Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the...

The distribution of species of the Drosophila ananassae complex on islands of the Pacific, Australia and New Guinea have been of interest to taxonomists, geneticists, and evolutionists for more than 80 years (Tobari, 1993). Polymorphism in pigmentation, in courtship and sexual behaviour, in polytene chromosomes, in male genital morphology, and in nuclear and mitochondrial DNA, correlate with isolated island populations, especially those at altitude on higher islands. Species’ distributions have been mapped by McEvey &...

To identify the association between the kinetics of viral load and clinical outcome in severe coronavirus disease 2019 (COVID-19) patients, a retrospective study was performed by involved 188 hospitalized severe COVID-19 patients in the LOTUS China trial. Among the collected 578 paired throat swab (TS) and anal swab (AS) samples, viral RNA was detected in 193 (33.4%) TS and 121 (20.9%) AS. A higher viral RNA load was found in TS than that of AS,...

Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

The relationship between sleeping disorders and chronic kidney disease (CKD) has already been reported. Snoring, a common clinical manifestation of obstructive sleep apnea–hypopnea syndrome, is of clinical value in assessing sleeping disorder severity. However, investigations of the connection between snoring and CKD are limited, especially in normal-weight populations. This study assessed the relationship between snoring frequency and CKD in obese and normal-weight people in China. A community-based retrospective cross-sectional study of 3250 participants was performed....

The relationship between sleeping disorders and chronic kidney disease (CKD) has already been reported. Snoring, a common clinical manifestation of obstructive sleep apnea–hypopnea syndrome, is of clinical value in assessing sleeping disorder severity. However, investigations of the connection between snoring and CKD are limited, especially in normal-weight populations. This study assessed the relationship between snoring frequency and CKD in obese and normal-weight people in China. A community-based retrospective cross-sectional study of 3250 participants was performed....

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This black and white line art is connected to a series of illustrations created as responses to research inquiries by reflecting on participant discussions and artworks within four ethics approved workshops.

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This black and white line art is connected to a series of illustrations created as responses to research inquiries by reflecting on participant discussions and artworks within four ethics approved workshops.

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This black and white line art is connected to a series of illustrations created as responses to research inquiries by reflecting on participant discussions and artworks within four ethics approved workshops.

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This black and white line art is connected to a series of illustrations created as responses to research inquiries by reflecting on participant discussions and artworks within four ethics approved workshops.

Diabetes mellitus, as the most common metabolic disease, is common worldwide and represents a crucial global health concern. The purpose of this research was to investigate the related risk factors and to develop a re-amputation risk nomogram in diabetic patients who have undergone an amputation. A observational analysis was performed on 459 patients who have underwent amputation for diabetic foot from January 2014 through December 2019 at the First Affiliated Hospital of Wenzhou Medical University....

'the spaces in-between: a part of the conversation' Exhibition Floorplans

Diabetes mellitus, as the most common metabolic disease, is common worldwide and represents a crucial global health concern. The purpose of this research was to investigate the related risk factors and to develop a re-amputation risk nomogram in diabetic patients who have undergone an amputation. A observational analysis was performed on 459 patients who have underwent amputation for diabetic foot from January 2014 through December 2019 at the First Affiliated Hospital of Wenzhou Medical University....

Additional file 1: Figure S1. Enrichment of differentially expressed genes in lung tissues of neonatal mice with intrauterine inflammation. A Immunofluorescence detection of Pro-SFTPC in the lung tissues of neonatal mice (green, DAPI: blue). C, D GO and KEGG enrichment of the upregulated genes. E, F GO and KEGG enrichment of the downregulated genes.Q-value ≤ 0.05 and fold-change ≥ 2 were used as the thresholds for screening the differentially expressed genes. Data show mean ±...

Additional file 1: Figure S1. Enrichment of differentially expressed genes in lung tissues of neonatal mice with intrauterine inflammation. A Immunofluorescence detection of Pro-SFTPC in the lung tissues of neonatal mice (green, DAPI: blue). C, D GO and KEGG enrichment of the upregulated genes. E, F GO and KEGG enrichment of the downregulated genes.Q-value ≤ 0.05 and fold-change ≥ 2 were used as the thresholds for screening the differentially expressed genes. Data show mean ±...

Additional file 5: Figure S5. The expression of DNA methylation related enzymes in lung tissues and TNF-α-treated MLE-12 cells. A Dnmt1, Dnmt3a, Mbd1, and Tet1 expression analysed using RT-qPCR in lung tissues of neonatal mice. B TNF-α expression analysed using RT-qPCR in lung tissues of neonatal mice. C Dnmt1, Dnmt3a, Mbd1, and Tet1 expression analysed using RT-qPCR in TNF-α-treated MLE-12 cells. D Serpine1 expression analysed using RT-qPCR in TNF-α-treated MLE-12 cells. Data show mean ±...

Supplementary Figure S1. Barplots depicting the metagenome bins recovered after each step from P. lutea and I. palifera skeleton samples. Only High-quality bins were used for performing all the analysis.

Supplementary Figure S1. Barplots depicting the metagenome bins recovered after each step from P. lutea and I. palifera skeleton samples. Only High-quality bins were used for performing all the analysis.

Supplementary Figure S3.Stacked barplots for Relative abundance (>1%) of MAGs taxonomic classes for P. lutea and I. palifera. p_Aenigmatarchaeota, p_Nanoarchaeota, p_Thermoproteota represents the Archaea domain.

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This research, as a 50/50 creative thesis, was an a/r/tographic conversation between a written exegesis and an a/r/t exhibition held on April 1, 2022, at The Melbourne Graduate School of Education. This exhibition presented...

Link to 3D model: https://unimelb.pedestal3d.com/r/nojFcF8kCt This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
‘The Three-Eyed-A/r/tographer’ is a papier mâché sculpture showing the a/r/tographer and their ability to be with the contiguous roles of the artist/researcher/teacher while looking at experiences as an act...

Link to 3D model: https://unimelb.pedestal3d.com/r/nojFcF8kCt This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
‘The Three-Eyed-A/r/tographer’ is a papier mâché sculpture showing the a/r/tographer and their ability to be with the contiguous roles of the artist/researcher/teacher while looking at experiences as an act...

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This black and white line art is connected to a series of illustrations created as responses to research inquiries by reflecting on participant discussions and artworks within four ethics approved workshops.

This artwork belongs to the funded doctoral research project, titled: How Can We Teach/Learn Emotion Words and Complex Abstract Meanings? – A Relational A/r/tographic Conversation In-between Images and Words. Nedasadat Sajadi The University of Melbourne Melbourne Graduate School of Education
This illustration is made using colour pencils on white A3 paper. The artwork is connected to a series of illustrations created as responses to research inquiries. The rhizome illustration shows a living/becoming/changing inquiry as...

'the spaces in-between: a part of the conversation' Exhibition Poster