Supplemental material, sj-png-1-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

Supplementary retrieval methods Supplementary tables 1-2 Supplementary figures 1-10 PRISMA

Supplementary retrieval methods Supplementary tables 1-2 Supplementary figures 1-10 PRISMA

Additional file12: Supplementary Figure S12. Spearman correlation between NRGs expression level and IC50 level of drugs. A Bubble chart for CESC. B Bubble chart for OV. C Bubble chart for UCEC. D Bubble chart for UCS. The bubble color indicates the degree of correlation index. The bubble size indicates the P-value. The correlation with P<0.05 & |Cor|>0.3 were retained to produce the figure.

Additional file 2 Supplementary Fig. 2. A phylogenetic tree demonstrates the genetic distance among all mouse KRAB-Zfp genes. The detailed description is the same as that in Fig. 1B.

Additional file 2: Figure S2. MICAL1 promoted the transcription of target genes by phosphorylating TBC1D1. A Exogenous immunoprecipitation assays confirmed that MICAL1 associated with TBC1D1. B Western blot was used to detect the expression of TBC1D1 phosphorylated at Ser660 site in cells treated with cytochalasin D (10uM). C Target genes of WNT/β-catenin pathway were detected in MICAL1 overexpression PC cells with or without interference of TBC1D1. D Target genes of WNT/β-catenin pathway were detected in...

Additional file 2: Fig. S2 Consistency of genomic alterations between tumor tissues and liquid biopsies.

Additional file 5: Fig. S5 Dynamic changes in ctDNA concentration and radiographic tumor responses.

Additional file 2. The function of tucidinostat on tumor immunity. a Functional annotation clustering of genes regulated in tumor from CT26 tumor-bearing mice on day 10 post treatment with tucidinostat (25 mg/kg, gavage, daily, n=3) or DMSO as vehicle control (DMSO, n=3). b Representative cytograms (left) or summary histograms (right) for the cell surface PD-L1 expression in CT26 cells following different doses (2.5, 5, 7.5 μM) of vorinostat, tucidinostat, and TMP-195 treatment for 24h. c...

Additional file 7 Supplementary Fig. 7. ZnF fingerprints analyses for human KRAB-ZFPs on chr19. The combined features about the ZnF fingerprints for KRAB-ZFPs for all the human KRAB-ZFPs on chromosome 19. The detailed description is the same as that in Fig. 1C. Each row represents a single KRAB-ZFP.

Additional file 6: Fig. S6 Concordance of ctDNA response and radiographic response.

Additional file 5: Figure S4. Prediction of 6 miRNAs (miR-29b-3p, miR-4677-3p, miR-144-3p, miR-30b-5p, miR-30e-5p and miR-374b-5p) targeting LIFR-AS1 in CRC.

Additional file 4: Figure S4. Percentage of integration events at each genomic features based on gender and transduction efficiency. Related to Figure 6.

Additional file 1: Supplementary figure 1. Functional enrichment analyses of differentially expressed genes (DEGs) in chronic lymphocytic leukemia (CLL) cell lines. (A) GO analysis results showed that changes in MF, CC and BP of DEGs between CLL cell lines and control were mainly enriched in sequence−specific DNA binding, Golgi membrane and cation transmembrane transport. (B) KEGG enrichment analysis of DEGs in CLL cell lines and control were mainly enriched in mTOR signaling pathway, NF-kappaB signaling...

Additional file 1: Supplementary figure 1. Functional enrichment analyses of differentially expressed genes (DEGs) in chronic lymphocytic leukemia (CLL) cell lines. (A) GO analysis results showed that changes in MF, CC and BP of DEGs between CLL cell lines and control were mainly enriched in sequence−specific DNA binding, Golgi membrane and cation transmembrane transport. (B) KEGG enrichment analysis of DEGs in CLL cell lines and control were mainly enriched in mTOR signaling pathway, NF-kappaB signaling...

