Long non-coding RNAs (lncRNAs) are involved in developing hepatocellular carcinoma (HCC). The present study explored the role of lncRNA LINC01194, which is upregulated in HCC tissues and might be a vital regulator in HCC progression. Levels of LINC01194, microRNA (miR)-655-3p, and SMAD family member 5 (SMAD5) were assessed using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). The bioactivity of Huh-7 cells was assessed using cell counting kit-8 and transwell assays and flow cytometry. Western...

SOCS3 is low-expressed in breast cancer and may be a potential target. Ultrasound targeted microbubble destruction (UTMD) improved the efficiency of gene transfection. We explored the effects of UTMD-mediated transfection of SOCS3 on the biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells (BCSCs). The expression of SOCS3 in breast cancer (BC) and its association with prognosis were evaluated by GEPIA and The Cancer Genome Atlas (TCGA) websites. BCSCs were sorted by flow...

Additional file 1: SupplementaryFigure 1. The top 10 cited countrys related to this field.

Additional file 2: SupplementaryFigure 2. The network map of top 10 institutions (A) and the top 10 cited networkmap of institutions in this field (B).

sj-tif-12-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

sj-tif-6-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

Coagulation factors participates in the inflammatory cascade, known to play a crucial role in the development of acute kidney injury (AKI). Thus, it’s likely that some factors may be associated with AKI. Among them, low levels of fibrinogen and antithrombin III (ATIII) activity have been proved to increase mortality in patients with sepsis. Moreover, they are also reported to be associated with higher incidence of AKI. However, the association between coagulation parameters, especially fibrinogen and...

BETA PRIME: Phase I study of AdAPT-001 as monotherapy and combined with a checkpoint inhibitor in superficially accessible, treatment-refractory solid tumors Infographic

Additional file 3: Figure S3. ShRNA Panx 1-AAV or Ctrl-AAV-labeled EGFP-positive cells have a sound co-localization with S100 β-labeled Schwann cells. Enlarged images in lower panel are from the inset boxes of upper panel. Upper panel, scale bar = 50 μm. Lower panel, scale bar = 25 μm. n = 3–4 mice/group.

Additional file 6: Figure S6. CBX and Panx 1-siRNA do not affect TGF-β mRNA expression in LPS-treated Schwann cells. A-B. Pretreatment with CBX (100 mM) for 2 h or Panx 1 siRNA for 36 h, qPCR was used to determine TGF-β mRNA expression levels in LPS-treated Schwann cells. All data are mean ± SEM. n = 4.

Additional file 2: Fig. S1. Multicollinearity analysis for Hb, ALT and ALB.

Additional file 2: Fig. S1. A Schematic diagram of the genomic locus of CEBPA-DT (www.ncbi.nlm.nih.gov/). B The protein-coding potential of CEBPA-DT predicted by Open reading frame (ORF) Finder software prediction ( https://www.ncbi.nlm.nih.gov/orffinder/ ). C The protein-coding potential of CEBPA-DT predicted by Coding-Potential Assessment Tool ( wlcb.oit.uci.edu/cpat/ ).

Additional file 6: Fig. S5. A-B The expression levels of DDR2 were measured by western blot and RT-qPCR in indicated HCCLM9 and SNU-449 cells transfected with negative control siRNA or siRNAs targeting DDR2. C-D Cell migration capacity of indicated HCCLM9 and SNU-449 cells were measured by scratch wound-healing assays. Scale bar, 100μm. E-F Cell migration and invasion capacity of indicated HCCLM9 and SNU-449 cells were measured by transwell migration and matrigel invasion assays. Scale bar,...

Additional file 7: Fig. S6. A-B Scratch wound-healing assays showed cell migration capacity of indicated Hep3B and Huh7 cells stably transfected with lentivirus of shDDR2 vectors and control/ CEBPA-DT overexpressing vectors. Scale bar, 100μm. C-D Transwell migration and matrigel invasion assays showed cell migration and invasion capacity of indicated Hep3B and Huh7 cells stably transfected with lentivirus of shDDR2 vectors and control/ CEBPA-DT overexpressing vectors. Scale bar, 100μm. E Representative images (fluorescence) of lung metastatic...

Additional file 4: Figures S3. KEGG pathway enrichment analysis of the 12 differentially expressed proteins.

Additional file 3: Figure S2. Correlation (P values derive from Spearman’s correlation) between DNA methylation and the expression of LIFR-AS1 in CRC samples.

Additional file 3: Figure S2. Correlation (P values derive from Spearman’s correlation) between DNA methylation and the expression of LIFR-AS1 in CRC samples.

Additional file 4: Figure S4. Targeted disruption of the mouse gene encoding SIGIRR. (A), Schematic of Sigirr deletion in C57BL/6 mice and primers for genotyping. The offspring were born at the expected Mendelian ratios. (B), Sigirr genotyping using the F1, F2 and R1 primers listed in the Materials and Methods. The red arrow shows the knockout band (700 bp), and the blue arrow shows the wild-type band (500 bp). (C), Splenomegaly in naïve SIGIRR KO...

Additional file 7: Figure S7. Ectopic expression of SIGIRR in purified CD4+ T cells after transfection with retrovirus packaged by phoenix helper-free retrovirus producer lines. The expression of SIGIRR (50 kDa) and GFP (27 kDa) in CD4 T-cell lysates was detected by immunoblotting with GAPDH as a loading control.

Supplemental material, sj-tif-3-onc-10.1177_11795549221134735 for First-Line Osimertinib in Patients With EGFR-Mutated Non-Small Cell Lung Cancer: Effectiveness, Resistance Mechanisms, and Prognosis of Different Subsequent Treatments by Naifu Nie, Jianghua Li, Jian Zhang, Jie Dai, Zhulin Liu, Zhenyu Ding, Yubo Wang, Mengxiao Zhu, Chen Hu, Rui Han, Huan Tang, Li Li and Yong He in Clinical Medicine Insights: Oncology

Additional file 1: Figure S1. WB raw data of Figure 2A.

Additional file 3: Figure S3. WB raw data of Figure 4A.

Additional file 3: Figure S3. WB raw data of Figure 4A.

Research Data for Risk factors for fracture in patients with fibrous dysplasia of the proximal femur by Wenzheng Liu, Ming Xu and Xiuchun Yu in Journal of International Medical Research

Additional file 10: Fig. S10 The association between extracranial and intracranial PFS with tumor/EGFR clonal status in CSF and plasma samples after 8 weeks of treatment.