Additional file 3: Figure S2. The correlation between LARRPM expression, 5hmC level at LINC00240 promoter, CpG43 methylation level and LINC00240 expression in LUAD tissues. A Correlation between LINC00240 and LARRPM expression analysed using the TCGA LUAD data. r = 0.6164, P < 0.0001 by Spearman correlation analysis. B Correlation between LINC00240 and LARRPM expression analyzed in our LUAD cohort. r = 0.5521, P < 0.0001 by Spearman correlation analysis. C 5hmC levels of CpG43 from...

Additional file 5: Figure S4. The correlation between LARRPM expression, 5hmC level at CSF1 promoter, CpG82 methylation level and CSF1 expression in LUAD tissues. A Correlation between CSF1 and LARRPM expression analysed using the TCGA LUAD data. r = − 0.3069, P < 0.0001 by Spearman correlation analysis. B Correlation between CSF1 and LARRPM expression analysed in our LUAD cohort. r = − 0.5774, P < 0.0001 by Spearman correlation analysis. C 5hmC levels of...

Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Additional file 3. Tucidinostat plus checkpoint blockade induces improved therapeutic efficacy. a Schema of the experiment. For bioluminescence imaging (BLI) in vivo, mouse 4T1-luc (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with vehicle (DMSO, n=7), tucidinostat (25 mg/kg, gavage, daily, n=7), aPD-L1 (200 μg, i.p. injection, once every 3 days, n=7), or combination (n=7). Tumors volume...

Supplemental material, sj-jpg-1-tag-10.1177_17562848221131132 for Clip-assisted endoloop ligation of the mucosal defect after resection of colorectal polyps decreased postprocedural delayed bleeding by Jian-hua Xu, Peng Gao, Min Zhou, Shuang Gao, Zhi-qi Dong, Yu-cui Shen and Qi-sheng Zhang in Therapeutic Advances in Gastroenterology

Additional file 2: Fig. S1. JAK1 overexpression suppresses EC cell growth and migration.

Additional file 3: Fig. S2. JAK1 knockdown elevates the expression of HIF downstream genes in SPEC-2 cells.

Additional file 4: Fig. S3. JAK1 overexpression downregulates the expression of HIF downstream genes in Ishikawa cells.

Additional file 3 Supplementary Fig. 3. The combined features about the zinc fingers (ZnFs) for all the mouse KRAB-ZFPs, including the composition specificity and frequency of occurrence. The detailed description is the same as that in Fig. 1C. Each row represents a single KRAB-ZFP.

Additional file 1: Fig. S1. Flowchart of the study design. A. Merge of WES cohorts from five published studies (Hellman et al. [10], Rizvi et al. [11], Miao et al [12, 13], Allen et al. [14], Liu et al. [15]). B. MSKCC cohort from the published study (Samstein et al [16]). C. The TCGA dataset was used to perform DDR-related gene mutation, tumor-infiltrating immune cells and prognostic analyses.

Additional file 2: Fig. S2. The pan-cancer landscape of MED12 mutations across human tumors. The proportion of MED12 mutated tumors identified for each cancer type with alteration frequency in TCGA pan-cancer cohorts.

Additional file 7: Figure S3. Comparsion of CsFLS2 and CsFLS3 with other proteins belonging to DOXC 28/47 subgroup of 2-ODD superfamily.

Additional file 7: Figure S3. Comparsion of CsFLS2 and CsFLS3 with other proteins belonging to DOXC 28/47 subgroup of 2-ODD superfamily.

Additional file 4: Supplementary Figure 4.

Additional file 6: Supplementary Figure 6.

Supplemental material, sj-tif-5-cll-10.1177_09636897221149444 for CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response by Lu Cao, Xiaoqian Ma, Juan Zhang, Min Yang, Zhenhu He, Cejun Yang, Sang Li, Pengfei Rong and Wei Wang in Cell Transplantation

Supplemental material, sj-tif-6-cll-10.1177_09636897221149444 for CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response by Lu Cao, Xiaoqian Ma, Juan Zhang, Min Yang, Zhenhu He, Cejun Yang, Sang Li, Pengfei Rong and Wei Wang in Cell Transplantation

Additional file 2: SupplementaryFigure 2. The network map of top 10 institutions (A) and the top 10 cited networkmap of institutions in this field (B).

Supplemental material, sj-tif-2-jet-10.1177_15266028231160101 for Deep Learning Prediction for Distal Aortic Remodeling After Thoracic Endovascular Aortic Repair in Stanford Type B Aortic Dissection by Min Zhou, Xiaoyuan Luo, Xia Wang, Tianchen Xie, Yonggang Wang, Zhenyu Shi, Manning Wang and Weiguo Fu in Journal of Endovascular Therapy