SOCS3 is low-expressed in breast cancer and may be a potential target. Ultrasound targeted microbubble destruction (UTMD) improved the efficiency of gene transfection. We explored the effects of UTMD-mediated transfection of SOCS3 on the biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells (BCSCs). The expression of SOCS3 in breast cancer (BC) and its association with prognosis were evaluated by GEPIA and The Cancer Genome Atlas (TCGA) websites. BCSCs were sorted by flow...

Additional file 2.

Additional file 12: Fig. S10. Relationship between median contacts and change in mobility and restrictions stringency.

Additional file 5: Fig. S3. Contacts by past SARS-CoV-2 infection status.

Additional file 6: Fig. S4. Contacts by vaccine acceptance attitude (Survey 2 only).

Additional file 1: Figure S1. The increase rate of frequency by slope from low to high. The increase rate of frequency was defined as the frequency at a specific slope was divided by the accumulated frequency at all observed slopes that were less than the specific slope.

Additional file 4: Figure S3. Association between small for gestational age (SGA) and malaria in pregnancy excluding all HIV seropositive women. Panels A and B shows the unadjusted odds ratio (uOR) for SGA when using STOPPAM (SGASTOPPAM) and Intergrowth-21 (SGAIG21) references. Panels C and D shows the adjusted odds ratio (aOR).

Additional file 6: Figure S5. Funnel plots for meta-analysis. The closed dots indicate the observed studies, panel A indicate the trim and fill funnel plot for STOPPAM (P = 0.10) and panel B for Intergrowth-21 reference (P = 0.35). The contour enhanced funnel plot for STOPPAM (panel C) and Intergrowth-21 (panel D) show the distribution of studies in both the small and large p-values contours, hence no publication bias.

Supplemental material, sj-jpg-3-tej-10.1177_20417314221147113 for Construction of a pancreatic cancer nerve invasion system using brain and pancreatic cancer organoids by Chenyun Song, Xinyu Chen, Jixin Ma, Hada Buhe, Yang Liu, Hexige Saiyin and Lixiang Ma in Journal of Tissue Engineering

Additional file 1. Map showing the location of the study villages in Bouaké, Côte d’Ivoire. The pie charts indicate the proportion of houses in each cluster that received the intervention.

Additional file 2. Graph showing the association between endline infection prevalence and malaria case incidence in children aged 6 months to 10 years.

Additional file 1: Figure S1. Dose–response effects of AZD3965 and VB124 for MCT1 and MCT4 on lactate transport. A and B Intracellular lactate levels in MNNG/HOS cells treated with DMSO and AZD3965 (AZD) (A) or VB124 (VB) (B) at different concentrations. C and D Intracellular lactate levels in U-2 OS cells treated with DMSO and AZD (C) or VB (D) at different concentrations. E and F Extracellular lactate levels in MNNG/HOS cells treated with DMSO...

Supplemental material, sj-jpg-1-tej-10.1177_20417314221147113 for Construction of a pancreatic cancer nerve invasion system using brain and pancreatic cancer organoids by Chenyun Song, Xinyu Chen, Jixin Ma, Hada Buhe, Yang Liu, Hexige Saiyin and Lixiang Ma in Journal of Tissue Engineering

Long non-coding RNAs (lncRNAs) are involved in developing hepatocellular carcinoma (HCC). The present study explored the role of lncRNA LINC01194, which is upregulated in HCC tissues and might be a vital regulator in HCC progression. Levels of LINC01194, microRNA (miR)-655-3p, and SMAD family member 5 (SMAD5) were assessed using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). The bioactivity of Huh-7 cells was assessed using cell counting kit-8 and transwell assays and flow cytometry. Western...

SOCS3 is low-expressed in breast cancer and may be a potential target. Ultrasound targeted microbubble destruction (UTMD) improved the efficiency of gene transfection. We explored the effects of UTMD-mediated transfection of SOCS3 on the biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells (BCSCs). The expression of SOCS3 in breast cancer (BC) and its association with prognosis were evaluated by GEPIA and The Cancer Genome Atlas (TCGA) websites. BCSCs were sorted by flow...

Additional file 5: Figure S4. Two stage individual participant data meta-analysis on the association between malaria in pregnancy (MIP) and small for gestational age (SGA) using the STOPPAM (SGASTOPPAM) vs. the Intergrowth-21 reference (SGAIG21). uOR: unadjusted odds ratio in panels A and B, aOR: adjusted odds ratio in panels C and D controlling for body mass index, gravidity, gestational age at enrolment, HIV, and hemoglobin level at enrolment. In addition, adjusted for gestational age at...

Additional file 4: Fig. S2. Contacts by self-reported general health.

Additional file 7: Fig. S5. Contacts by mask ownership.

Additional file 8: Fig. S6. Non-household contacts by household size.

Additional file 11: Fig. S9. Contacts by perceived impact of COVID-19 on health.

Additional file 3: Fig. S1. Contacts by household head education level.

Additional file 5: Fig. S3. Contacts by past SARS-CoV-2 infection status.

The emergence and recurrence of ovarian cancer are associated with ovarian cancer stem cells. For cancer treatment, gene delivery of microbubbles (MB)-mediated microRNA (miRNA) is considered as a promising approach. In this study, our aim is to investigate the effects of MB-mediated let-7b-5p inhibitor on the proliferation and stemness characteristics of ovarian cancer (OVCA) cells. Let-7b-5p inhibitor mediated by MB was prepared (termed MB-let-7b-5p inhibitor), and the effects of MB-let-7b-5p inhibitor and let-7b-5p inhibitor on...

Additional file 1: Figure S1. Analysis work flow, jpg image.

Additional file 1: Figure S1. Dose–response effects of AZD3965 and VB124 for MCT1 and MCT4 on lactate transport. A and B Intracellular lactate levels in MNNG/HOS cells treated with DMSO and AZD3965 (AZD) (A) or VB124 (VB) (B) at different concentrations. C and D Intracellular lactate levels in U-2 OS cells treated with DMSO and AZD (C) or VB (D) at different concentrations. E and F Extracellular lactate levels in MNNG/HOS cells treated with DMSO...