Supplemental material, sj-jpg-3-car-10.1177_19476035231158774 for Adeno-Associated Virus-Delivered Fibroblast Growth Factor 18 Gene Therapy Promotes Cartilage Anabolism by Judith M. Hollander, Alex Goraltchouk, Miraj Rawal, Jingshu Liu, Francesco Luppino, Li Zeng and Alexey Seregin in CARTILAGE

Supplemental material, sj-tif-2-jet-10.1177_15266028231160101 for Deep Learning Prediction for Distal Aortic Remodeling After Thoracic Endovascular Aortic Repair in Stanford Type B Aortic Dissection by Min Zhou, Xiaoyuan Luo, Xia Wang, Tianchen Xie, Yonggang Wang, Zhenyu Shi, Manning Wang and Weiguo Fu in Journal of Endovascular Therapy

Supplemental material, sj-tif-3-jet-10.1177_15266028231160101 for Deep Learning Prediction for Distal Aortic Remodeling After Thoracic Endovascular Aortic Repair in Stanford Type B Aortic Dissection by Min Zhou, Xiaoyuan Luo, Xia Wang, Tianchen Xie, Yonggang Wang, Zhenyu Shi, Manning Wang and Weiguo Fu in Journal of Endovascular Therapy

Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late INa) and Ca2+/calmodulin-dependent protein kinase (CaMKII)-mediated arrhythmogenic activities in β-adrenergic overactivation-associated AF. Monophasic action potential (MAP), conduction properties, protein phosphorylation, ion currents and cellular trigger activities were measured from rabbit-isolated hearts, atrial tissue and atrial myocytes, respectively. Isoproterenol (ISO, 1–15 nM) increased atrial conduction...

Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late INa) and Ca2+/calmodulin-dependent protein kinase (CaMKII)-mediated arrhythmogenic activities in β-adrenergic overactivation-associated AF. Monophasic action potential (MAP), conduction properties, protein phosphorylation, ion currents and cellular trigger activities were measured from rabbit-isolated hearts, atrial tissue and atrial myocytes, respectively. Isoproterenol (ISO, 1–15 nM) increased atrial conduction...

Concentration-response relationships of drug on atrial effective refractory period (aERP) perfused by ISO in the absence and presence of ATX-II.

Concentration-response relationships of drug on atrial effective refractory period (aERP) perfused by ISO in the absence and presence of ATX-II.

Supplemental material, sj-tif-3-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology

Supplemental material, sj-jpg-2-jcb-10.1177_0271678X221145090 for Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice by Tingting Chen, Rubing Shi, Qian Suo, Shengju Wu, Chang Liu, Shuxian Huang, Khan Haroon, Ze Liu, Yuyan He, Heng-Li Tian, Yongting Wang, Yaohui Tang, Guo-Yuan Yang and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-jpg-3-jcb-10.1177_0271678X221145090 for Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice by Tingting Chen, Rubing Shi, Qian Suo, Shengju Wu, Chang Liu, Shuxian Huang, Khan Haroon, Ze Liu, Yuyan He, Heng-Li Tian, Yongting Wang, Yaohui Tang, Guo-Yuan Yang and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-jpg-4-jcb-10.1177_0271678X221145090 for Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice by Tingting Chen, Rubing Shi, Qian Suo, Shengju Wu, Chang Liu, Shuxian Huang, Khan Haroon, Ze Liu, Yuyan He, Heng-Li Tian, Yongting Wang, Yaohui Tang, Guo-Yuan Yang and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-tiff-2-jhc-10.1369_00221554231161693 for Multiplex Immunofluorescence Image Quality Checking Using DAPI Channel–referenced Evaluation by Jun Jiang, Raymond Moore, Clarissa E. Jordan, Ruifeng Guo, Rachel L. Maus, Hongfang Liu, Ellen Goode, Svetomir N. Markovic and Chen Wang in Journal of Histochemistry & Cytochemistry

Genes with sex-biased expression are thought to underlie sexually dimorphic phenotypes and are therefore subject to different selection pressures in males and females. Many authors have proposed that sexual conflict leads to the evolution of sex-biased expression, which allows males and females to reach separate phenotypic and fitness optima. The selection pressures associated with domestication may cause changes in population architectures and mating systems, which in turn can alter their direction and strength. We compared...

Genes with sex-biased expression are thought to underlie sexually dimorphic phenotypes and are therefore subject to different selection pressures in males and females. Many authors have proposed that sexual conflict leads to the evolution of sex-biased expression, which allows males and females to reach separate phenotypic and fitness optima. The selection pressures associated with domestication may cause changes in population architectures and mating systems, which in turn can alter their direction and strength. We compared...

Supplemental material, sj-tif-2-tag-10.1177_17562848231155023 for An explainable artificial intelligence system for diagnosing Helicobacter Pylori infection under endoscopy: a case–control study by Mengjiao Zhang, Jie Pan, Jiejun Lin, Ming Xu, Lihui Zhang, Renduo Shang, Liwen Yao, Yanxia Li, Wei Zhou, Yunchao Deng, Zehua Dong, Yijie Zhu, Xiao Tao, Lianlian Wu and Honggang Yu in Therapeutic Advances in Gastroenterology

Additional file 5: Figure S4. Effect of IRAK-M on activation of JNK and p38 MAPK pathways in A549 cells. Protein expression of p-JNK, JNK, p-p38, p38 after (a) IL-1β (1 ng/ml), (b) TNF-α (10 ng/ml), (c) IL-33 (100 ng/ml) and (d) HDM (10 μg/ml) stimulation for 10, 30 and 60 min. P-JNK was normalized to total JNK, while p-p38 was normalized to total p38. Values are expressed as mean ± SEM (n = 3). *P...

Additional file 3: Fig. S3. Effect of lentivirus treatment for 12 weeks on GFP expression in the hippocampus CA1 and cortex in APP/PS1 mice (400 × , n = 4, bar = 50 μm).

Supplemental Data for "Estradiol Augments Tumor-Induced Neutrophil Production to Promote Tumor Cell Actions in Lymphangioleiomhyomatosis Models"

Additional file 1: Supplementary figure 1.

Additional file 2. Figure S1: Boxplots of GSE84437 (a) and GSE62254 (b) expression profile data.

Additional file 4. Sound field scanning of focused ultrasound transducer. (A) The concave transducer (OLYMPUS V302) with a custom-designed focusing cone (B) filled with agarose gel (1.5%, w/v). The ultrasound transducer’s sound field showed three-dimensional focused area (C) and focal depth (D). A black line shows the edge of the coupling cone; this is the level of contact with the skin. The focused sound field is distributed within 4mm depth (between black and white line)....

Additional file 6. Nerve endings terminate adjacent to ChAT-positive or α7nAChR-positive cell in spleen. Synaptophysin-positive (green) nerve endings were found in close proximity to ChAT-positive (A: red) or α7nAChR-positive (B: red) in LIPUS group of mice (especially white arrow). In statistical analysis, the number of target cell in LIPUS group is normalized to EAM group (bottom). (n=4) * represents LIPUS-0.35 MPa vs. EAM. (Data were shown as the mean ± SD, unpaired T test, Mann-Whitney...

Additional file 7: Supplementary figure 7. The volcano plot of DEGs between the high-risk and low-risk groups. The red dots represent upregulated genes, and the blue dots represent downregulated genes.

Additional file 3: Figure S3. Co expression of CgA, SYN, CD56 and NSE in Adeno-NEPC.

Additional file 2 : Fig. S2 The function validation of the five ERIGs in Hep3B cell using CCK8. *p < 0.05. Data are presented as mean ± SD of at least three independent experiments.