Additional file 3: Supplementary figure 3. The expression of TRIM34, SLC30A10, HOXD4 and circ_0007675 in CLL patients and normal B cells.(A) The expression of TRIM34 in patient specimens were significantly increased. (B) The expression of SLC30A10 in patient specimens were significantly increased. (C) The expression of HOXD4 in patient specimens were significantly increased. (D) The expression of circ_0007675 in patient specimens were significantly increased. All results are expressed as mean ± SEM.

Additional file 4: Supplementary figure 4. Efficiency of miR-185-3p transfection and functional enrichment analyses of target genes of circ_0002078. (A) Efficiency verification of miR-185-3p overexpression in MEC-1 cells by qRT-PCR. (B) GO analysis results demonstrated that the target genes of circ_0002078 were enriched in positive regulation of gene expression, lymphocyte proliferation, and regulation of B cell apoptotic process. (C) KEGG pathway analysis showed that the target genes were primarily relevant to JAK-STAT signaling pathway and...

Additional file 2: Supplementary Figure 1. Forest plots of ACE I/D polymorphism associated with susceptibility to prostate cancer based on HWE. ACE I/D: angiotensin-converting enzyme insertion/deletion. A: Model of allelic gene; B: Model of recessive gene inheritance; C: Model of dominant gene inheritance; D: Model of heterozygous gene inheritance; E: Model of homozygous gene inheritance. HWE: Hardy-Weinberg equilibrium.

Additional file 3: Supplementary Figure 2. Funnel plot to detect potential publication bias. A: Model of allelic gene; B: Model of recessive gene inheritance; C: Model of dominant gene inheritance; D: Model of heterozygous gene inheritance; E: Model of homozygous gene inheritance.

Additional file 1: Figure S1.Expression, purification and immunoblot analysis of recombinant PvRAMA protein. A Expression and purification of recombinant PvRAMA (appox. 43 kDa). M, Marker; T, total translation mix; S, supernatant; P, precipitate; Ft, flow through; Ne, elution treated with non-reducing buffer; E, elution treated with reducing buffer. b-d Recombinant PvRAMA protein (appox. 43 kDa) under reducing conditions was probed with the anti-His tag antibody (b), rPvRAMA-immunized mouse serum (c) and PBS-immunized mouse serum (d).

Additional file 7: Fig. S7. Only a few proteins and transcripts have potential impacts on TMA production. A Ranked abundance plot of proteins and transcripts in duck livers. The top 10 most abundant proteins accounted for 12.7% of the total proteins, and the top 10 most abundant transcripts covered 33.8% of all transcripts in this tissue. B Changes in protein and transcript abundances. The upper-right panel shows the proportion of significantly altered proteins and transcripts.

Additional file 6: Figure S1. The representative MS/MS spectrum of LTGMAFR, supporting both B. glabrata and S. mansoni glyceraldehyde-3-phosphate dehydrogenase (G3PDH).

Additional file 3: Figure S2.Comparison of PvRAMA amino acid sequences. The first line was the reference sequence: PvRAMA of the Sal-1 strain. The number of P. vivaxisolates with the same amino acid sequence is shown in parentheses.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that poses a great threat to women's health. MiR-1224-5p is downregulated in the follicular fluid of patients with PCOS, but its role remains largely unknown. In this study, mice were treated with dehydroepiandrosterone (DHEA) to establish an in vivo model of PCOS. We found that enhanced activation of NLRP3 inflammasome was accompanied by downregulation of miR-1224-5p in ovarian tissue of PCOS mice. The effect of miR-1224-5p...

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that poses a great threat to women's health. MiR-1224-5p is downregulated in the follicular fluid of patients with PCOS, but its role remains largely unknown. In this study, mice were treated with dehydroepiandrosterone (DHEA) to establish an in vivo model of PCOS. We found that enhanced activation of NLRP3 inflammasome was accompanied by downregulation of miR-1224-5p in ovarian tissue of PCOS mice. The effect of miR-1224-5p...