology
    427
  • Capital Medical University
    395
  • Chinese Academy of Sciences
    370
  • Nanjing Medical University
    357